|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
10-945 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1363.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 10 LPPVYGPADFEARVYACWEQRQAFSPRARGSGTSdsegcdghsrqieggartFVIAIPPPNITGVLHMGHCLNTVLQDIV 89
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEP------------------FTIVIPPPNVTGSLHMGHALNNTLQDIL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 90 IRYQRMAGACTLWIPGTDHAGIATQHVVERALRKEGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERF 169
Cdd:COG0525 65 IRYKRMQGYNTLWQPGTDHAGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 170 TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEKDGALYYVRYPLlprteEEGNGvppplgtaq 249
Cdd:COG0525 145 TMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPL-----ADGSG--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 250 vgeTIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVNRIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTR 329
Cdd:COG0525 211 ---YIVVATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKR 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 330 HSLEAINMLNPDGSLNDQvPAAYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPL 409
Cdd:COG0525 288 HNLPMINILDEDGTINEN-AGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPL 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 410 ASQALAAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQcAQQTVSRVDVQRCAHCGSADITQDPD 489
Cdd:COG0525 367 AKPAIEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTEPEACAKAGSVNLTQDED 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 490 VLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSK 569
Cdd:COG0525 446 VLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSK 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 570 SLNNGVDPLHIIRTYGADALRFTLAFMCAQGQDVLIEMDSFKMGSRFANKVWNASRYILGNLEGRRV-YAIAHVSLTELD 648
Cdd:COG0525 526 SKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVLMNLEGFDPgLDPDPEELSLAD 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 649 RWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQKPDEQEKDRAASVLCTLLEETLRLLHPFL 728
Cdd:COG0525 606 RWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFM 685
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 729 PFVTEEIYRSLSPSVHDTTqaipsgahalLMCAPYPVYVPSRVDARACAHIGAVQEIVRAVRTLRAACGIDPQKAVSVRL 808
Cdd:COG0525 686 PFITEEIWQKLPPRKEGES----------IMLAPWPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLL 755
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 809 RPSSPAQDanaaaqvscvhdpgAVARTYEELICVLAGISSLVYLESDAPKPqvAVATAGTGFELFLVTTEGIDRTMLCAR 888
Cdd:COG0525 756 KGADEADR--------------ARLEENAAYIKRLARLEEITILVDEKPEG--AASAVVGGAEVFLPLEGLIDVEAERAR 819
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*..
gi 3323365 889 LQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLAEARATCHTLAGYLADM 945
Cdd:COG0525 820 LEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARL 876
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
10-947 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1317.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 10 LPPVYGPADFEARVYACWEQRQAFSPrargsgtsdsegcDGHSRQieggarTFVIAIPPPNITGVLHMGHCLNTVLQDIV 89
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKP-------------DDNSKK------PFSIVIPPPNVTGSLHMGHALNNTLQDIL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 90 IRYQRMAGACTLWIPGTDHAGIATQHVVERALRKEGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERF 169
Cdd:PRK05729 66 IRYKRMQGYNTLWLPGTDHAGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERF 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 170 TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEKDGALYYVRYPLlprteEEGNgvppplgtaq 249
Cdd:PRK05729 146 TMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPL-----ADGS---------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 250 vgETIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVNRIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTR 329
Cdd:PRK05729 211 --DYLVVATTRPETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKR 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 330 HSLEAINMLNPDGSLNDQvPAAYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPL 409
Cdd:PRK05729 289 HNLPMINIMDEDGTINEN-PGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPL 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 410 ASQALAAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQCaQQTVSRVDVQRCAHCgsaDITQDPD 489
Cdd:PRK05729 368 AKPALEAVENGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDG-EVYVGREEPEAREKA---LLTQDED 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 490 VLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSK 569
Cdd:PRK05729 444 VLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSK 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 570 SLNNGVDPLHIIRTYGADALRFTLAFMCAQGQDVLIEMDSFKMGSRFANKVWNASRYILGNLEGRRVYAI-AHVSLTELD 648
Cdd:PRK05729 524 SKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWNASRFVLMNLEGADVGELpDPEELSLAD 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 649 RWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQkpdEQEKDRAASVLCTLLEETLRLLHPFL 728
Cdd:PRK05729 604 RWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFM 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 729 PFVTEEIYRSLSpsvhdttqaiPSGAHALLMCAPYPVYVPSRvDARACAHIGAVQEIVRAVRTLRAACGIDPQKAVSVRL 808
Cdd:PRK05729 681 PFITEELWQKLA----------PLGIEESIMLAPWPEADEAI-DEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLL 749
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 809 RPSSPAQDANAAAqvscvhdpgavartYEELICVLAGISSLVYLESDAPKPQVAVATAGTGFELFLVTTEGIDRTMLCAR 888
Cdd:PRK05729 750 KGADAEDRARLEA--------------NEAYIKRLARLESLEILADDEEAPEGAASAVVGGAELFLPLEGLIDVEAELAR 815
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 3323365 889 LQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLAEARATCHTLAGYLADMNG 947
Cdd:PRK05729 816 LEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
10-929 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1022.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 10 LPPVYGPADFEARVYACWEQRQAFSPrargSGTSDSEgcdghsrqieggarTFVIAIPPPNITGVLHMGHCLNTVLQDIV 89
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKP----DGNSNKP--------------PFCIDIPPPNVTGSLHIGHALNWSIQDII 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 90 IRYQRMAGACTLWIPGTDHAGIATQHVVERALRKEGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERF 169
Cdd:TIGR00422 63 ARYKRMKGYNVLWLPGTDHAGIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 170 TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEKDGALYYVRYPLLPRTEEEgngvppplgtaq 249
Cdd:TIGR00422 143 TMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSKDY------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 250 vgetIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVNRIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTR 329
Cdd:TIGR00422 211 ----LVVATTRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKR 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 330 HSLEAINMLNPDGSLNDQVPAaYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPL 409
Cdd:TIGR00422 287 HNLEFINILDEDGLLNENAGK-YQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKL 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 410 ASQALAAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQCAQQTVSRVD---VQRCAHCGSADITQ 486
Cdd:TIGR00422 366 ADKALEAAEEGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEplpDDKTNTGPSVELEQ 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 487 DPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRK 566
Cdd:TIGR00422 446 DTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRK 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 567 MSKSLNNGVDPLHIIRTYGADALRFTLAFMCAQGQDVLIEMDSFKMGSRFANKVWNASRYILGNLEGRRVYAIAHVSLTE 646
Cdd:TIGR00422 526 MSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLELSGGEEKLSL 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 647 LDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQKPDEQEKDRAASVLCTLLEETLRLLHP 726
Cdd:TIGR00422 606 ADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHP 685
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 727 FLPFVTEEIYrslspsvhdttQAIPSGAHAlLMCAPYPVYVPSRVDARACAHIGAVQEIVRAVRTLRAACGIDPQKAVSV 806
Cdd:TIGR00422 686 FMPFITEEIW-----------QHFKEGADS-IMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKV 753
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 807 RLRPSSpaqDANAAAQvscvhdpgavaRTYEELICVLAGISSLVYLeSDAPKPQVAVATAGTGFELFLVTTEGIDRTMLC 886
Cdd:TIGR00422 754 LLIYTE---AETAERL-----------KLNAVDIKGAINFSEVEVV-IEKPEVTEAVVELVPGFEIIIPVKGLINKAKEL 818
|
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 3323365 887 ARLQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLA 929
Cdd:TIGR00422 819 ARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
14-947 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 875.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 14 YGPADFEARVYACWEQRQAFsprargsgtsdsegcdgHSRQIEGGARTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQ 93
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYF-----------------HGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 94 RMAGACTLWIPGTDHAGIATQHVVERALRK-EGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERFTLD 172
Cdd:PRK14900 82 RMSGFNTLWLPGTDHAGIATQMIVEKELKKtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 173 AGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQE-KDGALYYVRYPLlprteEEGNGvppplgtaqvg 251
Cdd:PRK14900 162 EGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEaHQGELWSFAYPL-----ADGSG----------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 252 eTIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVNRIVPIIADS-YVAQDFGTGMVKITPAHDPNDWDIGTRH 330
Cdd:PRK14900 226 -EIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAiLVDPKFGTGAVKVTPAHDFNDFEVGKRH 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 331 SLEAINMLNPDGSLNDQVpAAYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPLA 410
Cdd:PRK14900 305 GLEMITVIGPDGRMTAEA-GPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLA 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 411 SQALAAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQcAQQTVSRVDVQRCAHCGSADITQDPDV 490
Cdd:PRK14900 384 RPAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPD-GHVTVARETPEACSTCGKAELRQDEDV 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 491 LDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSKS 570
