NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|327306684|ref|XP_003238033|]
View 

uncharacterized protein TERG_00027 [Trichophyton rubrum CBS 118892]

Protein Classification

F-box protein( domain architecture ID 10584247)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
SCOP:  4001927

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
4-67 1.90e-03

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.92  E-value: 1.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 327306684    4 IHSLPVEILYLILSFISAsppptaderalrdlpshavtssgtTDLKSVSRVCRQFREFSREHLF 67
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP------------------------KDLLRLALVCRRWRELASDDSL 40
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
4-67 1.90e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.92  E-value: 1.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 327306684    4 IHSLPVEILYLILSFISAsppptaderalrdlpshavtssgtTDLKSVSRVCRQFREFSREHLF 67
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP------------------------KDLLRLALVCRRWRELASDDSL 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
5-63 2.77e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 35.11  E-value: 2.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 327306684   5 HSLPVEILYLILSFISAsppptaderalrdlpshavtssgtTDLKSVSRVCRQFREFSR 63
Cdd:cd09917    1 SDLPDEILLKILSYLDP------------------------RDLLRLSLVCKRWRELAS 35
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
4-67 1.90e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.92  E-value: 1.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 327306684    4 IHSLPVEILYLILSFISAsppptaderalrdlpshavtssgtTDLKSVSRVCRQFREFSREHLF 67
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP------------------------KDLLRLALVCRRWRELASDDSL 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
5-63 2.77e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 35.11  E-value: 2.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 327306684   5 HSLPVEILYLILSFISAsppptaderalrdlpshavtssgtTDLKSVSRVCRQFREFSR 63
Cdd:cd09917    1 SDLPDEILLKILSYLDP------------------------RDLLRLSLVCKRWRELAS 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH