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Conserved domains on  [gi|324120893|ref|NP_001191295|]
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microsomal glutathione S-transferase 2 isoform 1 [Homo sapiens]

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein is a membrane associated protein; similar to mammalian prostaglandin E synthase, leukotriene C4 synthase, arachidonate 5-lipoxygenase-activating protein, microsomal glutathione S-transferases, and mitochondrial glutathione S-transferase 3

CATH:  1.20.120.550
Gene Ontology:  GO:0016020
PubMed:  10091672|10673221

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 8-111 2.90e-17

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 72.72  E-value: 2.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120893    8 LAAVSILSACQQSYFALQVGKARLKYKV--------TPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWY-FNQVF 78
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTgGSPGL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 324120893   79 ATCLGLVYIYGRHLYFWGY-SEAAKKRITGFRLS 111
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYaTGNPPLRSLGFLLG 114
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 8-111 2.90e-17

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 72.72  E-value: 2.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120893    8 LAAVSILSACQQSYFALQVGKARLKYKV--------TPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWY-FNQVF 78
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTgGSPGL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 324120893   79 ATCLGLVYIYGRHLYFWGY-SEAAKKRITGFRLS 111
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYaTGNPPLRSLGFLLG 114
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
21-108 2.95e-11

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 57.17  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120893  21 YFALQVGKARLKYKVTPPAvTGSPEFERVFRAQQNCVEFYPIFIITLWMAGwyFNQVFAT---CLGLVYIYGRHLYFWGY 97
Cdd:COG3788   19 VLSLRVVRLRRKYRVALGD-GGDPELQRAIRAHGNFVEYVPLALILLLLLE--LNGAPAWwlhLLGIALLLGRLLHAYGL 95

                         90
                 ....*....|....
gi 324120893  98 S---EAAKKRITGF 108
Cdd:COG3788   96 SrskGPSPGRAIGM 109
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 8-111 2.90e-17

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 72.72  E-value: 2.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120893    8 LAAVSILSACQQSYFALQVGKARLKYKV--------TPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWY-FNQVF 78
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTgGSPGL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 324120893   79 ATCLGLVYIYGRHLYFWGY-SEAAKKRITGFRLS 111
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYaTGNPPLRSLGFLLG 114
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
21-108 2.95e-11

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 57.17  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120893  21 YFALQVGKARLKYKVTPPAvTGSPEFERVFRAQQNCVEFYPIFIITLWMAGwyFNQVFAT---CLGLVYIYGRHLYFWGY 97
Cdd:COG3788   19 VLSLRVVRLRRKYRVALGD-GGDPELQRAIRAHGNFVEYVPLALILLLLLE--LNGAPAWwlhLLGIALLLGRLLHAYGL 95

                         90
                 ....*....|....
gi 324120893  98 S---EAAKKRITGF 108
Cdd:COG3788   96 SrskGPSPGRAIGM 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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