|
Name |
Accession |
Description |
Interval |
E-value |
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
4-764 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1177.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGG-DNIEEAQWEDVRGILSLGGTIIGTARCKEFRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDA 163
Cdd:TIGR02478 80 RPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPP-EEGWEDQLCHKLKRNRKA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:TIGR02478 239 GKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLP-KDKRLKIAIVNVG 402
Cdd:TIGR02478 319 PVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 403 APAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRVTPeEADLGMIAYYFQK 482
Cdd:TIGR02478 399 APAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLP-GDDLGTIAYYFQQ 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 483 YEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRA 562
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRV 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 563 FVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEkaegRGRFGKLILKSTNASKALSATKLAEV 642
Cdd:TIGR02478 557 FVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFA----EGRAGKLILRNEKASKVYTTDFIARI 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 643 ITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDnqaaiaearAAEENFNADDKTISDTAAVV-GVKG 721
Cdd:TIGR02478 633 ISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEE---------KIKANKHADKLSADDTSAVViGIRG 703
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 321159873 722 SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 764
Cdd:TIGR02478 704 SNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-754 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1145.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 3 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPeYIKEFHWEDVRGWSAEGGTNIGTARCMEFK 82
Cdd:cd00764 3 GKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGD-YIKQAEWESVSNWLQEGGTIIGSARCKEFR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 83 KREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTD 162
Cdd:cd00764 82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 163 ATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRS 242
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPP-EDGWEDQMCRRLSEHRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 243 RGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTP 322
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 323 SPLIAVNENKIVRKPLMESVKLTKAVAEA-----------IQAKDFKRAMSLRDTEFIEHLnnfmainsadhnePKLPKD 391
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAmdekrfdeaaaLRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 392 KRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRsLNWKDMLGWQSRGGSEIGTNRVTPEEa 471
Cdd:cd00764 388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVE-LGWIDVGGWTGRGGSELGTKRTLPKK- 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 472 DLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV 551
Cdd:cd00764 466 DLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRI 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 552 KQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNAS 631
Cdd:cd00764 546 KQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYT 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 632 KALSATKLAEVItaeaDGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKdnQAAIAEARAAEENFNADDKT-- 709
Cdd:cd00764 626 TVFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIE--QKLKENYAAGNEFANDPDFNcv 699
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 321159873 710 -ISDTAAVVGVKG-------------SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRL 754
Cdd:cd00764 700 nGVKKYAVLFEPVeelkqttfehripKEQWWLSLRPLLKILAKYKISADISDHGQLEHV 758
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
6-312 |
5.46e-132 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 392.47 E-value: 5.46e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 6 IAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKKRE 85
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD---IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 86 GRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWpslieellktnrisneqyermkHLNICGTVGSIDNDMSTTDATI 165
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 166 GAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVsKHRSRGK 245
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD----IEELCEKI-KELRKGK 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321159873 246 RTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVN 312
Cdd:pfam00365 212 RFSIIVVAEGASDGE-------FLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
4-348 |
2.40e-103 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 320.10 E-value: 2.40e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG---DIVKLDLKSVSDIINRGGTILGSARFPEFKD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFrSEwpslieellktnrisneqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:PRK03202 79 EEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-TE----------------------HGIPVIGLPGTIDNDIAGTDY 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD----IEELCAKIKKGRER 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLEstpDTPS 323
Cdd:PRK03202 212 GKKHAIIVVAEGVMPAE-------ELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281
|
330 340
....*....|....*....|....*
gi 321159873 324 PLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
4-348 |
2.34e-102 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 318.56 E-value: 2.34e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:COG0205 2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD---IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGA-----------------AKLAEE-----YGIPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADLTPISPSDVH---------------KVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGL 308
