NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|324026766|gb|ADY13525|]
View 

ADP-ribosylation/Crystallin J1 [Sphaerochaeta globosa str. Buddy]

Protein Classification

ADP-ribosylglycohydrolase family protein( domain architecture ID 10003641)

ADP-ribosylglycohydrolase family protein similar to vertebrate [protein ADP-ribosylarginine] hydrolase, which catalyzes the reverse reaction of mono-ADP-ribosylation, and Tripedalia cystophora major lens protein crystallin J1

CATH:  1.10.4080.10

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DraG COG1397
ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];
196-288 2.32e-11

ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 441007  Cd Length: 256  Bit Score: 62.96  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324026766 196 CLQAAINQKPLPlydakqSTFVLTTLLVVMHTLIAFDSYEAGMQALVMRGGNARLTCAVYGGLAAGLYGSQCIPERWIDE 275
Cdd:COG1397  165 AVAAALRGADLE------EGYVVETLPAALWALLRADDFEEALLLAVNLGGDTDTTAAIAGALAGALYGLEAIPERWLEP 238

                         90
                 ....*....|...
gi 324026766 276 IFPSAALESMIKK 288
Cdd:COG1397  239 LERRDRLEELAER 251
 
Name Accession Description Interval E-value
DraG COG1397
ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];
196-288 2.32e-11

ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441007  Cd Length: 256  Bit Score: 62.96  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324026766 196 CLQAAINQKPLPlydakqSTFVLTTLLVVMHTLIAFDSYEAGMQALVMRGGNARLTCAVYGGLAAGLYGSQCIPERWIDE 275
Cdd:COG1397  165 AVAAALRGADLE------EGYVVETLPAALWALLRADDFEEALLLAVNLGGDTDTTAAIAGALAGALYGLEAIPERWLEP 238

                         90
                 ....*....|...
gi 324026766 276 IFPSAALESMIKK 288
Cdd:COG1397  239 LERRDRLEELAER 251
ADP_ribosyl_GH pfam03747
ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ...
 195-271 8.98e-07

ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.


Pssm-ID: 461037 [Multi-domain]  Cd Length: 200  Bit Score: 48.72  E-value: 8.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324026766  195 TCLQAAINQKPLP--LYDAKQSTFVLTTLLVVMHTLIAF-DSYEAGMQALVMRGGNARLTCAVYGGLAAGLYGSQCIPER 271
Cdd:pfam03747 121 AAIAAALRGADLEeaLEAIGGGGYVVEALPAALYALLRAgDDFEEALLAAVNLGGDTDTTAAIAGALLGAYYGLEAIPEE 200
 
Name Accession Description Interval E-value
DraG COG1397
ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];
196-288 2.32e-11

ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441007  Cd Length: 256  Bit Score: 62.96  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324026766 196 CLQAAINQKPLPlydakqSTFVLTTLLVVMHTLIAFDSYEAGMQALVMRGGNARLTCAVYGGLAAGLYGSQCIPERWIDE 275
Cdd:COG1397  165 AVAAALRGADLE------EGYVVETLPAALWALLRADDFEEALLLAVNLGGDTDTTAAIAGALAGALYGLEAIPERWLEP 238

                         90
                 ....*....|...
gi 324026766 276 IFPSAALESMIKK 288
Cdd:COG1397  239 LERRDRLEELAER 251
ADP_ribosyl_GH pfam03747
ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ...
 195-271 8.98e-07

ADP-ribosylglycohydrolase; This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.


Pssm-ID: 461037 [Multi-domain]  Cd Length: 200  Bit Score: 48.72  E-value: 8.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324026766  195 TCLQAAINQKPLP--LYDAKQSTFVLTTLLVVMHTLIAF-DSYEAGMQALVMRGGNARLTCAVYGGLAAGLYGSQCIPER 271
Cdd:pfam03747 121 AAIAAALRGADLEeaLEAIGGGGYVVEALPAALYALLRAgDDFEEALLAAVNLGGDTDTTAAIAGALLGAYYGLEAIPEE 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH