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Conserved domains on  [gi|325651964|ref|NP_001191768|]
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zinc finger protein 568 isoform 6 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
73-133 1.52e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.15  E-value: 1.52e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325651964    73 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 133
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB smart00349
krueppel associated box;
1-38 9.35e-19

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 9.35e-19
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 325651964     1 MKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 38
Cdd:smart00349  18 LDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-501 1.59e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 224 RKCKNAFRYQSCPIQHEIIhNKEKEPECGECRKIFNSGSDLIKHQTLHESKKHSENNKCAFNHDSGIT--QPQSINTGEK 301
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVS-TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLsqSPSSLSSSDS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 302 PHKCKECGKAFRS--SSQISQHQRMHLGE-----KPYKCRECGKAFPSTAQLNLHQR--IHTDEKYYES----KACGKAF 368
Cdd:COG5048  254 SSSASESPRSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLF 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 369 TRPSHLFRHQRIHTGEKPHKCKecgkafrYDTQLSLHQIihtgerryecrecgKVYSCASQLSLHQRIHTGEKPHEC--K 446
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEK-------LLNSSSKFSP--------------LLNNEPPQSLQQYKDLKNDKKSETlsN 392

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 325651964 447 ECGKAFISDSHLIRHQSVHTGEKP--CKCKECGKSFRRGSELTRHQRAHTGEKPYEC 501
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-538 5.77e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651964  513 ELVRHQKVHTGERPHKCKECGKAFIR 538
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
73-133 1.52e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.15  E-value: 1.52e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325651964    73 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 133
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 75-113 2.61e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.61e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 325651964   75 FKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLG 113
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
1-38 9.35e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 9.35e-19
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 325651964     1 MKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 38
Cdd:smart00349  18 LDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 73-112 1.59e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 1.59e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 325651964  73 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLL 112
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-24 7.84e-10

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 54.40  E-value: 7.84e-10
                          10        20
                  ....*....|....*....|....
gi 325651964    1 MKPAQRNLYRDVMLENYSNLVTVG 24
Cdd:pfam01352  19 LDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 1-21 3.78e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 46.77  E-value: 3.78e-07
                         10        20
                 ....*....|....*....|.
gi 325651964   1 MKPAQRNLYRDVMLENYSNLV 21
Cdd:cd07765   18 LDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-501 1.59e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 224 RKCKNAFRYQSCPIQHEIIhNKEKEPECGECRKIFNSGSDLIKHQTLHESKKHSENNKCAFNHDSGIT--QPQSINTGEK 301
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVS-TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLsqSPSSLSSSDS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 302 PHKCKECGKAFRS--SSQISQHQRMHLGE-----KPYKCRECGKAFPSTAQLNLHQR--IHTDEKYYES----KACGKAF 368
Cdd:COG5048  254 SSSASESPRSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLF 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 369 TRPSHLFRHQRIHTGEKPHKCKecgkafrYDTQLSLHQIihtgerryecrecgKVYSCASQLSLHQRIHTGEKPHEC--K 446
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEK-------LLNSSSKFSP--------------LLNNEPPQSLQQYKDLKNDKKSETlsN 392

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 325651964 447 ECGKAFISDSHLIRHQSVHTGEKP--CKCKECGKSFRRGSELTRHQRAHTGEKPYEC 501
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-398 7.42e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.42e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651964  373 HLFRHQRIHTGEKPHKCKECGKAFRY 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-538 5.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651964  513 ELVRHQKVHTGERPHKCKECGKAFIR 538
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
73-133 1.52e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.15  E-value: 1.52e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325651964    73 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 133
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 75-113 2.61e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.61e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 325651964   75 FKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLG 113
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
1-38 9.35e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 9.35e-19
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 325651964     1 MKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 38
Cdd:smart00349  18 LDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 73-112 1.59e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 1.59e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 325651964  73 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLL 112
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-24 7.84e-10

