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Conserved domains on  [gi|330443617|ref|NP_012632|]
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uncharacterized protein YJR098C [Saccharomyces cerevisiae S288C]

Protein Classification

esterase/lipase family protein( domain architecture ID 10787203)

esterase/lipase family protein is an alpha/beta hydrolase, such as triacylglycerol lipase that catalyzes the hydrolysis of a triacylglycerol to form the corresponding diacylglycerol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0016787|GO:0016042
PubMed:  37582413|12369917|19508187|11099800

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 308-389 4.03e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


:

Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 51.75  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443617 308 KRLIKRLDANpNLNVQQFGYDWRL-SLDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLVAHKVLQDC--THLIRGII 384
Cdd:COG1075   22 APLAPRLRAA-GYPVYALNYPSTNgSIEDSAEQLAAFVDAVLAATGAEK-VDLVGHSMGGLVARYYLKRLggAAKVARVV 99


                 ....*
gi 330443617 385 YVGSP 389
Cdd:COG1075  100 TLGTP 104
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 308-389 4.03e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 51.75  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443617 308 KRLIKRLDANpNLNVQQFGYDWRL-SLDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLVAHKVLQDC--THLIRGII 384
Cdd:COG1075   22 APLAPRLRAA-GYPVYALNYPSTNgSIEDSAEQLAAFVDAVLAATGAEK-VDLVGHSMGGLVARYYLKRLggAAKVARVV 99


                 ....*
gi 330443617 385 YVGSP 389
Cdd:COG1075  100 TLGTP 104
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
 299-426 8.08e-05

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


Pssm-ID: 396835  Cd Length: 383  Bit Score: 45.23  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443617  299 THIGPVDISKRLIKRLDAN---PNLNVQQFGYDWRLSLDISAKHLtTKLE---EIYNKQKNKKgIYIIAHSMGGLVAHKV 372
Cdd:pfam02450  55 SKLAGYWIWHKVVQNLVNIgyeRNKTVRAAPYDWRLSLEERDKYF-HKLKqliEEAHKLYGKK-VVLIGHSMGNLLVLYF 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330443617  373 L------QDCTHLIRGIIYV-----GSPSQCPNILGPIRFGDDVMWNKTIFTkETNFFMRSSFYF 426
Cdd:pfam02450 133 LlwvvaeAWKDQHIDAFISLgapllGSPKAVRALASGYNFGIPILSEITLRG-LQRSFSSSPWML 196
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
 325-368 8.85e-05

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 45.39  E-value: 8.85e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 330443617 325 FGYDWRLS--LDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLV 368
Cdd:PLN02733 131 FGYDFRQSnrLPETMDGLKKKLETVYKASGGKK-VNIISHSMGGLL 175
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 308-389 4.03e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 51.75  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443617 308 KRLIKRLDANpNLNVQQFGYDWRL-SLDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLVAHKVLQDC--THLIRGII 384
Cdd:COG1075   22 APLAPRLRAA-GYPVYALNYPSTNgSIEDSAEQLAAFVDAVLAATGAEK-VDLVGHSMGGLVARYYLKRLggAAKVARVV 99


                 ....*
gi 330443617 385 YVGSP 389
Cdd:COG1075  100 TLGTP 104
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
 299-426 8.08e-05

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


Pssm-ID: 396835  Cd Length: 383  Bit Score: 45.23  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443617  299 THIGPVDISKRLIKRLDAN---PNLNVQQFGYDWRLSLDISAKHLtTKLE---EIYNKQKNKKgIYIIAHSMGGLVAHKV 372
Cdd:pfam02450  55 SKLAGYWIWHKVVQNLVNIgyeRNKTVRAAPYDWRLSLEERDKYF-HKLKqliEEAHKLYGKK-VVLIGHSMGNLLVLYF 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330443617  373 L------QDCTHLIRGIIYV-----GSPSQCPNILGPIRFGDDVMWNKTIFTkETNFFMRSSFYF 426
Cdd:pfam02450 133 LlwvvaeAWKDQHIDAFISLgapllGSPKAVRALASGYNFGIPILSEITLRG-LQRSFSSSPWML 196
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
 325-368 8.85e-05

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 45.39  E-value: 8.85e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 330443617 325 FGYDWRLS--LDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLV 368
Cdd:PLN02733 131 FGYDFRQSnrLPETMDGLKKKLETVYKASGGKK-VNIISHSMGGLL 175
DUF900 pfam05990
Alpha/beta hydrolase of unknown function (DUF900); This family consists of several ...
 325-374 8.99e-04

Alpha/beta hydrolase of unknown function (DUF900); This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.


Pssm-ID: 399172  Cd Length: 236  Bit Score: 41.26  E-value: 8.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 330443617  325 FGYDW-RLSLDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLVAHKVLQ 374
Cdd:pfam05990  64 FDYNYdKESANYSRPALEHLLRYLANDPPVKK-IYLIAHSMGTWLVMEALR 113
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
357-388 4.02e-03

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 39.21  E-value: 4.02e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 330443617 357 IYIIAHSMGGLVAHKVLQDCTHLIRGIIYVGS 388
Cdd:COG2267  101 VVLLGHSMGGLIALLYAARYPDRVAGLVLLAP 132
COG4782 COG4782
Esterase/lipase superfamily enzyme [General function prediction only];
321-375 9.46e-03

Esterase/lipase superfamily enzyme [General function prediction only];


Pssm-ID: 443812  Cd Length: 357  Bit Score: 38.78  E-value: 9.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 330443617 321 NVQQFGYDwRLSLDISAKHLTTKLEEIYNKQKNKKgIYIIAHSMGGLVAHKVLQD 375
Cdd:COG4782  166 SLLGYVYD-RESATYSRDALEELLRDLARDPGAER-IHIVAHSMGNWLTMEALRQ 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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