NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|325511343|sp|Q9QZS7|]
View 

RecName: Full=Nephrin; AltName: Full=Renal glomerulus-specific cell adhesion receptor; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 848-956 1.29e-61

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05773:

Pssm-ID: 472250  Cd Length: 109  Bit Score: 205.16  E-value: 1.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  848 VRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQ 927
Cdd:cd05773     1 VRFAPDLQKGPQLRKVASRGDGSSDANLVCQAQGVPRVQFRWAKNGVPLDLGNPRYEETTEHTGTVHTSILTIINVSAAL 80

                          90       100
                  ....*....|....*....|....*....
gi 325511343  928 DYALFKCTATNALGSDHTNIQLVSISRPD 956
Cdd:cd05773    81 DYALFTCTAHNSLGEDSLDIQLVSTSRPD 109
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 155-242 3.62e-21

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 89.01  E-value: 3.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   155 TPEAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGS 234
Cdd:pfam08205    2 TIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTCQVS 81


                   ....*...
gi 325511343   235 NPALATPI 242
Cdd:pfam08205   82 YGALRGSI 89
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 358-442 3.38e-15

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 72.07  E-value: 3.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   358 TILGSTSQSENKN--VTLCCLTKSSRPRVLLRWWLGGRQLLP-TDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAF 434
Cdd:pfam08205    2 TIEPPASLLEGEGpeVVATCSSAGGKPAPRITWYLDGKPLEAaETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTCQVS 81


                   ....*...
gi 325511343   435 SDAFSKET 442
Cdd:pfam08205   82 YGALRGSI 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 955-1049 7.77e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 7.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  955 PDPPLGLKVVSVSPHSVGLEWK-PGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNAL 1033
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 325511343 1034 GDSGLTDkgiQVSITT 1049
Cdd:cd00063    81 GESPPSE---SVTVTT 93
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 754-834 7.89e-10

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 56.42  E-value: 7.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   754 PTIRALKDPTEVNVGGSVDIVCTVDANPilPEMFSWERLGEdeEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVD 833
Cdd:pfam13927    2 PVITVSPSSVTVREGETVTLTCEATGSP--PPTITWYKNGE--PISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77


                   .
gi 325511343   834 N 834
Cdd:pfam13927   78 N 78
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 563-646 5.95e-08

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam08205:

Pssm-ID: 472250  Cd Length: 89  Bit Score: 51.27  E-value: 5.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   563 TILANSSALRPGDA-LNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVF-LRVSSRDHGHRVTCRAH 640
Cdd:pfam08205    2 TIEPPASLLEGEGPeVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQDPESGLVTVTSELkLVPSRSDHGQSLTCQVS 81


                   ....*.
gi 325511343   641 SEALRE 646
Cdd:pfam08205   82 YGALRG 87
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 251-344 5.99e-08

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05761:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 51.66  E-value: 5.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  251 LFPPGPPVIDwpGLnEGHVRAGENLELPCIARGGNPPATLQWLKN-----GKPVSIAWGTEHAQAVAhSVLVMTVRPEDH 325
Cdd:cd05761     1 LGVPEKPVIT--GF-TSPVVEGDEITLTCTTSGSKPAADIRWFKNdkelkGVKEVQESGAGKTFTVT-STLRFRVDRDDD 76

                          90       100
                  ....*....|....*....|...
gi 325511343  326 GARLSCQ----SYNSVSAETQER 344
Cdd:cd05761    77 GVAVICRvdheSLTSTPKQTQQV 99
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 52-127 1.26e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 1.26e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343     52 SENLTVVEGSTVKLWCGVRA-PGSVVQWAKDGLLLgpnpkIPGFPRYSLEGDSakGEFHLLIEACDLSDDAEYECQV 127
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQGGKL-----LAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAA 70
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 472-555 2.05e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05856:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 47.16  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  472 GTRVRLVCLAiGGNPEPSLTWLKDSRPVnDPRQSQEPRRVQLgsveksgstfsrELVLIIGPPDNLAKFSC----KAGQL 547
Cdd:cd05856    19 GSSVRLKCVA-SGNPRPDITWLKDNKPL-TPPEIGENKKKKW------------TLSLKNLKPEDSGKYTChvsnRAGEI 84


                  ....*...
gi 325511343  548 SASTQLVV 555
Cdd:cd05856    85 NATYKVDV 92
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 660-750 4.43e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04969:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 89  Bit Score: 43.22  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  660 PEFLGEQVRAVTVVEQG-QALLPVSVSANPAPeAFNWTFRGYRLSpaGGPRHRILSGGALQLWNVTRADDGFYQLHCQNS 738
Cdd:cd04969     1 PDFELNPVKKKILAAKGgDVIIECKPKASPKP-TISWSKGTELLT--NSSRICILPDGSLKIKNVTKSDEGKYTCFAVNF 77

                          90
                  ....*....|..
gi 325511343  739 EGTAEALLKLDV 750
Cdd:cd04969    78 FGKANSTGSLSV 89
 
Name Accession Description Interval E-value
IgC1_hNephrin_like cd05773
Immunoglobulin-like domain of human nephrin and similar proteins; member of the C1-set of Ig ...
 848-956 1.29e-61

Immunoglobulin-like domain of human nephrin and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin-like domain in human nephrin and similar proteins. Nephrin is an integral component of the slit diaphragm and is a central component of the glomerular ultrafilter. Nephrin plays a structural role and has a role in signaling. Nephrin is a transmembrane protein having a short intracellular portion, an extracellular portion comprised of eight Ig-like domains, and one fibronectin type III-like domain. The extracellular portions of nephrin from neighboring foot processes of separate podocyte cells may interact with each other, and in association with other components of the slit diaphragm form a porous molecular sieve within the slit pore. The intracellular portion of nephrin is associated with linker proteins, which connect nephrin to the actin cytoskeleton. The intracellular portion is tyrosine phosphorylated, and mediates signaling from the slit diaphragm into the podocytes.


Pssm-ID: 143250  Cd Length: 109  Bit Score: 205.16  E-value: 1.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  848 VRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQ 927
Cdd:cd05773     1 VRFAPDLQKGPQLRKVASRGDGSSDANLVCQAQGVPRVQFRWAKNGVPLDLGNPRYEETTEHTGTVHTSILTIINVSAAL 80

                          90       100
                  ....*....|....*....|....*....
gi 325511343  928 DYALFKCTATNALGSDHTNIQLVSISRPD 956
Cdd:cd05773    81 DYALFTCTAHNSLGEDSLDIQLVSTSRPD 109
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 155-242 3.62e-21

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 89.01  E-value: 3.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   155 TPEAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGS 234
Cdd:pfam08205    2 TIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTCQVS 81


                   ....*...
gi 325511343   235 NPALATPI 242
Cdd:pfam08205   82 YGALRGSI 89
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 358-442 3.38e-15

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 72.07  E-value: 3.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   358 TILGSTSQSENKN--VTLCCLTKSSRPRVLLRWWLGGRQLLP-TDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAF 434
Cdd:pfam08205    2 TIEPPASLLEGEGpeVVATCSSAGGKPAPRITWYLDGKPLEAaETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTCQVS 81


                   ....*...
gi 325511343   435 SDAFSKET 442
Cdd:pfam08205   82 YGALRGSI 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 955-1049 7.77e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 7.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  955 PDPPLGLKVVSVSPHSVGLEWK-PGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNAL 1033
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 325511343 1034 GDSGLTDkgiQVSITT 1049
Cdd:cd00063    81 GESPPSE---SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
956-1039 4.99e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 4.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   956 DPPLGLKVVSVSPHSVGLEWKPGFDGGLP-QRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALG 1034
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 325511343  1035 DSGLT 1039
Cdd:pfam00041   81 EGPPS 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 859-949 8.66e-12

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.14  E-value: 8.66e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    859 PLTKVAAAGDStssATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVhsslLTIANVSaAQDYALFKCTATN 938
Cdd:smart00410    1 PPSVTVKEGES---VTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGSTST----LTISNVT-PEDSGTYTCAATN 72

                            90
                    ....*....|.
gi 325511343    939 ALGSDHTNIQL 949
Cdd:smart00410   73 SSGSASSGTTL 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 955-1036 1.23e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.23e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    955 PDPPLGLKVVSVSPHSVGLEWKPGFDGGlPQRFQIRYEALESPGFLYMDVL--PAQATTFTLTGLKPSTRYRIWLLASNA 1032
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 325511343   1033 LGDS 1036
Cdd:smart00060   80 AGEG 83
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 754-834 7.89e-10

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 56.42  E-value: 7.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   754 PTIRALKDPTEVNVGGSVDIVCTVDANPilPEMFSWERLGEdeEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVD 833
Cdd:pfam13927    2 PVITVSPSSVTVREGETVTLTCEATGSP--PPTITWYKNGE--PISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77


                   .
gi 325511343   834 N 834
Cdd:pfam13927   78 N 78
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 157-250 2.57e-09

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 55.53  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  157 EAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGSNP 236
Cdd:cd05759     5 EGGPVISLQAGVPYNLTCRARGAKPAAEIIWFRDGEQLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFTCRARNE 84

                          90
                  ....*....|....
gi 325511343  237 ALATPIKASFTMNI 250
Cdd:cd05759    85 AIPNGKETSITLDV 98
I-set pfam07679
Immunoglobulin I-set domain;
871-949 2.60e-08

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 52.64  E-value: 2.60e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 325511343   871 SSATLHCRARGVPNIDFTWTKNGVPLdLQDPRYTEHKyhQGVVHSslLTIANVSAAqDYALFKCTATNALGSDHTNIQL 949
Cdd:pfam07679   16 ESARFTCTVTGTPDPEVSWFKDGQPL-RSSDRFKVTY--EGGTYT--LTISNVQPD-DSGKYTCVATNSAGEAEASAEL 88
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 563-646 5.95e-08

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 51.27  E-value: 5.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   563 TILANSSALRPGDA-LNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVF-LRVSSRDHGHRVTCRAH 640
Cdd:pfam08205    2 TIEPPASLLEGEGPeVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQDPESGLVTVTSELkLVPSRSDHGQSLTCQVS 81


                   ....*.
gi 325511343   641 SEALRE 646
Cdd:pfam08205   82 YGALRG 87
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 251-344 5.99e-08

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 51.66  E-value: 5.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  251 LFPPGPPVIDwpGLnEGHVRAGENLELPCIARGGNPPATLQWLKN-----GKPVSIAWGTEHAQAVAhSVLVMTVRPEDH 325
Cdd:cd05761     1 LGVPEKPVIT--GF-TSPVVEGDEITLTCTTSGSKPAADIRWFKNdkelkGVKEVQESGAGKTFTVT-STLRFRVDRDDD 76

                          90       100
                  ....*....|....*....|...
gi 325511343  326 GARLSCQ----SYNSVSAETQER 344
Cdd:cd05761    77 GVAVICRvdheSLTSTPKQTQQV 99
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 558-656 3.96e-07

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 49.35  E-value: 3.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  558 PPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTC 637
Cdd:cd05761     3 VPEKPVITGFTSPVVEGDEITLTCTTSGSKPAADIRWFKNDKELKGVKEVQESGAGKTFTVTSTLRFRVDRDDDGVAVIC 82

                          90       100
                  ....*....|....*....|
gi 325511343  638 RAHSEALRET-VSSFYRLNV 656
Cdd:cd05761    83 RVDHESLTSTpKQTQQVLEV 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 762-848 6.58e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 48.27  E-value: 6.58e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    762 PTEVNVGGSVDIVCTVDANPilPEMFSWERlgEDEEELNLDDMEKMSK-GSTGRLRIRQAKLSQAGAYQCIVDNGVAPAA 840
Cdd:smart00410    3 SVTVKEGESVTLSCEASGSP--PPEVTWYK--QGGKLLAESGRFSVSRsGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                    ....*...
gi 325511343    841 RGlVRLVV 848
Cdd:smart00410   79 SG-TTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 52-127 1.26e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 1.26e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343     52 SENLTVVEGSTVKLWCGVRA-PGSVVQWAKDGLLLgpnpkIPGFPRYSLEGDSakGEFHLLIEACDLSDDAEYECQV 127
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQGGKL-----LAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAA 70
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 272-332 1.46e-06

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 47.41  E-value: 1.46e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325511343   272 GENLELPCIARGGNPPATLQWLKNGKPVSIAW-----GTEHAQAVAHSVLVMTVRPEDHGARLSCQ 332
Cdd:pfam08205   14 GPEVVATCSSAGGKPAPRITWYLDGKPLEAAEtsseqDPESGLVTVTSELKLVPSRSDHGQSLTCQ 79
IgI_2_FGFRL1-like cd05856
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1 ...
 472-555 2.05e-06

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.


Pssm-ID: 409442  Cd Length: 92  Bit Score: 47.16  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  472 GTRVRLVCLAiGGNPEPSLTWLKDSRPVnDPRQSQEPRRVQLgsveksgstfsrELVLIIGPPDNLAKFSC----KAGQL 547
Cdd:cd05856    19 GSSVRLKCVA-SGNPRPDITWLKDNKPL-TPPEIGENKKKKW------------TLSLKNLKPEDSGKYTChvsnRAGEI 84


                  ....*...
gi 325511343  548 SASTQLVV 555
Cdd:cd05856    85 NATYKVDV 92
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 459-544 4.37e-06

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 46.26  E-value: 4.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   459 WIEgPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRrvqlgsVEKSGSTFSRELVLIIGPPDNLA 538
Cdd:pfam08205    2 TIE-PPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQD------PESGLVTVTSELKLVPSRSDHGQ 74


                   ....*.
gi 325511343   539 KFSCKA 544
Cdd:pfam08205   75 SLTCQV 80
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
 761-852 1.36e-05

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 45.23  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  761 DPTEVNVGGSVDIVCTVDANPILPEMFSWERLGE--DEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNgVAP 838
Cdd:cd04970    10 SNADITVGENATLQCHASHDPTLDLTFTWSFNGVpiDLEKIEGHYRRRYGKDSNGDLEIVNAQLKHAGRYTCTAQT-VVD 88

                          90
                  ....*....|....
gi 325511343  839 AARGLVRLVVRFAP 852
Cdd:cd04970    89 SDSASATLVVRGPP 102
Ig5_Contactin cd04969
Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...
 660-750 4.43e-05

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409358 [Multi-domain]  Cd Length: 89  Bit Score: 43.22  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  660 PEFLGEQVRAVTVVEQG-QALLPVSVSANPAPeAFNWTFRGYRLSpaGGPRHRILSGGALQLWNVTRADDGFYQLHCQNS 738
Cdd:cd04969     1 PDFELNPVKKKILAAKGgDVIIECKPKASPKP-TISWSKGTELLT--NSSRICILPDGSLKIKNVTKSDEGKYTCFAVNF 77

                          90
                  ....*....|..
gi 325511343  739 EGTAEALLKLDV 750
Cdd:cd04969    78 FGKANSTGSLSV 89
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
928-1066 4.65e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 48.02  E-value: 4.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  928 DYaLFKCTATNALG--SDHTNIQLVSIS----RPDPPLGLKVVSvSPHSVGLEWKPGFDGGLPqRFQIRYEALESPGFLY 1001
Cdd:COG4733   598 DY-EVRVRAINALGvsSAWAASSETTVTgktaPPPAPTGLTATG-GLGGITLSWSFPVDADTL-RTEIRYSTTGDWASAT 674

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325511343 1002 MDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGltDKGIQVSITTPGLDQAPEDTDQPLPTE 1066
Cdd:COG4733   675 VAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVS--AWWVSGQASADAAGILDAITGQILETE 737
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1051 5.13e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.69  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  847 VVRFAPQVDHPTPLTKVAAAGDSTSSATLhcrargvpnidfTWTKNGVPlDLQdpRYT-------EHKYHQ-GVVHSSLL 918
Cdd:COG3401   223 EVSVTTPTTPPSAPTGLTATADTPGSVTL------------SWDPVTES-DAT--GYRvyrsnsgDGPFTKvATVTTTSY 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  919 TIANVSAAQDYaLFKCTATNALG--SDHTNI--QLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLpQRFQIrYEAl 994
Cdd:COG3401   288 TDTGLTNGTTY-YYRVTAVDAAGneSAPSNVvsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADV-TGYNV-YRS- 363

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  995 ESPGFLYMDV-LPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSITTPG 1051
Cdd:COG3401   364 TSGGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAA 421
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 52-128 6.93e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.22  E-value: 6.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    52 SENLTVVEGSTVKLWC----GVRAPGSVVQWAKDGLLLGPNPKIPGF----------PRYSLEGDSAKGEFHLLIEACDL 117
Cdd:pfam07686    3 PREVTVALGGSVTLPCtyssSMSEASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNLTL 82

                           90
                   ....*....|.
gi 325511343   118 SDDAEYECQVG 128
Cdd:pfam07686   83 SDSGTYTCAVI 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 670-750 7.20e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 7.20e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    670 VTVVEQGQALLPVSVSANPAPEaFNWTFRGYRLsPAGGPRHRILSGG---ALQLWNVTRADDGFYQLHCQNSEGTAEALL 746
Cdd:smart00410    4 VTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL-LAESGRFSVSRSGstsTLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                    ....
gi 325511343    747 KLDV 750
Cdd:smart00410   82 TLTV 85
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 357-433 8.30e-05

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 42.80  E-value: 8.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343  357 VTILGSTSQsENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEA 433
Cdd:cd05761     9 ITGFTSPVV-EGDEITLTCTTSGSKPAADIRWFKNDKELKGVKEVQESGAGKTFTVTSTLRFRVDRDDDGVAVICRV 84
IgI_C2_MyBP-C-like cd20967
Domain C2 of human cardiac Myosin Binding Protein C and similar domains; a member of the I-set ...
 50-136 1.03e-04

Domain C2 of human cardiac Myosin Binding Protein C and similar domains; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig) Domain C2 of human cardiac Myosin Binding Protein C (MyBP-C) and similar domains. MyBP-C is a thick filament protein involved in the regulation of muscle contraction. Mutations in cardiac MyBP-C gene are the second most frequent cause of hypertrophic cardiomyopathy. MyBP-C binds to myosin with two binding sites, one at its C-terminus and another at its N-terminus. The N-terminal binding site, consisting of immunoglobulin (lg) domains C1 and C2 connected by a flexible linker, interacts with the S2 segment of myosin in a phosphorylation-regulated manner. The C1 and C2 Ig domains can bind to and activate or inhibit the thin filament. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structures of the Ig domains of MyBP-C lack this strand and thus belong to the I-set of Ig superfamily domains. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.


Pssm-ID: 409559  Cd Length: 82  Bit Score: 42.23  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   50 ALSENLTVVEGSTVKLWCGVRAPGSVVQWAKDGlllgpnPKIPGFPRYSLEGDSAKGEfhLLIEACDLSDDAEYECQVGR 129
Cdd:cd20967     2 KAQPAVQVSKGHKIRLTVELADPDAEVKWYKDG------QELQSSSKVIFESIGAKRT--LTVQQASLADAGEYQCVAGG 73


                  ....*..
gi 325511343  130 SELGPEL 136
Cdd:cd20967    74 EKCSFEL 80
I-set pfam07679
Immunoglobulin I-set domain;
660-750 1.97e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.47  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   660 PEFLGeQVRAVTVVEQGQALLPVSVSANPAPEaFNWTFRGYRLSPagGPRHRIL-SGGALQLW--NVTRADDGFYQLHCQ 736
Cdd:pfam07679    1 PKFTQ-KPKDVEVQEGESARFTCTVTGTPDPE-VSWFKDGQPLRS--SDRFKVTyEGGTYTLTisNVQPDDSGKYTCVAT 76

                           90
                   ....*....|....
gi 325511343   737 NSEGTAEALLKLDV 750
Cdd:pfam07679   77 NSAGEAEASAELTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 268-350 2.92e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 2.92e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    268 HVRAGENLELPCIARgGNPPATLQWLKNGKPVSIAWGTEHAQAVAH-SVLVMT-VRPEDHGaRLSCQSYNsvSAETQERS 345
Cdd:smart00410    5 TVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGStSTLTISnVTPEDSG-TYTCAATN--SSGSASSG 80


                    ....*
gi 325511343    346 ITLQV 350
Cdd:smart00410   81 TTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 464-555 2.59e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.59e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    464 PEGQSIRTGTRVRLVCLAIGgNPEPSLTWLKdsrpvNDPRQSQEPRRVqlgSVEKSGSTFSrelvLIIGP--PDNLAKFS 541
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYK-----QGGKLLAESGRF---SVSRSGSTST----LTISNvtPEDSGTYT 67

                            90
                    ....*....|....*...
gi 325511343    542 CKA----GQLSASTQLVV 555
Cdd:smart00410   68 CAAtnssGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgC1_hNephrin_like cd05773
Immunoglobulin-like domain of human nephrin and similar proteins; member of the C1-set of Ig ...
 848-956 1.29e-61

Immunoglobulin-like domain of human nephrin and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin-like domain in human nephrin and similar proteins. Nephrin is an integral component of the slit diaphragm and is a central component of the glomerular ultrafilter. Nephrin plays a structural role and has a role in signaling. Nephrin is a transmembrane protein having a short intracellular portion, an extracellular portion comprised of eight Ig-like domains, and one fibronectin type III-like domain. The extracellular portions of nephrin from neighboring foot processes of separate podocyte cells may interact with each other, and in association with other components of the slit diaphragm form a porous molecular sieve within the slit pore. The intracellular portion of nephrin is associated with linker proteins, which connect nephrin to the actin cytoskeleton. The intracellular portion is tyrosine phosphorylated, and mediates signaling from the slit diaphragm into the podocytes.


