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Conserved domains on  [gi|321159877]
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Chain H, 6-phosphofructokinase subunit beta

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 1003451)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

CATH:  3.40.50.460|3.40.50.450
EC:  2.7.1.11
Gene Ontology:  GO:0006007|GO:0006002|GO:0003872|GO:0000166|GO:0046872|GO:0070095

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
6PF1K_euk super family cl37119
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 4-764 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


The actual alignment was detected with superfamily member TIGR02478:

Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1177.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGG-DNIEEAQWEDVRGILSLGGTIIGTARCKEFRE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDA 163
Cdd:TIGR02478  80 RPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPP-EEGWEDQLCHKLKRNRKA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:TIGR02478 239 GKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPS 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLP-KDKRLKIAIVNVG 402
Cdd:TIGR02478 319 PVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVG 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  403 APAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRVTPeEADLGMIAYYFQK 482
Cdd:TIGR02478 399 APAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLP-GDDLGTIAYYFQQ 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  483 YEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRA 562
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRV 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  563 FVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEkaegRGRFGKLILKSTNASKALSATKLAEV 642
Cdd:TIGR02478 557 FVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFA----EGRAGKLILRNEKASKVYTTDFIARI 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  643 ITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDnqaaiaearAAEENFNADDKTISDTAAVV-GVKG 721
Cdd:TIGR02478 633 ISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEE---------KIKANKHADKLSADDTSAVViGIRG 703

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 321159877  722 SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 764
Cdd:TIGR02478 704 SNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 4-764 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1177.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGG-DNIEEAQWEDVRGILSLGGTIIGTARCKEFRE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDA 163
Cdd:TIGR02478  80 RPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPP-EEGWEDQLCHKLKRNRKA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:TIGR02478 239 GKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPS 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLP-KDKRLKIAIVNVG 402
Cdd:TIGR02478 319 PVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVG 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  403 APAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRVTPeEADLGMIAYYFQK 482
Cdd:TIGR02478 399 APAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLP-GDDLGTIAYYFQQ 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  483 YEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRA 562
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRV 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  563 FVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEkaegRGRFGKLILKSTNASKALSATKLAEV 642
Cdd:TIGR02478 557 FVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFA----EGRAGKLILRNEKASKVYTTDFIARI 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  643 ITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDnqaaiaearAAEENFNADDKTISDTAAVV-GVKG 721
Cdd:TIGR02478 633 ISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEE---------KIKANKHADKLSADDTSAVViGIRG 703

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 321159877  722 SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 764
Cdd:TIGR02478 704 SNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 3-754 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1145.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   3 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPeYIKEFHWEDVRGWSAEGGTNIGTARCMEFK 82
Cdd:cd00764    3 GKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGD-YIKQAEWESVSNWLQEGGTIIGSARCKEFR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  83 KREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTD 162
Cdd:cd00764   82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 163 ATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRS 242
Cdd:cd00764  162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPP-EDGWEDQMCRRLSEHRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 243 RGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTP 322
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 323 SPLIAVNENKIVRKPLMESVKLTKAVAEA-----------IQAKDFKRAMSLRDTEFIEHLnnfmainsadhnePKLPKD 391
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAmdekrfdeaaaLRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 392 KRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRsLNWKDMLGWQSRGGSEIGTNRVTPEEa 471
Cdd:cd00764  388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVE-LGWIDVGGWTGRGGSELGTKRTLPKK- 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 472 DLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV 551
Cdd:cd00764  466 DLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRI 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 552 KQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNAS 631
Cdd:cd00764  546 KQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYT 625

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 632 KALSATKLAEVItaeaDGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKdnQAAIAEARAAEENFNADDKT-- 709
Cdd:cd00764  626 TVFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIE--QKLKENYAAGNEFANDPDFNcv 699

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 321159877 710 -ISDTAAVVGVKG-------------SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRL 754
Cdd:cd00764  700 nGVKKYAVLFEPVeelkqttfehripKEQWWLSLRPLLKILAKYKISADISDHGQLEHV 758
PFK pfam00365
Phosphofructokinase;
6-312 5.46e-132