Cdd:PRK14900 463 LDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKT 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 571 LNNGVDPLHIIRTYGADALRFTLAFMCAQGQDVLIEMDSFKMGSRFANKVWNASRYILGNLEG--RRVYAIAHVSLTELD 648
Cdd:PRK14900 543 KGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNLSGyqERGEDPARLARTPAD 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 649 RWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQKPDEQEKDRAASVLCTLLEETLRLLHPFL 728
Cdd:PRK14900 623 RWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFM 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 729 PFVTEEIYRSLSPSVHdttqaiPSGAHALLMCAPYPvyVPSRVDARACAHIGAVQEIVRAVRTLRAACGIDPQkavsVRL 808
Cdd:PRK14900 703 PFITEELWHVLRAQVG------ASAWADSVLAAEYP--RKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIPWK----VKL 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 809 RPSSPAQDANAAAQVSCVHDPGAVARTYEelicvLAGISS--LVYLESDAPKPQVAVATaGTGFELFLVTTEGIDRTMLC 886
Cdd:PRK14900 771 GAQAPVEIAVADPALRDLLQAGELARVHR-----VAGVEGsrLVVAAATAPAPQSAVGV-GPGFEVRVPLAGVIDLAAET 844
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3323365 887 ARLQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLAEARATCHTLAGYLADMNG 947
Cdd:PRK14900 845 ARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARAEELREKRGKLEAHRAMLSG 905
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-930 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 795.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 1 MTQKLQKIVLPPV---YGPADFEARVYACWEQRQAFSPRARgsgtsdsegcdghsRQIEGGARTFVIAIPPPNITGVLHM 77
Cdd:PTZ00419 12 DEKKNKKRNISSMaasYDPKEVESGWYEWWEKSGFFKPAED--------------AKSLNSGKKFVIVLPPPNVTGYLHI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 78 GHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERAL-RKEGIHKREVTREQFVARTQQIKDSHQDTIRMQLR 156
Cdd:PTZ00419 78 GHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLmKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 157 KMGASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEKD---------------- 220
Cdd:PTZ00419 158 RLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvev 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 221 GALYYVRYPLLPRTEEEgngvppplgtaqvgetIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVN-RIVPII 299
Cdd:PTZ00419 238 GVLWHFAYPLEDSGQEE----------------IVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPII 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 300 ADS-YVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAINMLNPDGSLNdQVPAAYRGLSCAQARIQIVADLQAHGLLSREE 378
Cdd:PTZ00419 302 ADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKIN-ENGGEFAGMHRFDCRRKIEEELKEMGLLRDKV 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 379 RIVHSVGVCYRCEAVIEPYLSLQWFVKMKPLASQALAAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPV- 457
Cdd:PTZ00419 381 PNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAy 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 458 ----------------WYCAQCAQQTVSRVDVQRCAHCGSADITQDPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTS 521
Cdd:PTZ00419 461 rviskgpetdpsdeepWVVARSEEEALEKAKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTS 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 522 AVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHII-------------------- 581
Cdd:PTZ00419 541 LLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIegislqdlnqklyegnlpek 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 582 ----------RTY-------GADALRFTLAFMCAQGQDVLIEMDSFkMGSR-FANKVWNASRYILGNLEGRRVYAIAHV- 642
Cdd:PTZ00419 621 eikraielqkKEFpngipecGTDALRFGLLAYTQQGRNINLDINRV-VGYRhFCNKLWNAVKFALMKLLKDFNLPNSTLf 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 643 ------SLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQKPDEQEKDRAAS-VLCT 715
Cdd:PTZ00419 700 kpnnveSLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGERKQHAQdVLHT 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 716 LLEETLRLLHPFLPFVTEEIYRSLsPSVHDTTQAIpsgahallMCAPYPVYVPSRVDARACAHIGAVQEIVRAVRTLRAA 795
Cdd:PTZ00419 780 VLDIGLRLLHPMMPFITEELYQRL-PNYLRKSESI--------SIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIAT 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 796 CGIDPQKAVSVRLRpsspAQDANAAAQVScvhdpgavarTYEELICVLAGISSLVYL----ESDAPKPQVAVATAGTGFE 871
Cdd:PTZ00419 851 LGIPNKTKPDCYVT----AKDAELIELIE----------SAENLISTLAKIGSVSVIppieEEAEVPKGCGFDVVDNKVI 916
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*....
gi 3323365 872 LFLVTTEGIDRTMLCARLQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLAE 930
Cdd:PTZ00419 917 IYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRKLNDEKIDE 975
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
18-931 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 764.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 18 DF--EARVYACWEQRQAFSPRArgsgtsdsegcdghsrqiEGGARTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRM 95
Cdd:PLN02943 62 DFtsEERIYNWWESQGYFKPNF------------------DRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 96 AGACTLWIPGTDHAGIATQHVVERALRKEGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERFTLDAGM 175
Cdd:PLN02943 124 KGRPTLWIPGTDHAGIATQLVVEKMLASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 176 SASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEKDGALYYVRYPLLPRTEeegngvppplgtaqvgETII 255
Cdd:PLN02943 204 SRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSE----------------DFLT 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 256 IATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMV-NRIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEA 334
Cdd:PLN02943 268 IATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPI 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 335 INMLNPDGSLNDqVPAAYRglscAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPLASQAL 414
Cdd:PLN02943 348 LNVMNKDGTLNE-VAGLYW----FEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKAL 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 415 AAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYC--AQCAQQ-TVSR-----VDVQRCAHCGSADITQ 486
Cdd:PLN02943 423 KAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIvgKDCEEDyIVARsaeeaLEKAREKYGKDVEIYQ 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 487 DPDVLDTWFSSWLWPFSTLGWPQ-ETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGR 565
Cdd:PLN02943 503 DPDVLDTWFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGR 582
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 566 KMSKSLNNGVDPLHIIRTYGADALRFTLAFMCAqGQDVLIEMDSFKMGSRFANKVWNASRYILGNLEGRR-VYAIAHVSL 644
Cdd:PLN02943 583 KMSKTLGNVIDPLDTIKEFGTDALRFTLALGTA-GQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSdTSAWEHILA 661
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 645 TELD------------RWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCS-FQKPDEQEKDRAAS 711
Cdd:PLN02943 662 CKFDkeesllslplpeCWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRlYHSGDNSALSRAQA 741
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 712 VLCTLLEETLRLLHPFLPFVTEEIYrslspsvhdttQAIPSGAHAlLMCAPYPVYVPSRvDARACAHIGAVQEIVRAVRT 791
Cdd:PLN02943 742 VLLYVFENILKLLHPFMPFVTEELW-----------QALPYRKEA-LIVSPWPQTSLPK-DLKSIKRFENLQSLTRAIRN 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 792 LRAACGIDPQKAVSVRLRPSSpaqdanaaaqvscvhdpgAVARTYEELICVLAGISSL----VYLESDAP--KPQVAVAT 865
Cdd:PLN02943 809 ARAEYSVEPAKRISASIVASA------------------EVIEYISKEKEVLALLSRLdlqnVHFTDSPPgdANQSVHLV 870
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3323365 866 AGTGFELFLVTTEGIDRTMLCARLQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLAEA 931
Cdd:PLN02943 871 ASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEA 936
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
3-929 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 646.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 3 QKLQKIVLPPVYGPADFEARVYACWEQRQAFSPRARGSGTSdsegcdghsrqieggartFVIAIPPPNITGVLHMGHCLN 82
Cdd:PLN02381 89 KKRLSSQMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPP------------------FVIVLPPPNVTGALHIGHALT 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 83 TVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERAL-RKEGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGAS 161
Cdd:PLN02381 151 AAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLmRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGAS 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 162 CDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFH---QEKD-------------GALYY 225
Cdd:PLN02381 231 LDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYidiKERTllkvpgydkpvefGVLTS 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 226 VRYPLlprteEEGngvppplgtaqVGEtIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVNRIVPIIADS-YV 304
Cdd:PLN02381 311 FAYPL-----EGG-----------LGE-IVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAiLV 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 305 AQDFGTGMVKITPAHDPNDWDIGTRHSLEAINMLNPDGSLNDQVPAAYRGLSCAQARIQIVADLQAHGLLSREERIVHSV 384
Cdd:PLN02381 374 DPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRL 453
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 385 GVCYRCEAVIEPYLSLQWFVKMKPLASQALAA---WKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCA 461
Cdd:PLN02381 454 GLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAaidGENKKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVT 533
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 462 QCAQQ-----------TVSRVDVQRCAHCGSA------DITQDPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVI 524
Cdd:PLN02381 534 LEDDQlkelgsyndhwVVARNESDALLEASQKfpgkkfELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLE 613
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 525 TAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTY-------------------- 584
Cdd:PLN02381 614 TGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGIsleglhkrleegnldpkelv 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 585 -----------------GADALRFTLAFMCAQGQDVLIEMDSFKMGSRFANKVWNASRYILGNLeGRRVYAIAHVSLTEL 647
Cdd:PLN02381 694 vakegqkkdfpngiaecGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKL-GDDYTPPATLSVETM 772
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 648 D---RWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQKPD---EQEKDRAASVLCTLLEETL 721
Cdd:PLN02381 773 PfscKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAQDTLWICLDTGL 852
