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Conserved domains on  [gi|333944015|ref|NP_001207417|]
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cadherin-13 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 3.69e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 117.04  E-value: 3.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 151
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 333944015  152 DMAELVI 158
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 535-628 1.20e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 535 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 613
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944015 614 GTGTLLITLEDVNDN 628
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 296-406 1.02e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 296 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 375
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 333944015 376 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 406
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 208-290 4.37e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.32  E-value: 4.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   208 KVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 287
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 333944015   288 NRP 290
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
415-516 1.71e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  415 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 492
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944015  493 NEDPlvpdvsYGPSSTATVHITVL 516
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 636-727 1.80e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  636 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 711
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944015  712 GKPPMTNITDLRVQVC 727
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 3.69e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.04  E-value: 3.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 151
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 333944015  152 DMAELVI 158
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 535-628 1.20e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 535 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 613
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944015 614 GTGTLLITLEDVNDN 628
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 296-406 1.02e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 296 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 375
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 333944015 376 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 406
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 5.70e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 87.72  E-value: 5.70e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015    74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 151
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 333944015   152 DMAELVI 158
Cdd:smart01055  81 EKKEIKV 87
Cadherin pfam00028
Cadherin domain;
297-398 7.04e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 7.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  297 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 376
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|..
gi 333944015  377 IIEAQDMAGldVGLTGTATATI 398
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 547-630 2.51e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.51e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   547 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 625
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 333944015   626 NDNAP 630
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 208-290 4.37e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.32  E-value: 4.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   208 KVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 287
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 333944015   288 NRP 290
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
415-516 1.71e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  415 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 492
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944015  493 NEDPlvpdvsYGPSSTATVHITVL 516
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
535-623 2.32e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  535 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 613
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 333944015  614 GTGTLLITLE 623
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 414-520 2.88e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 414 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 491
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 333944015 492 enEDPLVPdvsyGPSSTATVHITVLDVNE 520
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 192-288 3.40e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 3.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 192 ILIPENQRQPFPrdVGKV--VDSDRPERSK--FRLtgkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDV 267
Cdd:cd11304    4 VSVPENAPPGTV--VLTVsaTDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 333944015 268 NGKTLEGPVPLEVIVIDQNDN 288
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 315-408 2.23e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 2.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   315 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 394
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 333944015   395 TATIMIDDKNDHSP 408
Cdd:smart00112  68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
191-283 7.14e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 7.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  191 PILIPENQR-QPFPRDVGkVVDSDRPERSK--FRLTGkgvdQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDV 267
Cdd:pfam00028   2 SASVPENAPvGTEVLTVT-ATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944015  268 NGKTLEGPVPLEVIVI 283
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 431-522 1.41e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   431 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 510
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 333944015   511 VHITVLDVNEGP 522
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
636-727 1.80e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  636 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 711
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944015  712 GKPPMTNITDLRVQVC 727
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 636-727 1.46e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 636 VAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 711
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 333944015 712 GKPPMTNITDLRVQVC 727
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 653-727 7.32e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 7.32e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333944015   653 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 727
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 3.69e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.04  E-value: 3.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 151
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 333944015  152 DMAELVI 158
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 535-628 1.20e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 535 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 613
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944015 614 GTGTLLITLEDVNDN 628
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 296-406 1.02e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 296 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 375
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 333944015 376 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 406
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 74-158 5.70e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 87.72  E-value: 5.70e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015    74 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 151
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 333944015   152 DMAELVI 158
Cdd:smart01055  81 EKKEIKV 87
Cadherin pfam00028
Cadherin domain;
297-398 7.04e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 7.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  297 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 376
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|..
gi 333944015  377 IIEAQDMAGldVGLTGTATATI 398
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 547-630 2.51e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.51e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   547 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 625
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 333944015   626 NDNAP 630
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 208-290 4.37e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.32  E-value: 4.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   208 KVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 287
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 333944015   288 NRP 290
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
415-516 1.71e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  415 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 492
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944015  493 NEDPlvpdvsYGPSSTATVHITVL 516
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
535-623 2.32e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  535 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 613
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 333944015  614 GTGTLLITLE 623
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 414-520 2.88e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 414 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 491
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 333944015 492 enEDPLVPdvsyGPSSTATVHITVLDVNE 520
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 192-288 3.40e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 3.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 192 ILIPENQRQPFPrdVGKV--VDSDRPERSK--FRLtgkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDV 267
Cdd:cd11304    4 VSVPENAPPGTV--VLTVsaTDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 333944015 268 NGKTLEGPVPLEVIVIDQNDN 288
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 315-408 2.23e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 2.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   315 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 394
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 333944015   395 TATIMIDDKNDHSP 408
Cdd:smart00112  68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
191-283 7.14e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 7.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  191 PILIPENQR-QPFPRDVGkVVDSDRPERSK--FRLTGkgvdQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDV 267
Cdd:pfam00028   2 SASVPENAPvGTEVLTVT-ATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944015  268 NGKTLEGPVPLEVIVI 283
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 431-522 1.41e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015   431 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 510
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 333944015   511 VHITVLDVNEGP 522
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
636-727 1.80e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015  636 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 711
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944015  712 GKPPMTNITDLRVQVC 727
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 191-288 4.17e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.88  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 191 PILIPENQRQPfpRDVGKVvDSDRPERSK--FRLTGKGVDQEPkGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVN 268
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSI-PTDLIASSGeiIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                         90       100
                 ....*....|....*....|
gi 333944015 269 GKTLEGPVPLEVIVIDQNDN 288
Cdd:cd00031   79 ANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 636-727 1.46e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944015 636 VAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 711
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 333944015 712 GKPPMTNITDLRVQVC 727
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 653-727 7.32e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 7.32e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333944015   653 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 727
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 509-580 7.94e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 35.62  E-value: 7.94e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 333944015  509 ATVHITVLDVNEGPVFYPDpmMVTRQEDLSV-GSVLLTVNATDPDSlqhQTIRYSVYKDPA--GWLNINPiNGTV 580
Cdd:pfam17803   1 ATVTITVTGVNDAPVAVDD--TATVDEDTPVtITGNVLANDTDVDG---DTLTVTSVTGAPayGTLTLNA-DGSF 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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