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 392.47  E-value: 5.46e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    6 IAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKKRE 85
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD---IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   86 GRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWpslieellktnrisneqyermkHLNICGTVGSIDNDMSTTDATI 165
Cdd:pfam00365  79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  166 GAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVsKHRSRGK 245
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD----IEELCEKI-KELRKGK 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321159877  246 RTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVN 312
Cdd:pfam00365 212 RFSIIVVAEGASDGE-------FLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
4-348 2.40e-103

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 320.10  E-value: 2.40e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG---DIVKLDLKSVSDIINRGGTILGSARFPEFKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFrSEwpslieellktnrisneqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:PRK03202  79 EEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-TE----------------------HGIPVIGLPGTIDNDIAGTDY 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD----IEELCAKIKKGRER 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 244 GKRTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLEstpDTPS 323
Cdd:PRK03202 212 GKKHAIIVVAEGVMPAE-------ELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281

                        330       340
                 ....*....|....*....|....*
gi 321159877 324 PLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 4-348 2.34e-102

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 318.56  E-value: 2.34e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD---IIDLTREDVSGILQRGGTILGSSRSKPFKT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:COG0205   79 EEGREKALENLKKLGIDALVVIGGDGSLDGA-----------------AKLAEE-----YGIPVVGIPKTIDNDLPGTDY 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:COG0205  137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 244 GKRTTIVVVAEGAIAADLTPISPSDVH---------------KVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGL 308
Cdd:COG0205  213 GKGYSIIVVAEGAGDEDGEAVLEADTDafghvrlggigeylaKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 321159877 309 EAVNAVLESTPDTpspLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:COG0205  293 AAVELLLEGKTGV---MVGIRRGEIVLVPLEEVANKEKPV 329
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 4-764 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1177.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGG-DNIEEAQWEDVRGILSLGGTIIGTARCKEFRE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDA 163
Cdd:TIGR02478  80 RPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPP-EEGWEDQLCHKLKRNRKA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:TIGR02478 239 GKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPS 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLP-KDKRLKIAIVNVG 402
Cdd:TIGR02478 319 PVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVG 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  403 APAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRVTPeEADLGMIAYYFQK 482
Cdd:TIGR02478 399 APAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLP-GDDLGTIAYYFQQ 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  483 YEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRA 562
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRV 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  563 FVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEkaegRGRFGKLILKSTNASKALSATKLAEV 642
Cdd:TIGR02478 557 FVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFA----EGRAGKLILRNEKASKVYTTDFIARI 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  643 ITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDnqaaiaearAAEENFNADDKTISDTAAVV-GVKG 721
Cdd:TIGR02478 633 ISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEE---------KIKANKHADKLSADDTSAVViGIRG 703

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 321159877  722 SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 764
Cdd:TIGR02478 704 SNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 3-754 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1145.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   3 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPeYIKEFHWEDVRGWSAEGGTNIGTARCMEFK 82
Cdd:cd00764    3 GKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGD-YIKQAEWESVSNWLQEGGTIIGSARCKEFR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  83 KREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTD 162
Cdd:cd00764   82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 163 ATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRS 242
Cdd:cd00764  162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPP-EDGWEDQMCRRLSEHRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 243 RGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTP 322
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 323 SPLIAVNENKIVRKPLMESVKLTKAVAEA-----------IQAKDFKRAMSLRDTEFIEHLnnfmainsadhnePKLPKD 391
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAmdekrfdeaaaLRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 392 KRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRsLNWKDMLGWQSRGGSEIGTNRVTPEEa 471
Cdd:cd00764  388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVE-LGWIDVGGWTGRGGSELGTKRTLPKK- 465

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 472 DLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV 551
Cdd:cd00764  466 DLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRI 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 552 KQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNAS 631
Cdd:cd00764  546 KQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYT 625

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 632 KALSATKLAEVItaeaDGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKdnQAAIAEARAAEENFNADDKT-- 709
Cdd:cd00764  626 TVFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIE--QKLKENYAAGNEFANDPDFNcv 699