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 722 RLLHPFLPFVTEEIYRSLsPSVHDTTQaipsgaHALLMCAPYPVYVPSRVDARACAHIGAVQEIVRAVRTLRAACgidPQ 801
Cdd:PLN02381 853 RLLHPFMPFVTEELWQRL-PQPKDHTR------KDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAEV---LE 922
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 802 KAVSVRLRPSSPAQDANAAAQVSCvhdpgavartYEELICVLAGISSLVYL--ESDAPKPQVAVATAGTGFELFLVTTEG 879
Cdd:PLN02381 923 KQKNERLPAFALCRNQEIAAIIKS----------HQLEILTLANLSSLKVLlsENDAPPAGCAFENVNENLKVYLQAQGA 992
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|
gi 3323365 880 IDRTMLCARLQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLA 929
Cdd:PLN02381 993 VNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPANIQEEDARKLT 1042
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
44-594 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 617.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 44 DSEGCDGHSRQIEGGARTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERAL-R 122
Cdd:pfam00133 7 DEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLgI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 123 KEGIHKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWC 202
Cdd:pfam00133 87 KEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 203 PRCGTALSDDEVFHQEKDGALYYVRYPLlprteeegngvppplgTAQVGETIIIATTRPETILADVAVAVHPD------- 275
Cdd:pfam00133 167 PALNTALSNLEVEYKDVKGPSIHVAFPL----------------ADDEGASLVIWTTTPWTLPGNTAVAVNPEfdyvitg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 276 ------------------------DARYQSLIGRKVCVPMVNRIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTRHS 331
Cdd:pfam00133 231 egyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 332 LEAINMLNPDGSLNDQVPAaYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPLAS 411
Cdd:pfam00133 311 LEVINPVDDDGTFTEEAPD-FQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELAD 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 412 QALAAWKraDVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQ-----CAQQTVSRV--------------- 471
Cdd:pfam00133 390 QALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDteevvCRGELFELVagrfeeegsikwlhr 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 472 DVQRCAHCGSADITQDPDVLDTWFSSWLWPFSTLGWP-QETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPF 550
Cdd:pfam00133 468 EAKDKLGYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPfVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPF 547
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 3323365 551 RDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLA 594
Cdd:pfam00133 548 KNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLA 591
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
61-605 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 603.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 61 TFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERALRKEGIHKREVTREQFVART 140
Cdd:cd00817 2 VFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEKC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 141 QQIKDSHQDTIRMQLRKMGASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVfhqekd 220
Cdd:cd00817 82 WEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 221 galyyvrypllprteeegngvppplgtaqvgetiiiattrpetiladvavavhpddaryqsligrkvcvpmvnrivpiia 300
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 301 dsyvaqdfgtgmvkitpahdpndwdigtrhsleainmlnpdgslndqvpaayrglscaqariqivadlqahgllsreeri 380
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 381 vhsvgvCYRCEAVIEPYLSLQWFVKMKPLASQALAAWKRADVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYC 460
Cdd:cd00817 156 ------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 461 AQCAQQTVSRVDVQR--------CAHCGSADITQDPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFF 532
Cdd:cd00817 230 KDGGHWVVAREEDEAidkaapeaCVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFF 309
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3323365 533 WVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAFMCAQGQDVLI 605
Cdd:cd00817 310 WVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
61-803 |
5.51e-178 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 536.31 E-value: 5.51e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 61 TFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERalrKEGIHKREVTREQFVART 140
Cdd:PRK13208 39 VYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPTERKVEK---YYGIRKDDISREEFIELC 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 141 QQIKDSHQDTIRMQLRKMGASCDWTCERFTldagMSASVR----EAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFH 216
Cdd:PRK13208 116 RELTDEDEKKFRELWRRLGLSVDWSLEYQT----ISPEYRrisqKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEY 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 217 QEKDGALYYVRYPLlprteeegngvppplgtaQVGETIIIATTRPETILADVAVAVHPDDARYQSLIGRKVCVPMVNRIV 296
Cdd:PRK13208 192 REREGKLNYIKFPV------------------EDGEEIEIATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 297 PIIADSYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAINMLNPDGSLNDqVPAAYRGLSCAQARIQIVADLQAHGLLSR 376
Cdd:PRK13208 254 PILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTE-AAGKLAGLTIEEARKKIVEDLKSGGLLGK 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 377 EERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPLASQALaawKRAD-VQFHPKKWENTYVRWLEHIR-DWCISRQLWWGHR 454
Cdd:PRK13208 333 QEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELL---ERGKeINWYPEHMRVRLENWIEGLNwDWCISRQRYFGTP 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 455 IPVWYCAQCAQQTVSR-----VD-------VQRCAHCGSADITQDPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSA 522
Cdd:PRK13208 410 IPVWYCKDCGHPILPDeedlpVDptkdeppGYKCPQCGSPGFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDL 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 523 VITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAfMCAQGQD 602
Cdd:PRK13208 490 RPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAA-SARLGSD 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 603 VLIEMDSFKMGSRFANKVWNASRYILgNLEGRRVYAIAHVsLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFF 682
Cdd:PRK13208 569 TPFDEKQVKIGRRLLTKLWNASRFVL-HFSADPEPDKAEV-LEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFF 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 683 WNSFCDWYVEASKCSFQKPDEQEKDRAA-SVLCTLLEETLRLLHPFLPFVTEEIYRSL-SPSVHDttqaipsgahallmc 760
Cdd:PRK13208 647 WHVFCDDYLELVKSRAYGEDEEEEQKSArYTLYTVLDTLLRLLAPFLPFITEEVWSWLyGGSVHR--------------- 711
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 3323365 761 APYPVYVPSRVDARACAHIGAVQEIVRAVRTLRAACGIdPQKA 803
Cdd:PRK13208 712 ASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGL-SLNA 753
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
14-793 |
8.09e-122 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 391.35 E-value: 8.09e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 14 YGPADFEARVYACWEQRQAFsprargsgtsdsegcdGHSRQIEGGARTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQ 93
Cdd:TIGR00392 6 GNLSKREEKILAFWQENDIF----------------EKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 94 RMAGACTLWIPGTDHAGIATQHVVERALrkeGIHKRE----VTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERF 169
Cdd:TIGR00392 70 TMQGFNVTRKPGWDTHGLPIEHKVEKKL---GISGKKeissLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 170 TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEV-----FHQEKDGALYyVRYPLLPRTEEEGNGVPPP 244
Cdd:TIGR00392 147 TMDPSYEESQWWLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVeykenYKDVKDPSIY-VKFPVKKDKKTYLKVKLSS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 245 LgtaqvgetiIIATTRPETILADVAVAVHPD--------DARYQSLIGRKVCV--------------------------- 289
Cdd:TIGR00392 226 L---------LIWTTTPWTLPSNLAIAVHPDfeyalvqdNTKVEYFILAKKLVeklynkagsdyeiiktfkgsdlegley 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 290 --PMVNRIVP-------IIADSYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAINMLNPDGSLNDQVP------AAYRG 354
Cdd:TIGR00392 297 ehPLYDFVSQlkegapvVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNdfqgrfVKDAD 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 355 LSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFVKMKPLASQALAAWKRadVQFHPKKWENTYV 434
Cdd:TIGR00392 377 KDIIKANKIIIEQLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKK--VNWVPEWGEGRFG 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 435 RWLEHIRDWCISRQLWWGHRIPVWYCAQCAQQTVSRV---------------------------DVQRCAHCGsaDITQD 487
Cdd:TIGR00392 455 NWLENRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGSieelielielkgidawfedlhrdfldkITLKSGDGG--EYRRV 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 488 PDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKM 567
Cdd:TIGR00392 533 PDVLDVWFDSGSMPYASIHYPFENEKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKM 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 568 SKSLNNGVDPLHIIRTYGADALRFTLAfMCAQGQDVLIEMDSFK-MGSRFANKVWNASRYIL--GNLEG--RRVYAIAHV 642
Cdd:TIGR00392 613 SKSLGNVVDPLKVINKYGADILRLYVA-SSDPWEDLRFSDEILKqVVEKYRKIRWNTYRFLLtyANLDKfdPLFNSVAVE 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 643 SLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQKPDEQEKDRAA-SVLCTLLEETL 721
Cdd:TIGR00392 692 KFPEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDNDKRAAqTTLYYALLTLV 771
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3323365 722 RLLHPFLPFVTEEIYRSLS-----PSVHDTtqaipsgahallmcaPYPVYVPSRVDARACAHIGAVQEIVRAVRTLR 793
Cdd:TIGR00392 772 RLLAPFLPHTAEEIYQNLPggeeeESVHLN---------------LWPEVDEEFIDEALEANMAIVREIVEAFLALR 833
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
68-879 |
6.35e-117 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 380.19 E-value: 6.35e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 68 PPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTD-HaGIATQHVVERALRKEGIHKREVTREQFVAR-----TQ 141
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GLPIELKVEKELGIKKKDIEKVGIAEFREKcreyaLK 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 142 QIKDSHQDTIRMqlrkmGASCDWtcER--FTLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEV-FHQE 218
Cdd:COG0060 133 YVDEQREDFKRL-----GVWGDW--DNpyLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVeYKDV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 219 KDGALYyVRYPLLPRTEEEGNGvppplgtaqvGETIIIATTRPETILADVAVAVHPD----------------------- 275