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 54.40  E-value: 7.84e-10
                          10        20
                  ....*....|....*....|....
gi 325651964    1 MKPAQRNLYRDVMLENYSNLVTVG 24
Cdd:pfam01352  19 LDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 1-21 3.78e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 46.77  E-value: 3.78e-07
                         10        20
                 ....*....|....*....|.
gi 325651964   1 MKPAQRNLYRDVMLENYSNLV 21
Cdd:cd07765   18 LDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-501 1.59e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 224 RKCKNAFRYQSCPIQHEIIhNKEKEPECGECRKIFNSGSDLIKHQTLHESKKHSENNKCAFNHDSGIT--QPQSINTGEK 301
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVS-TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLsqSPSSLSSSDS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 302 PHKCKECGKAFRS--SSQISQHQRMHLGE-----KPYKCRECGKAFPSTAQLNLHQR--IHTDEKYYES----KACGKAF 368
Cdd:COG5048  254 SSSASESPRSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLF 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 369 TRPSHLFRHQRIHTGEKPHKCKecgkafrYDTQLSLHQIihtgerryecrecgKVYSCASQLSLHQRIHTGEKPHEC--K 446
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEK-------LLNSSSKFSP--------------LLNNEPPQSLQQYKDLKNDKKSETlsN 392

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 325651964 447 ECGKAFISDSHLIRHQSVHTGEKP--CKCKECGKSFRRGSELTRHQRAHTGEKPYEC 501
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-557 1.64e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 214 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 285
Cdd:COG5048   55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 286 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 345
Cdd:COG5048  122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 346 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 413
Cdd:COG5048  202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 414 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 478
Cdd:COG5048  282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 479 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 549
Cdd:COG5048  362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                 ....*...
gi 325651964 550 TGEKPYEC 557
Cdd:COG5048  442 TNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-546 9.95e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 255 RKIFNSGSDLIKHQTLHESKKHSENNKCAFNHDSGITQPQSINTGEKPHKCKEcgkafRSSSQISQHQRMHLGEKPYKCR 334
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSSSDSSSSASESPRSSL 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 335 eCGKAFPSTAQLNLHQRIHTDEKY-YESKACGKAFTRPSHLFRHQR--IHTGE--KPHKCKE--CGKAFRYDTQLSLHQI 407
Cdd:COG5048  266 -PTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 408 IHTGERRYECREC-------GKVYSCASQLSLHQRIHTGEKPHEC--KECGKAFISDSHLIRHQSVHTGEKPCKCKecgk 478
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK---- 420

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325651964 479 sfrrgseltrhqrahtgekpyeCKECEKAFTCSTELVRHQKVHTGERPHKCKECGKAFIRRSELTHHE 546
Cdd:COG5048  421 ----------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-398 7.42e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.42e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651964  373 HLFRHQRIHTGEKPHKCKECGKAFRY 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-501 1.17e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325651964 441 KPHECKECGKAFISDSHLIRHQSVHTGEKPCKC--KECGKSFRRGSELTRHQRAHTGEKPYEC 501
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-538 5.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651964  513 ELVRHQKVHTGERPHKCKECGKAFIR 538
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-454 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 325651964  430 LSLHQRIHTGEKPHECKECGKAFIS 454
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-510 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*.
gi 325651964  485 ELTRHQRAHTGEKPYECKECEKAFTC 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
364-406 3.91e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 325651964 364 CGKAFTRPSHLFRHQRIHTGEKPHKCKECGKAFRYDTQLSLHQ 406
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-340 5.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.05e-03
                          10        20
                  ....*....|....*....|.
gi 325651964  320 QHQRMHLGEKPYKCRECGKAF 340
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
329-558 5.97e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 329 KPYKCRECGKAFPSTAQLNLHQRIHTDEKYYESKA--CGKAFTRPSHLFRHQRIHTGEKPHKCK---------------- 390
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 391 ECGKAFRYDTQLSLH--------QIIHTGERRYECREC---------------------------GKVYSCASQLSLHQR 435
Cdd:COG5048  112 SSSSNSNDNNLLSSHslppssrdPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 436 IHTGEKPHECKECGKAFISDSHLI----------------------------RHQSVHTGEKPCKCKECGKSFR--RGSE 485
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSsdqnlensssslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651964 486 LTRHQRAHTGE-----KPYECKECEKAFTCSTELVRHQ--KVHTGE--RPHKCKE--CGKAFIRRSELTHHERSHTGEKP 554
Cdd:COG5048  272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                 ....
gi 325651964 555 YECK 558
Cdd:COG5048  352 AKEK 355
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 527-549 9.90e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.90e-03
                          10        20
                  ....*....|....*....|...
gi 325651964  527 HKCKECGKAFIRRSELTHHERSH 549
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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