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVLEADTDafghvrlggigeylaKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 321159873 309 EAVNAVLESTPDTpspLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:COG0205 293 AAVELLLEGKTGV---MVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
4-764 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1177.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGG-DNIEEAQWEDVRGILSLGGTIIGTARCKEFRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDA 163
Cdd:TIGR02478 80 RPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPP-EEGWEDQLCHKLKRNRKA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:TIGR02478 239 GKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLP-KDKRLKIAIVNVG 402
Cdd:TIGR02478 319 PVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 403 APAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRVTPeEADLGMIAYYFQK 482
Cdd:TIGR02478 399 APAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLP-GDDLGTIAYYFQQ 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 483 YEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRA 562
Cdd:TIGR02478 477 HKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRV 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 563 FVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEkaegRGRFGKLILKSTNASKALSATKLAEV 642
Cdd:TIGR02478 557 FVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFA----EGRAGKLILRNEKASKVYTTDFIARI 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 643 ITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDnqaaiaearAAEENFNADDKTISDTAAVV-GVKG 721
Cdd:TIGR02478 633 ISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEE---------KIKANKHADKLSADDTSAVViGIRG 703
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 321159873 722 SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 764
Cdd:TIGR02478 704 SNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-754 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1145.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 3 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPeYIKEFHWEDVRGWSAEGGTNIGTARCMEFK 82
Cdd:cd00764 3 GKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGD-YIKQAEWESVSNWLQEGGTIIGSARCKEFR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 83 KREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTD 162
Cdd:cd00764 82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 163 ATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRS 242
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPP-EDGWEDQMCRRLSEHRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 243 RGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTP 322
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 323 SPLIAVNENKIVRKPLMESVKLTKAVAEA-----------IQAKDFKRAMSLRDTEFIEHLnnfmainsadhnePKLPKD 391
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAmdekrfdeaaaLRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 392 KRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRsLNWKDMLGWQSRGGSEIGTNRVTPEEa 471
Cdd:cd00764 388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVE-LGWIDVGGWTGRGGSELGTKRTLPKK- 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 472 DLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV 551
Cdd:cd00764 466 DLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRI 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 552 KQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNAS 631
Cdd:cd00764 546 KQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYT 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 632 KALSATKLAEVItaeaDGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKdnQAAIAEARAAEENFNADDKT-- 709
Cdd:cd00764 626 TVFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIE--QKLKENYAAGNEFANDPDFNcv 699
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 321159873 710 -ISDTAAVVGVKG-------------SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRL 754
Cdd:cd00764 700 nGVKKYAVLFEPVeelkqttfehripKEQWWLSLRPLLKILAKYKISADISDHGQLEHV 758
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-362 |
2.71e-166 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 482.95 E-value: 2.71e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG---DIKELDWESVSDIINRGGTIIGSARCKEFRT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEellktnrisneqyermkHLNICGTVGSIDNDMSTTDA 163
Cdd:cd00363 78 EEGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQ-----------------GFNVIGLPGTIDNDIKGTDY 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPAtSSEWQDQMCDIVSKHRSR 243
Cdd:cd00363 141 TIGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPA-ADEWEEEMVDVIKKRRER 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPS 323
Cdd:cd00363 220 GKRHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPV 299
|
330 340 350
....*....|....*....|....*....|....*....
gi 321159873 324 PLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMS 362
Cdd:cd00363 300 GIQNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
6-312 |
5.46e-132 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 392.47 E-value: 5.46e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 6 IAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKKRE 85
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD---IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 86 GRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWpslieellktnrisneqyermkHLNICGTVGSIDNDMSTTDATI 165
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 166 GAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVsKHRSRGK 245
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD----IEELCEKI-KELRKGK 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321159873 246 RTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVN 312
Cdd:pfam00365 212 RFSIIVVAEGASDGE-------FLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
4-348 |