Cdd:COG0060 206 TSPSIY-VKFPVKDEKALLLLE----------DAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtggerlilaealvea 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 276 ---DARYQS-----------LIGRKV-----CVPMVNRIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAIN 336
Cdd:COG0060 275 vlkELGIEDyevlatfkgaeLEGLRYehpfyYVVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLN 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 337 MLNPDGSLNDQVPAaYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEA-VIepYLSL-QWFVKMKPLASQAL 414
Cdd:COG0060 355 PVDDDGRFTEEAPL-FAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTpLI--YRATpQWFISMDKLRDRAL 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 415 AAWKraDVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQC-----AQQTVSRV------------------ 471
Cdd:COG0060 432 EAIE--KVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCgelhrTEEVIGSVaelleeegadawfeldlh 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 472 -----DVQRCAHCGSaDITQDPDVLDTWF---SSwlwPFSTL---------------------GWpqetqklraFYptSA 522
Cdd:COG0060 510 rpfldETLKCPKCGG-TMRRVPDVLDVWFdsgSM---HFAVLenreelhfpadfylegsdqtrGW---------FY--SS 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 523 VITAydiiffwvarMIMAGleftqTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFtlaFMCAQ--G 600
Cdd:COG0060 575 LLTS----------TALFG-----RAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRL---WVASSdyW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 601 QDVLIEMDSFKMGSRFANKVWNASRYILGNLEG--RRVYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAV 678
Cdd:COG0060 637 GDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDfdPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRAL 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 679 YEFFWNSFCDWYVEASK----CSfqKPDEQEKdRAA-SVLCTLLEETLRLLHPFLPFVTEEIYRSL----SPSVHdttqa 749
Cdd:COG0060 717 HNFCVEDLSNWYLDISKdrlyTE--AADSLDR-RAAqTTLYEVLETLVRLLAPILPFTAEEIWQNLpgeaEESVH----- 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 750 ipsgahaLlmcAPYPVYVPSRVDARACAHIGAVQEIVRAVRT----LRAAcGIdpqkavsVRlrpsSPAQdanaAAQVsc 825
Cdd:COG0060 789 -------L---ADWPEVDEELIDEELEAKWDLVREVRSAVLKaleaARKE-KL-------IR----QPLE----AAVV-- 840
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 826 VHDPGAVA---RTYEELICVLAGISSLVYLESDAPKPQVAVAT---AGTGFELFLVTTEG 879
Cdd:COG0060 841 LYADEELAaalESLGDLLAEELNVSEVELVDDAEDLGKDALKAldvEGISVTVEVEKADG 900
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
61-603 |
1.13e-58 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 203.80 E-value: 1.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 61 TFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERALrkeGIHKREVTREQFVART 140
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKG---GRKKKTIWIEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 141 QQIKDSHQDTIRMQLRKMGASCDWTCERFTLDAGMSASVREAFVTLYERGLlyrsmylvnwcprcgtalsddevfhqekd 220
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGL----------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 221 gaLYYVRYPllprteeegngvppplgtaqvgetiiiattrpetiladvavavhpddaryqsligrkvcvpmvnrivpiia 300
Cdd:cd00668 129 --IYRGTHP----------------------------------------------------------------------- 135
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 301 dsyvaqdfgtgmVKITPahdpndwdigtrhsleainmlnpdgslndqvpaayrglscaqariqivadlqahgllsreeri 380
Cdd:cd00668 136 ------------VRITE--------------------------------------------------------------- 140
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 381 vhsvgvcyrceaviepylslQWFVKMKPLASQALAAWKRADvqFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPvwyc 460
Cdd:cd00668 141 --------------------QWFFDMPKFKEKLLKALRRGK--IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 461 aqcaqqtvsrvdvqrcahcgsaditqdPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPTSAVITAYDIIFFWVARMIMA 540
Cdd:cd00668 195 ---------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITM 247
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3323365 541 GLEFTQTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAFMCAQGQDV 603
Cdd:cd00668 248 LVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDI 310
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
20-739 |
4.90e-53 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 201.15 E-value: 4.90e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 20 EARVYACWEQRQAFSpraRGSGTSDSEgcdghsrqieggarTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGAC 99
Cdd:PLN02843 9 EPEIQKLWEENQVYK---RVSDRNNGE--------------SFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 100 TLWIPGTDHAGIATQHVVERALRKEGihKREVTREQFVARTQQIKDSHQDTIRMQLRKMGASCDWTCERFTLDAGMSASV 179
Cdd:PLN02843 72 VHYVPGWDCHGLPIELKVLQSLDQEA--RKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 180 REAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEkdGAL---YYVRYPLLPRTEEEGNGVPPPLGTAQVGetiiI 256
Cdd:PLN02843 150 IEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPE--GHVsksIYVAFPVVSPSETSPEELEEFLPGLSLA----I 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 257 ATTRPETILADVAVAVHPD--------------------------DARYQSLIGRKVCV--------------------- 289
Cdd:PLN02843 224 WTTTPWTMPANAAVAVNDKlqysvvevqsfsedestsggnkkkrpGNVLKEQQKLFLIVatdlvpaleakwgvklvvlkt 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 290 -------------PMVNRIVPIIAD-SYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAINMLNPDGSLNDQVpAAYRGL 355
Cdd:PLN02843 304 fpgsdlegcryihPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEA-GQFSGL 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 356 SC-AQARIQIVADLQAHGLLSREERIVHSVGVCYRCEaviEPYL---SLQWFVKMKPLASQALAAWKRadVQFHPKKWEN 431
Cdd:PLN02843 383 SVlGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTK---KPTIfraTEQWFASVEGFRQAALDAIDK--VKWIPAQGEN 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 432 TYVRWLEHIRDWCISRQLWWGHRIPVWYCAQC-----AQQTVSRVD---VQRCAHC----------------GSADITQD 487
Cdd:PLN02843 458 RIRAMVSGRSDWCISRQRTWGVPIPVFYHVETkeplmNEETIAHVKsivAQKGSDAwwymdvedllpekyrdKASDYEKG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 488 PDVLDTWF---SSWLwpfstlGWPQETQKLRafYPTSAVITAYDIIFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQG 564
Cdd:PLN02843 538 TDTMDVWFdsgSSWA------GVLGSREGLS--YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKG 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 565 RKMSKSLNNGVDPLHIIR---------TYGADALRFTLAFMCAQGqDVLIEMDSFKMGSRFANKVWNASRYILGNL-EGR 634
Cdd:PLN02843 610 FKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWVASVDYTG-DVLIGPQILKQMSDIYRKLRGTLRYLLGNLhDWK 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 635 RVYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASK--CSFQKPDEQEKDRAASV 712
Cdd:PLN02843 689 PDNAVPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKdrLYVGGTTSFTRRSCQTV 768
|
810 820
....*....|....*....|....*..
gi 3323365 713 LCTLLEETLRLLHPFLPFVTEEIYRSL 739
Cdd:PLN02843 769 LAAHLLSLLRAIAPILPHLAEDAWQNL 795
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
607-739 |
4.00e-51 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 175.82 E-value: 4.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 607 MDSFKMGSRFANKVWNASRYILGNLEGRRVYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSF 686
Cdd:cd07962 3 EKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDF 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 3323365 687 CDWYVEASKCSFQKPDEQEKDRAASVLCTLLEETLRLLHPFLPFVTEEIYRSL 739
Cdd:cd07962 83 CDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
8-793 |
4.03e-46 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 180.31 E-value: 4.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 8 IVLPPVYGPADFEARVYACWEQRQAFSPRARGSgtsdsegcdghsrqiEGGARtFVIAIPPPNITGVLHMGHCLNTVLQD 87
Cdd:PLN02882 2 VCEGKDFSFPKQEEKILSLWSEIDAFKTQLKRT---------------EGLPE-YIFYDGPPFATGLPHYGHILAGTIKD 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 88 IVIRYQRMAGACTLWIPGTDHAGIATQHVVERALrkeGIHKREvtreqfvartqqikdshqDTIRMQLRKMGASC----- 162
Cdd:PLN02882 66 IVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKL---GIKRRD------------------DVLKMGIDKYNEECrsivt 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 163 ----DW--TCERF-----------TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEV---FHQEKDGA 222
Cdd:PLN02882 125 ryskEWekTVTRTgrwidfendykTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglnYKDVSDPA 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 223 LYyVRYPLlprteeegngVPPPLGTAQVGetiiiATTRPETILADVAVAVHPD------------------DARYQSLIG 284
Cdd:PLN02882 205 VM-VSFPI----------VGDPDNASFVA-----WTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaESRLSALPT 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 285 RKV-------------------CVP---MVN-RIVPI--------------IADSYVAQDFGTGMVKITPAHDPNDWDIG 327
Cdd:PLN02882 269 AKPkskkgskpenaaegyevlaKVPgssLVGkKYEPLfdyfsefsdtafrvVADDYVTDDSGTGVVHCAPAFGEDDYRVC 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 328 TRHSL--EAINMLNP---DGSLNDQVPAaYRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCE------AVieP 396
Cdd:PLN02882 349 LANGIieKGGNLPVPvddDGCFTEKVTD-FSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDtpliyrAV--P 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 397 ylslQWFVKMKPLASQALAAWKRAdvqfhpkKWENTYVR------WLEHIRDWCISRQLWWGHRIPVWyCAQCAQQTV-- 468
Cdd:PLN02882 426 ----SWFVKVEEIKDRLLENNKQT-------YWVPDYVKekrfhnWLENARDWAVSRSRFWGTPLPIW-ISDDGEEVVvi 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 469 -SRVDVQRCAHCGSADITQD-------P--------------DVLDTWFSSWLWPFSTLGWPQETQKL--RAFyPTSAVI 524
Cdd:PLN02882 494 gSIAELEKLSGVKVTDLHRHfidhitiPssrgpefgvlrrvdDVFDCWFESGSMPYAYIHYPFENKELfeKNF-PADFVA 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 525 TAYDIIFFWV-ARMIMAGLEFTQTVpFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAfmcaQGQDV 603
Cdd:PLN02882 573 EGLDQTRGWFyTLMVLSTALFDKPA-FKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLI----NSPVV 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 604 LIEMDSFKMGSRFA--NKV----WNASRYILGNLEGRRVYAIAHVSLTE----------LDRWIFHTFNETVQQVRTALE 667
Cdd:PLN02882 648 RAEPLRFKEEGVFGvvKDVflpwYNAYRFLVQNAKRLEVEGGAPFVPLDlaklqnsanvLDRWINSATQSLVKFVREEMG 727
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 668 AYRFNDAAQAVYEFFwNSFCDWYVEASKCSFQ-KPDEQEKDRAASVLCTLLEETLRLLHPFLPFVTEEIYRSL------- 739
Cdd:PLN02882 728 AYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLKgRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrkvlpgs 806
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....