Pssm-ID: 143250  Cd Length: 109  Bit Score: 205.16  E-value: 1.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  848 VRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQ 927
Cdd:cd05773     1 VRFAPDLQKGPQLRKVASRGDGSSDANLVCQAQGVPRVQFRWAKNGVPLDLGNPRYEETTEHTGTVHTSILTIINVSAAL 80

                          90       100
                  ....*....|....*....|....*....
gi 325511343  928 DYALFKCTATNALGSDHTNIQLVSISRPD 956
Cdd:cd05773    81 DYALFTCTAHNSLGEDSLDIQLVSTSRPD 109
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 155-242 3.62e-21

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 89.01  E-value: 3.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   155 TPEAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGS 234
Cdd:pfam08205    2 TIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTCQVS 81


                   ....*...
gi 325511343   235 NPALATPI 242
Cdd:pfam08205   82 YGALRGSI 89
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 358-442 3.38e-15

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 72.07  E-value: 3.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   358 TILGSTSQSENKN--VTLCCLTKSSRPRVLLRWWLGGRQLLP-TDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAF 434
Cdd:pfam08205    2 TIEPPASLLEGEGpeVVATCSSAGGKPAPRITWYLDGKPLEAaETSSEQDPESGLVTVTSELKLVPSRSDHGQSLTCQVS 81


                   ....*...
gi 325511343   435 SDAFSKET 442
Cdd:pfam08205   82 YGALRGSI 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 955-1049 7.77e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 7.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  955 PDPPLGLKVVSVSPHSVGLEWK-PGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNAL 1033
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTpPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 325511343 1034 GDSGLTDkgiQVSITT 1049
Cdd:cd00063    81 GESPPSE---SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
956-1039 4.99e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 4.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   956 DPPLGLKVVSVSPHSVGLEWKPGFDGGLP-QRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALG 1034
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 325511343  1035 DSGLT 1039
Cdd:pfam00041   81 EGPPS 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 859-949 8.66e-12

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.14  E-value: 8.66e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    859 PLTKVAAAGDStssATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVhsslLTIANVSaAQDYALFKCTATN 938
Cdd:smart00410    1 PPSVTVKEGES---VTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGSTST----LTISNVT-PEDSGTYTCAATN 72

                            90
                    ....*....|.
gi 325511343    939 ALGSDHTNIQL 949
Cdd:smart00410   73 SSGSASSGTTL 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 955-1036 1.23e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.23e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    955 PDPPLGLKVVSVSPHSVGLEWKPGFDGGlPQRFQIRYEALESPGFLYMDVL--PAQATTFTLTGLKPSTRYRIWLLASNA 1032
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 325511343   1033 LGDS 1036
Cdd:smart00060   80 AGEG 83
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 754-834 7.89e-10

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 56.42  E-value: 7.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   754 PTIRALKDPTEVNVGGSVDIVCTVDANPilPEMFSWERLGEdeEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVD 833
Cdd:pfam13927    2 PVITVSPSSVTVREGETVTLTCEATGSP--PPTITWYKNGE--PISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77


                   .
gi 325511343   834 N 834
Cdd:pfam13927   78 N 78
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 157-250 2.57e-09

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 55.53  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  157 EAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGSNP 236
Cdd:cd05759     5 EGGPVISLQAGVPYNLTCRARGAKPAAEIIWFRDGEQLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFTCRARNE 84

                          90
                  ....*....|....
gi 325511343  237 ALATPIKASFTMNI 250
Cdd:cd05759    85 AIPNGKETSITLDV 98
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 873-945 1.20e-08

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 52.72  E-value: 1.20e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325511343  873 ATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHkyhqgVVHSSLLTIANVSaAQDYALFKCTATNALGSDHT 945
Cdd:cd00096     1 VTLTCSASGNPPPTITWYKNGKPLPPSSRDSRRS-----ELGNGTLTISNVT-LEDSGTYTCVASNSAGGSAS 67
IgI_L1-CAM_like cd05733
Immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins; ...
 868-950 1.65e-08

Immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains NrCAM [Ng(neuronglia)CAM-related cell adhesion molecule], which is primarily expressed in the nervous system, and human neurofascin. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lacks a C" strand.


Pssm-ID: 409396 [Multi-domain]  Cd Length: 94  Bit Score: 53.18  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  868 DSTSSATLHCRARGVPNIDFTWTKNGVPLDL-QDPRYTEHKyhqgvvHSSLLTI-ANVSAAQDY-ALFKCTATNALGSDH 944
Cdd:cd05733    14 DPRDNITIKCEAKGNPQPTFRWTKDGKFFDPaKDPRVSMRR------RSGTLVIdNHNGGPEDYqGEYQCYASNELGTAI 87


                  ....*..
gi 325511343  945 TN-IQLV 950
Cdd:cd05733    88 SNeIRLV 94
I-set pfam07679
Immunoglobulin I-set domain;
871-949 2.60e-08

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 52.64  E-value: 2.60e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 325511343   871 SSATLHCRARGVPNIDFTWTKNGVPLdLQDPRYTEHKyhQGVVHSslLTIANVSAAqDYALFKCTATNALGSDHTNIQL 949
Cdd:pfam07679   16 ESARFTCTVTGTPDPEVSWFKDGQPL-RSSDRFKVTY--EGGTYT--LTISNVQPD-DSGKYTCVATNSAGEAEASAEL 88
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 858-938 3.14e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 51.80  E-value: 3.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   858 TPLTKVAAAGDStssATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHkyhqgVVHSSLLTIANVSaAQDYALFKCTAT 937
Cdd:pfam13927    7 SPSSVTVREGET---VTLTCEATGSPPPTITWYKNGEPISSGSTRSRSL-----SGSNSTLTISNVT-RSDAGTYTCVAS 77


                   .
gi 325511343   938 N 938
Cdd:pfam13927   78 N 78
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 563-646 5.95e-08

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 51.27  E-value: 5.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   563 TILANSSALRPGDA-LNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVF-LRVSSRDHGHRVTCRAH 640
Cdd:pfam08205    2 TIEPPASLLEGEGPeVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQDPESGLVTVTSELkLVPSRSDHGQSLTCQVS 81


                   ....*.
gi 325511343   641 SEALRE 646
Cdd:pfam08205   82 YGALRG 87
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 251-344 5.99e-08

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 51.66  E-value: 5.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  251 LFPPGPPVIDwpGLnEGHVRAGENLELPCIARGGNPPATLQWLKN-----GKPVSIAWGTEHAQAVAhSVLVMTVRPEDH 325
Cdd:cd05761     1 LGVPEKPVIT--GF-TSPVVEGDEITLTCTTSGSKPAADIRWFKNdkelkGVKEVQESGAGKTFTVT-STLRFRVDRDDD 76

                          90       100
                  ....*....|....*....|...
gi 325511343  326 GARLSCQ----SYNSVSAETQER 344
Cdd:cd05761    77 GVAVICRvdheSLTSTPKQTQQV 99
I-set pfam07679
Immunoglobulin I-set domain;
754-836 1.23e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 50.72  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   754 PTIRALKDPTEVNVGGSVDIVCTVDANPiLPEmFSWERlgeDEEELNLDDMEKMS-KGSTGRLRIRQAKLSQAGAYQCIV 832
Cdd:pfam07679    1 PKFTQKPKDVEVQEGESARFTCTVTGTP-DPE-VSWFK---DGQPLRSSDRFKVTyEGGTYTLTISNVQPDDSGKYTCVA 75


                   ....
gi 325511343   833 DNGV 836
Cdd:pfam07679   76 TNSA 79
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 858-951 2.10e-07

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 49.70  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  858 TPLTKVAAAGDSTssATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTehkyhqgvVHSSLLTIANVSaAQDYALFKCTAT 937
Cdd:cd20978     6 KPEKNVVVKGGQD--VTLPCQVTGVPQPKITWLHNGKPLQGPMERAT--------VEDGTLTIINVQ-PEDTGYYGCVAT 74

                          90
                  ....*....|....
gi 325511343  938 NALGSDHTNIQLVS 951
Cdd:cd20978    75 NEIGDIYTETLLHV 88
IgI_2_Robo cd05724
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 859-941 3.51e-07

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409389 [Multi-domain]  Cd Length: 87  Bit Score: 49.32  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  859 PLTKVAAAGDStssATLHCRA-RGVPNIDFTWTKNGVPLDLQDPRYTEhkyhqgvVHSSLLTIANVSAAqDYALFKCTAT 937
Cdd:cd05724     4 PSDTQVAVGEM---AVLECSPpRGHPEPTVSWRKDGQPLNLDNERVRI-------VDDGNLLIAEARKS-DEGTYKCVAT 72


                  ....
gi 325511343  938 NALG 941
Cdd:cd05724    73 NMVG 76
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 558-656 3.96e-07

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 49.35  E-value: 3.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  558 PPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTC 637
Cdd:cd05761     3 VPEKPVITGFTSPVVEGDEITLTCTTSGSKPAADIRWFKNDKELKGVKEVQESGAGKTFTVTSTLRFRVDRDDDGVAVIC 82

                          90       100
                  ....*....|....*....|
gi 325511343  638 RAHSEALRET-VSSFYRLNV 656
Cdd:cd05761    83 RVDHESLTSTpKQTQQVLEV 102
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 852-950 4.22e-07

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 49.04  E-value: 4.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  852 PQVDHPTPLTKVAAagDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYtehkyhqgVVHSS--LLTIANVSAAqDY 929
Cdd:cd20970     1 PVISTPQPSFTVTA--REGENATFMCRAEGSPEPEISWTRNGNLIIEFNTRY--------IVRENgtTLTIRNIRRS-DM 69

                          90       100
                  ....*....|....*....|..
gi 325511343  930 ALFKCTATN-ALGSDHTNIQLV 950
Cdd:cd20970    70 GIYLCIASNgVPGSVEKRITLQ 91
IgI_NrCAM cd05874
Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); ...
 852-946 5.22e-07

Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule). NrCAM belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region, and an intracellular domain. NrCAM is primarily expressed in the nervous system.