2.40e-103 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 320.10 E-value: 2.40e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG---DIVKLDLKSVSDIINRGGTILGSARFPEFKD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFrSEwpslieellktnrisneqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:PRK03202 79 EEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-TE----------------------HGIPVIGLPGTIDNDIAGTDY 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD----IEELCAKIKKGRER 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLEstpDTPS 323
Cdd:PRK03202 212 GKKHAIIVVAEGVMPAE-------ELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281
|
330 340
....*....|....*....|....*
gi 321159873 324 PLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
395-683 |
5.70e-103 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 317.36 E-value: 5.70e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 395 KIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLArHESVRSLNWKDMLGWQSRGGSEIGTNRVTP--EEAD 472
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLV-EGDIDELTWRDVSGILNRGGTILGTSRSKPfkTEEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 473 LGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERAREsypafrIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVK 552
Cdd:pfam00365 80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 553 QSASSTRgRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAqsfekaegRGRFGKLILKSTNASk 632
Cdd:pfam00365 154 DTASSHN-RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR--------KGKRFSIIVVAEGAS- 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 321159873 633 alSATKLAEVItaEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAV 683
Cdd:pfam00365 224 --DGEFLAKLI--EEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
4-348 |
2.34e-102 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 318.56 E-value: 2.34e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGpeyIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:COG0205 2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD---IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEqyermKHLNICGTVGSIDNDMSTTDA 163
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGA-----------------AKLAEE-----YGIPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQDQMCDIVSKHRSR 243
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADLTPISPSDVH---------------KVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGL 308
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVLEADTDafghvrlggigeylaKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 321159873 309 EAVNAVLESTPDTpspLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:COG0205 293 AAVELLLEGKTGV---MVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
6-342 |
2.53e-92 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 290.79 E-value: 2.53e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 6 IAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKRE 85
Cdd:TIGR02482 2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING---KIEPLESKNVSGIIHRGGTILGTARCPEFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 86 GRLLGAQHLIEAGVDALIVCGGDGSLTGADLFrsewpslieellktnrisneqyERMKHLNICGTVGSIDNDMSTTDATI 165
Cdd:TIGR02482 79 VREKAVENLKKLGIEGLVVIGGDGSYTGAQKL----------------------YEEGGIPVIGLPGTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 166 GAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSsewqDQMCDIVSKHRSRGK 245
Cdd:TIGR02482 137 GFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDI----DELIQRLKEQHEAGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 246 RTTIVVVAEGAIAADLTpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTpspL 325
Cdd:TIGR02482 213 KHSIIIVAEGNIVGSAK-----EVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---M 284
|
330
....*....|....*..
gi 321159873 326 IAVNENKIVRKPLMESV 342
Cdd:TIGR02482 285 IGIQNNKIVTHPIEEAL 301
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-342 |
5.42e-79 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 256.18 E-value: 5.42e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGgpeYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK 83
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG---DIVPLDRYSVSDIINRGGTFLGSARFPEFKD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 84 REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLfrsewpsLIEEllktnrisneqyermkHLNICGTVGSIDNDMSTTDA 163
Cdd:cd00763 78 EEGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-------LTEH----------------GFPCVGLPGTIDNDIPGTDY 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 164 TIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEwqdqMCDIVSKHRSR 243
Cdd:cd00763 135 TIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREE----VANRIKAGIER 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 244 GKRTTIVVVAEGAIAADltpispsDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTps 323
Cdd:cd00763 211 GKKHAIVVVAEGVYDVD-------ELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGL-- 281
|
330
....*....|....*....
gi 321159873 324 pLIAVNENKIVRKPLMESV 342
Cdd:cd00763 282 -AVGIQNEQLVHHDIIDAI 299
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
2-348 |
4.08e-50 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 179.88 E-value: 4.08e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 2 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFK-GCRAFVVMEGYEGLVRGGPEYIkEFHWEDVRGWSAEGGTNIGT----- 75
Cdd:PRK14071 3 EKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYI-ELDLDQVDDLLRMGGTILGTtnkgd 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 76 --ARCME---FKKREGRLLGAQHliEAGVDALIVCGGDGSLtgadlfrsewpSLIEELLKTNRIsneqyermkhlNICGT 150
Cdd:PRK14071 82 pfAFPMPdgsLRDRSQEIIDGYH--SLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGI 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 151 VGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATssewQ 230
Cdd:PRK14071 138 PKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT----L 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 231 DQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSD-------------VHKVLVDRLGLDTRITTLGHVQRGGTAVA 297