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 321159877 710 -ISDTAAVVGVKG-------------SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRL 754
Cdd:cd00764  700 nGVKKYAVLFEPVeelkqttfehripKEQWWLSLRPLLKILAKYKISADISDHGQLEHV 758
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 4-362 2.71e-166

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 482.95  E-value: 2.71e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:cd00363    1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG---DIKELDWESVSDIINRGGTIIGSARCKEFRT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEellktnrisneqyermkHLNICGTVGSIDNDMSTTDA 163
Cdd:cd00363   78 EEGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQ-----------------GFNVIGLPGTIDNDIKGTDY 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:cd00363  141 TIGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPA-ADEWEEEMVDVIKKRRER 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:cd00363  220 GKRHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPV 299

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 321159877 324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMS 362
Cdd:cd00363  300 GIQNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
6-312 5.46e-132

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 392.47  E-value: 5.46e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    6 IAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKKRE 85
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD---IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   86 GRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWpslieellktnrisneqyermkHLNICGTVGSIDNDMSTTDATI 165
Cdd:pfam00365  79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  166 GAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVsKHRSRGK 245
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD----IEELCEKI-KELRKGK 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321159877  246 RTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVN 312
Cdd:pfam00365 212 RFSIIVVAEGASDGE-------FLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
4-348 2.40e-103

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 320.10  E-value: 2.40e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG---DIVKLDLKSVSDIINRGGTILGSARFPEFKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFrSEwpslieellktnrisneqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:PRK03202  79 EEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-TE----------------------HGIPVIGLPGTIDNDIAGTDY 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD----IEELCAKIKKGRER 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 244 GKRTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLEstpDTPS 323
Cdd:PRK03202 212 GKKHAIIVVAEGVMPAE-------ELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281

                        330       340
                 ....*....|....*....|....*
gi 321159877 324 PLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
PFK pfam00365
Phosphofructokinase;
395-683 5.70e-103

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 317.36  E-value: 5.70e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  395 KIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLArHESVRSLNWKDMLGWQSRGGSEIGTNRVTP--EEAD 472
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLV-EGDIDELTWRDVSGILNRGGTILGTSRSKPfkTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  473 LGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERAREsypafrIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVK 552
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  553 QSASSTRgRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAqsfekaegRGRFGKLILKSTNASk 632
Cdd:pfam00365 154 DTASSHN-RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR--------KGKRFSIIVVAEGAS- 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 321159877  633 alSATKLAEVItaEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAV 683
Cdd:pfam00365 224 --DGEFLAKLI--EEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 4-348 2.34e-102

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 318.56  E-value: 2.34e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD---IIDLTREDVSGILQRGGTILGSSRSKPFKT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:COG0205   79 EEGREKALENLKKLGIDALVVIGGDGSLDGA-----------------AKLAEE-----YGIPVVGIPKTIDNDLPGTDY 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:COG0205  137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 244 GKRTTIVVVAEGAIAADLTPISPSDVH---------------KVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGL 308
Cdd:COG0205  213 GKGYSIIVVAEGAGDEDGEAVLEADTDafghvrlggigeylaKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 321159877 309 EAVNAVLESTPDTpspLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:COG0205  293 AAVELLLEGKTGV---MVGIRRGEIVLVPLEEVANKEKPV 329
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 6-342 2.53e-92

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 290.79  E-value: 2.53e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    6 IAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKRE 85
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING---KIEPLESKNVSGIIHRGGTILGTARCPEFKTEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   86 GRLLGAQHLIEAGVDALIVCGGDGSLTGADLFrsewpslieellktnrisneqyERMKHLNICGTVGSIDNDMSTTDATI 165
Cdd:TIGR02482  79 VREKAVENLKKLGIEGLVVIGGDGSYTGAQKL----------------------YEEGGIPVIGLPGTIDNDIPGTDYTI 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  166 GAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSsewqDQMCDIVSKHRSRGK 245
Cdd:TIGR02482 137 GFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDI----DELIQRLKEQHEAGK 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  246 RTTIVVVAEGAIAADLTpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTpspL 325
Cdd:TIGR02482 213 KHSIIIVAEGNIVGSAK-----EVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---M 284