gi 3323365 740 SPSVHdttqaipsgahallMCApYPVYVPSRVDARACAHIGAVQEIVRAVRTLR 793
Cdd:PLN02882 807 EESIH--------------YCS-FPQVDEGELDERIEQSVSRMQTVIELARNIR 845
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
68-605 |
1.29e-44 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 164.71 E-value: 1.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 68 PPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIATQHVVERALRKEGIHKRE-VTREQFVARTQQIKDS 146
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEkMGIAEFNAKCREFALR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 147 HQDTIRMQLRKMGASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWcprcgtalsddevfhqekdgalyyv 226
Cdd:cd00818 89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 227 rypllprteeegngvppPLgtaqvgetIIIATTrpetiladvavavhpddaryqsligrkvcvpmvnrivpiiadsyvaq 306
Cdd:cd00818 144 -----------------PL--------IYRATP----------------------------------------------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 307 dfgtgmvkitpahdpndwdigtrhsleainmlnpdgslndqvpaayrglscaqariqivadlqahgllsreerivhsvgv 386
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 387 cyrceaviepylslQWFVKMKPLASQALAAWKRadVQFHPKKWENTYVRWLEHIRDWCISRQLWWGHRIPVWYCAQCAQQ 466
Cdd:cd00818 152 --------------QWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEV 215
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 467 TVSRVdvqrcahcgsaditqdPDVLDTWFSSWLWPFSTLGWPQETQKLRAFYPtsavitaydiiffwvARMIMAGLE--- 543
Cdd:cd00818 216 LVRRV----------------PDVLDVWFDSGSMPYAQLHYPFENEDFEELFP---------------ADFILEGSDqtr 264
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3323365 544 ---FTQTV---------PFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAFMCAQGQDVLI 605
Cdd:cd00818 265 gwfYSLLLlstalfgkaPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
20-739 |
1.83e-41 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 165.52 E-value: 1.83e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 20 EARVYACWEQRQAFSPrargsgtsdsegcdghSRQIEGGARTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGAC 99
Cdd:PTZ00427 78 EEKVLKYWKSIDAFNT----------------SNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 100 TLWIPGTDHAGIATQHVVERalrKEGIHKRE--------VTREQfvARTQQIKDSHQDTIRMQlrKMGASCDWTCERFTL 171
Cdd:PTZ00427 142 VERKFGWDCHGLPIEYEIEK---ENNINKKEdilkmgidVYNEK--CRGIVLKYSNEWVKTVE--RIGRWIDFKNDYKTM 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 172 DAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQEKDGA-----LYYVRYPLLPRTEEEGNG--VPPP 244
Cdd:PTZ00427 215 DKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPdpsiiISFVLCSDFPKVEEECNIeeDKQL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 245 LG------------------------TAQVGETIIIA-TTRPETILADVAVAV--HPDDARYQSLIGRKVCV-------- 289
Cdd:PTZ00427 295 LGekysvlynnkrensnngnnnstnnVCYAQHSEILAwTTTPWTLPSNLALCVneHFTYLRIHHVKSNRVVIvgecrlew 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 290 -----------------------------PMVN----------RIVPIIADSYVAQDFGTGMVKITPAHDPNDWDIGTRH 330
Cdd:PTZ00427 375 imkelkwnvedlkivnrfkgkelkglrykPLFTnfyekynfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKN 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 331 SL---EA---INMLNPDGSLNDQVPAAyRGLSCAQARIQIVADLQAHGLLSREERIVHSVGVCYRCEAVIEPYLSLQWFV 404
Cdd:PTZ00427 455 GVidpEKnifIDPLDANGYFTNEVEEV-QNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFI 533
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 405 KM-----KPLASQALAAWKRADVQfhPKKWENtyvrWLEHIRDWCISRQLWWGHRIPVWycaqCAQQTVSRVDVQRCAH- 478
Cdd:PTZ00427 534 RVsnstnELVKNNETTYWIPAHIK--EKKFHN----WIKDAKDWCISRNRYWGTPIPIW----ADEKMETVICVESIKHl 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 479 ---CGSADIT------------------------QDPDVLDTWFSSWLWPFSTLGWP--QETQKLRAFYPTSAVITAYDI 529
Cdd:PTZ00427 604 eelSGVKNINdlhrhfidhieiknpkgktypklkRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQ 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 530 IFFWVARMIMAGLEFTQTVPFRDVYLHGLVRDKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAfmcaqgQDVLIEMDS 609
Cdd:PTZ00427 684 TRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI------NSVAVRAEN 757
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 610 FKMGSRFANKVwnASRYILGNLEGRRVYAiAHVSLTE--------------------LDRWIFHTFNETVQQVRTALEAY 669
Cdd:PTZ00427 758 LKFQEKGVNEV--VKSFILPFYHSFRFFS-QEVTRYEclnkkqflfntdyiykndniMDQWIFSSVQSLTKSVHTEMKAY 834
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3323365 670 RFNDAAQAVYEFFWNsFCDWYVEASKCSFQKP-DEQEKDRAASVLCTLLEETLRLLHPFLPFVTEEIYRSL 739
Cdd:PTZ00427 835 KLYNVLPKLLQFIEN-LTNWYIRLNRDRMRGSlGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQL 904
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
73-769 |
3.71e-41 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 163.30 E-value: 3.71e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 73 GVLHMGHCLNTVLQDIVIRYQRMAGACTL----WipgtD----HAgiatqhvvERALRKEGIHKREVTREQfvartqqIk 144
Cdd:COG0495 46 GRLHMGHVRNYTIGDVVARYKRMQGYNVLhpmgW----DafglPA--------ENAAIKNGVHPAEWTYEN-------I- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 145 dshqDTIRMQLRKMGASCDW-----TCE----RFT--LdagmsasvreaFVTLYERGLLYRSMYLVNWCPRCGTALSDDE 213
Cdd:COG0495 106 ----ANMRRQLKRLGLSYDWsreiaTCDpeyyKWTqwI-----------FLQLYEKGLAYRKEAPVNWCPVDQTVLANEQ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 214 VF--HQEKDGAL--------YYVR---Y--------PLLPRTEE-------------EGngvppplgtAQV-------GE 252
Cdd:COG0495 171 VIdgRCWRCGAPvekkelpqWFLKitdYadellddlDKLDGWPEkvktmqrnwigrsEG---------AEVdfpvegsDE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 253 TIIIATTRPETI-------------LADVAVAVHPDDA--------RYQSLI--------------GRKVCVPMVNRIVP 297
Cdd:COG0495 242 KITVFTTRPDTLfgatfmvlapehpLVKELATPEQNAAvaafieeaKKKSEIertsetkektgvftGLYAINPLTGEKIP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 298 I-IADsYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAIN-MLNPDGSLNDQVPAAYR------------GLSCAQARIQ 363
Cdd:COG0495 322 IwIAD-YVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQvIAPEDGDDPDILEEAYTgdgvlinsgefdGLDSEEAKEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 364 IVADLQAHGLLSREerivhsvgVCYRceaviepylslqwfvkmkplasqalaawkradvqfhpkkwentyvrwlehIRDW 443
Cdd:COG0495 401 IIEWLEEKGLGKRK--------VNYR--------------------------------------------------LRDW 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 444 CISRQLWWGHRIPVWYCAQCAQQTVSR---------------------------VDVQrCAHCGsADITQDPDVLDTWF- 495
Cdd:COG0495 423 LISRQRYWGEPIPIIHCEDCGVVPVPEdqlpvelpedvdfdptggsplarapewVNVT-CPKCG-GPARRETDTMDTFVd 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 496 SSWLWpfstlgwpqetqkLRafY--------PTSAVITAYdiiffW--V----------------ARMIM-----AGL-- 542
Cdd:COG0495 501 SSWYY-------------LR--YtdphndeaPFDPEAANY-----WlpVdqyiggiehailhllyARFFTkvlrdLGLvs 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 543 --EftqtvPFRDVYLHGLVRD--KQGR------KMSKSLNNGVDPLHIIRTYGADALRFTLAFMcaqG--------QDVL 604
Cdd:COG0495 561 fdE-----PFKRLLTQGMVLEvgKDGVviggieKMSKSKGNVVDPDEIIEKYGADTLRLFEMFA---GpperdlewSDSG 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 605 IEmdsfkmGS-RFANKVWnasRYILGNLEGrrvYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFw 683
Cdd:COG0495 633 VE------GAyRFLNRVW---RLVVDEAEA---LKLDVADLSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELV- 699
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 684 NsfcdwyvEASKcsfqKPDEQEKDRAAS-------VLCtlleetlrlLHPFLPFVTEEIYRSL--SPSVHDttqaipsga 754
Cdd:COG0495 700 N-------ALYK----AKDSGEADRAVLrealetlVLL---------LAPFAPHIAEELWERLghEGSVAD--------- 750
|
890
....*....|....*
gi 3323365 755 hallmcAPYPVYVPS 769
Cdd:COG0495 751 ------APWPEADEA 759
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
648-808 |
8.86e-34 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 126.75 E-value: 8.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 648 DRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASKCSFQkpDEQEKDRAASVLCTLLEETLRLLHPF 727
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLY--GEEPDSRAQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 728 LPFVTEEIYRSLSpsvhdttqaipsgahalLMCAPYPVyVPSRVDARACAHIGAVQEIVRAVRTLRAACGIDPQKAVSVR 807
Cdd:pfam08264 79 MPFITEELWQKES-----------------IHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
|
.
gi 3323365 808 L 808
Cdd:pfam08264 141 I 141
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
75-804 |
1.33e-29 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 126.91 E-value: 1.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 75 LHMGHCLNTVLQDIVIRYQRMAGACTLW-----IPGTDHAGIAtqhvvERALRKE-----------GIHKREVtrEQFvA 138
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIA-----ERIARGDpetielykslyGIPEEEL--EKF-K 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 139 RTQQIKDSHQDTIRMQLRKMGASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFHQE 218
Cdd:PRK12300 73 DPEYIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 219 KDGALYYVryplLPRTEEEGNGVppplgtaqvgetIIIATTRPETILADVAVAVHPD-----------------DA---- 277
Cdd:PRK12300 153 EPEIVEYT----LIKFEESEDLI------------LPAATLRPETIFGVTNLWVNPDatyvkaevdgekwivskEAaekl 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 278 RYQ-------------SLIGRKVCVPMVNRIVPIIADSYVAQDFGTGMVKITPAHDPNDW----DIGTRHSL-------- 332
Cdd:PRK12300 217 SFQdrdveiieeikgsELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldviepip 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 333 -------------EAINMLNPD---------------------GSLNDQVPAaYRGLSCAQARIQIVADLQAHGLLSR-- 376
Cdd:PRK12300 297 lievegygefpakEVVEKLGIKsqedpeleeatkevyraefhkGVLKENTGE-YAGKPVREAREKITKDLIEKGIADImy 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 377 --EERIVhsvgVCyRC--EAVIEpYLSLQWFVK-----MKPLASQALAAwkradVQFHP----KKWENTyVRWLehiRDW 443
Cdd:PRK12300 376 efSNRPV----YC-RCgtECVVK-VVKDQWFIDysdpeWKELAHKALDN-----MEIIPeeyrKEFENT-IDWL---KDR 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 444 CISRQLWWGHRIPvW--------------YCAQcaqQTVSRvdvqRCAHCGSADITQDPDVLDTWFSSWLWP---FSTLG 506
Cdd:PRK12300 441 ACARRRGLGTRLP-WdeewiieslsdstiYMAY---YTIAH----KIREYGIKPEQLTPEFFDYVFLGKGDPeevSKKTG 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 507 WPQET-QKLRA----FYPTSAVITAYDII-----FFW---VA--------RMIMagleftqtvpfrdvyLHGLVRdKQGR 565
Cdd:PRK12300 513 IPKEIlEEMREeflyWYPVDWRHSGKDLIpnhltFFIfnhVAifpeekwpRGIV---------------VNGFVL-LEGK 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 566 KMSKSLNNgVDPL-HIIRTYGADALRFTLAFMCAQGQDvlieMDsfkmgsrfankvWNAS--RYILGNLEgrRVYAIA-- 640
Cdd:PRK12300 577 KMSKSKGN-VIPLrKAIEEYGADVVRLYLTSSAELLQD----AD------------WREKevESVRRQLE--RFYELAke 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 641 ------HVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFcDWYVEASkcsfqkpDEQEKDRAASVLc 714
Cdd:PRK12300 638 lieiggEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDL-RWYLRRV-------GEANNKVLREVL- 708
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 715 tllEETLRLLHPFLPFVTEEIYRSLspsvhdttqaipsGAHALLMCAPYPVYVPSRVDARACAHIGAVQEIVRAVRTLRA 794
Cdd:PRK12300 709 ---EIWIRLLAPFTPHLAEELWHKL-------------GGEGFVSLEKWPEPDESKIDEEAELAEEYVKRLIEDIREILK 772
|
890
....*....|
gi 3323365 795 ACGIDPQKAV 804
Cdd:PRK12300 773 VAKIKPKKVY 782
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
60-739 |
5.37e-26 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 113.67 E-value: 5.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 60 RTFVI--AIPPPNitGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTD-HaGIAtqhvVERALRKEGIhkrevTREQF 136
Cdd:COG0143 1 KKFLVttAIPYAN--GPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDeH-GTK----IELAAEKEGI-----TPQEL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 137 VARtqqIKDSHQDTirmqLRKMGASCDwtceRF--TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDdev 214
Cdd:COG0143 69 VDR---IHAEFKEL----FEKLGISFD----NFirTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPD--- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 215 fhqekdgalyyvRYpllprteEEGNGvpPPLGTAqvgetiiiattrpetiladvavavhpddaryqsligrkvcvpmvnr 294
Cdd:COG0143 135 ------------RY-------VEGTC--PKCGAE---------------------------------------------- 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 295 ivpiiaDSYVAQDFGTGmvkitpahdpndwdigtrHSLEAINMLNPDGSLNDQVPaayrglscaqariqivadlqahglL 374
Cdd:COG0143 148 ------DAYGDQCENCG------------------ATLEPTELINPRSAISGAPP------------------------E 179
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 375 SREERivhsvgvcyrceaviepylslQWFVKMKPLAsQALAAW--KRADVQfhpkkwENTY---VRWLE-HIRDWCISRQ 448
Cdd:COG0143 180 LREEE---------------------HYFFRLSKYQ-DRLLEWieENPDIQ------PEVRnevLSWLKeGLQDLSISRD 231
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 449 LWWG--------HRIPVWycaqcaqqtvsrVDvqrcAHCGSadITqdpdvldtwfsswlwpfSTLGWPQET---QKLRAF 517
Cdd:COG0143 232 FDWGipvpgdpgKVFYVW------------FD----ALIGY--IS-----------------ATKGYADDRglpEDFEKY 276
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 518 YPTSAVITAY----DIIFF----WVArMIMA-GLEftqtVPfRDVYLHG--LVRdkqGRKMSKSLNNGVDPLHIIRTYGA 586
Cdd:COG0143 277 WPAPDTELVHfigkDIIRFhaiiWPA-MLMAaGLP----LP-KKVFAHGflTVE---GEKMSKSRGNVIDPDDLLDRYGP 347
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 587 DALRFTLAFMCAQGQDVLIEMDSF--KMGSRFANKVWN-ASRyILG----NLEGrRVYAIAhvSLTELDRWIFHTFNETV 659
Cdd:COG0143 348 DALRYYLLREVPFGQDGDFSWEDFvaRVNSDLANDLGNlASR-TLSmihkYFDG-KVPEPG--ELTEADEELLAEAEAAL 423
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 660 QQVRTALEAYRFNDAAQAVYEFFwnSFCDWYVEAskcsfQKP----DEQEKDRAASVL---CTLLEETLRLLHPFLPFVT 732
Cdd:COG0143 424 EEVAEAMEAFEFRKALEEIMALA--RAANKYIDE-----TAPwklaKDEDPERLATVLytlLEALRILAILLKPFLPETA 496
|
....*..
gi 3323365 733 EEIYRSL 739
Cdd:COG0143 497 EKILEQL 503
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
2-681 |
1.50e-24 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 110.68 E-value: 1.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 2 TQKLQKIVLPPVYGPADFEARVYACWEQRQAFSprargsgTSDsegcdghsrQIEGGARTFVI--AIPPPNITGvLHMGH 79
Cdd:PLN02563 68 TTAKTTPAAKRAYPFHEIEPKWQRYWEENRTFR-------TPD---------DVDTSKPKFYVldMFPYPSGAG-LHVGH 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 80 CLNTVLQDIVIRYQRMAGACTLWIPGTDHAGI-ATQHVVEralrkEGIHKREVTREQfVARtqqikdshqdtIRMQLRKM 158
Cdd:PLN02563 131 PEGYTATDILARYKRMQGYNVLHPMGWDAFGLpAEQYAIE-----TGTHPKITTLKN-IAR-----------FRSQLKSL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 159 GASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVFH--QEKdGALYYVRYPL------ 230
Cdd:PLN02563 194 GFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglSER-GGHPVIRKPMrqwmlk 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 231 ----LPRTEEEGNGVPPPLGT-------------AQVG------------ETIIIATTRPETILADVAVAVHPD------ 275
Cdd:PLN02563 273 itayADRLLEDLDDLDWPESIkemqrnwigrsegAELDfsvldgegkerdEKITVYTTRPDTLFGATYLVVAPEhpllss 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 276 ---------------------DARYQSLIGRKVCV--------PMVNRIVPI-IADsYVAQDFGTGMVKITPAHDPNDWD 325
Cdd:PLN02563 353 lttaeqkeaveeyvdaasrksDLERTELQKEKTGVftgsyainPATGEAIPIwVAD-YVLGSYGTGAIMAVPAHDTRDFE 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 326 IGTRHSLEAINMLNPDGSLNDQVPAAYRGL-----SCAQAriqivadLQAHGLLSREERivhsvgvcyrcEAVIEpylsl 400
Cdd:PLN02563 432 FAQKFDLPIKWVVKPADGNEDDAEKAYTGEgvivnSSSSG-------LDINGLSSKEAA-----------KKVIE----- 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 401 qWfvkmkplASQALAAWKRAdvqfhpkkwenTYvrwleHIRDWCISRQLWWGHRIPVWYCAQCAQQ----------TVSR 470
Cdd:PLN02563 489 -W-------LEETGNGKKKV-----------NY-----KLRDWLFARQRYWGEPIPVVFLEDSGEPvpvpesdlplTLPE 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 471 VDVQRCAHCGSADITQDPDVLDTWFSSWLWPFS--TLGWPQ---------------------ETQKLRAFYPTS------ 521
Cdd:PLN02563 545 LDDFTPTGTGEPPLAKAVSWVNTVDPSSGKPARreTNTMPQwagscwyylrfmdpknsnalvDKEKEKYWMPVDlyvgga 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 522 --AVI----------TAYDI-------IFFWVAR--MIMAGLEFT-----------------------QTVPFRDVYLHG 557
Cdd:PLN02563 625 ehAVLhllyarfwhkVLYDIgvvstkePFQCLVNqgMILGEVEYTafkdsdgeyvsadtadrlgelqqEKIPEEKVIKSG 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 558 ----LVRDKQGR------KMSKSLNNGVDPLHIIRTYGADALRFTLAFMcAQGQDVLIEMDSFKMG-SRFANKVWnasRY 626
Cdd:PLN02563 705 dsfvLKDDPSIRliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFM-GPLRDSKTWSTSGVEGvHRFLGRTW---RL 780
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 3323365 627 ILGN-LEGRRVYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEF 681
Cdd:PLN02563 781 VVGApLPDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEF 836
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
614-790 |
2.11e-18 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 83.75 E-value: 2.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 614 SRFANKVWNASRYILGNLE----GRRVYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFwnsfcD- 688
Cdd:cd07961 11 RKVLLPLWNAYRFFVTYANldgfDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-----De 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 689 ---WYVEASKCSFQKPDEQEKDRAA-SVLCTLLEETLRLLHPFLPFVTEEIYRSLSP-------SVHdttqaipsgahaL 757
Cdd:cd07961 86 ltnWYIRRNRKRFWGEEGDDDKLAAyATLYEVLLTLSRLMAPFTPFITEEIYQNLRRelgdapeSVH------------L 153
|
170 180 190
....*....|....*....|....*....|...