Cdd:PRK14071 214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSP 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 321159873 298 YDRILATLQGLEAVNAVLESTPDTpspLIAVNENKIVRKPLMESVKLTKAV 348
Cdd:PRK14071 294 RDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAV 341
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
395-690 |
1.24e-42 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 158.31 E-value: 1.24e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 395 KIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLArHESVRSLNWKDMLGWQSRGGSEIGTNRVTP--EEAD 472
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLL-EGDIIDLTREDVSGILQRGGTILGSSRSKPfkTEEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 473 LGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERAREsypafrIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVK 552
Cdd:COG0205 82 REKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 553 QSASSTRgRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEK------AEGRGRFG--KLI 624
Cdd:COG0205 156 DTAASHE-RVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGysiivvAEGAGDEDgeAVL 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 625 LKSTNASKALS----ATKLAEVITAEADgrFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQ 690
Cdd:COG0205 235 EADTDAFGHVRlggiGEYLAKEIEERTG--IETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGK 302
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
395-690 |
5.08e-38 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 144.45 E-value: 5.08e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 395 KIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLArHESVRSLNWKDMLGWQSRGGSEIGTNRvTPEEADLG 474
Cdd:PRK03202 3 RIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLL-EGDIVKLDLKSVSDIINRGGTILGSAR-FPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 475 M---IAYYFQKYEFDGLIIVGGFEAFESLHQLERaresypaFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV 551
Cdd:PRK03202 81 GrakAIENLKKLGIDALVVIGGDGSYMGAKRLTE-------HGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 552 KQSASStRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLsedIEYLAQSFEkaegRGRFGKLILKstnAS 631
Cdd:PRK03202 154 RDTASS-HERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL---CAKIKKGRE----RGKKHAIIVV---AE 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 321159873 632 KALSATKLAEVITAEADgrFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQ 690
Cdd:PRK03202 223 GVMPAEELAKEIEERTG--LETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGK 279
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
394-683 |
2.11e-35 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 137.43 E-value: 2.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 394 LKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHEsVRSLNWKDMLGWQSRGGSEIGTNRV----TPE 469
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGD-IKELDWESVSDIINRGGTIIGSARCkefrTEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 470 EADLGmiAYYFQKYEFDGLIIVGGFEafeSLHQLERARESYPAFR--IPMVLIPATLSNNVPGTEYSLGSDTALNALMEY 547
Cdd:cd00363 80 GRAKA--AENLKKHGIDALVVIGGDG---SYTGADLLTEEWPSKYqgFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 548 CDVVKQSASStRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEgislEQLSEDIEYLAQSFEKAEGRG-RFGKLILK 626
Cdd:cd00363 155 IDRIRDTASS-HQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEE----PAADEWEEEMVDVIKKRRERGkRHGIVIVA 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 627 S---TNASKALSATKLAEVITAEadGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAV 683
Cdd:cd00363 230 EgaiDFIPKPITEKLLAKLVEER--LGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAV 287
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
6-275 |
1.23e-24 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 107.82 E-value: 1.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 6 IAVMTSGGDAPGMNSNVRAIVRSAI--FKGCRAFVVMEGYEGLVRGG-----PEYIKEFHwedvrgwsAEGGTNIGTARC 78
Cdd:PTZ00286 90 AGIVTCGGLCPGLNVVIRELVMNLInnYGVKTIYGAKYGYKGLYKEDwikldPKDVKTIH--------RLGGTILGSSRG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 79 MEFKKregrlLGAQHLIEAGVDALIVCGGDGSLTGADlfrsewpSLIEELLKTN-RISneqyermkhlnICGTVGSIDND 157
Cdd:PTZ00286 162 GFDPK-----VMVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKTIDND 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 158 MSTTDATIGAYSALDRICKAIDYVEATANSHSRAF-VVEVMGRNCGWLALLAGIAT-SADYIFIPEKPATssewQDQMCD 235
Cdd:PTZ00286 219 IPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASaDVNVCLIPEFDIP----LEGVLE 294
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 321159873 236 IVsKHRSRGKRTTIVVVAEGAIAA--DLTPISPSDV--HKVLVD 275
Cdd:PTZ00286 295 YI-EQRLQKKGHCVIVVAEGAGQSlkDADLDLGTDAsgNKKLWD 337
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
388-686 |
6.48e-18 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 86.28 E-value: 6.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 388 LPKDKRlkIAIVNVGAPAGGINSAVYSMATYCMSQ-GHRPYAIYNGWSGL-ARHESVRSLNWKDMLGWQSRGGSEIGT-N 464
Cdd:PRK14071 1 MGEKKR--IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLmARPPQYIELDLDQVDDLLRMGGTILGTtN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 465 RVTP----------EEADLGMIAYYfQKYEFDGLIIVGGFEAFESLHQLerARESypafRIPMVLIPATLSNNVPGTEYS 534
Cdd:PRK14071 79 KGDPfafpmpdgslRDRSQEIIDGY-HSLGLDALIGIGGDGSLAILRRL--AQQG----GINLVGIPKTIDNDVGATEVS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 535 LGSDTALNALMEYCDVVKQSASStRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEegisleqLSEDIEYLAQSFEKA 614
Cdd:PRK14071 152 IGFDTAVNIATEALDRLHFTAAS-HNRVMILEVMGRDAGHIALAAGIAGGADVILIPE-------IPYTLENVCKKIRER 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 615 EGRGRFGKLILKS----TNASKALSATK-------------LAEVItAEADGRfDAKPAYPGHVQQGGLPSPIDRTRATR 677
Cdd:PRK14071 224 QEEGKNFCLVVVSeavrTEEGEQVTKTQalgedryggigqyLAEQI-AERTGA-ETRVTVLGHIQRGGIPSPRDRLLASA 301
|
....*....