                         330
                  ....*....|....*..
gi 321159877  326 IAVNENKIVRKPLMESV 342
Cdd:TIGR02482 285 IGIQNNKIVTHPIEEAL 301
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 4-342 5.42e-79

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 256.18  E-value: 5.42e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:cd00763    1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG---DIVPLDRYSVSDIINRGGTFLGSARFPEFKD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLfrsewpsLIEEllktnrisneqyermkHLNICGTVGSIDNDMSTTDA 163
Cdd:cd00763   78 EEGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-------LTEH----------------GFPCVGLPGTIDNDIPGTDY 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEwqdqMCDIVSKHRSR 243
Cdd:cd00763  135 TIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREE----VANRIKAGIER 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 244 GKRTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTps 323
Cdd:cd00763  211 GKKHAIVVVAEGVYDVD-------ELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGL-- 281

                        330
                 ....*....|....*....
gi 321159877 324 pLIAVNENKIVRKPLMESV 342
Cdd:cd00763  282 -AVGIQNEQLVHHDIIDAI 299
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
2-348 4.08e-50

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 179.88  E-value: 4.08e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   2 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFK-GCRAFVVMEGYEGLVRGGPEYIkEFHWEDVRGWSAEGGTNIGT----- 75
Cdd:PRK14071   3 EKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYI-ELDLDQVDDLLRMGGTILGTtnkgd 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  76 --ARCME---FKKREGRLLGAQHliEAGVDALIVCGGDGSLtgadlfrsewpSLIEELLKTNRIsneqyermkhlNICGT 150
Cdd:PRK14071  82 pfAFPMPdgsLRDRSQEIIDGYH--SLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 151 VGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQ 230
Cdd:PRK14071 138 PKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT----L 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 231 DQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSD-------------VHKVLVDRLGLDTRITTLGHVQRGGTAVA 297
Cdd:PRK14071 214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSP 293

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 321159877 298 YDRILATLQGLEAVNAVLESTPDTpspLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:PRK14071 294 RDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAV 341
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 395-690 1.24e-42

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 158.31  E-value: 1.24e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 395 KIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLArHESVRSLNWKDMLGWQSRGGSEIGTNRVTP--EEAD 472
Cdd:COG0205    3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLL-EGDIIDLTREDVSGILQRGGTILGSSRSKPfkTEEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 473 LGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERAREsypafrIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVK 552
Cdd:COG0205   82 REKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 553 QSASSTRgRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEK------AEGRGRFG--KLI 624
Cdd:COG0205  156 DTAASHE-RVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGysiivvAEGAGDEDgeAVL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 625 LKSTNASKALS----ATKLAEVITAEADgrFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQ 690
Cdd:COG0205  235 EADTDAFGHVRlggiGEYLAKEIEERTG--IETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGK 302
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
395-690 5.08e-38

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 144.45  E-value: 5.08e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 395 KIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLArHESVRSLNWKDMLGWQSRGGSEIGTNRvTPEEADLG 474
Cdd:PRK03202   3 RIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLL-EGDIVKLDLKSVSDIINRGGTILGSAR-FPEFKDEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 475 M---IAYYFQKYEFDGLIIVGGFEAFESLHQLERaresypaFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV 551
Cdd:PRK03202  81 GrakAIENLKKLGIDALVVIGGDGSYMGAKRLTE-------HGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 552 KQSASStRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLsedIEYLAQSFEkaegRGRFGKLILKstnAS 631
Cdd:PRK03202 154 RDTASS-HERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL---CAKIKKGRE----RGKKHAIIVV---AE 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 321159877 632 KALSATKLAEVITAEADgrFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQ 690
Cdd:PRK03202 223 GVMPAEELAKEIEERTG--LETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGK 279
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 394-683 2.11e-35

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 137.43  E-value: 2.11e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 394 LKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRV----TPE 469
Cdd:cd00363    1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGD-IKELDWESVSDIINRGGTIIGSARCkefrTEE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 470 EADLGmiAYYFQKYEFDGLIIVGGFEafeSLHQLERARESYPAFR--IPMVLIPATLSNNVPGTEYSLGSDTALNALMEY 547
Cdd:cd00363   80 GRAKA--AENLKKHGIDALVVIGGDG---SYTGADLLTEEWPSKYqgFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 548 CDVVKQSASStRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEgislEQLSEDIEYLAQSFEKAEGRG-RFGKLILK 626
Cdd:cd00363  155 IDRIRDTASS-HQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEE----PAADEWEEEMVDVIKKRRERGkRHGIVIVA 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 627 S---TNASKALSATKLAEVITAEadGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAV 683
Cdd:cd00363  230 EgaiDFIPKPITEKLLAKLVEER--LGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAV 287
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 6-275 1.23e-24

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 107.82  E-value: 1.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   6 IAVMTSGGDAPGMNSNVRAIVRSAI--FKGCRAFVVMEGYEGLVRGG-----PEYIKEFHwedvrgwsAEGGTNIGTARC 78
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLInnYGVKTIYGAKYGYKGLYKEDwikldPKDVKTIH--------RLGGTILGSSRG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  79 MEFKKregrlLGAQHLIEAGVDALIVCGGDGSLTGADlfrsewpSLIEELLKTN-RISneqyermkhlnICGTVGSIDND 157
Cdd:PTZ00286 162 GFDPK-----VMVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKTIDND 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 158 MSTTDATIGAYSALDRICKAIDYVEATANSHSRAF-VVEVMGRNCGWLALLAGIAT-SADYIFIPEKPATssewQDQMCD 235
Cdd:PTZ00286 219 IPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASaDVNVCLIPEFDIP----LEGVLE 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 321159877 236 IVsKHRSRGKRTTIVVVAEGAIAA--DLTPISPSDV--HKVLVD 275
Cdd:PTZ00286 295 YI-EQRLQKKGHCVIVVAEGAGQSlkDADLDLGTDAsgNKKLWD 337
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
388-686 6.48e-18

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 86.28  E-value: 6.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 388 LPKDKRlkIAIVNVGAPAGGINSAVYSMATYCMSQ-GHRPYAIYNGWSGL-ARHESVRSLNWKDMLGWQSRGGSEIGT-N 464
Cdd:PRK14071   1 MGEKKR--IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLmARPPQYIELDLDQVDDLLRMGGTILGTtN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 465 RVTP----------EEADLGMIAYYfQKYEFDGLIIVGGFEAFESLHQLerARESypafRIPMVLIPATLSNNVPGTEYS 534
Cdd:PRK14071  79 KGDPfafpmpdgslRDRSQEIIDGY-HSLGLDALIGIGGDGSLAILRRL--AQQG----GINLVGIPKTIDNDVGATEVS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 535 LGSDTALNALMEYCDVVKQSASStRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEegisleqLSEDIEYLAQSFEKA 614
Cdd:PRK14071 152 IGFDTAVNIATEALDRLHFTAAS-HNRVMILEVMGRDAGHIALAAGIAGGADVILIPE-------IPYTLENVCKKIRER 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 615 EGRGRFGKLILKS----TNASKALSATK-------------LAEVItAEADGRfDAKPAYPGHVQQGGLPSPIDRTRATR 677
Cdd:PRK14071 224 QEEGKNFCLVVVSeavrTEEGEQVTKTQalgedryggigqyLAEQI-AERTGA-ETRVTVLGHIQRGGIPSPRDRLLASA 301


                 ....*....
gi 321159877 678 MAIKAVGFI 686
Cdd:PRK14071 302 FGVAAVDLI 310
PLN02884 PLN02884
6-phosphofructokinase
 7-313 1.40e-15

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 79.47  E-value: 1.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   7 AVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFV-VMEGYEGLVRGGPEYIkEFHWEDVRGWSAEGGTNIGTARCmefkkre 85
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVFTLEIYGVKNIVgIPFGYRGFFEKGLSEM-PLSRKVVQNIHLSGGSLLGVSRG------- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  86 grllGAQ------HLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEQYERMKHLNICGTVGSIDNDMS 159
Cdd:PLN02884 129 ----GAKtsdivdSIEARGINMLFVLGGNGTHAGA-----------------NAIHNECRKRKMKVSVVGVPKTIDNDIL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 160 TTDATIGAYSALDRICKAID--YVEATANSHSRAfVVEVMGRNCGWLALLAGIAT-SADYIFIPEKPATSSEWQDQMCDI 236
Cdd:PLN02884 188 LMDKTFGFDTAVEEAQRAINsaYIEAHSAYHGIG-LVKLMGRSSGFIAMHASLASgQVDICLIPEVPFTLDGPNGVLRHL 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 237 vsKHRSRGKRTTIVVVAEGAIAADLTPISPSDV--HKVLVDrLGLDTRITTLGHVQRGGT-----------------AVA 297
Cdd:PLN02884 267 --EHLIETKGSAVVCVAEGAGQDLLQKTNATDAsgNPVLGD-IGVHLQQEIKKHFKDIGVpadvkyidptymiracrANA 343

                        330
                 ....*....|....*.
gi 321159877 298 YDRILATLQGLEAVNA 313
Cdd:PLN02884 344 SDAILCTVLGQNAVHG 359
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 331-618 3.39e-14

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 75.46  E-value: 3.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 331 NKIVRKPL--MESVKLTKAVAEAIQAKDFKRAMSLRDtEFIEHlnNFMAINSADHNEPKLPKD----------------- 391
Cdd:PTZ00286   9 NLIIDLPDapLPSVVNPDLGECNLRGVFGGNGFLPRE-AFVDT--NSYILSTPRFGPDDVIVNtkrwlragprkhlyfnp 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 392 KRLKIAIVNVGAPAGGINSAVYS--MATYCMSQGHRPYAIYNGWSGLARHESVRsLNWKDMLGWQSRGGSEIGTNRvTPE 469
Cdd:PTZ00286  86 KEVKAGIVTCGGLCPGLNVVIRElvMNLINNYGVKTIYGAKYGYKGLYKEDWIK-LDPKDVKTIHRLGGTILGSSR-GGF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 470 eaDLGMIAYYFQKYEFDGLIIVGGFEAFESLHQL--ERARESYPafrIPMVLIPATLSNNVPGTEYSLGSDTALNALMEY 547
Cdd:PTZ00286 164 --DPKVMVDTLIRHGINILFTLGGDGTHRGALAIykELRRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 548 CDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVG-AQVSYVPEEGISLEQLsedIEYLAQSFEK--------AEGRG 618
Cdd:PTZ00286 239 IRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPLEGV---LEYIEQRLQKkghcvivvAEGAG 315
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
7-256 3.55e-13

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 72.21  E-value: 3.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   7 AVMTSGGDAPGMNSNVRAIVRSAIFK-GCRAFV-VMEGYEGLV-RGG-------PEYIKEFHwedvrgwsAEGGTNIGTA 76
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIVLELHHHyGVRRILgIRYGYQGLIpRYGhdpveltPEVVADIH--------EFGGTILGSS 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  77 RcmefkkregrllGAQH-------LIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEQYERMKHLNICG 149
Cdd:PRK06830 156 R------------GPQDpeeivdtLERMNINILFVIGGDGTLRGA-----------------SAIAEEIERRGLKISVIG 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 150 TVGSIDNDMSTTDATIGAYSALDRICKAID--YVEATAnshsrAF----VVEVMGRNCGWLALLAGIATS-ADYIFIPEK 222
Cdd:PRK06830 207 IPKTIDNDINFIQKSFGFETAVEKATEAIRcaHVEANG-----APngigLVKLMGRHSGFIAAYAALASKdVNFVLIPEV 281

                        250       260       270
                 ....*....|....*....|....*....|....
gi 321159877 223 PATSSEWQDQMCDIVSKHRSRGKrtTIVVVAEGA 256
Cdd:PRK06830 282 PFDLEGPNGLLAALEKRLAERGH--AVIVVAEGA 313
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
154-316 2.83e-12

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 69.50  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 154 IDNDMSTTDATIGAYSALDRICKAI-----DyVEATANShSRAFVVEVMGRNCGWLALLAGIATS-----ADYIFIPEKP 223
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIATSVleaalD-VAAMANT-SKVFILEVMGRHAGWLAAAAALAKQnpddaPHLIYLPERP 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 224 ATssewQDQMCDIVSKHRSRGKRtTIVVVAEGAIAADLTPIS----PSDVH-------------KVLVDRLGLDTRITTL 286
Cdd:PRK14072 220 FD----EEKFLADVRAIVKRYGY-CVVVVSEGIRDADGKFIAeaglAEDAFghaqlggvapvlaNLIKEKLGKKVHWAVL 294

                        170       180       190
                 ....*....|....*....|....*....|..
gi 321159877 287 GHVQR--GGTAVAYDRILATLQGLEAVNAVLE 316
Cdd:PRK14072 295 DYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 4-217 6.47e-11

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 65.03  E-value: 6.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   4 KAIAVMTSGGDAPGMNSNVRAIVR--SAIFKGCRAFVVMEGYEGLVRGgpEYIkEFHwEDVRGWSAE----GGTNIGTAR 77
Cdd:PRK06555   4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLG--DSI-EIT-PAVRANAGLlhryGGSPIGNSR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  78 --------CME---FKKREGRL-LGAQHLIEAGVDALIVCGGDGS-LTGADLFRsewpslieeLLKTNrisneQYermkH 144
Cdd:PRK06555  80 vkltnvadCVKrglVKEGENPLkVAAERLAADGVDILHTIGGDDTnTTAADLAA---------YLAEN-----GY----D 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 321159877 145 LNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVV-EVMGRNCGWLAllagIATSADYI 217
Cdd:PRK06555 142 LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLT----AATARAYR 211
PLN02564 PLN02564
6-phosphofructokinase
 7-256 2.65e-09

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 60.15  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   7 AVMTSGGDAPGMNSNVRAIV--RSAIFKGCRAFVVMEGYEGL-----VRGGPEYIKEFHwedvrgwsAEGGTNIGTARcm 79
Cdd:PLN02564  91 CIVTCGGLCPGLNTVIREIVcgLSYMYGVTRILGIDGGYRGFysrntIPLTPKVVNDIH--------KRGGTILGTSR-- 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  80 efkkregrllGAQ-------HLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEQYERMKHLNICGTVG 152
Cdd:PLN02564 161 ----------GGHdtskivdSIQDRGINQVYIIGGDGTQKGA-----------------SVIYEEIRRRGLKVAVAGIPK 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 153 SIDNDMSTTDATIGAYSALDRICKAID--YVEATANsHSRAFVVEVMGRNCGWLALLAGIAT-SADYIFIPEKPaTSSEW 229
Cdd:PLN02564 214 TIDNDIPVIDKSFGFDTAVEEAQRAINaaHVEAESV-ENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESP-FYLEG 291

                        250       260
                 ....*....|....*....|....*..
gi 321159877 230 QDQMCDIVSKhRSRGKRTTIVVVAEGA 256
Cdd:PLN02564 292 KGGLFEFIEK-RLKENGHMVIVVAEGA 317
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 2-257 7.96e-08

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 56.14  E-value: 7.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877    2 PQKAIAVMTSGGDAPGmNSNVRAIVRSAIfKGCRAFVVMEGYeglvRGGPEYI-----KEFHWEDVRGWSAEGGTNIGTA 76
Cdd:PTZ00468  101 PARRIGVVLSGGQASG-GHNVIAGLMSYI-KLCNQSSQLFGF----LGGPEGVyseryRELTEDDINGILNQGGFNIICS 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   77 RCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpSLIEELLKTNRISneqyermkhLNICGTVGSIDN 156
Cdd:PTZ00468  175 GRHKIETEEQMRASLEICEKLKLHGLVVIGGDDSNTNA--------AVLAEYFKRNSSS---------TVVVGCPKTIDG 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  157 DM--STTDATIGAYSALDRICKAIDYV-EATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIF----IPEKPATSSEW 229
Cdd:PTZ00468  238 DLknEVIETSFGYDTAVKTYSEQIGSImDAIKTEGYGYYFVRLMGRSASHITLECGLQTRANMILigeeIKEENRSLMSI 317