gi 3323365 758 LMcapYPVYVPSRVDARACAHIGAVQEIVRAVR 790
Cdd:cd07961 154 LD---WPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
503-739 |
6.29e-18 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 88.70 E-value: 6.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 503 STLGWPQETQKL-RAFYPTSAVITAYDII-F---FWVArMIMA-GLEftqtvPFRDVYLHG-LVRDkqGRKMSKSLNNGV 575
Cdd:PRK12267 237 TALGYGSDDDELfKKFWPADVHLVGKDILrFhaiYWPI-MLMAlGLP-----LPKKVFAHGwWLMK--DGKMSKSKGNVV 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 576 DPLHIIRTYGADALRFTL----AFmcaqGQD------VLIEmdsfKMGSRFANKvwnasryiLGNLEGRRVYAI------ 639
Cdd:PRK12267 309 DPEELVDRYGLDALRYYLlrevPF----GSDgdfspeALVE----RINSDLAND--------LGNLLNRTVAMInkyfdg 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 640 ---AHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFwnSFCDWYVEASkcsfqKP-----DEQEKDRAAS 711
Cdd:PRK12267 373 eipAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLI--SRANKYIDET-----APwvlakDEGKKERLAT 445
|
250 260 270
....*....|....*....|....*....|.
gi 3323365 712 V---LCTLLEETLRLLHPFLPFVTEEIYRSL 739
Cdd:PRK12267 446 VmyhLAESLRKVAVLLSPFMPETSKKIFEQL 476
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
60-678 |
1.55e-17 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 86.86 E-value: 1.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 60 RTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGiatQHVvERALRKEGIHKREVTREQfvar 139
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHG---QKI-QRKAEEAGISPQELADRN---- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 140 TQQIKDShqdtirmqLRKMGASCDwtceRF--TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCgtalsddEVFHQ 217
Cdd:PRK11893 73 SAAFKRL--------WEALNISYD----DFirTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRC-------EEFYT 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 218 EKDgalyyvrypLLprteeegngvppplgtaqvgetiiiattrpetiladvavavhpDDARYQSLIGRKVcvpmvnrivp 297
Cdd:PRK11893 134 ESE---------LI-------------------------------------------EDGYRCPPTGAPV---------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 298 iiadsyvaqdfgtgmvkitpahdpnDWdigtrhsleainmlnpdgslndqvpaayrglscaqariqivadlqahgllsRE 377
Cdd:PRK11893 152 -------------------------EW---------------------------------------------------VE 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 378 ErivHSvgvcyrceaviepylslqWFVKMKPLASQALAAWKRADVQFHPKKWENTYVRWL-EHIRDWCISRQ-LWWGhrI 455
Cdd:PRK11893 156 E---ES------------------YFFRLSKYQDKLLELYEANPDFIQPASRRNEVISFVkSGLKDLSISRTnFDWG--I 212
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 456 PVwycaqcaqqtvsrvdvqrcahcgsadiTQDPD-VLDTWF-------SSWLWPFSTlgwPQETQKLRAFYPTSAVITAY 527
Cdd:PRK11893 213 PV---------------------------PGDPKhVIYVWFdaltnylTALGYPDDE---ELLAELFNKYWPADVHLIGK 262
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 528 DIIFF----WVARMIMAGLEftqtVPFRdVYLHG-LVRDkqGRKMSKSLNNGVDPLHIIRTYGADALRFTLA----Fmca 598
Cdd:PRK11893 263 DILRFhavyWPAFLMAAGLP----LPKR-VFAHGfLTLD--GEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLreipF--- 332
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 599 qGQDVLIEMDSFK--MGSRFANKVWN-ASRyILG----NLEGrRVYAIAhvSLTELDRWIFHTFNETVQQVRTALEAYRF 671
Cdd:PRK11893 333 -GQDGDFSREAFInrINADLANDLGNlAQR-TLSmiakNFDG-KVPEPG--ALTEADEALLEAAAALLERVRAAMDNLAF 407
|
....*..
gi 3323365 672 NDAAQAV 678
Cdd:PRK11893 408 DKALEAI 414
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
65-594 |
2.21e-14 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 76.17 E-value: 2.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 65 AIPPPNitGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIAtqhvVERALRKEGIhkrevTREQFVARTQQIk 144
Cdd:pfam09334 6 ALPYAN--GPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTP----IELKAEKEGI-----TPEELVDRYHEI- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 145 dsHQDTirmqLRKMGASCDwtcerftlDAGMSAS------VREAFVTLYERGLLYRSMYLVNWCPRCGTALSDDEVfhqe 218
Cdd:pfam09334 74 --HRED----FKKFNISFD--------DYGRTTSerhhelVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYV---- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 219 kdgalyyvrypllprteeEGngvppplgtaqvgetiiiatTRPETiladvavavHPDDARyqsligrkvcvpmvnrivpi 298
Cdd:pfam09334 136 ------------------EG--------------------TCPHC---------GSEDAR-------------------- 148
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 299 iADSYvaqdfgtgmvkitpahdpndwDIGTRHsLEAINMLNPdgslndqvpaayrglscaqariqivadlqahgllsree 378
Cdd:pfam09334 149 -GDQC---------------------ENCGRH-LEPTELINP-------------------------------------- 167
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 379 rivhsvgVCYRCEAVIEPYLSLQWFVKMKPLASQaLAAWKRADVQFHPKKWENTYVRWL-EHIRDWCISRQLWWGHRIP- 456
Cdd:pfam09334 168 -------KCVICGTTPEVKETEHYFFDLSKFQDK-LREWIEENNPEWPENVKNMVLEWLkEGLKDRAISRDLDWGIPVPg 239
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 457 -------VWycaqcaqqtvsrVDvqrcAHCGSADITQDPDVLDTWFSSWlwpfstlgWPQETQklrafypTSAV-ITAYD 528
Cdd:pfam09334 240 aegkvfyVW------------LD----APIGYISATKELSGNEEKWKEW--------WPNDPD-------TELVhFIGKD 288
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 529 IIFF----WVARMIMAGLEFTQTvpfrdVYLHGLVRDKqGRKMSKSLNNGVDPLHIIRTYGADALRFTLA 594
Cdd:pfam09334 289 IIYFhtifWPAMLLGAGYRLPTT-----VFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPPDALRYYLA 352
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
619-747 |
2.32e-14 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 72.17 E-value: 2.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 619 KVWNASRYILGNLEG--RRVYAIAHVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFCDWYVEASK- 695
Cdd:cd07960 15 KIRNTFRFLLGNLNDfdPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIKd 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3323365 696 ---CSfqKPDEQEKdRAA-SVLCTLLEETLRLLHPFLPFVTEEIYRSLSP-----SVHDTT 747
Cdd:cd07960 95 rlyCD--AKDSLER-RSAqTVLYHILDALLKLLAPILPFTAEEVWEHLPGekkeeSVFLED 152
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
62-202 |
3.19e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 71.51 E-value: 3.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 62 FVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDhagiATQHVVERALRKEGIHKREVTrEQFVARtq 141
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAENAAIKIGRDPEDWT-EYNIKK-- 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3323365 142 qikdshqdtIRMQLRKMGASCDWTCERFTLDAGMSASVREAFVTLYERGLLYRSMYLVNWC 202
Cdd:cd00812 75 ---------MKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
385-603 |
8.97e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 70.35 E-value: 8.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 385 GVCYRCEAVIEpYLSL--QWFVKM-----KPLASQALAAWKradvqfhpkKWENTYVRWLEHIRDwcISRQLWWGHRIPv 457
Cdd:cd00812 114 GLAYKKEAPVN-WCKLldQWFLKYsetewKEKLLKDLEKLD---------GWPEEVRAMQENWIG--CSRQRYWGTPIP- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 458 wycaqcaqqtvsrvdvqrcahcgsadITqdpDVLDTWF-SSWLWPFST------LGWPQETQKLRA----FYPTSAVITA 526
Cdd:cd00812 181 --------------------------WT---DTMESLSdSTWYYARYTdahnleQPYEGDLEFDREefeyWYPVDIYIGG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 527 YDII--------FFWVArmiMAGLEFTQTVPFRDVYLHGLVRdKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAFMCA 598
Cdd:cd00812 232 KEHApnhllysrFNHKA---LFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP 307
|
....*
gi 3323365 599 QGQDV 603
Cdd:cd00812 308 PDADF 312
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
402-602 |
1.04e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 70.25 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 402 WFVKMKPLASQALAAWKRADVQFHPKKWENTYVRWLEH-IRDWCISRQLW-WGHRIP--------VWycaqcaqqtvsrV 471
Cdd:cd00814 140 YFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWLKEgLKDLSITRDLFdWGIPVPldpgkviyVW------------F 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 472 DvqrcAHCGSADITQDPDvlDTWFSSWLWpfstlgWPQETqklRAFYptsaVItAYDIIFF----WVARMIMAGLEftqt 547