gi 321159873 678 MAIKAVGFI 686
Cdd:PRK14071 302 FGVAAVDLI 310
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
7-313 |
1.40e-15 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 79.47 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 7 AVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFV-VMEGYEGLVRGGPEYIkEFHWEDVRGWSAEGGTNIGTARCmefkkre 85
Cdd:PLN02884 57 AIVTCGGLCPGLNDVIRQIVFTLEIYGVKNIVgIPFGYRGFFEKGLSEM-PLSRKVVQNIHLSGGSLLGVSRG------- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 86 grllGAQ------HLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEQYERMKHLNICGTVGSIDNDMS 159
Cdd:PLN02884 129 ----GAKtsdivdSIEARGINMLFVLGGNGTHAGA-----------------NAIHNECRKRKMKVSVVGVPKTIDNDIL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 160 TTDATIGAYSALDRICKAID--YVEATANSHSRAfVVEVMGRNCGWLALLAGIAT-SADYIFIPEKPATSSEWQDQMCDI 236
Cdd:PLN02884 188 LMDKTFGFDTAVEEAQRAINsaYIEAHSAYHGIG-LVKLMGRSSGFIAMHASLASgQVDICLIPEVPFTLDGPNGVLRHL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 237 vsKHRSRGKRTTIVVVAEGAIAADLTPISPSDV--HKVLVDrLGLDTRITTLGHVQRGGT-----------------AVA 297
Cdd:PLN02884 267 --EHLIETKGSAVVCVAEGAGQDLLQKTNATDAsgNPVLGD-IGVHLQQEIKKHFKDIGVpadvkyidptymiracrANA 343
|
330
....*....|....*.
gi 321159873 298 YDRILATLQGLEAVNA 313
Cdd:PLN02884 344 SDAILCTVLGQNAVHG 359
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
331-618 |
3.39e-14 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 75.46 E-value: 3.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 331 NKIVRKPL--MESVKLTKAVAEAIQAKDFKRAMSLRDtEFIEHlnNFMAINSADHNEPKLPKD----------------- 391
Cdd:PTZ00286 9 NLIIDLPDapLPSVVNPDLGECNLRGVFGGNGFLPRE-AFVDT--NSYILSTPRFGPDDVIVNtkrwlragprkhlyfnp 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 392 KRLKIAIVNVGAPAGGINSAVYS--MATYCMSQGHRPYAIYNGWSGLARHESVRsLNWKDMLGWQSRGGSEIGTNRvTPE 469
Cdd:PTZ00286 86 KEVKAGIVTCGGLCPGLNVVIRElvMNLINNYGVKTIYGAKYGYKGLYKEDWIK-LDPKDVKTIHRLGGTILGSSR-GGF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 470 eaDLGMIAYYFQKYEFDGLIIVGGFEAFESLHQL--ERARESYPafrIPMVLIPATLSNNVPGTEYSLGSDTALNALMEY 547
Cdd:PTZ00286 164 --DPKVMVDTLIRHGINILFTLGGDGTHRGALAIykELRRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 548 CDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVG-AQVSYVPEEGISLEQLsedIEYLAQSFEK--------AEGRG 618
Cdd:PTZ00286 239 IRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPLEGV---LEYIEQRLQKkghcvivvAEGAG 315
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
7-256 |
3.55e-13 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 72.21 E-value: 3.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 7 AVMTSGGDAPGMNSNVRAIVRSAIFK-GCRAFV-VMEGYEGLV-RGG-------PEYIKEFHwedvrgwsAEGGTNIGTA 76
Cdd:PRK06830 84 AIVTCGGLCPGLNDVIRAIVLELHHHyGVRRILgIRYGYQGLIpRYGhdpveltPEVVADIH--------EFGGTILGSS 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 77 RcmefkkregrllGAQH-------LIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEQYERMKHLNICG 149
Cdd:PRK06830 156 R------------GPQDpeeivdtLERMNINILFVIGGDGTLRGA-----------------SAIAEEIERRGLKISVIG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 150 TVGSIDNDMSTTDATIGAYSALDRICKAID--YVEATAnshsrAF----VVEVMGRNCGWLALLAGIATS-ADYIFIPEK 222
Cdd:PRK06830 207 IPKTIDNDINFIQKSFGFETAVEKATEAIRcaHVEANG-----APngigLVKLMGRHSGFIAAYAALASKdVNFVLIPEV 281
|
250 260 270
....*....|....*....|....*....|....