                         250       260
                  ....*....|....*....|....*...
gi 321159877  230 QDQMCDIVSKHRSRGKRTTIVVVAEGAI 257
Cdd:PTZ00468  318 VDEIVEMILKRDSLGKKHGIVLLPEGLI 345
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 6-257 1.77e-06

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 51.41  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877   6 IAVMTSGGDAPGMNSnvraiVRSAIFKGCRAFVVMEGYEGLvRGGP------EYIkEFHWEDVRGWSAEGGTNIGTARCM 79
Cdd:cd00765   75 IGIVLSGGQAPGGHN-----VISGLFDYLKERAKGSTLYGF-KGGPagilkcDYI-ELNAEYIQPYRNTGGFDMICSGRT 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877  80 EFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpSLIEELLKTNRISNEqyermkhlnICGTVGSIDNDMS 159
Cdd:cd00765  148 KIETEDQFKQAEETAKKLDLDALVVIGGDDSNTNA--------ALLAENFRSKGLKTR---------VIGVPKTIDGDLK 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 160 T--TDATIGAYSALDRICKAIDYVEATANSHSRAF-VVEVMGRNCGWLALLAGIATSADYIFIPE----KPATSSEWQDQ 232
Cdd:cd00765  211 NkeIETSFGFDTATKIYSELIGNVMRDARSTGKYWhFVKLMGRSASHIALECALKTHPNICIISEevsaQKQTLKNITDY 290

                        250       260
                 ....*....|....*....|....*
gi 321159877 233 MCDIVSKHRSRGKRTTIVVVAEGAI 257
Cdd:cd00765  291 MVDVICKRAELGYNFGVVLVPEGLI 315
PLN02564 PLN02564
6-phosphofructokinase
 395-637 1.37e-05

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 48.21  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 395 KIAIVNVGAPAGGINSAVYSM--ATYCMSQGHRPYAIYNGWSGLARHESVrSLNWKDMLGWQSRGGSEIGTNRvtpEEAD 472
Cdd:PLN02564  89 RACIVTCGGLCPGLNTVIREIvcGLSYMYGVTRILGIDGGYRGFYSRNTI-PLTPKVVNDIHKRGGTILGTSR---GGHD 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 473 LGMIAYYFQKYEFDGLIIVGG---FEAFESLHQLERAResypAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCD 549
Cdd:PLN02564 165 TSKIVDSIQDRGINQVYIIGGdgtQKGASVIYEEIRRR----GLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAIN 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 550 VVKQSASSTRGRAFVVDCQGGNSGYLATYASLAV-GAQVSYVPEEGISLEQLSEDIEYLAQSFEK--------AEGRGRf 620
Cdd:PLN02564 241 AAHVEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPFYLEGKGGLFEFIEKRLKEnghmvivvAEGAGQ- 319

                        250
                 ....*....|....*..
gi 321159877 621 gKLILKSTNASKALSAT 637
Cdd:PLN02564 320 -DLIAESMESSDLQDAS 335
PLN02884 PLN02884
6-phosphofructokinase
 457-633 3.05e-04

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 44.03  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 457 GGSEIGTNRVTPEEADlgmIAYYFQKYEFDGLIIVGG---FEAFESLHQLERAREsypaFRIPMVLIPATLSNNVPGTEY 533
Cdd:PLN02884 119 GGSLLGVSRGGAKTSD---IVDSIEARGINMLFVLGGngtHAGANAIHNECRKRK----MKVSVVGVPKTIDNDILLMDK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159877 534 SLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVG-AQVSYVPEEGISLEQLSEDIEYLAQSFE 612
Cdd:PLN02884 192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHLIE 271

                        170       180
                 ....*....|....*....|....*....
gi 321159877 613 K--------AEGRgrfGKLILKSTNASKA 633
Cdd:PLN02884 272 TkgsavvcvAEGA---GQDLLQKTNATDA 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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