Cdd:cd00814 208 D----ALIGYISATGYYN--EEWGNSWWW------KDGWP---ELVH----FI-GKDIIRFhaiyWPAMLLGAGLP---- 263
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 3323365 548 vPFRDVYLHGLVRDKqGRKMSKSLNNGVDPLHIIRTYGADALRFTLAFMCAQGQD 602
Cdd:cd00814 264 -LPTRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
611-710 |
3.72e-12 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 64.06 E-value: 3.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 611 KMGSRFANKVWNASRYILGNLEGRRVYAIAHvSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSfcDWY 690
Cdd:cd07375 5 KQARAFLNRLYRLLSFFRKALGGTQPKWDNE-LLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL--NWY 81
|
90 100
....*....|....*....|
gi 3323365 691 VEASKCSFQKPDEQEKDRAA 710
Cdd:cd07375 82 LDELKPALQTEELREAVLAV 101
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
65-219 |
5.52e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 67.94 E-value: 5.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 65 AIPPPNitGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGIAtqhvVERALRKEGIHKREvtreqFVARTQQIk 144
Cdd:cd00814 7 ALPYVN--GVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTK----IEQKAEEEGVTPQE-----LCDKYHEI- 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3323365 145 dsHQDTirmqLRKMGASCDwtceRF--TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSddeVFHQEK 219
Cdd:cd00814 75 --FKDL----FKWLNISFD----YFirTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP---EWREEE 138
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
425-680 |
5.98e-09 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 59.73 E-value: 5.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 425 HPKKWENTYVRWLEH-IRDWCISRQLW-WGHRIPvwycaqcaqqtvsrvdvqrcahcgsadiTQDPDVLDTWFSSWLWPF 502
Cdd:PLN02224 249 QPSYRLNEVQSWIKSgLRDFSISRALVdWGIPVP----------------------------DDDKQTIYVWFDALLGYI 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 503 STLGWPQETQKLRAF----YPTSAVITAYDIIFF----WVARMIMAGLEFTQTVpfrdvYLHGLVrDKQGRKMSKSLNNG 574
Cdd:PLN02224 301 SALTEDNKQQNLETAvsfgWPASLHLIGKDILRFhavyWPAMLMSAGLELPKMV-----FGHGFL-TKDGMKMGKSLGNT 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 575 VDPLHIIRTYGADALRFTLAFMCAQGQDVLIEMDSF--KMGSRFANKVWNASRYILG----NLEGRRV----YAIAHVSL 644
Cdd:PLN02224 375 LEPFELVQKFGPDAVRYFFLREVEFGNDGDYSEDRFikIVNAHLANTIGNLLNRTLGllkkNCESTLVedstVAAEGVPL 454
|
250 260 270
....*....|....*....|....*....|....*.
gi 3323365 645 TEldrwifhTFNETVQQVRTALEAYRFNDAAQAVYE 680
Cdd:PLN02224 455 KD-------TVEKLVEKAQTNYENLSLSSACEAVLE 483
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
887-945 |
4.79e-08 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 50.73 E-value: 4.79e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 3323365 887 ARLQKAWQKARQKVQQVERKLADAQFCTHAPEEVVTAERKKLAEARATCHTLAGYLADM 945
Cdd:pfam10458 7 ARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKL 65
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
528-753 |
2.64e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 51.31 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 528 DIIF----FWVArMIMAGlEFTQtvPfRDVYLHGLVRdKQGRKMSKSLNNGVDPLHIIRTYGADALRFTLAF-MCAQGQD 602
Cdd:PRK00133 293 DIIYfhtlFWPA-MLEGA-GYRL--P-TNVFAHGFLT-VEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAkLPETIDD 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 603 VLIEMDSF--KMGSRFANKVWN-ASR---YILGNLEGRrvyaiahVSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQ 676
Cdd:PRK00133 367 LDFNWEDFqqRVNSELVGKVVNfASRtagFINKRFDGK-------LPDALADPELLEEFEAAAEKIAEAYEAREFRKALR 439
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 677 AVYEFfwNSFCDWYVEAskcsfQKP---DEQEKDRAA---SVLCTLLEETLRLLHPFLPFVTEEIYRSL--SPSVHDTTQ 748
Cdd:PRK00133 440 EIMAL--ADFANKYVDD-----NEPwklAKQDGERLQavcSVGLNLFRALAIYLKPVLPELAERAEAFLnlEELTWDDAQ 512
|
....*
gi 3323365 749 AIPSG 753
Cdd:PRK00133 513 QPLAG 517
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
59-205 |
4.86e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 50.48 E-value: 4.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 59 ARTFVIAIPPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAG--IATQhvveralrkegihkrevtreqf 136
Cdd:PLN02224 68 ADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATS---------------------- 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3323365 137 VARTQQIKDSHQDTIRMQLRKMGASCDWTCERF--TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRC 205
Cdd:PLN02224 126 AAANGRNPPEHCDIISQSYRTLWKDLDIAYDKFirTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNC 196
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
251-352 |
6.71e-06 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 47.54 E-value: 6.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 251 GETIIIATTRPETI--LADVAVAV-HP----------------DDARYQSLI--------------GRKVCVPMVNRIVP 297
Cdd:pfam13603 20 DEKIEVFTTRPDTLmgVTFVALAPeHPlveklaeknpevaafiEECKNTSEIertsetkekegvftGLYAIHPITGEKIP 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 3323365 298 I-IADsYVAQDFGTGMVKITPAHDPNDWDIGTRHSLEAIN-MLNPDGSLN-DQVPAAY 352
Cdd:pfam13603 100 IwIAN-FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPvIQPEDGDLDlDIMTEAY 156
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
644-739 |
1.03e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 45.66 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 644 LTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFWNSFcDWYVEASkcsfqkPDEQEKDraasVLCTLLEETLRL 723
Cdd:cd07959 33 LTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDL-DWYRERG------GAGMNKD----LLRRFIEVWTRL 101
|
90
....*....|....*.
gi 3323365 724 LHPFLPFVTEEIYRSL 739
Cdd:cd07959 102 LAPFAPHLAEEIWHEL 117
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
60-211 |
4.62e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 47.45 E-value: 4.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 60 RTFVI-AIPPPNitGVLHMGHcLNTVLQ-DIVIRYQRMAGACTLWIPGTDHAGIAtqhVVERAlRKEGIhkrevTREQFV 137
Cdd:PRK00133 3 KILVTcALPYAN--GPIHLGH-LVEYIQaDIWVRYQRMRGHEVLFVCADDAHGTP---IMLKA-EKEGI-----TPEELI 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3323365 138 ARTQQIkdsHQDTirmqLRKMGASCDwtceRF--TLDAGMSASVREAFVTLYERGLLYRSMYLVNWCPRCGTALSD 211
Cdd:PRK00133 71 ARYHAE---HKRD----FAGFGISFD----NYgsTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLPD 135
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
628-739 |
6.70e-05 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 43.63 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 628 LGNLEGRrVYAIAH----------VSLTELDRWIFHTFNETVQQVRTALEAYRFNDAAQAVYEFFwnSFCDWYVEAskcs 697
Cdd:cd07957 9 LGNLVNR-TLNMASkyfggvvpefGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA--RAANKYIDE---- 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 3323365 698 fQKP----DEQEKDRAASVL---CTLLEETLRLLHPFLPFVTEEIYRSL 739
Cdd:cd07957 82 -TAPwklaKEEDPERLATVLyvlLELLRILAILLSPFMPETAEKILDQL 129
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
67-164 |
1.39e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 40.16 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3323365 67 PPPNITGVLHMGHCLNTVLQDIVIRYQRMAGACTLWIPGTDHAGiatQHVVERALRKEGIHKREVtrEQFVARTQQIKDS 146
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAG---GLIGDPANKKGENAKAFV--ERWIERIKEDVEY 78
|
90
....*....|....*...
gi 3323365 147 HQDTIRMQLRKMGASCDW 164
Cdd:cd00802 79 MFLQAADFLLLYETECDI 96
|
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| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
549-593 |
4.58e-03 |
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catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 39.48 E-value: 4.58e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 3323365 549 PFRDVYLH-GLVRDKqGRKMSKSLNNGVDPLHIIRTYGADALRFTL 593
Cdd:cd00672 157 PFARYWLHtGHLTID-GEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
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