gi 321159873 223 PATSSEWQDQMCDIVSKHRSRGKrtTIVVVAEGA 256
Cdd:PRK06830 282 PFDLEGPNGLLAALEKRLAERGH--AVIVVAEGA 313
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
154-316 |
2.83e-12 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 69.50 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 154 IDNDMSTTDATIGAYSALDRICKAI-----DyVEATANShSRAFVVEVMGRNCGWLALLAGIATS-----ADYIFIPEKP 223
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIATSVleaalD-VAAMANT-SKVFILEVMGRHAGWLAAAAALAKQnpddaPHLIYLPERP 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 224 ATssewQDQMCDIVSKHRSRGKRtTIVVVAEGAIAADLTPIS----PSDVH-------------KVLVDRLGLDTRITTL 286
Cdd:PRK14072 220 FD----EEKFLADVRAIVKRYGY-CVVVVSEGIRDADGKFIAeaglAEDAFghaqlggvapvlaNLIKEKLGKKVHWAVL 294
|
170 180 190
....*....|....*....|....*....|..
gi 321159873 287 GHVQR--GGTAVAYDRILATLQGLEAVNAVLE 316
Cdd:PRK14072 295 DYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
4-217 |
6.47e-11 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 65.03 E-value: 6.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 4 KAIAVMTSGGDAPGMNSNVRAIVR--SAIFKGCRAFVVMEGYEGLVRGgpEYIkEFHwEDVRGWSAE----GGTNIGTAR 77
Cdd:PRK06555 4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLG--DSI-EIT-PAVRANAGLlhryGGSPIGNSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 78 --------CME---FKKREGRL-LGAQHLIEAGVDALIVCGGDGS-LTGADLFRsewpslieeLLKTNrisneQYermkH 144
Cdd:PRK06555 80 vkltnvadCVKrglVKEGENPLkVAAERLAADGVDILHTIGGDDTnTTAADLAA---------YLAEN-----GY----D 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 321159873 145 LNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVV-EVMGRNCGWLAllagIATSADYI 217
Cdd:PRK06555 142 LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLT----AATARAYR 211
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
7-256 |
2.65e-09 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 60.15 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 7 AVMTSGGDAPGMNSNVRAIV--RSAIFKGCRAFVVMEGYEGL-----VRGGPEYIKEFHwedvrgwsAEGGTNIGTARcm 79
Cdd:PLN02564 91 CIVTCGGLCPGLNTVIREIVcgLSYMYGVTRILGIDGGYRGFysrntIPLTPKVVNDIH--------KRGGTILGTSR-- 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 80 efkkregrllGAQ-------HLIEAGVDALIVCGGDGSLTGAdlfrsewpslieellktNRISNEQYERMKHLNICGTVG 152
Cdd:PLN02564 161 ----------GGHdtskivdSIQDRGINQVYIIGGDGTQKGA-----------------SVIYEEIRRRGLKVAVAGIPK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 153 SIDNDMSTTDATIGAYSALDRICKAID--YVEATANsHSRAFVVEVMGRNCGWLALLAGIAT-SADYIFIPEKPaTSSEW 229
Cdd:PLN02564 214 TIDNDIPVIDKSFGFDTAVEEAQRAINaaHVEAESV-ENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESP-FYLEG 291
|
250 260
....*....|....*....|....*..
gi 321159873 230 QDQMCDIVSKhRSRGKRTTIVVVAEGA 256
Cdd:PLN02564 292 KGGLFEFIEK-RLKENGHMVIVVAEGA 317
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
2-257 |
7.96e-08 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 56.14 E-value: 7.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 2 PQKAIAVMTSGGDAPGmNSNVRAIVRSAIfKGCRAFVVMEGYeglvRGGPEYI-----KEFHWEDVRGWSAEGGTNIGTA 76
Cdd:PTZ00468 101 PARRIGVVLSGGQASG-GHNVIAGLMSYI-KLCNQSSQLFGF----LGGPEGVyseryRELTEDDINGILNQGGFNIICS 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 77 RCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpSLIEELLKTNRISneqyermkhLNICGTVGSIDN 156
Cdd:PTZ00468 175 GRHKIETEEQMRASLEICEKLKLHGLVVIGGDDSNTNA--------AVLAEYFKRNSSS---------TVVVGCPKTIDG 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 157 DM--STTDATIGAYSALDRICKAIDYV-EATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIF----IPEKPATSSEW 229
Cdd:PTZ00468 238 DLknEVIETSFGYDTAVKTYSEQIGSImDAIKTEGYGYYFVRLMGRSASHITLECGLQTRANMILigeeIKEENRSLMSI 317
|
250 260
....*....|....*....|....*...
