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Conserved domains on  [gi|326807039|ref|NP_001192048|]
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autophagy-related protein 13 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATG13 super family cl12374
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-192 5.13e-07

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.3].


The actual alignment was detected with superfamily member pfam10033:

Pssm-ID: 431003  Cd Length: 228  Bit Score: 50.67  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807039   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKK----ALAGQLPAvgrsMCVEISLKTS----- 89
Cdd:pfam10033   4 FF-TKAALLILQSRLNLPPSSSGSGSKKVNKWFNLETDDTDLFREELRLwrscDSLSENPP----LVIETYLDLSdlspn 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807039   90 --------EG---DSME---------LEIWCLE------MNEKCDKEIKVSYTVYNRlslllksllAI---------TRV 134
Cdd:pfam10033  79 qslvlrddDGkrwDVDKgggkkteivLERWLIEldptspTDPSDFGSILELPTVYKK---------AIvlfrslytlLRL 149
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 326807039  135 TPAYRLSR-----KQGHEYVIL-YRIYFGEVQLSGLGE-GF-------------QTVRVGTVGTPVGTITLSCAYRIN 192
Cdd:pfam10033 150 LPAWKLYKrlnksKGSHPALKLgCRILDGSKPILSKGRdGLskplipsysnvhlEQYKFTPIETPLGRLRISVSYRND 227
 
Name Accession Description Interval E-value
ATG13 pfam10033
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-192 5.13e-07

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.3].


Pssm-ID: 431003  Cd Length: 228  Bit Score: 50.67  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807039   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKK----ALAGQLPAvgrsMCVEISLKTS----- 89
Cdd:pfam10033   4 FF-TKAALLILQSRLNLPPSSSGSGSKKVNKWFNLETDDTDLFREELRLwrscDSLSENPP----LVIETYLDLSdlspn 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807039   90 --------EG---DSME---------LEIWCLE------MNEKCDKEIKVSYTVYNRlslllksllAI---------TRV 134
Cdd:pfam10033  79 qslvlrddDGkrwDVDKgggkkteivLERWLIEldptspTDPSDFGSILELPTVYKK---------AIvlfrslytlLRL 149
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 326807039  135 TPAYRLSR-----KQGHEYVIL-YRIYFGEVQLSGLGE-GF-------------QTVRVGTVGTPVGTITLSCAYRIN 192
Cdd:pfam10033 150 LPAWKLYKrlnksKGSHPALKLgCRILDGSKPILSKGRdGLskplipsysnvhlEQYKFTPIETPLGRLRISVSYRND 227
 
Name Accession Description Interval E-value
ATG13 pfam10033
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-192 5.13e-07

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.3].


Pssm-ID: 431003  Cd Length: 228  Bit Score: 50.67  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807039   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKK----ALAGQLPAvgrsMCVEISLKTS----- 89
Cdd:pfam10033   4 FF-TKAALLILQSRLNLPPSSSGSGSKKVNKWFNLETDDTDLFREELRLwrscDSLSENPP----LVIETYLDLSdlspn 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326807039   90 --------EG---DSME---------LEIWCLE------MNEKCDKEIKVSYTVYNRlslllksllAI---------TRV 134
Cdd:pfam10033  79 qslvlrddDGkrwDVDKgggkkteivLERWLIEldptspTDPSDFGSILELPTVYKK---------AIvlfrslytlLRL 149
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 326807039  135 TPAYRLSR-----KQGHEYVIL-YRIYFGEVQLSGLGE-GF-------------QTVRVGTVGTPVGTITLSCAYRIN 192
Cdd:pfam10033 150 LPAWKLYKrlnksKGSHPALKLgCRILDGSKPILSKGRdGLskplipsysnvhlEQYKFTPIETPLGRLRISVSYRND 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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