Chain B, NITROPHORIN 1
Protein Classification
lipocalin/fatty acid-binding family protein( domain architecture ID 3669)
lipocalin/fatty acid-binding family protein contains a large beta-barrel cavity that binds hydrophobic ligands
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| lipocalin_FABP super family | cl10502 | lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low ... |
1-184 | 3.26e-116 | ||||
lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They have a large beta-barrel ligand-binding cavity. Members include retinol-binding protein, retinoic acid-binding protein, complement protein C8 gamma, Can f 2, apolipoprotein D, extracellular fatty acid-binding protein, beta-lactoglobulin, oderant-binding protein, and bacterial lipocalin Blc. Lipocalins are involved in many important processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty acid-binding proteins also bind hydrophobic ligands in a non-covalent, reversible manner, and are involved in protection and shuttling of fatty acids within the cell, and in acquisition and removal of fatty acids from intracellular sites. The actual alignment was detected with superfamily member cd19455: Pssm-ID: 471979 Cd Length: 184 Bit Score: 327.46 E-value: 3.26e-116
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| Name | Accession | Description | Interval | E-value | ||||
| lipocalin_NP1 | cd19455 | nitrophorin 1; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme ... |
1-184 | 3.26e-116 | ||||
nitrophorin 1; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381230 Cd Length: 184 Bit Score: 327.46 E-value: 3.26e-116
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| Nitrophorin | pfam02087 | Nitrophorin; |
2-181 | 7.24e-97 | ||||
Nitrophorin; Pssm-ID: 111029 Cd Length: 178 Bit Score: 278.02 E-value: 7.24e-97
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| Name | Accession | Description | Interval | E-value | ||||
| lipocalin_NP1 | cd19455 | nitrophorin 1; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme ... |
1-184 | 3.26e-116 | ||||
nitrophorin 1; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381230 Cd Length: 184 Bit Score: 327.46 E-value: 3.26e-116
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| lipocalin_NP4 | cd19456 | nitrophorin 4; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme ... |
2-184 | 1.36e-101 | ||||
nitrophorin 4; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381231 Cd Length: 184 Bit Score: 290.50 E-value: 1.36e-101
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| Nitrophorin | pfam02087 | Nitrophorin; |
2-181 | 7.24e-97 | ||||
Nitrophorin; Pssm-ID: 111029 Cd Length: 178 Bit Score: 278.02 E-value: 7.24e-97
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| lipocalin_NPs-like | cd19424 | nitrophorins and similar proteins; Nitrophorins (NPs) represent a group of nitric oxide (NO) ... |
1-175 | 2.36e-85 | ||||
nitrophorins and similar proteins; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase, R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. Besides NO, NPs also show high affinities for histamine (Hm). This group also includes Rhodnius prolixus amine-binding protein (ABP) which plays an important role in biogenic amine binding; it binds serotonin and norepinephrine with high affinity. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381199 Cd Length: 175 Bit Score: 248.99 E-value: 2.36e-85
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| lipocalin_NP2 | cd19453 | nitrophorin 2; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme ... |
2-175 | 2.91e-44 | ||||
nitrophorin 2; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381228 Cd Length: 179 Bit Score: 144.92 E-value: 2.91e-44
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| lipocalin_NP7 | cd19615 | nitrophorin 7; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme ... |
1-175 | 8.70e-40 | ||||
nitrophorin 7; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. NP7 displays peculiar properties, such as an abnormally high isoelectric point, the ability to bind negatively charged membranes, and a strong pH sensitivity of NO affinity. In contrast to NP1-4, which show high affinities for histamine (Hm), Np7 does not appear to sequester Hm. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381248 Cd Length: 174 Bit Score: 133.32 E-value: 8.70e-40
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| lipocalin_NP3 | cd19454 | nitrophorin 3; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme ... |
2-175 | 1.17e-39 | ||||
nitrophorin 3; Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. In its adult phase R. prolixus expresses at least 4 nitrophorins (designated NP1-4 in order of their increasing abundance in the saliva of adult insects). Two additional nitrophorins, NP5 and NP6, have been detected mainly in the five instar nymphal stages of insect development. NP7 has not been isolated from the insects but was instead recognized in a cDNA library. NPs belong to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381229 Cd Length: 189 Bit Score: 133.37 E-value: 1.17e-39
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| lipocalin_ABP | cd19452 | Rhodnius prolixus amine-binding protein and similar proteins; Rhodnius prolixus amine-binding ... |
5-184 | 2.07e-07 | ||||
Rhodnius prolixus amine-binding protein and similar proteins; Rhodnius prolixus amine-binding protein (ABP) plays an important role in biogenic amine binding; it binds serotonin and norepinephrine with high affinity. It is a subgroup of the lipocalin NP-like family. Nitrophorins (NPs) represent a group of nitric oxide (NO)-carrying heme proteins found in the saliva of Rhodnius prolixus. The lipocalin NP-like family belongs to the lipocalin/cytosolic fatty-acid binding protein family which has a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381227 Cd Length: 189 Bit Score: 49.00 E-value: 2.07e-07
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| lipocalin_LTBP1-like | cd19423 | Triatominae salivary lipocalins such as Rhodnius prolixus LTBP1 and Meccus pallidipennis ... |
8-140 | 8.94e-06 | ||||
Triatominae salivary lipocalins such as Rhodnius prolixus LTBP1 and Meccus pallidipennis triabin, and similar proteins; This subfamily includes various insect proteins found in the saliva of Triatominae (kissing bugs), including Rhodnius prolixus leukotriene-binding LTBP1. Rhodnius prolixus, a vector of the pathogen Trypanosoma cruzi, sequesters cysteinyl leukotrienes during feeding to inhibit immediate inflammatory responses; LTBP1 binds leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4). Meccus pallidipennis (syn Triatoma pallidipennis) triabin is a potent and selective thrombin inhibitor. It also includes Triatoma protracta procalin, a major salivary allergen which causes an allergic reaction in humans. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development. Pssm-ID: 381198 Cd Length: 132 Bit Score: 43.11 E-value: 8.94e-06
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