Pssm-ID: 409458  Cd Length: 95  Bit Score: 48.83  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  852 PQVDHPTPLTKVAaagDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVhssLLTIANVSAAQDY-A 930
Cdd:cd05874     1 PTITHQSPKDYIV---DPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPKVTMKPNTGTL---VINIMNGEKAEAYeG 74

                          90
                  ....*....|....*.
gi 325511343  931 LFKCTATNALGSDHTN 946
Cdd:cd05874    75 VYQCTARNERGAAVSN 90
IgI_1_Contactin-5 cd05848
First immunoglobulin (Ig) domain of contactin-5; member of the I-set of Ig superfamily domains; ...
 875-942 5.56e-07

First immunoglobulin (Ig) domain of contactin-5; member of the I-set of Ig superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-5. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains, anchored to the membrane by glycosylphosphatidylinositol. The different contactins show different expression patterns in the central nervous system. In rats, a lack of contactin-5 (NB-2) results in an impairment of the neuronal activity in the auditory system. Contactin-5 is expressed specifically in the postnatal nervous system, peaking at about 3 weeks postnatal. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala; lower levels of expression have been detected in the corpus callosum, caudate nucleus, and spinal cord. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409435  Cd Length: 96  Bit Score: 48.79  E-value: 5.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  875 LHCRARGVPNIDFTWTKNGVPLDlqdpryTEHKYHQGVVHSSLLtIANVSAAQDYALFKCTATNALGS 942
Cdd:cd05848    24 LNCEARGNPVPTYRWLRNGTEID------TESDYRYSLIDGNLI-ISNPSEVKDSGRYQCLATNSIGS 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 762-848 6.58e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 48.27  E-value: 6.58e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    762 PTEVNVGGSVDIVCTVDANPilPEMFSWERlgEDEEELNLDDMEKMSK-GSTGRLRIRQAKLSQAGAYQCIVDNGVAPAA 840
Cdd:smart00410    3 SVTVKEGESVTLSCEASGSP--PPEVTWYK--QGGKLLAESGRFSVSRsGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                    ....*...
gi 325511343    841 RGlVRLVV 848
Cdd:smart00410   79 SG-TTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 52-127 1.26e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 1.26e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343     52 SENLTVVEGSTVKLWCGVRA-PGSVVQWAKDGLLLgpnpkIPGFPRYSLEGDSakGEFHLLIEACDLSDDAEYECQV 127
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQGGKL-----LAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAA 70
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 272-332 1.46e-06

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 47.41  E-value: 1.46e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325511343   272 GENLELPCIARGGNPPATLQWLKNGKPVSIAW-----GTEHAQAVAHSVLVMTVRPEDHGARLSCQ 332
Cdd:pfam08205   14 GPEVVATCSSAGGKPAPRITWYLDGKPLEAAEtsseqDPESGLVTVTSELKLVPSRSDHGQSLTCQ 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 256-335 1.70e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.79  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   256 PPVIDWPGLNEgHVRAGENLELPCIARgGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMT-VRPEDHGaRLSCQSY 334
Cdd:pfam13927    1 KPVITVSPSSV-TVREGETVTLTCEAT-GSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISnVTRSDAG-TYTCVAS 77


                   .
gi 325511343   335 N 335
Cdd:pfam13927   78 N 78
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 146-250 1.79e-06

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 47.81  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  146 LVSPKVLQLTpeaGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVsSSVNEGSEEKLFFTEAEARVTPQSSDN 225
Cdd:cd05761     1 LGVPEKPVIT---GFTSPVVEGDEITLTCTTSGSKPAADIRWFKNDKELKGV-KEVQESGAGKTFTVTSTLRFRVDRDDD 76

                          90       100
                  ....*....|....*....|....*.
gi 325511343  226 GQLLVCEGSNPAL-ATPIKASFTMNI 250
Cdd:cd05761    77 GVAVICRVDHESLtSTPKQTQQVLEV 102
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 860-937 1.94e-06

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 47.45  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  860 LTKVAAAGDSTSSATLHCRARGV--PNIDFTWTKNGVPLDL-QDPRYTEHKYHQGVVHSSLLTIANVSaAQDYALFKCTA 936
Cdd:cd00098     4 LLPPSPEEKGGGKVTLVCLVSGFypKDITVTWLKNGVPLTSgVSTSSPVEPNDGTYSVTSSLTVPPSD-WDEGATYTCVV 82


                  .
gi 325511343  937 T 937
Cdd:cd00098    83 T 83
IgI_2_FGFRL1-like cd05856
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1 ...
 472-555 2.05e-06

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.


Pssm-ID: 409442  Cd Length: 92  Bit Score: 47.16  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  472 GTRVRLVCLAiGGNPEPSLTWLKDSRPVnDPRQSQEPRRVQLgsveksgstfsrELVLIIGPPDNLAKFSC----KAGQL 547
Cdd:cd05856    19 GSSVRLKCVA-SGNPRPDITWLKDNKPL-TPPEIGENKKKKW------------TLSLKNLKPEDSGKYTChvsnRAGEI 84


                  ....*...
gi 325511343  548 SASTQLVV 555
Cdd:cd05856    85 NATYKVDV 92
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 257-348 3.56e-06

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 46.41  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  257 PVIDWPGlnegHVRAGENLELPCIARGGNP--PATLQWLKN---GKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGARLSC 331
Cdd:cd20987     1 PNIHVPE----ELEAGQEVTLTCSVPDNCPalSPEFSWLGAaltPLPPVLGRLEEEGTTTHSSVLTFTPRPEDHGTNLTC 76

                          90
                  ....*....|....*..
gi 325511343  332 QSYNSVSAETQERSITL 348
Cdd:cd20987    77 QVKFPGATVTTERTIQL 93
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 459-544 4.37e-06

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 46.26  E-value: 4.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   459 WIEgPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRrvqlgsVEKSGSTFSRELVLIIGPPDNLA 538
Cdd:pfam08205    2 TIE-PPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSSEQD------PESGLVTVTSELKLVPSRSDHGQ 74


                   ....*.
gi 325511343   539 KFSCKA 544
Cdd:pfam08205   75 SLTCQV 80
IgI_1_Contactin cd04967
First immunoglobulin (Ig) domain of contactin; member of the I-set of (Ig) superfamily domains; ...
 874-942 4.82e-06

First immunoglobulin (Ig) domain of contactin; member of the I-set of (Ig) superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409356 [Multi-domain]  Cd Length: 96  Bit Score: 46.08  E-value: 4.82e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  874 TLHCRARGVPNIDFTWTKNGVPLDLQ-DPRYTehkyhqgVVHSSLLtIANVSAAQDYALFKCTATNALGS 942
Cdd:cd04967    23 ALNCRARANPVPSYRWLMNGTEIDLEsDYRYS-------LVDGTLV-ISNPSKAKDAGHYQCLATNTVGS 84
IgI_3_NCAM-1 cd05730
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...
 861-949 8.72e-06

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.


Pssm-ID: 143207 [Multi-domain]  Cd Length: 95  Bit Score: 45.69  E-value: 8.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  861 TKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKyhqgvvHSSLLTIANVSaAQDYALFKCTATNAL 940
Cdd:cd05730     9 SEVNATANLGQSVTLACDADGFPEPTMTWTKDGEPIESGEEKYSFNE------DGSEMTILDVD-KLDEAEYTCIAENKA 81


                  ....*....
gi 325511343  941 GSDHTNIQL 949
Cdd:cd05730    82 GEQEAEIHL 90
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 254-350 8.97e-06

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 45.52  E-value: 8.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  254 PGPPVIDwpglneghVRAGENLELPCIARGGNPPATLQWLKNGKPvsIAWGTEHAQAVAH-----SVLVMTVRPEDH--G 326
Cdd:cd05759     5 EGGPVIS--------LQAGVPYNLTCRARGAKPAAEIIWFRDGEQ--LEGAVYSKELLKDgkretTVSTLLITPSDLdtG 74

                          90       100
                  ....*....|....*....|....
gi 325511343  327 ARLSCQSYNSVSAETQERSITLQV 350
Cdd:cd05759    75 RTFTCRARNEAIPNGKETSITLDV 98
I-set pfam07679
Immunoglobulin I-set domain;
460-555 9.74e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 45.33  E-value: 9.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   460 IEGPPEGQSIRTGTRVRLVCLAIGgNPEPSLTWLKDSRPVndpRQSQEprrvqlGSVEKSGSTFSrelvLIIGP--PDNL 537
Cdd:pfam07679    3 FTQKPKDVEVQEGESARFTCTVTG-TPDPEVSWFKDGQPL---RSSDR------FKVTYEGGTYT----LTISNvqPDDS 68

                           90       100
                   ....*....|....*....|..
gi 325511343   538 AKFSCKA----GQLSASTQLVV 555
Cdd:pfam07679   69 GKYTCVAtnsaGEAEASAELTV 90
IgI_4_Dscam cd20956
Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 846-942 9.95e-06

Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409548 [Multi-domain]  Cd Length: 96  Bit Score: 45.24  E-value: 9.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  846 LVVRFAPQVDHPTPltkvaaagdstsSATLHCRARGVPNIDFTWTKNGVPLDlQDPRYTEHKY--HQGVVHSSLltiaNV 923
Cdd:cd20956     4 LLETFSEQTLQPGP------------SVSLKCVASGNPLPQITWTLDGFPIP-ESPRFRVGDYvtSDGDVVSYV----NI 66

                          90       100
                  ....*....|....*....|.
gi 325511343  924 SAAQ--DYALFKCTATNALGS 942
Cdd:cd20956    67 SSVRveDGGEYTCTATNDVGS 87
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
 761-852 1.36e-05

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 45.23  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  761 DPTEVNVGGSVDIVCTVDANPILPEMFSWERLGE--DEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNgVAP 838
Cdd:cd04970    10 SNADITVGENATLQCHASHDPTLDLTFTWSFNGVpiDLEKIEGHYRRRYGKDSNGDLEIVNAQLKHAGRYTCTAQT-VVD 88

                          90
                  ....*....|....
gi 325511343  839 AARGLVRLVVRFAP 852
Cdd:cd04970    89 SDSASATLVVRGPP 102
IgI_2_Necl-2 cd05883
Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set ...
 251-332 3.76e-05

Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2; also known as cell adhesion molecule 1 (CADM1)). Nectin-like molecules (Necls) have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-2 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409466  Cd Length: 99  Bit Score: 43.76  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  251 LFPPGPPVIDwpgLNEGHVRAGENLELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSV---LVMTVRPEDHGA 327
Cdd:cd05883     1 LVPPRNLVID---IQKDTAVEGEEIELNCTAMASKPAATIRWFKGNKELTGKSEVEEWYSRMFTVtsqLMLKVTKEDDGV 77


                  ....*
gi 325511343  328 RLSCQ 332
Cdd:cd05883    78 PVICL 82
Ig5_Contactin cd04969
Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...
 660-750 4.43e-05

