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Conserved domains on  [gi|3319031]
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Chain A, PROTEIN (ZIF268 ZINC FINGER PEPTIDE)

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-90 4.97e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 4.97e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3319031   32 QKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDERKRHTKIHLRQKD 90
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
3-47 4.26e-05

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.26e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 3319031    3 RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRS 47
Cdd:COG5048 320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-90 4.97e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 4.97e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3319031   32 QKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDERKRHTKIHLRQKD 90
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-47 4.26e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.26e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 3319031    3 RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRS 47
Cdd:COG5048 320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
49-74 6.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.37e-04
                         10        20
                 ....*....|....*....|....*.
gi 3319031    49 HLTTHIRTHTGEKPFACDICGRKFAR 74
Cdd:pfam13465  1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 34-81 4.83e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 33.70  E-value: 4.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 3319031    34 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDICGRKFARSDERKRH 81
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
PHA00733 PHA00733
hypothetical protein
 4-54 5.52e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 33.31  E-value: 5.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 3319031     4 PYACPVesCDRRFSRSDELTRHIRIHTGQKpfQCRICMRNFSRSDHLTTHI 54
Cdd:PHA00733  73 PYVCPL--CLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-90 4.97e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 4.97e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3319031   32 QKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDERKRHTKIHLRQKD 90
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 2-83 3.05e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3319031    2 ERPYACPVESCDRRFSRSDELTRHiRIHTGQKPFQCR----ICMRNFSRSDhltthirthtgeKPFACDICGRKFARSDE 77
Cdd:COG5189 347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHEnpspEKMNIFSAKD------------KPYRCEVCDKRYKNLNG 413


                ....*.
gi 3319031   78 RKRHTK 83
Cdd:COG5189 414 LKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-71 9.51e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 9.51e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3319031    3 RPYACPveSCDRRFSRSDELTRHIRIHTGQKPFQCRICMR--NFSRSDHLTTHIRTHTGEKPFACDICGRK 71
Cdd:COG5048  32 RPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
7-89 1.30e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3319031    7 CPVESCDRRFSRSDELTRHIR--IHTGQ--KPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDER 78
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNN 369

                        90
                ....*....|.
gi 3319031   79 KRHTKIHLRQK 89
Cdd:COG5048 370 EPPQSLQQYKD 380
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-47 4.26e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.26e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 3319031    3 RPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRS 47
Cdd:COG5048 320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-85 1.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 1.31e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3319031   32 QKPFQCRICMRNFSRSDHLTTHIRT--HTGE--KPFACDI--CGRKFARSDERKRHTKIH 85
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
49-74 6.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.37e-04
                         10        20
                 ....*....|....*....|....*.
gi 3319031    49 HLTTHIRTHTGEKPFACDICGRKFAR 74
Cdd:pfam13465  1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
21-46 4.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 31.96  E-value: 4.59e-03
                         10        20
                 ....*....|....*....|....*.
gi 3319031    21 ELTRHIRIHTGQKPFQCRICMRNFSR 46
Cdd:pfam13465  1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 34-81 4.83e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 33.70  E-value: 4.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 3319031    34 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDICGRKFARSDERKRH 81
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
PHA00733 PHA00733
hypothetical protein
 4-54 5.52e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 33.31  E-value: 5.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 3319031     4 PYACPVesCDRRFSRSDELTRHIRIHTGQKpfQCRICMRNFSRSDHLTTHI 54
Cdd:PHA00733  73 PYVCPL--CLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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