gi 321159873 230 QDQMCDIVSKHRSRGKRTTIVVVAEGAI 257
Cdd:PTZ00468 318 VDEIVEMILKRDSLGKKHGIVLLPEGLI 345
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
6-257 |
1.77e-06 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 51.41 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 6 IAVMTSGGDAPGMNSnvraiVRSAIFKGCRAFVVMEGYEGLvRGGP------EYIkEFHWEDVRGWSAEGGTNIGTARCM 79
Cdd:cd00765 75 IGIVLSGGQAPGGHN-----VISGLFDYLKERAKGSTLYGF-KGGPagilkcDYI-ELNAEYIQPYRNTGGFDMICSGRT 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 80 EFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGAdlfrsewpSLIEELLKTNRISNEqyermkhlnICGTVGSIDNDMS 159
Cdd:cd00765 148 KIETEDQFKQAEETAKKLDLDALVVIGGDDSNTNA--------ALLAENFRSKGLKTR---------VIGVPKTIDGDLK 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 160 T--TDATIGAYSALDRICKAIDYVEATANSHSRAF-VVEVMGRNCGWLALLAGIATSADYIFIPE----KPATSSEWQDQ 232
Cdd:cd00765 211 NkeIETSFGFDTATKIYSELIGNVMRDARSTGKYWhFVKLMGRSASHIALECALKTHPNICIISEevsaQKQTLKNITDY 290
|
250 260
....*....|....*....|....*
gi 321159873 233 MCDIVSKHRSRGKRTTIVVVAEGAI 257
Cdd:cd00765 291 MVDVICKRAELGYNFGVVLVPEGLI 315
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
395-637 |
1.37e-05 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 48.21 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 395 KIAIVNVGAPAGGINSAVYSM--ATYCMSQGHRPYAIYNGWSGLARHESVrSLNWKDMLGWQSRGGSEIGTNRvtpEEAD 472
Cdd:PLN02564 89 RACIVTCGGLCPGLNTVIREIvcGLSYMYGVTRILGIDGGYRGFYSRNTI-PLTPKVVNDIHKRGGTILGTSR---GGHD 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 473 LGMIAYYFQKYEFDGLIIVGG---FEAFESLHQLERAResypAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCD 549
Cdd:PLN02564 165 TSKIVDSIQDRGINQVYIIGGdgtQKGASVIYEEIRRR----GLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAIN 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 550 VVKQSASSTRGRAFVVDCQGGNSGYLATYASLAV-GAQVSYVPEEGISLEQLSEDIEYLAQSFEK--------AEGRGRf 620
Cdd:PLN02564 241 AAHVEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPFYLEGKGGLFEFIEKRLKEnghmvivvAEGAGQ- 319
|
250
....*....|....*..
gi 321159873 621 gKLILKSTNASKALSAT 637
Cdd:PLN02564 320 -DLIAESMESSDLQDAS 335
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
457-633 |
3.05e-04 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 44.03 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 457 GGSEIGTNRVTPEEADlgmIAYYFQKYEFDGLIIVGG---FEAFESLHQLERAREsypaFRIPMVLIPATLSNNVPGTEY 533
Cdd:PLN02884 119 GGSLLGVSRGGAKTSD---IVDSIEARGINMLFVLGGngtHAGANAIHNECRKRK----MKVSVVGVPKTIDNDILLMDK 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321159873 534 SLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVG-AQVSYVPEEGISLEQLSEDIEYLAQSFE 612
Cdd:PLN02884 192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHLIE 271
|
170 180
....*....|....*....|....*....
gi 321159873 613 K--------AEGRgrfGKLILKSTNASKA 633
Cdd:PLN02884 272 TkgsavvcvAEGA---GQDLLQKTNATDA 297
|
|
| |