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409358 [Multi-domain]  Cd Length: 89  Bit Score: 43.22  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  660 PEFLGEQVRAVTVVEQG-QALLPVSVSANPAPeAFNWTFRGYRLSpaGGPRHRILSGGALQLWNVTRADDGFYQLHCQNS 738
Cdd:cd04969     1 PDFELNPVKKKILAAKGgDVIIECKPKASPKP-TISWSKGTELLT--NSSRICILPDGSLKIKNVTKSDEGKYTCFAVNF 77

                          90
                  ....*....|..
gi 325511343  739 EGTAEALLKLDV 750
Cdd:cd04969    78 FGKANSTGSLSV 89
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
928-1066 4.65e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 48.02  E-value: 4.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  928 DYaLFKCTATNALG--SDHTNIQLVSIS----RPDPPLGLKVVSvSPHSVGLEWKPGFDGGLPqRFQIRYEALESPGFLY 1001
Cdd:COG4733   598 DY-EVRVRAINALGvsSAWAASSETTVTgktaPPPAPTGLTATG-GLGGITLSWSFPVDADTL-RTEIRYSTTGDWASAT 674

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325511343 1002 MDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGltDKGIQVSITTPGLDQAPEDTDQPLPTE 1066
Cdd:COG4733   675 VAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVS--AWWVSGQASADAAGILDAITGQILETE 737
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1051 5.13e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.69  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  847 VVRFAPQVDHPTPLTKVAAAGDSTSSATLhcrargvpnidfTWTKNGVPlDLQdpRYT-------EHKYHQ-GVVHSSLL 918
Cdd:COG3401   223 EVSVTTPTTPPSAPTGLTATADTPGSVTL------------SWDPVTES-DAT--GYRvyrsnsgDGPFTKvATVTTTSY 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  919 TIANVSAAQDYaLFKCTATNALG--SDHTNI--QLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLpQRFQIrYEAl 994
Cdd:COG3401   288 TDTGLTNGTTY-YYRVTAVDAAGneSAPSNVvsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADV-TGYNV-YRS- 363

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  995 ESPGFLYMDV-LPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSITTPG 1051
Cdd:COG3401   364 TSGGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAA 421
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 771-836 6.86e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 42.32  E-value: 6.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325511343  771 VDIVCTVDANPilPEMFSWERLGEDEEELNLDDMEkmSKGSTGRLRIRQAKLSQAGAYQCIVDNGV 836
Cdd:cd00096     1 VTLTCSASGNP--PPTITWYKNGKPLPPSSRDSRR--SELGNGTLTISNVTLEDSGTYTCVASNSA 62
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 52-128 6.93e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.22  E-value: 6.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    52 SENLTVVEGSTVKLWC----GVRAPGSVVQWAKDGLLLGPNPKIPGF----------PRYSLEGDSAKGEFHLLIEACDL 117
Cdd:pfam07686    3 PREVTVALGGSVTLPCtyssSMSEASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNLTL 82

                           90
                   ....*....|.
gi 325511343   118 SDDAEYECQVG 128
Cdd:pfam07686   83 SDSGTYTCAVI 93
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 460-505 6.97e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 6.97e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 325511343   460 IEGPPEGQSIRTGTRVRLVCLAiGGNPEPSLTWLKDSRPVNDPRQS 505
Cdd:pfam13927    4 ITVSPSSVTVREGETVTLTCEA-TGSPPPTITWYKNGEPISSGSTR 48
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 670-750 7.20e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 7.20e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    670 VTVVEQGQALLPVSVSANPAPEaFNWTFRGYRLsPAGGPRHRILSGG---ALQLWNVTRADDGFYQLHCQNSEGTAEALL 746
Cdd:smart00410    4 VTVKEGESVTLSCEASGSPPPE-VTWYKQGGKL-LAESGRFSVSRSGstsTLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                    ....
gi 325511343    747 KLDV 750
Cdd:smart00410   82 TLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 275-342 7.28e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 42.32  E-value: 7.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 325511343  275 LELPCIARGgNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMT-VRPEDHGaRLSCQSYNSVSAETQ 342
Cdd:cd00096     1 VTLTCSASG-NPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISnVTLEDSG-TYTCVASNSAGGSAS 67
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 874-941 7.37e-05

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 42.62  E-value: 7.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  874 TLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHkyhqgvVHSSLLTIANVSaAQDYALFKCTATNALG 941
Cdd:cd20976    20 VAQCSARGKPVPRITWIRNAQPLQYAADRSTCE------AGVGELHIQDVL-PEDHGTYTCLAKNAAG 80
Ig4_L1-NrCAM_like cd04978
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), ...
 871-941 7.95e-05

Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related); The members here are composed of the fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.


Pssm-ID: 409367 [Multi-domain]  Cd Length: 89  Bit Score: 42.44  E-value: 7.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325511343  871 SSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEhkyhqgVVHSSLLTIANVSaAQDYALFKCTATNALG 941
Cdd:cd04978    15 ETGELICEAEGNPQPTITWRLNGVPIEPAPEDMRR------TVDGRTLIFSNLQ-PNDTAVYQCNASNVHG 78
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 357-433 8.30e-05

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 42.80  E-value: 8.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343  357 VTILGSTSQsENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEA 433
Cdd:cd05761     9 ITGFTSPVV-EGDEITLTCTTSGSKPAADIRWFKNDKELKGVKEVQESGAGKTFTVTSTLRFRVDRDDDGVAVICRV 84
IgI_C2_MyBP-C-like cd20967
Domain C2 of human cardiac Myosin Binding Protein C and similar domains; a member of the I-set ...
 50-136 1.03e-04

Domain C2 of human cardiac Myosin Binding Protein C and similar domains; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig) Domain C2 of human cardiac Myosin Binding Protein C (MyBP-C) and similar domains. MyBP-C is a thick filament protein involved in the regulation of muscle contraction. Mutations in cardiac MyBP-C gene are the second most frequent cause of hypertrophic cardiomyopathy. MyBP-C binds to myosin with two binding sites, one at its C-terminus and another at its N-terminus. The N-terminal binding site, consisting of immunoglobulin (lg) domains C1 and C2 connected by a flexible linker, interacts with the S2 segment of myosin in a phosphorylation-regulated manner. The C1 and C2 Ig domains can bind to and activate or inhibit the thin filament. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structures of the Ig domains of MyBP-C lack this strand and thus belong to the I-set of Ig superfamily domains. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.


Pssm-ID: 409559  Cd Length: 82  Bit Score: 42.23  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   50 ALSENLTVVEGSTVKLWCGVRAPGSVVQWAKDGlllgpnPKIPGFPRYSLEGDSAKGEfhLLIEACDLSDDAEYECQVGR 129
Cdd:cd20967     2 KAQPAVQVSKGHKIRLTVELADPDAEVKWYKDG------QELQSSSKVIFESIGAKRT--LTVQQASLADAGEYQCVAGG 73


                  ....*..
gi 325511343  130 SELGPEL 136
Cdd:cd20967    74 EKCSFEL 80
Ig6_Contactin-2 cd05854
Sixth immunoglobulin (Ig) domain of contactin-2; The members here are composed of the sixth ...
 861-950 1.58e-04

Sixth immunoglobulin (Ig) domain of contactin-2; The members here are composed of the sixth immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-2-like. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. It may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module by contacts between IG domains 1 and 4, and domains 2 and 3. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-2 is also expressed in retinal amacrine cells (AC) in the developing chick retina, corresponding to the period of formation and maturation of AC processes.


Pssm-ID: 409440  Cd Length: 102  Bit Score: 42.34  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  861 TKVAAAGDST-----SSATLHCRARGVPNID--FTWTKNGVPLDLQDPrytEHKYHQGVVHSSLLTIANVSAAQDYA-LF 932
Cdd:cd05854     3 TKITLAPSSAdinqgENLTLQCHASHDPTMDltFTWSLDDFPIDLDKP---NGHYRRMEVKETIGDLVIVNAQLSHAgTY 79

                          90
                  ....*....|....*...
gi 325511343  933 KCTATNALGSDHTNIQLV 950
Cdd:cd05854    80 TCTAQTVVDSASASATLV 97
IgI_2_FGFR_like cd05729
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and similar ...
 472-542 1.89e-04

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and similar domains; member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor. FGF receptors bind FGF signaling polypeptides. FGFs participate in multiple processes such as morphogenesis, development, and angiogenesis. FGFs bind to four FGF receptor tyrosine kinases (FGFR1, FGFR2, FGFR3, FGFR4). Receptor diversity is controlled by alternative splicing producing splice variants with different ligand binding characteristics and different expression patterns. FGFRs have an extracellular region comprised of three Ig-like domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding and specificity reside in the Ig-like domains 2 and 3, and the linker region that connects these two. FGFR activation and signaling depend on FGF-induced dimerization, a process involving cell surface heparin or heparin sulfate proteoglycans. This group also contains fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.


Pssm-ID: 409393 [Multi-domain]  Cd Length: 95  Bit Score: 41.82  E-value: 1.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325511343  472 GTRVRLVCLAiGGNPEPSLTWLKDSRPVndprqsQEPRRVQLGSVEKSGSTFSRELVLiigpPDNLAKFSC 542
Cdd:cd05729    19 ANKVRLECGA-GGNPMPNITWLKDGKEF------KKEHRIGGTKVEEKGWSLIIERAI----PRDKGKYTC 78
I-set pfam07679
Immunoglobulin I-set domain;
660-750 1.97e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.47  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   660 PEFLGeQVRAVTVVEQGQALLPVSVSANPAPEaFNWTFRGYRLSPagGPRHRIL-SGGALQLW--NVTRADDGFYQLHCQ 736
Cdd:pfam07679    1 PKFTQ-KPKDVEVQEGESARFTCTVTGTPDPE-VSWFKDGQPLRS--SDRFKVTyEGGTYTLTisNVQPDDSGKYTCVAT 76

                           90
                   ....*....|....
gi 325511343   737 NSEGTAEALLKLDV 750
Cdd:pfam07679   77 NSAGEAEASAELTV 90
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 52-138 2.10e-04

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 41.33  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   52 SENLTVVEGSTVKLWCgvRAPGS---VVQWAKDG-LLLGPNPKIPGFPRYSLEGDSAKgefhllieacdLSDDAEYECqV 127
Cdd:cd20952     6 PQNQTVAVGGTVVLNC--QATGEpvpTISWLKDGvPLLGKDERITTLENGSLQIKGAE-----------KSDTGEYTC-V 71

                          90
                  ....*....|.
gi 325511343  128 GRSELGPELVS 138
Cdd:cd20952    72 ALNLSGEATWS 82
I-set pfam07679
Immunoglobulin I-set domain;
54-127 2.29e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.09  E-value: 2.29e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325511343    54 NLTVVEGSTVKLWCGVR-APGSVVQWAKDGLLLGPNPKIpgfpRYSLEGDSAkgefHLLIEACDLSDDAEYECQV 127
Cdd:pfam07679    9 DVEVQEGESARFTCTVTgTPDPEVSWFKDGQPLRSSDRF----KVTYEGGTY----TLTISNVQPDDSGKYTCVA 75
IgI_2_Necl-4 cd05885
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...
 165-243 2.34e-04

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409468  Cd Length: 100  Bit Score: 41.48  E-value: 2.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 325511343  165 VAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGseeKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIK 243
Cdd:cd05885    16 VEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSGQENG---KVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHS 91
Ig3_Peroxidasin cd05745
Third immunoglobulin (Ig)-like domain of peroxidasin; The members here are composed of the ...
 875-950 2.35e-04

Third immunoglobulin (Ig)-like domain of peroxidasin; The members here are composed of the third immunoglobulin (Ig)-like domain in peroxidasin. Peroxidasin has a peroxidase domain and interacting extracellular motifs containing four Ig-like domains. It has been suggested that peroxidasin is secreted and has functions related to the stabilization of the extracellular matrix. It may play a part in various other important processes such as removal and destruction of cells which have undergone programmed cell death and protection of the organism against non-self.


