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Conserved domains on  [gi|321460414|gb|EFX71456|]
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hypothetical protein DAPPUDRAFT_308810 [Daphnia pulex]

Protein Classification

APOPT family protein( domain architecture ID 10562973)

APOPT family protein is a DUF2315 domain-containing protein similar to Homo sapiens mitochondrial apoptogenic protein 1, which is required for cytochrome c complex (COX) IV assembly and function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 45-169 1.37e-61

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


:

Pssm-ID: 463011  Cd Length: 119  Bit Score: 186.31  E-value: 1.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321460414   45 DVYGPPDPKSSLRLITFYIPPDETEAEKKYRLRRAQVQEWNHLFWTIHNVQFTQAKEEFVTSVLERRGKDasttgqpLTA 124
Cdd:pfam10231   2 DWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLE-------ERA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 321460414  125 DDLSEFYRAFLDQNREKHLKYNVEWHMKNMGLLWPGIKANLSRFK 169
Cdd:pfam10231  75 GEMSEFYKSFLDKNWKRHMNYNKEWYKRNFAILWLAARVALSRFF 119
 
Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 45-169 1.37e-61

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


Pssm-ID: 463011  Cd Length: 119  Bit Score: 186.31  E-value: 1.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321460414   45 DVYGPPDPKSSLRLITFYIPPDETEAEKKYRLRRAQVQEWNHLFWTIHNVQFTQAKEEFVTSVLERRGKDasttgqpLTA 124
Cdd:pfam10231   2 DWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLE-------ERA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 321460414  125 DDLSEFYRAFLDQNREKHLKYNVEWHMKNMGLLWPGIKANLSRFK 169
Cdd:pfam10231  75 GEMSEFYKSFLDKNWKRHMNYNKEWYKRNFAILWLAARVALSRFF 119
 
Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 45-169 1.37e-61

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


Pssm-ID: 463011  Cd Length: 119  Bit Score: 186.31  E-value: 1.37e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321460414   45 DVYGPPDPKSSLRLITFYIPPDETEAEKKYRLRRAQVQEWNHLFWTIHNVQFTQAKEEFVTSVLERRGKDasttgqpLTA 124
Cdd:pfam10231   2 DWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLE-------ERA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 321460414  125 DDLSEFYRAFLDQNREKHLKYNVEWHMKNMGLLWPGIKANLSRFK 169
Cdd:pfam10231  75 GEMSEFYKSFLDKNWKRHMNYNKEWYKRNFAILWLAARVALSRFF 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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