Pssm-ID: 143222 [Multi-domain]  Cd Length: 74  Bit Score: 40.69  E-value: 2.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325511343  875 LHCRARGVPNIDFTWTKNGVPLDLqDPRYTehkyhqgVVHSSLLTIANVsAAQDYALFKCTATNALGSDHTNIQLV 950
Cdd:cd05745     7 FLCEAQGYPQPVIAWTKGGSQLSV-DRRHL-------VLSSGTLRISRV-ALHDQGQYECQAVNIVGSQRTVAQLT 73
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 671-750 2.48e-04

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 41.33  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  671 TVVEQGQALLPVSVSANPAPEAFnWTFRGYRLSPAGgpRHRIL--SGG--ALQLWNVTRADDGFYQLHCQNSEGTAEALL 746
Cdd:cd05744    11 EVQEGRLCRFDCKVSGLPTPDLF-WQLNGKPVRPDS--AHKMLvrENGrhSLIIEPVTKRDAGIYTCIARNRAGENSFNA 87


                  ....
gi 325511343  747 KLDV 750
Cdd:cd05744    88 ELVV 91
IgI_1_Contactin-2 cd05850
First immunoglobulin (Ig) domain of contactin-2; member of the I-set of Ig superfamily domains; ...
 859-942 2.53e-04

First immunoglobulin (Ig) domain of contactin-2; member of the I-set of Ig superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-2-like. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. It may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module by contacts between IG domains 1 and 4, and domains 2 and 3. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-2 is also expressed in retinal amacrine cells in the developing chick retina, corresponding to the period of formation and maturation of AC processes. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409437 [Multi-domain]  Cd Length: 97  Bit Score: 41.45  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  859 PLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQ-DPRYTehkyhqgvVHSSLLTIANVSAAQDYALFKCTAT 937
Cdd:cd05850     9 PSSTLFPEGSAEEKVTLACRARASPPATYRWKMNGTELKMEpDSRYR--------LVAGNLVISNPVKAKDAGSYQCLAS 80


                  ....*
gi 325511343  938 NALGS 942
Cdd:cd05850    81 NRRGT 85
IgI_2_Necl-4 cd05885
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...
 251-350 2.82e-04

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409468  Cd Length: 100  Bit Score: 41.48  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  251 LFPPGPPVIDwpgLNEGHVRAGEnLELPCIARGGNPPATLQWLKNGKPV-SIAWGTEHAQAVA-HSVLVMTVRPEDHGAR 328
Cdd:cd05885     1 LVAPENPVVE---VREQAVEGGE-VELSCLVPRSRPAATLRWYRDRKELkGVSSGQENGKVWSvASTVRFRVDRKDDGGI 76

                          90       100
                  ....*....|....*....|....
gi 325511343  329 LSCQSYNS--VSAETQERSITLQV 350
Cdd:cd05885    77 VICEAQNQalPSGHSKQTQYVLDV 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 268-350 2.92e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 2.92e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    268 HVRAGENLELPCIARgGNPPATLQWLKNGKPVSIAWGTEHAQAVAH-SVLVMT-VRPEDHGaRLSCQSYNsvSAETQERS 345
Cdd:smart00410    5 TVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGStSTLTISnVTPEDSG-TYTCAATN--SSGSASSG 80


                    ....*
gi 325511343    346 ITLQV 350
Cdd:smart00410   81 TTLTV 85
IgI_2_Necl-1 cd07705
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set ...
 367-431 2.93e-04

Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1; also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains is essential to cell-cell adhesion and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409502  Cd Length: 103  Bit Score: 41.49  E-value: 2.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325511343  367 ENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISM-SNLTLLVKREDNGLSLTC 431
Cdd:cd07705    18 EKDKAKLRCTSSGSKPAANIKWRKGDQELEGAPTSVQEDGNGKTFTVsSSVEFQVTREDDGAEITC 83
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 272-350 3.33e-04

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 40.84  E-value: 3.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 325511343  272 GENLELPCIARGgNPPATLQWLKNGKPVSIAWGTehAQAVAHSVLVMTVRPEDHGaRLSCQSYNsvSAETQERSITLQV 350
Cdd:cd20978    16 GQDVTLPCQVTG-VPQPKITWLHNGKPLQGPMER--ATVEDGTLTIINVQPEDTG-YYGCVATN--EIGDIYTETLLHV 88
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 670-750 3.53e-04

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 40.56  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  670 VTVVEQGQALLPVSVSANPAPeAFNWtFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLD 749
Cdd:cd20952     9 QTVAVGGTVVLNCQATGEPVP-TISW-LKDGVPLLGKDERITTLENGSLQIKGAEKSDTGEYTCVALNLSGEATWSAVLD 86


                  .
gi 325511343  750 V 750
Cdd:cd20952    87 V 87
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 871-950 3.55e-04

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 40.87  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  871 SSATLHCRARGVPNIDFTWTKNGVPLD-LQDPRytEHKYH-QGVVHSSLLTIANVSaaqDYALFKCTATNALGSDHTNIQ 948
Cdd:cd20951    16 SDAKLRVEVQGKPDPEVKWYKNGVPIDpSSIPG--KYKIEsEYGVHVLHIRRVTVE---DSAVYSAVAKNIHGEASSSAS 90


                  ..
gi 325511343  949 LV 950
Cdd:cd20951    91 VV 92
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 269-350 4.31e-04

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 40.61  E-value: 4.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  269 VRAGENLELPCIARGgNPPATLQWLKNGKPVSI---AWGTEHAQAVAHSVLVMTV----RPEDHGARLSCQSYNSVsAET 341
Cdd:cd07693    12 VSKGDPATLNCKAEG-RPTPTIQWLKNGQPLETdkdDPRSHRIVLPSGSLFFLRVvhgrKGRSDEGVYVCVAHNSL-GEA 89


                  ....*....
gi 325511343  342 QERSITLQV 350
Cdd:cd07693    90 VSRNASLEV 98
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 269-346 4.45e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 40.26  E-value: 4.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   269 VRAGENLELPCIARGGNPPATLQWLKNGK-PVSIAWGTEHAQAVAHSVLVM-TVRPEDHGArLSCQSYNSVSAETQERSI 346
Cdd:pfam00047    8 VLEGDSATLTCSASTGSPGPDVTWSKEGGtLIESLKVKHDNGRTTQSSLLIsNVTKEDAGT-YTCVVNNPGGSATLSTSL 86
Ig4_L1-CAM_like cd05867
Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); The members ...
 872-941 5.05e-04

Fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM); The members here are composed of the fourth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region, and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM.


Pssm-ID: 409453 [Multi-domain]  Cd Length: 89  Bit Score: 40.26  E-value: 5.05e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  872 SATLHCRARGVPNIDFTWTKNGVPLDLQDPrytEHKYHqgvVHSSLLTIANVSAAqDYALFKCTATNALG 941
Cdd:cd05867    16 TARLDCQVEGIPTPNITWSINGAPIEGTDP---DPRRH---VSSGALILTDVQPS-DTAVYQCEARNRHG 78
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 55-125 5.30e-04

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 40.48  E-value: 5.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 325511343   55 LTVVEGSTVKLWCGVRA-PGSVVQWAKDGLLLGPNPKIPgfpRYSLEgdSAKGEFHLLIEACDLSDDAEYEC 125
Cdd:cd20951    10 HTVWEKSDAKLRVEVQGkPDPEVKWYKNGVPIDPSSIPG---KYKIE--SEYGVHVLHIRRVTVEDSAVYSA 76
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
932-1049 5.41e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 5.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  932 FKCTATNALG-SDHTNIQLVSISR--PDPPLGLKVVSVSPHSVGLEWKPGFDGGLpQRFQIRYEALESPGFLYmdVLPAQ 1008
Cdd:COG3401   207 YRVAATDTGGeSAPSNEVSVTTPTtpPSAPTGLTATADTPGSVTLSWDPVTESDA-TGYRVYRSNSGDGPFTK--VATVT 283

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 325511343 1009 ATTFTLTGLKPSTRYRIWLLASNALGD-SGLTDkgiQVSITT 1049
Cdd:COG3401   284 TTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSN---VVSVTT 322
IgI_telokin-like cd20973
immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF ...
 471-555 5.48e-04

immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig) domain in telokin, the C-terminal domain of myosin light chain kinase which is identical to telokin, and similar proteins. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the telokin Ig domain lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409565 [Multi-domain]  Cd Length: 88  Bit Score: 40.25  E-value: 5.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  471 TGTRVRLVCLaIGGNPEPSLTWLKDSRPVndprqsQEPRRVQLGSVEKSGSTfsreLVLIIGPPDNLAKFSCKA----GQ 546
Cdd:cd20973    11 EGSAARFDCK-VEGYPDPEVKWMKDDNPI------VESRRFQIDQDEDGLCS----LIISDVCGDDSGKYTCKAvnslGE 79


                  ....*....
gi 325511343  547 LSASTQLVV 555
Cdd:cd20973    80 ATCSAELTV 88
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 270-351 5.50e-04

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 39.79  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  270 RAGENLELPCIARGgNPPATLQWLKNGKPvsiawgtehaQAVAHSVLVMTVRPEDHGArLSCQSYNsvSAETQERSITLQ 349
Cdd:cd20948     8 LSGENLNLSCHAAS-NPPAQYSWTINGTF----------QTSSQELFLPAITENNEGT-YTCSAHN--SLTGKNISLVLS 73


                  ..
gi 325511343  350 VT 351
Cdd:cd20948    74 VT 75
IgI_1_Contactin-1 cd05849
First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains; ...
 859-941 5.70e-04

First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-1. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409436 [Multi-domain]  Cd Length: 95  Bit Score: 40.32  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  859 PLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTehkyhqgVVHSSLLtIANVSAAQDYALFKCTATN 938
Cdd:cd05849     8 PIDTIYPEESTEGKVSVNCRARANPFPIYKWRKNNLDIDLTNDRYS-------MVGGNLV-INNPDKYKDAGRYVCIVSN 79


                  ...
gi 325511343  939 ALG 941
Cdd:cd05849    80 IYG 82
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 256-350 5.90e-04

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 40.17  E-value: 5.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  256 PPVIDWPGLNEGHVRAGENLELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAH-SVLVMTVRPEDHGARLSCQSY 334
Cdd:cd20959     1 PPRIIPFAFGEGAAQVGMRAQLHCGVPGGDLPLNIRWTLDGQPISDDLGITVSRLGRRsSILSIDSLEASHAGNYTCHAR 80

                          90
                  ....*....|....*.
gi 325511343  335 NsvSAETQERSITLQV 350
Cdd:cd20959    81 N--SAGSASYTAPLTV 94
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 52-127 6.45e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 6.45e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343    52 SENLTVVEGSTVKLWCGVRA-PGSVVQWAKDGLLLGPNPkipgfprySLEGDSAKGEFHLLIEACDLSDDAEYECQV 127
Cdd:pfam13927    8 PSSVTVREGETVTLTCEATGsPPPTITWYKNGEPISSGS--------TRSRSLSGSNSTLTISNVTRSDAGTYTCVA 76
IgI_2_RPTP_IIa_LAR_like cd05738
Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; ...
 868-945 6.68e-04

Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain found in the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR. LAR belongs to the RPTP type IIa subfamily. Members of this subfamily are cell adhesion molecule-like proteins involved in central nervous system (CNS) development. They have large extracellular portions comprised of multiple Ig-like domains and two to nine fibronectin type III (FNIII) domains and a cytoplasmic portion having two tandem phosphatase domains.


Pssm-ID: 409400 [Multi-domain]  Cd Length: 91  Bit Score: 40.00  E-value: 6.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  868 DSTSSATLHCRARGVPNIDFTWTKNGVPLdlqDPRYTEHKYHQgvVHSSLLTIANvSAAQDYALFKCTATNALGSDHT 945
Cdd:cd05738    12 EKARTATMLCAASGNPDPEISWFKDFLPV---DTATSNGRIKQ--LRSGALQIEN-SEESDQGKYECVATNSAGTRYS 83
IgI_2_Necl-3 cd05884
Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set ...
 559-647 7.13e-04

Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3; also known as cell adhesion molecule 2 (CADM2)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409467  Cd Length: 104  Bit Score: 40.30  E-value: 7.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  559 PTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVA-AKPQSAPFKGSAASRSVFLRVSSRDHGHRVTC 637
Cdd:cd05884     5 PEKPQISGFTSPVMEGDHIQLTCKTSGSKPAADIRWFKNDKEVKDVKyLKAEDANRKTFTVSSSLDFHVDRDDDGVAITC 84

                          90
                  ....*....|
gi 325511343  638 RAHSEALRET 647
Cdd:cd05884    85 RVDHESLTAT 94
IgI_2_Necl-4 cd05885
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...
 558-644 7.17e-04

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409468  Cd Length: 100  Bit Score: 40.33  E-value: 7.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  558 PPTNLTILANSSALRPGDaLNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSApfKGSAASRSVFLRVSSRDHGHRVTC 637
Cdd:cd05885     3 APENPVVEVREQAVEGGE-VELSCLVPRSRPAATLRWYRDRKELKGVSSGQENG--KVWSVASTVRFRVDRKDDGGIVIC 79


                  ....*..
gi 325511343  638 RAHSEAL 644
Cdd:cd05885    80 EAQNQAL 86
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 467-556 7.32e-04

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 40.10  E-value: 7.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  467 QSIRTGTRVRLVClAIGGNPEPSLTWLKDSRPVNdprQSQEPRRVQLgsveksgSTFSRELVLIIGP--PDNLAKFSCKA 544
Cdd:cd20951    10 HTVWEKSDAKLRV-EVQGKPDPEVKWYKNGVPID---PSSIPGKYKI-------ESEYGVHVLHIRRvtVEDSAVYSAVA 78

                          90
                  ....*....|....*.
gi 325511343  545 ----GQLSASTQLVVQ 556
Cdd:cd20951    79 knihGEASSSASVVVE 94
IgI_2_MuSK cd20968
agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ...
 670-742 8.13e-04

agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ectodomain; a member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin-like (Ig) domains of the Muscle-specific kinase (MuSK) ectodomain. MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409560 [Multi-domain]  Cd Length: 88  Bit Score: 39.53  E-value: 8.13e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325511343  670 VTVVEQGQALLPVSVSANPAPEAfNWtFRGYRLSPAGGpRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTA 742
Cdd:cd20968     9 VTIIEGLKAVLPCTTMGNPKPSV-SW-IKGDDLIKENN-RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGIA 78
IgI_2_Necl-4 cd05885
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...
 353-433 1.08e-03

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409468  Cd Length: 100  Bit Score: 39.56  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  353 PPSAVTILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLlptdETVMDGLHGGHI-SMSN-LTLLVKREDNGLSLT 430
Cdd:cd05885     3 APENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKEL----KGVSSGQENGKVwSVAStVRFRVDRKDDGGIVI 78


                  ...
gi 325511343  431 CEA 433
Cdd:cd05885    79 CEA 81
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 268-350 1.16e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.92  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   268 HVRAGENLELPCiARGGNPPATLQWLKNGKPVSiawgtehaqaVAHSVLVMTVRPEDHGaRLSCQSYNSVSAEtQERSIT 347
Cdd:pfam13895   10 VVTEGEPVTLTC-SAPGNPPPSYTWYKDGSAIS----------SSPNFFTLSVSAEDSG-TYTCVARNGRGGK-VSNPVE 76


                   ...
gi 325511343   348 LQV 350
Cdd:pfam13895   77 LTV 79
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
 671-755 1.42e-03

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 38.98  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  671 TVVEQGQALLPVSVSANPAPEAfnWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSeGTAEALLKLDV 750
Cdd:cd04979     7 SVKEGDTVILSCSVKSNNAPVT--WIHNGKKVPRYRSPRLVLKTERGLLIRSAQEADAGVYECHSGER-VLGSTLRSVTL 83


                  ....*
gi 325511343  751 HYAPT 755
Cdd:cd04979    84 HVLER 88
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 660-750 1.50e-03

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 38.91  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  660 PEFLGEQVRAVTVVEQGQALLPVSVSANPAPEaFNWTFRGYRLSpaGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSE 739
Cdd:cd20978     1 PKFIQKPEKNVVVKGGQDVTLPCQVTGVPQPK-ITWLHNGKPLQ--GPMERATVEDGTLTIINVQPEDTGYYGCVATNEI 77

                          90
                  ....*....|.
gi 325511343  740 GTAEALLKLDV 750
Cdd:cd20978    78 GDIYTETLLHV 88
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
 53-138 1.55e-03

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 38.98  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   53 ENLTVVEGSTVKLWCGVRAPGSVVQWakdgLLLGPNPKIPGFPRYSLEGDSAkgefhLLIEACDLSDDAEYECQVGRSEL 132
Cdd:cd04979     4 KQISVKEGDTVILSCSVKSNNAPVTW----IHNGKKVPRYRSPRLVLKTERG-----LLIRSAQEADAGVYECHSGERVL 74


                  ....*.
gi 325511343  133 GPELVS 138
Cdd:cd04979    75 GSTLRS 80
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 765-848 1.68e-03

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 39.03  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  765 VNVGGSVDIVCTVDANPiLPEMfSWERLGEDEEELNlDDMEKMSKGSTgrLRIRQAKLSQAGAYQCIVDNGVAPAARGLV 844
Cdd:cd20970    14 AREGENATFMCRAEGSP-EPEI-SWTRNGNLIIEFN-TRYIVRENGTT--LTIRNIRRSDMGIYLCIASNGVPGSVEKRI 88


                  ....
gi 325511343  845 RLVV 848
Cdd:cd20970    89 TLQV 92
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 854-941 1.80e-03

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 39.07  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  854 VDHPTPLtkVAAAGDStssATLHCRARGVPNIDFTWTKNGVPL--DLQDPRytehkYHQGVVHSSLL----TIANVSAAQ 927
Cdd:cd07693     4 VEHPSDL--IVSKGDP---ATLNCKAEGRPTPTIQWLKNGQPLetDKDDPR-----SHRIVLPSGSLfflrVVHGRKGRS 73

                          90
                  ....*....|....
gi 325511343  928 DYALFKCTATNALG 941
Cdd:cd07693    74 DEGVYVCVAHNSLG 87
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 872-950 1.82e-03

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 38.63  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  872 SATLHCRARGVPNIDFTWTKNGVPLDLQDprytEHKYHQ--GVVHSslLTIANVSaAQDYALFKCTATNALGSDHTNIQL 949
Cdd:cd05744    17 LCRFDCKVSGLPTPDLFWQLNGKPVRPDS----AHKMLVreNGRHS--LIIEPVT-KRDAGIYTCIARNRAGENSFNAEL 89


                  .
gi 325511343  950 V 950
Cdd:cd05744    90 V 90
I-set pfam07679
Immunoglobulin I-set domain;
269-350 2.08e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   269 VRAGENLELPCIARGgNPPATLQWLKNGKPVSIawgTEHAQAVA---HSVLVMT-VRPEDHGaRLSCQSYNsvSAETQER 344
Cdd:pfam07679   12 VQEGESARFTCTVTG-TPDPEVSWFKDGQPLRS---SDRFKVTYeggTYTLTISnVQPDDSG-KYTCVATN--SAGEAEA 84


                   ....*.
gi 325511343   345 SITLQV 350
Cdd:pfam07679   85 SAELTV 90
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 460-544 2.12e-03

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 38.97  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  460 IEGPPEgQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEprrvqLGSVEKSGSTFSrelVLIIGPP--DNL 537
Cdd:cd05759     4 IEGGPV-ISLQAGVPYNLTCRARGAKPAAEIIWFRDGEQLEGAVYSKE-----LLKDGKRETTVS---TLLITPSdlDTG 74


                  ....*..
gi 325511343  538 AKFSCKA 544
Cdd:cd05759    75 RTFTCRA 81
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 272-348 2.13e-03

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 38.77  E-value: 2.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325511343  272 GENLELPCIARGgNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGArLSCQSYNSVSAETQERSITL 348
Cdd:cd20976    16 GQDFVAQCSARG-KPVPRITWIRNAQPLQYAADRSTCEAGVGELHIQDVLPEDHGT-YTCLAKNAAGQVSCSAWVTV 90
IgI_2_Necl-1 cd07705
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set ...
 559-656 2.28e-03

Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1; also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains is essential to cell-cell adhesion and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409502  Cd Length: 103  Bit Score: 38.80  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  559 PTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGS-AASRSVFLRVSSRDHGHRVTC 637
Cdd:cd07705     4 PQKPQITGYESAFKEKDKAKLRCTSSGSKPAANIKWRKGDQELEGAPTSVQEDGNGKTfTVSSSVEFQVTREDDGAEITC 83

                          90       100
                  ....*....|....*....|
gi 325511343  638 RAHSEALRETV-SSFYRLNV 656
Cdd:cd07705    84 SVGHESLHDSDrSTSQRIEV 103
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 464-555 2.59e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.59e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343    464 PEGQSIRTGTRVRLVCLAIGgNPEPSLTWLKdsrpvNDPRQSQEPRRVqlgSVEKSGSTFSrelvLIIGP--PDNLAKFS 541
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYK-----QGGKLLAESGRF---SVSRSGSTST----LTISNvtPEDSGTYT 67

                            90
                    ....*....|....*...
gi 325511343    542 CKA----GQLSASTQLVV 555
Cdd:smart00410   68 CAAtnssGSASSGTTLTV 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 561-640 2.80e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 37.76  E-value: 2.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   561 NLTILANSSALRPGDALNLTCvSISSNPPVNLSLDKEGERLDDvaakpqsapfkgsaaSRSVFLRVSSRDHGHRVTCRAH 640
Cdd:pfam13895    1 KPVLTPSPTVVTEGEPVTLTC-SAPGNPPPSYTWYKDGSAISS---------------SPNFFTLSVSAEDSGTYTCVAR 64
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 762-839 2.97e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.94  E-value: 2.97e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343   762 PTEVNVGGSVDIVCTVDANPILPEmFSWERLGeDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPA 839
Cdd:pfam00047    5 TVTVLEGDSATLTCSASTGSPGPD-VTWSKEG-GTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGSA 80
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 872-942 3.01e-03

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 38.24  E-value: 3.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 325511343  872 SATLHCR-ARGVPNIDFTWTKNGVPLdLQDPRYTEHKYHQgvvHSSLLTIANVSAAQDyALFKCTATNALGS 942
Cdd:cd20959    19 RAQLHCGvPGGDLPLNIRWTLDGQPI-SDDLGITVSRLGR---RSSILSIDSLEASHA-GNYTCHARNSAGS 85
IgI_4_Dscam cd20956
Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 269-339 3.05e-03

Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409548 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 3.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  269 VRAGENLELPCIARGgNPPATLQWLKNGKPVS----IAWG---TEHAQAVAHsVLVMTVRPEDhGARLSCQSYNSVSA 339
Cdd:cd20956    13 LQPGPSVSLKCVASG-NPLPQITWTLDGFPIPesprFRVGdyvTSDGDVVSY-VNISSVRVED-GGEYTCTATNDVGS 87
Ig4_L1-NrCAM_like cd04978
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), ...
 459-511 4.25e-03

Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related); The members here are composed of the fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.


Pssm-ID: 409367 [Multi-domain]  Cd Length: 89  Bit Score: 37.81  E-value: 4.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 325511343  459 WIEGPPEGQSiRTGTRVRLVCLAiGGNPEPSLTWLKDSRPVNDprQSQEPRRV 511
Cdd:cd04978     2 WIIEPPSLVL-SPGETGELICEA-EGNPQPTITWRLNGVPIEP--APEDMRRT 50
Ig6_Contactin-4 cd05853
Sixth immunoglobulin (Ig) domain of contactin-4; The members here are composed of the sixth ...
 754-852 4.29e-03

Sixth immunoglobulin (Ig) domain of contactin-4; The members here are composed of the sixth immunoglobulin (Ig) domain of the neural cell adhesion molecule contactin-4. Contactins are neural cell adhesion molecules, and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The different contactins show different expression patterns in the central nervous system. Highest expression of contactin-4 is in testes, thyroid, small intestine, uterus, and brain. Contactin-4 plays a role in the response of neuroblastoma cells to differentiating agents, such as retinoids. The contactin 4 gene is associated with cerebellar degeneration in spinocerebellar ataxia type 16.


Pssm-ID: 409439  Cd Length: 102  Bit Score: 38.07  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  754 PTiRALKDPT--EVNVGGSVDIVCTVDANPILPEMFSWERLGE-DEEELNLDDMEKMS-KGSTGRLRIRQAKLSQAGAYQ 829
Cdd:cd05853     2 PT-RVMVPPSsmDVTVGESIVLPCQVSHDHSLDIVFTWSFNGHlIDFQKDGDHFERVGgQDSAGDLMIRSIQLKHAGKYV 80

                          90       100
                  ....*....|....*....|...
gi 325511343  830 CIVDNGVAPAARGlVRLVVRFAP 852
Cdd:cd05853    81 CMVQTSVDKLSAA-ADLIVRGPP 102
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 659-732 5.42e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 5.42e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325511343   659 PPEFLGEQvRAVTVVEQGQALLPVSVSANPAPEaFNWTFRGYRLSPAGGPRHRILSGGA-LQLWNVTRADDGFYQ 732
Cdd:pfam13927    1 KPVITVSP-SSVTVREGETVTLTCEATGSPPPT-ITWYKNGEPISSGSTRSRSLSGSNStLTISNVTRSDAGTYT 73
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 678-744 5.94e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 5.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325511343  678 ALLPVSVSANPAPEaFNWTFRGYRLSPAGGPRHRILSGGA-LQLWNVTRADDGFYQLHCQNSEGTAEA 744
Cdd:cd00096     1 VTLTCSASGNPPPT-ITWYKNGKPLPPSSRDSRRSELGNGtLTISNVTLEDSGTYTCVASNSAGGSAS 67
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 859-942 6.78e-03

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 37.09  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  859 PLTKVAAAGdstSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKyhQGVvhsslLTIANVSaAQDYALFKCTATN 938
Cdd:cd20952     6 PQNQTVAVG---GTVVLNCQATGEPVPTISWLKDGVPLLGKDERITTLE--NGS-----LQIKGAE-KSDTGEYTCVALN 74


                  ....
gi 325511343  939 ALGS 942
Cdd:cd20952    75 LSGE 78
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 457-501 7.17e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 36.60  E-value: 7.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 325511343   457 KLWIEGPPegQSIRTGTRVRLVClAIGGNPEPSLTWLKDSRPVND 501
Cdd:pfam13895    1 KPVLTPSP--TVVTEGEPVTLTC-SAPGNPPPSYTWYKDGSAISS 42
IgC1_2_PVR_like cd05719
Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), ...
 559-656 7.43e-03

Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and Necl-5), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (Necl-5)) and similar proteins. Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), these result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted, while CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" and has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the second Ig-like domain of nectin-1, also known as poliovirus receptor related protein(PVRL)1 or CD111.


Pssm-ID: 409384  Cd Length: 96  Bit Score: 37.09  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  559 PTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEgerLDDVAAKPQSAPFKGSAASRSVFLRVSSRD-HGHRVTC 637
Cdd:cd05719     1 PTNSLEGGPALLIGGEPTLVATCISANGKPPASVTWETD---LKGEASTTQVRGSNGTVTVTSRYRLVPSREaDGQPLTC 77

                          90
                  ....*....|....*....
gi 325511343  638 RAHSEALRETVSSFYRLNV 656
Cdd:cd05719    78 VVEHPSLEKDQRISVTLNV 96
IgI_2_Necl-3 cd05884
Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set ...
 145-250 8.33e-03

Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3; also known as cell adhesion molecule 2 (CADM2)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409467  Cd Length: 104  Bit Score: 37.21  E-value: 8.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  145 ILVSPKVLQLTpeaGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSD 224
Cdd:cd05884     1 VLGVPEKPQIS---GFTSPVMEGDHIQLTCKTSGSKPAADIRWFKNDKEVKDVKYLKAEDANRKTFTVSSSLDFHVDRDD 77

                          90       100
                  ....*....|....*....|....*..
gi 325511343  225 NGQLLVCEGSNPAL-ATPIKASFTMNI 250
Cdd:cd05884    78 DGVAITCRVDHESLtATPQIAMQVLEI 104
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 353-433 8.77e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.39  E-value: 8.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   353 PPSAVTILGSTSQSENKNVTLCCLTKSSrPRVLLRWWLGGRQLLPTDETVMDGLHGGhismSNLTLL-VKREDNGlSLTC 431
Cdd:pfam13927    1 KPVITVSPSSVTVREGETVTLTCEATGS-PPPTITWYKNGEPISSGSTRSRSLSGSN----STLTISnVTRSDAG-TYTC 74


                   ..
gi 325511343   432 EA 433
Cdd:pfam13927   75 VA 76
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 753-835 8.99e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 36.60  E-value: 8.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343   753 APTIRAlkDPTEVNVGGSVDIVCTVDANPilPEMFSWERlgeDEEELNlddmekmskgSTGRLRIRQAKLSQAGAYQCIV 832
Cdd:pfam13895    1 KPVLTP--SPTVVTEGEPVTLTCSAPGNP--PPSYTWYK---DGSAIS----------SSPNFFTLSVSAEDSGTYTCVA 63


                   ...
gi 325511343   833 DNG 835
Cdd:pfam13895   64 RNG 66
IgI_3_WFIKKN-like cd05765
Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz ...
 754-857 9.93e-03

Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein), and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein) and similar proteins. WFIKKN is a secreted protein that consists of multiple types of protease inhibitory modules, including two tandem Kunitz-type protease inhibitor-domains. The Ig superfamily is a heterogenous group of proteins built on a common fold comprised of a sandwich of two beta sheets. Members of the Ig superfamily are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409422 [Multi-domain]  Cd Length: 95  Bit Score: 36.76  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325511343  754 PTIRALKDPTEVNVGGSVDIVCTVDANPiLPEMfSWERLGEDEEELNL--DDME-KMSKGSTGRLRIRQAKLSQAGAYQC 830
Cdd:cd05765     1 PALVNSPTHQTVKVGETASFHCDVTGRP-QPEI-TWEKQVPGKENLIMrpNHVRgNVVVTNIGQLVIYNAQPQDAGLYTC 78

                          90       100
                  ....*....|....*....|....*..
gi 325511343  831 IVDNgvapaARGLVRlvvrfapqVDHP 857
Cdd:cd05765    79 TARN-----SGGLLR--------ANFP 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH