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Conserved domains on  [gi|320021654|gb|ADV96640|]
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site-specific tyrosine recombinase XerC [Bacillus subtilis BSn5]

Protein Classification

tyrosine recombinase XerC( domain architecture ID 11493900)

site-specific tyrosine recombinase XerC acts by catalyzing the cutting and rejoining of recombining DNA molecules

Gene Symbol:  xerC
Gene Ontology:  GO:0009037|GO:0007059|GO:0003677
PubMed:  28373867

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
recomb_XerC TIGR02224
tyrosine recombinase XerC; The phage integrase family describes a number of recombinases with ...
 9-302 1.42e-155

tyrosine recombinase XerC; The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 274042 [Multi-domain]  Cd Length: 295  Bit Score: 436.27  E-value: 1.42e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654    9 KLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG-INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFL 87
Cdd:TIGR02224   1 EAFLEYLRLERNYSPHTVRAYRRDLEAFLEFLEEEGgLASLAEVTAADLRSFLAELHARGLSRRSLARKLSALRSFYRFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   88 MREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQ--PAGMRDQALLELLYATGMRVSECCSITINDVDLFM 165
Cdd:TIGR02224  81 LRRGLIDANPAAGVRAPKQPKKLPKFLSEDEMEALLDAPEEDDedWLALRDRAILELLYSSGLRVSELVGLDLSDLDLDF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  166 DTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLmkAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHP 245
Cdd:TIGR02224 161 GEVRVRGKGNKERIVPFGPYARDALQAYLEARRSPLL--ASEGQDALFLNRRGGRLTPRGVQYRLQQLRAKAGLPKHVHP 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320021654  246 HMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRAFK 302
Cdd:TIGR02224 239 HALRHSFATHLLNNGADLRAVQELLGHASLSTTQIYTHVDFQHLAKVYDQAHPRAKK 295
 
Name Accession Description Interval E-value
recomb_XerC TIGR02224
tyrosine recombinase XerC; The phage integrase family describes a number of recombinases with ...
 9-302 1.42e-155

tyrosine recombinase XerC; The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274042 [Multi-domain]  Cd Length: 295  Bit Score: 436.27  E-value: 1.42e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654    9 KLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG-INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFL 87
Cdd:TIGR02224   1 EAFLEYLRLERNYSPHTVRAYRRDLEAFLEFLEEEGgLASLAEVTAADLRSFLAELHARGLSRRSLARKLSALRSFYRFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   88 MREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQ--PAGMRDQALLELLYATGMRVSECCSITINDVDLFM 165
Cdd:TIGR02224  81 LRRGLIDANPAAGVRAPKQPKKLPKFLSEDEMEALLDAPEEDDedWLALRDRAILELLYSSGLRVSELVGLDLSDLDLDF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  166 DTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLmkAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHP 245
Cdd:TIGR02224 161 GEVRVRGKGNKERIVPFGPYARDALQAYLEARRSPLL--ASEGQDALFLNRRGGRLTPRGVQYRLQQLRAKAGLPKHVHP 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320021654  246 HMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRAFK 302
Cdd:TIGR02224 239 HALRHSFATHLLNNGADLRAVQELLGHASLSTTQIYTHVDFQHLAKVYDQAHPRAKK 295
xerC PRK00236
site-specific tyrosine recombinase XerC; Reviewed
 1-300 1.15e-148

site-specific tyrosine recombinase XerC; Reviewed


Pssm-ID: 234698 [Multi-domain]  Cd Length: 297  Bit Score: 418.79  E-value: 1.15e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   1 MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISAL 80
Cdd:PRK00236   3 DADLPAALEAFLEYLRVERGLSPHTLRAYRRDLRAFLAFLEEHGISSLQDLDAADLRSFLARRRRQGLSARSLARRLSAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  81 RSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND 160
Cdd:PRK00236  83 RSFYRWLVRRGLLKANPAAGLRAPKIPKRLPKPLDVDQAKRLLDAIDEDDPLALRDRAILELLYGSGLRLSELVGLDIDD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 161 VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRqcllmKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST 240
Cdd:PRK00236 163 LDLASGTLRVLGKGNKERTVPLGRAAREALEAYLALRP-----LFLPDDDALFLGARGGRLSPRVVQRRVKKLGKKAGLP 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 241 LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRA 300
Cdd:PRK00236 238 SHITPHKLRHSFATHLLESGGDLRAVQELLGHASLSTTQIYTHVDFQHLAEVYDAAHPRA 297
XerD COG4974
Site-specific recombinase XerD [Replication, recombination and repair];
2-298 3.84e-110

Site-specific recombinase XerD [Replication, recombination and repair];


Pssm-ID: 443999 [Multi-domain]  Cd Length: 291  Bit Score: 321.17  E-value: 3.84e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   2 ENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALR 81
Cdd:COG4974    1 LTLADLLEAFLEELKREKGLSPNTIKAYRRDLRRFLRFLEELGKIPLAEITPEDIRAYLNYLRERGLSPSTINRYLAALR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  82 SFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDV 161
Cdd:COG4974   81 SFFRYAVREGLLEDNPAAKVKLPKKPRKLPRVLTEEEIEALLEALDTETPEGLRDRALLLLLYATGLRVSELLGLKWSDI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 162 DLFMDTVLVH-GKGKKQRYIPFGSYAREALKVYMNSGRqcllmkaKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST 240
Cdd:COG4974  161 DLDRGTIRVRrGKGGKERTVPLSPEALEALREYLEERR-------PRDSDYLFPTRRGRPLSRRAIRKILKRLAKRAGIP 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 320021654 241 LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHP 298
Cdd:COG4974  234 KRVTPHSLRHTFATHLLEAGVDLRTVQELLGHSSISTTQIYTHVSDEELREAVEKLHP 291
INT_XerDC_C cd00798
XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in ...
 116-289 1.42e-96

XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance. They share the same fold in their catalytic domain containing six conserved active site residues and the overall reaction mechanism with the DNA breaking-rejoining enzyme superfamily. In Escherichia coli, the Xer site-specific recombination system acts to convert dimeric chromosomes, which are formed by homologous recombination to monomers. Two related recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E. coli chromosome. Each recombinase catalyzes the exchange of one pair of DNA strand in a reaction that proceeds through a Holliday junction intermediate. These enzymes can bridge two different and well-separated DNA sequences called arm- and core-sites. The C-terminal domain binds, cleaves, and re-ligates DNA strands at the core-sites, while the N-terminal domain is largely responsible for high-affinity binding to the arm-type sites.


Pssm-ID: 271179 [Multi-domain]  Cd Length: 172  Bit Score: 282.09  E-value: 1.42e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 116 QKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMN 195
Cdd:cd00798    1 VDEVERLLDAPDTDTPLGLRDRAILELLYASGLRVSELVGLDLSDVDLDEGLVRVTGKGNKERLVPFGSYAVEALEEYLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 196 SGRQCLLMKakEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNL 275
Cdd:cd00798   81 ERRPLLLKK--KPPDALFLNKRGKRLSRRGVWRILKKYAERAGLPKHVSPHTLRHSFATHLLEGGADLRVVQELLGHASL 158

                        170
                 ....*....|....
gi 320021654 276 SSTQIYTHVSKEML 289
Cdd:cd00798  159 STTQIYTHVSFERL 172
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 113-286 2.23e-67

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 207.94  E-value: 2.23e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  113 FLYQKELEELFEVSDISqPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVH-GKGKKQRYIPFGSYAREALK 191
Cdd:pfam00589   1 RLTEDEVERLLDAAETG-PLSIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVHrGKGNKERTVPLSDAALELLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  192 VYMNSGrqcllMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLG 271
Cdd:pfam00589  80 EWLSKR-----LLEAPKSDYLFASKRGKPLSRQTVRKIFKRAGKEAGLELPLHPHMLRHSFATHLLEAGVDLRVVQKLLG 154

                         170
                  ....*....|....*
gi 320021654  272 HSNLSSTQIYTHVSK 286
Cdd:pfam00589 155 HSSISTTQIYTHVAD 169
 
Name Accession Description Interval E-value
recomb_XerC TIGR02224
tyrosine recombinase XerC; The phage integrase family describes a number of recombinases with ...
 9-302 1.42e-155

tyrosine recombinase XerC; The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274042 [Multi-domain]  Cd Length: 295  Bit Score: 436.27  E-value: 1.42e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654    9 KLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG-INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFL 87
Cdd:TIGR02224   1 EAFLEYLRLERNYSPHTVRAYRRDLEAFLEFLEEEGgLASLAEVTAADLRSFLAELHARGLSRRSLARKLSALRSFYRFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   88 MREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQ--PAGMRDQALLELLYATGMRVSECCSITINDVDLFM 165
Cdd:TIGR02224  81 LRRGLIDANPAAGVRAPKQPKKLPKFLSEDEMEALLDAPEEDDedWLALRDRAILELLYSSGLRVSELVGLDLSDLDLDF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  166 DTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLmkAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHP 245
Cdd:TIGR02224 161 GEVRVRGKGNKERIVPFGPYARDALQAYLEARRSPLL--ASEGQDALFLNRRGGRLTPRGVQYRLQQLRAKAGLPKHVHP 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320021654  246 HMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRAFK 302
Cdd:TIGR02224 239 HALRHSFATHLLNNGADLRAVQELLGHASLSTTQIYTHVDFQHLAKVYDQAHPRAKK 295
xerC PRK00236
site-specific tyrosine recombinase XerC; Reviewed
 1-300 1.15e-148

site-specific tyrosine recombinase XerC; Reviewed


Pssm-ID: 234698 [Multi-domain]  Cd Length: 297  Bit Score: 418.79  E-value: 1.15e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   1 MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISAL 80
Cdd:PRK00236   3 DADLPAALEAFLEYLRVERGLSPHTLRAYRRDLRAFLAFLEEHGISSLQDLDAADLRSFLARRRRQGLSARSLARRLSAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  81 RSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND 160
Cdd:PRK00236  83 RSFYRWLVRRGLLKANPAAGLRAPKIPKRLPKPLDVDQAKRLLDAIDEDDPLALRDRAILELLYGSGLRLSELVGLDIDD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 161 VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRqcllmKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST 240
Cdd:PRK00236 163 LDLASGTLRVLGKGNKERTVPLGRAAREALEAYLALRP-----LFLPDDDALFLGARGGRLSPRVVQRRVKKLGKKAGLP 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 241 LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRA 300
Cdd:PRK00236 238 SHITPHKLRHSFATHLLESGGDLRAVQELLGHASLSTTQIYTHVDFQHLAEVYDAAHPRA 297
recomb_XerD TIGR02225
tyrosine recombinase XerD; The phage integrase family describes a number of recombinases with ...
 11-300 2.75e-124

tyrosine recombinase XerD; The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274043 [Multi-domain]  Cd Length: 291  Bit Score: 356.89  E-value: 2.75e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   11 FVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINgFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMRE 90
Cdd:TIGR02225   3 FLDYLWVERGLSQNTLEAYRRDLEKFLEFLEERGID-LEEVDRGDIVDFLAELKEAGLSARSIARALSALRSFYRFLLRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   91 KLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLV 170
Cdd:TIGR02225  82 GIREDDPSALIEPPKVARKLPKVLTVEEVEALLAAPDVDTPLGLRDRAMLELLYATGLRVSELVGLRLEDVNLDEGFVRV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  171 HGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRH 250
Cdd:TIGR02225 162 RGKGNKERLVPLGEEAIEALERYLKEARPLLLKKKVKESDALFLNRRGGPLSRQGVWKILKEYAKRAGIEKPISPHTLRH 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 320021654  251 TFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRA 300
Cdd:TIGR02225 242 SFATHLLENGADLRVVQELLGHADISTTQIYTHVARERLKEVHKKHHPRA 291
XerD COG4974
Site-specific recombinase XerD [Replication, recombination and repair];
2-298 3.84e-110

Site-specific recombinase XerD [Replication, recombination and repair];


Pssm-ID: 443999 [Multi-domain]  Cd Length: 291  Bit Score: 321.17  E-value: 3.84e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   2 ENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALR 81
Cdd:COG4974    1 LTLADLLEAFLEELKREKGLSPNTIKAYRRDLRRFLRFLEELGKIPLAEITPEDIRAYLNYLRERGLSPSTINRYLAALR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  82 SFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDV 161
Cdd:COG4974   81 SFFRYAVREGLLEDNPAAKVKLPKKPRKLPRVLTEEEIEALLEALDTETPEGLRDRALLLLLYATGLRVSELLGLKWSDI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 162 DLFMDTVLVH-GKGKKQRYIPFGSYAREALKVYMNSGRqcllmkaKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST 240
Cdd:COG4974  161 DLDRGTIRVRrGKGGKERTVPLSPEALEALREYLEERR-------PRDSDYLFPTRRGRPLSRRAIRKILKRLAKRAGIP 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 320021654 241 LHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHP 298
Cdd:COG4974  234 KRVTPHSLRHTFATHLLEAGVDLRTVQELLGHSSISTTQIYTHVSDEELREAVEKLHP 291
xerD PRK00283
tyrosine recombinase;
1-300 2.85e-109

tyrosine recombinase;


Pssm-ID: 234713 [Multi-domain]  Cd Length: 299  Bit Score: 319.06  E-value: 2.85e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   1 MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGInGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISAL 80
Cdd:PRK00283   2 MMADRALIEQFLDALWVERGLAENTLSSYRRDLELFAEWLAARGL-SLAEATRDDLQAFLAELAEGGYKATSSARRLSAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  81 RSFYKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND 160
Cdd:PRK00283  81 RRFFQFLLREGLREDDPSALLDSPKLPRRLPKTLSEAQVEALLDAPDIDTPLGLRDRAMLELLYATGLRVSELVGLTLDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 161 VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHdlLFVNQRGGPLTARGIRHILSGLVQKAS-S 239
Cdd:PRK00283 161 VSLRQGVVRVTGKGNKERLVPLGEEAVYAIERYLERGRPALLNGRSSDA--LFPSARGGQLTRQTFWHRIKHYAKRAGiD 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320021654 240 TLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHPRA 300
Cdd:PRK00283 239 PKKLSPHVLRHAFATHLLNHGADLRVVQELLGHSDISTTQIYTHVATERLKELHAQHHPRA 299
INT_XerDC_C cd00798
XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in ...
 116-289 1.42e-96

XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance. They share the same fold in their catalytic domain containing six conserved active site residues and the overall reaction mechanism with the DNA breaking-rejoining enzyme superfamily. In Escherichia coli, the Xer site-specific recombination system acts to convert dimeric chromosomes, which are formed by homologous recombination to monomers. Two related recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E. coli chromosome. Each recombinase catalyzes the exchange of one pair of DNA strand in a reaction that proceeds through a Holliday junction intermediate. These enzymes can bridge two different and well-separated DNA sequences called arm- and core-sites. The C-terminal domain binds, cleaves, and re-ligates DNA strands at the core-sites, while the N-terminal domain is largely responsible for high-affinity binding to the arm-type sites.


Pssm-ID: 271179 [Multi-domain]  Cd Length: 172  Bit Score: 282.09  E-value: 1.42e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 116 QKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMN 195
Cdd:cd00798    1 VDEVERLLDAPDTDTPLGLRDRAILELLYASGLRVSELVGLDLSDVDLDEGLVRVTGKGNKERLVPFGSYAVEALEEYLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 196 SGRQCLLMKakEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNL 275
Cdd:cd00798   81 ERRPLLLKK--KPPDALFLNKRGKRLSRRGVWRILKKYAERAGLPKHVSPHTLRHSFATHLLEGGADLRVVQELLGHASL 158

                        170
                 ....*....|....
gi 320021654 276 SSTQIYTHVSKEML 289
Cdd:cd00798  159 STTQIYTHVSFERL 172
XerC COG4973
Site-specific recombinase XerC [Replication, recombination and repair];
4-293 1.23e-87

Site-specific recombinase XerC [Replication, recombination and repair];


Pssm-ID: 443998 [Multi-domain]  Cd Length: 287  Bit Score: 263.75  E-value: 1.23e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   4 VKNFVKLFVEYLQiEKNYSQYTIVNYVDSIEEFETFLRVQGINgFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSF 83
Cdd:COG4973    4 LAEALEAYLEHLR-ERRLSPKTLEAYRRDLRRLIPLLGDADLP-LEELTPADVRRFLARLHRRGLSPRTLNRRLSALRSF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  84 YKFLMREKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSDiSQPAGMRDQALLELLYATGMRVSECCSITINDVDL 163
Cdd:COG4973   82 FNWAVREGLLEANPAAGVKAPKAPRKLPRALTVDELAQLLDALA-DDPLAVRDRAIVELLYSTGLRLGELVGLDWEDVDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 164 FMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCllmkAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHI 243
Cdd:COG4973  161 DAGEVRVRGKTGKSRTVPLGPKALAALREWLAVRPEL----AAPDEGALFPSRRGTRLSPRNVQKRLRRLAKKAGLPKHV 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 320021654 244 HPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTY 293
Cdd:COG4973  237 HPHDLRHSFATHLLESGGDLRAVQELLGHASISTTQIYTHLDFQHLAEVY 286
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 113-286 2.23e-67

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 207.94  E-value: 2.23e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  113 FLYQKELEELFEVSDISqPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVH-GKGKKQRYIPFGSYAREALK 191
Cdd:pfam00589   1 RLTEDEVERLLDAAETG-PLSIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVHrGKGNKERTVPLSDAALELLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  192 VYMNSGrqcllMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLG 271
Cdd:pfam00589  80 EWLSKR-----LLEAPKSDYLFASKRGKPLSRQTVRKIFKRAGKEAGLELPLHPHMLRHSFATHLLEAGVDLRVVQKLLG 154

                         170
                  ....*....|....*
gi 320021654  272 HSNLSSTQIYTHVSK 286
Cdd:pfam00589 155 HSSISTTQIYTHVAD 169
xerC PRK01287
site-specific tyrosine recombinase XerC; Reviewed
 11-298 1.84e-54

site-specific tyrosine recombinase XerC; Reviewed


Pssm-ID: 234935 [Multi-domain]  Cd Length: 358  Bit Score: 180.71  E-value: 1.84e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  11 FVEYLQiEKNYSQYTIVNYVDSIEEFETFLRVQGINgfeeAAYQDTRIFLtEAYE-----------KGLSRRTISKKISA 79
Cdd:PRK01287  28 FLAWLQ-ERNWSERTLKVYTEHLYPFILWCEERGLY----YAADVTLPVL-ERYQrylygyrkangEPLSTRTQRTQLSP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  80 LRSFYKFLMREKLIEENPFQLVHLPKQEKRIPK-FLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITI 158
Cdd:PRK01287 102 LRVWFRWLLKRHHILYNPAEDLELPKEEKRLPRqILSEAETEQVLASPDLTTLQGLRDRALLELLWSTGIRRGELARLDL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 159 NDVDLFMDTVLV-HGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHdlLFVNQRGGPLTARGI-----RHILSG 232
Cdd:PRK01287 182 YDVDASRGVVTVrQGKGNKDRVVPVGERALAWLQRYLQDVRPQLAVRPDSGA--LFVAMDGDGLARNTLtnmvgRYIRAA 259

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320021654 233 LVQKASSTlhihpHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRNTYMSHHP 298
Cdd:PRK01287 260 GIEKAGAC-----HLFRHAMATQMLENGADTRHIQAILGHAKLETTQIYTRVSIGHLQAVHASTHP 320
INT_IntI_C cd01193
Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases ...
 109-284 8.38e-43

Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases mediate site-specific DNA recombination between a proximal primary site (attI) and a secondary target site (attC) found within mobile gene cassettes encoding resistance or virulence factors. Unlike other site specific recombinases, the attC sites lack sequence conservation. Integron integrase exhibits broader DNA specificity by recognizing the non-conserved attC sites. The structure shows that DNA target site recognition are not dependent on canonical DNA but on the position of two flipped-out bases that interact in cis and in trans with the integrase. Integron-integrases are present in many natural occurring mobile elements, including transposons and conjugative plasmids. Vibrio, Shewanella, Xanthomonas, and Pseudomonas species harbor chromosomal super-integrons. All integron-integrases carry large inserts unlike the TnpF ermF-like proteins also seen in this group.


Pssm-ID: 271193 [Multi-domain]  Cd Length: 176  Bit Score: 145.11  E-value: 8.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 109 RIPKFLYQKELEELFEVSDisqpaGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVH-GKGKKQRYIPFGSYAR 187
Cdd:cd01193    1 KLPVVLSPDEVRRILGALT-----ELRHRLILSLLYGAGLRISELLRLRVKDIDFERGVIRVRqGKGGKDRVVPLPEKLL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 188 EALKVYMNSGRQCLLM----KAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADL 263
Cdd:cd01193   76 EPLRRYLKSARPKEELdpaeGRAGVLDPRTGVERRHHISETTVQRALKKAVEQAGITKRVTPHTLRHSFATHLLEAGTDI 155

                        170       180
                 ....*....|....*....|.
gi 320021654 264 RSVQELLGHSNLSSTQIYTHV 284
Cdd:cd01193  156 RTIQELLGHSDLSTTMIYTHV 176
INT_RitC_C_like cd01182
C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio; ...
 114-290 4.16e-42

C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio; Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.


Pssm-ID: 271183 [Multi-domain]  Cd Length: 186  Bit Score: 143.57  E-value: 4.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 114 LYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLfmD---TVLVHGKGKKQRYIPFGSYAREAL 190
Cdd:cd01182    1 LTREEMKALLAAPDRNTSLGRRDHALLLLLYDTGARVQELADLTIRDLRL--DdpaTVRLHGKGRKERTVPLWKETVAAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 191 KVYMnsgRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASST-----LHIHPHMLRHTFATHLLNEGADLRS 265
Cdd:cd01182   79 KAYL---QEFHLTPDPKQLFPLFPNRRGQPLTRDGVAYILNKYVALASNRcpslpKRITPHTLRHTKAMHLLQAGVDLTV 155

                        170       180
                 ....*....|....*....|....*
gi 320021654 266 VQELLGHSNLSSTQIYTHVSKEMLR 290
Cdd:cd01182  156 IRDWLGHESVETTQIYAEADLEMKR 180
DNA_BRE_C cd00397
DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme ...
 118-282 1.22e-41

DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271175 [Multi-domain]  Cd Length: 167  Bit Score: 141.85  E-value: 1.22e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 118 ELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKG---KKQRYIPFGSYAREALKVYM 194
Cdd:cd00397    1 ELEKLLDAIDEDKKIDLRDRAILLLLLETGLRISELLALKVKDIDLDNGTIRVRGKKtkgGKERTVPLPKELAEELKEYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 195 NS-GRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASstLHIHPHMLRHTFATHLLNEGADLRSVQELLGHS 273
Cdd:cd00397   81 KErRDKRGPLLKSLYLNKLFGTKLGERLSRRTLRRIFKKAGIEAG--RKITPHSLRHTFATNLLENGVDIKVVQKLLGHS 158


                 ....*....
gi 320021654 274 NLSSTQIYT 282
Cdd:cd00397  159 SISTTQRYL 167
integrase_gron TIGR02249
integron integrase; Members of this family are integrases associated with integrons (and ...
 19-284 5.68e-32

integron integrase; Members of this family are integrases associated with integrons (and super-integrons), which are systems for incorporating and expressing cassettes of laterally transferred DNA. Incorporation occurs at an attI site. A super-integron, as in Vibrio sp., may include over 100 cassettes. This family belongs to the phage integrase family (pfam00589) that also includes recombinases XerC (TIGR02224) and XerD (TIGR02225), which are bacterial housekeeping proteins. Within this family of integron integrases, some are designated by class, e.g. IntI4, a class 4 integron integrase from Vibrio cholerae N16961. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 131303 [Multi-domain]  Cd Length: 315  Bit Score: 120.58  E-value: 5.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   19 KNYSQYTIVNYVDSIEEFETFLRVQGingFEEAAYQDTRIFLTE-AYEKGLSRRTISKKISALRSFYKFLMREKLIEENP 97
Cdd:TIGR02249  12 RHYAKRTEEAYLHWIKRFIRFHNKRH---PSTMGDTEVEAFLSDlAVDGKVAASTQNQALNALLFLYKEILKTPLSLMER 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   98 FQLvhlPKQEKRIPKFLYQKELEELFEVSDisqpagMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVH-GKGKK 176
Cdd:TIGR02249  89 FVR---AKRPRKLPVVLTREEVRRLLEHLE------GKYRLIAKLLYGSGMRLMECLRLRIQDIDFDYGEIRIRqGKGGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  177 QRYIPFGSYAREALKVYMNSGRQCLLMKAKE-------PHDL---------------LFVNQRGG--PLTARGIRHILSG 232
Cdd:TIGR02249 160 DRTVTLPKELIPPLREQIELARAYHEADLAEgyggvylPHALarkypnapkewgwqyLFPSHRLSrdPESGVIRRHHINE 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320021654  233 ---------LVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHV 284
Cdd:TIGR02249 240 ttiqravrrAVERAGIEKPVTCHTLRHSFATHLLESGADIRTVQELLGHSDVKTTQIYTHV 300
INT_RitA_C_like cd01188
C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio; ...
 118-290 9.84e-32

C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio; Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271188 [Multi-domain]  Cd Length: 179  Bit Score: 116.19  E-value: 9.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 118 ELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHG-KGKKQRYIPFGSYAREALKVYMNS 196
Cdd:cd01188    4 EVRRLLAAIDRLTPVGLRDYAILLLLARLGLRAGDVAGLRLDDIDWRSGTITVRQkKTGRPVELPLTEPVGEALADYLRD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 197 GRqcllmkAKEPHDLLFVNQR---GGPLTARGIRHILSGLVQKASSTLHIH-PHMLRHTFATHLLNEGADLRSVQELLGH 272
Cdd:cd01188   84 GR------PRTDSREVFLRARapyRPLSSTSQISSIVRRYLRKAGIEPSHRgTHSLRHSLATRMLRAGTSLKVIADLLGH 157

                        170
                 ....*....|....*...
gi 320021654 273 SNLSSTQIYTHVSKEMLR 290
Cdd:cd01188  158 RSIETTAIYAKIDVDDLR 175
xerS PRK05084
site-specific tyrosine recombinase XerS; Reviewed
 1-291 7.59e-30

site-specific tyrosine recombinase XerS; Reviewed


Pssm-ID: 235339 [Multi-domain]  Cd Length: 357  Bit Score: 115.79  E-value: 7.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   1 MENVKNFVKLFVEYlQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAA--------------------YQDTRIFL 60
Cdd:PRK05084  14 KAKMPWYVQEYYQS-KLATPYSPTTLYEYLTEYRRFFNWLISEGLSDASKIKdiplstlenltkkdveafilYLRERPLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  61 TE-AYEKGLSRRTISKKISALRSFYKFL------------------------------------MREKLIEEN-PFQLVH 102
Cdd:PRK05084  93 NGhSTKKGNSQTTINRTLSALKSLFKYLteeaenedgepyfyrnvmkkielkkkketlaarahnLKQKLFLGDeDYEFLD 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 103 LPKQE-------KRIPKFLYQKEleelfevsdisqpagmRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGK 175
Cdd:PRK05084 173 FIDNEyeqklsnRALSSFKKNKE----------------RDLAIIALILGSGLRVSELVNLDLSDLNLKQMTIDVTRKGG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 176 KQRYIPFGSYAREALKVYMNSGRQclLMKAKEPHDLLFVNQRGG---PLTARGIRHilsgLVQKASSTLHIH--PHMLRH 250
Cdd:PRK05084 237 KRDSVNIAPFALPYLEEYLKIRAS--RYKAEKQEKALFLTKYRGkpnRISARAIEK----MVAKYSEAFGVRltPHKLRH 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 320021654 251 TFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEMLRN 291
Cdd:PRK05084 311 TLATRLYDATKDQVLVADQLGHTSTETTDLYTHIVNDEQKE 351
INT_Rci_Hp1_C cd00796
Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal ...
 112-283 7.05e-26

Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain; Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271177 [Multi-domain]  Cd Length: 162  Bit Score: 100.48  E-value: 7.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 112 KFLYQKELEELFEVSDISQPAGMRDQALLelLYATGMRVSECCSITINDVDLFMDTVLVHG-KGKKQRYIPFGSYAREAL 190
Cdd:cd00796    3 RFLTEDEEARLLAALEESTNPHLRLIVLL--ALYTGARRGEILSLRWDDIDLEVGLIVLPEtKNGKPRTVPLSDEAIAIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 191 KvymnsgrqclLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASstLH-IHPHMLRHTFATHLLNEGADLRSVQEL 269
Cdd:cd00796   81 K----------ELKRKRGKDGFFVDGRFFGIPIASLRRAFKKARKRAG--LEdLRFHDLRHTFASRLVQAGVPIKTVAKI 148

                        170
                 ....*....|....
gi 320021654 270 LGHSNLSSTQIYTH 283
Cdd:cd00796  149 LGHSSIKMTMRYAH 162
INT_C_like_4 cd01194
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 118-283 1.35e-25

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271194 [Multi-domain]  Cd Length: 174  Bit Score: 100.14  E-value: 1.35e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 118 ELEELFEVSDI--SQPaGMRDQALLELLYATGMRVSECCSITINDVD--LFMDTVLVHGKGK--KQRYIPFGSYAREALK 191
Cdd:cd01194    5 QARQLLASLPIddSII-GLRDRAIISLMVTEGLRTVEIVRADVGDLRqeGEGTILYVQGKGKtsKDDFVYLRPDVLKALQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 192 VYMNSgrqcllMKAKEPHDLLFV----NQRGGPLTARGIRHILSGLVQKASST-LHIHPHMLRHTFATHLLNEGADLRSV 266
Cdd:cd01194   84 AYLKA------RGKLDFEEPLFTslsnNSKGQRLTTRSIRRIIKKYLRKAGLDdDRLTAHSLRHTAGTLALKAGKSLREV 157

                        170
                 ....*....|....*..
gi 320021654 267 QELLGHSNLSSTQIYTH 283
Cdd:cd01194  158 QQLLRHSDPNTTMIYAH 174
INT_FimBE_like cd01197
FimB and FimE and related proteins, integrase/recombinases; This CD includes proteins similar ...
 112-291 3.12e-25

FimB and FimE and related proteins, integrase/recombinases; This CD includes proteins similar to E.coli FimE and FimB and Proteus mirabilis MrpI. FimB and FimE are the regulatory proteins during expression of type 1 fimbriae in Escherichia coli. The fimB and fimE proteins direct the phase switch into the 'on' and 'off' position. MrpI is the regulatory protein of proteus mirabilis fimbriae expression. This family belongs to the integrase/recombinase superfamily.


Pssm-ID: 271197 [Multi-domain]  Cd Length: 181  Bit Score: 99.50  E-value: 3.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 112 KFLYQKELEELFEVSDISQpAGMRDQALLELLYATGMRVSECCSITINDVDLfmDTVLVHGKGKKQRYI---PFGSYARE 188
Cdd:cd01197    5 KYLTGKEVQALLQAACRGR-TPARDYCLLLLAFRHGFRVSELCDLHLSDVDL--ESRRLHIRRLKNGFStthPLRFDERE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 189 ALKVYMNSGRQcllMKAKEPhDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQE 268
Cdd:cd01197   82 ALEAWLKERAN---WKGADT-DWIFLSRRGGPLSRQQAYRIIRDLGKEAGTVTQTHPHMLRHACGYALADRGADTRLIQD 157

                        170       180
                 ....*....|....*....|...
gi 320021654 269 LLGHSNLSSTQIYTHVSKEMLRN 291
Cdd:cd01197  158 YLGHRNIRHTVIYTASNAARFAN 180
INT_RitB_C_like cd00797
C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio; ...
 118-290 1.37e-24

C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio; Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.


Pssm-ID: 271178 [Multi-domain]  Cd Length: 198  Bit Score: 98.15  E-value: 1.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 118 ELEELFEVSDISQPA-GMRDQA---LLELLYATGMRVSECCSITINDVDLFMDTVLV-HGKGKKQRYIPFGSYAREALKV 192
Cdd:cd00797    5 EIRRLLAAADQLPPEsPLRPLTyatLFGLLYATGLRVGEALRLRLEDVDLDSGILTIrQTKFGKSRLVPLHPSTVGALRD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 193 YMNSGRQCLlmkAKEPHDLLFVNQRGGPLTARGIRHILSGLVQK-----ASSTLHIHPHMLRHTFATHLL----NEGAD- 262
Cdd:cd00797   85 YLARRDRLL---PSPSSSYFFVSQQGGRLTGGGVYRVFRRLLRRiglrgAGDGRGPRLHDLRHTFAVNRLtrwyREGADv 161

                        170       180       190
                 ....*....|....*....|....*....|.
gi 320021654 263 ---LRSVQELLGHSNLSSTQIYTHVSKEMLR 290
Cdd:cd00797  162 erkLPVLSTYLGHVNVTDTYWYLTATPELME 192
Phage_int_SAM_1 pfam02899
Phage integrase, N-terminal SAM-like domain;
8-91 5.81e-24

Phage integrase, N-terminal SAM-like domain;


Pssm-ID: 427047 [Multi-domain]  Cd Length: 83  Bit Score: 92.71  E-value: 5.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654    8 VKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRvQGINGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFL 87
Cdd:pfam02899   1 IDQFLEYLSLERGLSPHTLRAYRRDLLAFLKFLS-EGGSSLEQITTSDVRAFLAELRAQGLSASSLARRLSALRSFYQFL 79


                  ....
gi 320021654   88 MREK 91
Cdd:pfam02899  80 IREG 83
INT_C_like_5 cd01195
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 118-283 1.67e-23

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271195 [Multi-domain]  Cd Length: 170  Bit Score: 94.46  E-value: 1.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 118 ELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGKKQRYIPFGSYA-REALKVYMNS 196
Cdd:cd01195    4 EARQRLDAADRHTAKGKRDEALVRLLLDNALRRSEAVALDVEDLEKEHRRLRILGKGKKQREVVTLPPTtREALAAWLAA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 197 GRqcllmKAKEPhdlLFV----NQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADL-RSVQELLG 271
Cdd:cd01195   84 RG-----EAEGP---LFVsldrASRGRRLSPQAVYRIVRRLAERIGLGKRLSPHGLRHSAITLALDAGAGLiRKVQDFSR 155

                        170
                 ....*....|..
gi 320021654 272 HSNLSSTQIYTH 283
Cdd:cd01195  156 HADLRTLQVYDD 167
PRK09870 PRK09870
tyrosine recombinase; Provisional
 107-282 2.62e-22

tyrosine recombinase; Provisional


Pssm-ID: 182125  Cd Length: 200  Bit Score: 91.92  E-value: 2.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 107 EKRipKFLYQKELEELFEVSDiSQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVH--GKGKKQRYiPFGS 184
Cdd:PRK09870   8 KKR--NFLTHSEIESLLKAAN-TGPHAARNYCLTLLCFIHGFRASEICRLRISDIDLKAKCIYIHrlKKGFSTTH-PLLN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 185 YAREALKVYMNsgrqcllMKAKEPH---DLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGA 261
Cdd:PRK09870  84 KEIQALKNWLS-------IRTSYPHaesEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRHSCGFALANMGI 156

                        170       180
                 ....*....|....*....|.
gi 320021654 262 DLRSVQELLGHSNLSSTQIYT 282
Cdd:PRK09870 157 DTRLIQDYLGHRNIRHTVWYT 177
INT_ICEBs1_C_like cd01189
C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; ...
 119-283 3.38e-21

C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271189 [Multi-domain]  Cd Length: 147  Bit Score: 87.61  E-value: 3.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 119 LEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHG---------------KGKKQ-RYIPF 182
Cdd:cd01189    1 PEELKKLLEALKKRGDRYYLLFLLALLTGLRRGELLALTWSDIDFENGTIRINRtlvrkkkggyvikppKTKSSiRTIPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 183 GSYAREALKVYMNSGRqcLLMKAKEPhdllfvnqrggpltargirhilsglvqkasstlHIHPHMLRHTFATHLLNEGAD 262
Cdd:cd01189   81 PDELIELLKELKAFKK--LLKKAGLP---------------------------------RITPHDLRHTFASLLLEAGVP 125

                        170       180
                 ....*....|....*....|..
gi 320021654 263 LRSVQELLGHSNLSST-QIYTH 283
Cdd:cd01189  126 LKVIAERLGHSDISTTlDVYAH 147
INT_tnpA_C_Tn554 cd01186
Putative Transposase A from transposon Tn554, C-terminal catalytic domain; This family ...
 135-291 8.42e-21

Putative Transposase A from transposon Tn554, C-terminal catalytic domain; This family includes putative Transposase A from transposon Tn554. It belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271186 [Multi-domain]  Cd Length: 184  Bit Score: 87.47  E-value: 8.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 135 RDQALLELLYATGMRVSECCSITINDVDlfMDTVLVH------------GKGKKQRYIPFGSYAREALKVYMNSgrqcLL 202
Cdd:cd01186   18 RDKFLLALLYETGLRIGEALGLRIEDID--MADNQIElvpredntnearAKSMRERRIPVSQDLIDLYADYLTY----IY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 203 MKAKEPHDLLFVNQRGG----PLTARGIRHILSGLVQKASstLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSST 278
Cdd:cd01186   92 CEEAEFSITVFVNVKGGnqgkAMNYSDVYDLVRRLKKRTG--IDFTPHMFRHTHATALIRAGWSIEVVARRLGHAHVQTT 169

                        170
                 ....*....|....
gi 320021654 279 -QIYTHVSKEMLRN 291
Cdd:cd01186  170 lNTYGHLSEEDIRR 183
PRK15417 PRK15417
integron integrase;
12-286 6.34e-19

integron integrase;


Pssm-ID: 185315 [Multi-domain]  Cd Length: 337  Bit Score: 85.48  E-value: 6.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  12 VEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQGINGFEEAAYQDTRIFLTE-AYEKGLSRRTISKKISALRSFYKFLMRE 90
Cdd:PRK15417  17 LDQLRERIRYLHYSLRTEQAYVHWVRAFIRFHGVRHPATLGSSEVEAFLSWlANERKVSVSTHRQALAALLFFYGKVLCT 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  91 KLieenPF-QLVHLPKQEKRIPKFLYQKELEELFEVSDISQpagmrdQALLELLYATGMRVSECCSITINDVDLFMDTVL 169
Cdd:PRK15417  97 DL----PWlQEIGRPRPSRRLPVVLTPDEVVRILGFLEGEH------RLFAQLLYGTGMRISEGLQLRVKDLDFDHGTII 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 170 V-HGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKE-------PHDLLFVNQRGG-----------------PLTAR 224
Cdd:PRK15417 167 VrEGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEgrsgvalPDALERKYPRAGhswpwfwvfaqhthstdPRSGV 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320021654 225 GIRH---------ILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSK 286
Cdd:PRK15417 247 VRRHhmydqtfqrAFKRAVEQAGITKPATPHTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLK 317
PRK09871 PRK09871
tyrosine recombinase; Provisional
 112-282 1.51e-18

tyrosine recombinase; Provisional


Pssm-ID: 182126  Cd Length: 198  Bit Score: 81.95  E-value: 1.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 112 KFLYQKELEELFEVSDiSQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHG-KGKKQRYIPFGSYAREAL 190
Cdd:PRK09871   5 RYLTGKEVQAMMQAVC-YGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRINIRRlKNGFSTVHPLRFDEREAV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 191 KVYmnsGRQCLLMKAKEPHDLLFVNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELL 270
Cdd:PRK09871  84 ERW---TQERANWKGADRTDAIFISRRGSRLSRQQAYRIIRDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYL 160

                        170
                 ....*....|..
gi 320021654 271 GHSNLSSTQIYT 282
Cdd:PRK09871 161 GHRNIRHTVRYT 172
INTN1_C_like cd01185
Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal ...
 134-289 3.77e-17

Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain; IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271185 [Multi-domain]  Cd Length: 161  Bit Score: 76.92  E-value: 3.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 134 MRDQALLELLyaTGMRVSECCSITINDVDLFMDTVLVHG---KGKKQRYIPFGSYAREALKVYMNSgrqcllmkakEPHD 210
Cdd:cd01185   20 VRDMFLFSCY--TGLRFSDLKNLTWKNIVEASGRTWIRYrrkKTGKPVTVPLLPVAREILEKYKDD----------RSEG 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320021654 211 LLFvnqrgGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSKEML 289
Cdd:cd01185   88 KLF-----PVLSNQKINRYLKEIAKIAGIDKHLTFHVARHTFATLLLLKGVDIETISKLLGHSSIKTTQIYAKIVDSKK 161
FimB COG0582
Integrase/recombinase, includes phage integrase [Replication, recombination and repair, ...
 65-283 4.74e-14

Integrase/recombinase, includes phage integrase [Replication, recombination and repair, Mobilome: prophages, transposons];


Pssm-ID: 440347 [Multi-domain]  Cd Length: 391  Bit Score: 71.99  E-value: 4.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  65 EKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH--LPKQEKRIPKFLYQKELEELFEvsDISQPAGMRD-QALLE 141
Cdd:COG0582  155 EARGAPETARRVRQRLRQVFRYAVARGLIERNPAADLKgaLPKPKVKHHPALTPEELPELLR--ALDAYRGSPVtRLALR 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 142 LLYATGMRVSECCSITINDVDLFMDTVLVHG---KGKKQRYIPFGSYAREALKvymnsgrqcLLMKAKEPHDLLFVNQRG 218
Cdd:COG0582  233 LLLLTGVRPGELRGARWSEIDLEAALWTIPAermKTRRPHIVPLSRQALEILK---------ELKPLTGDSEYVFPSRRG 303

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320021654 219 G--PLTARGIRHILsglvqKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQ-IYTH 283
Cdd:COG0582  304 PkkPMSENTLNKAL-----RRMGYGRFTPHGFRHTASTLLNEAGFPPDVIERQLAHKDGNKVRaAYNR 366
INT_C_like_6 cd01196
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 117-291 1.54e-13

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271196  Cd Length: 183  Bit Score: 67.51  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 117 KELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLV--HGKGKKQRYIPFGSYAREALKVYM 194
Cdd:cd01196    3 PEARRLLESIDSTHPVGLRDRALIALMVYSFARIGAVLAMRVEDVYDQGRRLWVrlAEKGGKQHEMPCHHDLEEYLRAYL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 195 NSGRQcllmkAKEPHDLLFVNQRGG-------PLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQ 267
Cdd:cd01196   83 EAAEI-----EEDPKGPLFRTTRGGtrklthnPLTQANAYRMVRRRAIAADIPTAIGNHSFRATGITAYLKNGGTLEDAQ 157

                        170       180
                 ....*....|....*....|....
gi 320021654 268 ELLGHSNLSSTQIYTHVSKEMLRN 291
Cdd:cd01196  158 NMANHASTRTTQLYDRRSDKITLD 181
INT_Cre_C cd00799
C-terminal catalytic domain of Cre recombinase (also called integrase); Cre-like recombinases ...
 119-282 7.05e-13

C-terminal catalytic domain of Cre recombinase (also called integrase); Cre-like recombinases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre recombinase maintains the circular phage replicon in a monomeric state by catalyzing a site-specific recombination between two loxP sites. The catalytic core domain of Cre recombinase is linked to a more divergent helical N-terminal domain, which interacts primarily with the DNA major groove proximal to the crossover region.


Pssm-ID: 271180  Cd Length: 188  Bit Score: 65.78  E-value: 7.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 119 LEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLV----------HGKGkKQRYIPFGSY--- 185
Cdd:cd00799    1 LKAMLATLDDTTLRGLRDRALLLLGFAGALRRSELVALRVEDLTRFVDGGLLirlrrsktdqDGEG-EIKALPYGPEtcp 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 186 AReALKVYmnsgrqclLMKAKEPHDLLFV------NQRGGPLTARGIRHILSGLVQKASS-TLHIHPHMLRHTFATHLLN 258
Cdd:cd00799   80 VR-ALRAW--------LEAAGIPSGPLFRrirrggSVGTTRLSDRSVARIVKRRAALAGLdPGDFSGHSLRRGFATEAAR 150

                        170       180
                 ....*....|....*....|....
gi 320021654 259 EGADLRSVQELLGHSNLSSTQIYT 282
Cdd:cd00799  151 AGASLPEIMAQGGHKSVATVMRYI 174
INT_C_like_3 cd01192
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 112-281 2.17e-12

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271192 [Multi-domain]  Cd Length: 178  Bit Score: 64.24  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 112 KFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITINDVDLFMDTVLVHGKGKKQRYIPFGSYAREALK 191
Cdd:cd01192    2 IVEPIKDKKLIKEIKLYLKKANPRNYLLFIVGINTGLRISDLLSLKVEDVTNKDKLSIKEQKTGKQKTFPLNPTLVKALK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 192 VYMNSgrqcllmKAKEPHDLLF---VNQRGGPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQE 268
Cdd:cd01192   82 EYIDD-------LDLKRNDYLFkslKQGPEKPISRKQAYKILKKAADDLGLNYNIGTHSLRKTFGYHVYKQGKDIELLMK 154

                        170
                 ....*....|...
gi 320021654 269 LLGHSNLSSTQIY 281
Cdd:cd01192  155 LLNHSSPSITLRY 167
int PHA02601
integrase; Provisional
 51-291 3.79e-12

integrase; Provisional


Pssm-ID: 222904 [Multi-domain]  Cd Length: 333  Bit Score: 65.90  E-value: 3.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654  51 AAYQDTRI--FLTEAYEKGLSRRTISKKISALRSFYKFLMR-EKLIEENPFQLVHLPKQEKRIPKFLYQKELEELFEVSD 127
Cdd:PHA02601 107 ADYRARRLsgEFKVNKGRPIKPATVNRELAYLSAVFNELIKlGKWSGPNPLDGIRPFKEAEPELAFLTKEEIERLLDACD 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 128 ISQPAGMRDQALLELlyATGMRVSECCSITINDVDLFMDTvLVHGKGKKQRYIPFgsyAREALKVY-MNSGRqcllmkak 206
Cdd:PHA02601 187 GSRSPDLGLIAKICL--ATGARWSEAETLKRSQISPYKIT-FVKTKGKKNRTVPI---SEELYKMLpKRRGR-------- 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 207 ephdlLFVNQRGGplTARGIRHILSGLvQKASSTlhihpHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTHVSK 286
Cdd:PHA02601 253 -----LFKDAYES--FERAVKRAGIDL-PEGQAT-----HVLRHTFASHFMMNGGNILVLQRILGHATIEMTMAYAHFAP 319


                 ....*
gi 320021654 287 EMLRN 291
Cdd:PHA02601 320 DHLED 324
INT_tnpB_C_Tn554 cd01187
Putative Transposase B from transposon Tn554, C-terminal catalytic domain; This family ...
 138-283 5.67e-11

Putative Transposase B from transposon Tn554, C-terminal catalytic domain; This family includes putative Transposase B from transposon Tn554. It belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271187 [Multi-domain]  Cd Length: 142  Bit Score: 59.37  E-value: 5.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 138 ALLELLYATGMRVSE-------CCSITINDVDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYmnsgrqcllmkakephd 210
Cdd:cd01187   17 PVVQAAVFTGARASElatlkfgCLHAQTSDDGTFLYWLKWENKGGKQLDIPISKKVAELIKTI----------------- 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320021654 211 llfvNQRGGPLTARGIRHILSGLVQkasstlHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIYTH 283
Cdd:cd01187   80 ----NWTLNELSELKNISDDHGERF------RFHTHRFRHTVATRLANSGMGILVLQQLLGHSSPEMTLRYAL 142
INT_C_like_2 cd01191
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 143-281 5.01e-10

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271191  Cd Length: 176  Bit Score: 57.43  E-value: 5.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 143 LYATGMRVSECCSITINDVDL-FMDtvlVHGKGKKQR--YIPFgSYAREALKVYMNSGRQCllmkakephDLLFVNQRGG 219
Cdd:cd01191   29 LAATGARVSELIKIKVEHVELgYFD---IYSKGGKLRrlYIPK-KLRNEALEWLKSTNRKS---------GYIFLNRFGE 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320021654 220 PLTARGIRHILSGLVQKAS-STLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLSSTQIY 281
Cdd:cd01191   96 RITTRGIAQQLKNYARKYGlNPKVVYPHSFRHRFAKNFLEKYNDIALLADLMGHESIETTRIY 158
INT_Lambda_C cd00800
C-terminal catalytic domain of Lambda integrase, a tyrosine-based site-specific recombinase; ...
 137-282 4.61e-06

C-terminal catalytic domain of Lambda integrase, a tyrosine-based site-specific recombinase; Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They are tyrosine-based site-specific recombinase and belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The phage lambda integrase can bridge two different and well-separated DNA sequences called arm- and core-sites. The C-terminal domain binds, cleaves and re-ligates DNA strands at the core-sites, while the N-terminal domain is largely responsible for high-affinity binding to the arm-type sites.


Pssm-ID: 271181 [Multi-domain]  Cd Length: 161  Bit Score: 45.80  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 137 QALLELLYATGMRVSECCSITINDVdlfMDTVL--VHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMkakephdlLFV 214
Cdd:cd00800   15 RLAMELALLTGQRQGDLLRLKWSDI---TDGGLlvEQSKTGKKLLIPWTPSLRALVDRIRALPRKRSEY--------LIN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320021654 215 NQRGGPLTARGIRHILSGLVQKASSTLHIHP---HMLRHTFAThLLNEGADLRSVQELLGHSNLSSTQIYT 282
Cdd:cd00800   84 SRKGGPLSYDTLKSAWRRARKAAGLKGETEGftfHDLRAKAAT-DYAEQGGSTDAQALLGHKSDAMTERYT 153
INT_C_like_1 cd01184
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ...
 143-273 1.01e-05

Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271184 [Multi-domain]  Cd Length: 180  Bit Score: 44.99  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 143 LYaTGMRVSECCSITINDV-----DLFMDTVLVH-GKGKKQ----RYIP---------FGSYAREalkvyMNSGRQCLLM 203
Cdd:cd01184   33 LY-TGARLNEICQLRVDDIkeedgIWCIDINDDAeGRRLKTkasrRLVPihprlielgFLDYVEA-----LRADGKLFLF 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320021654 204 KAKEPHDllfvNQRGGPLTARGIRHILS-GLVQKASSTLHihphMLRHTFATHLLNEGADLRSVQELLGHS 273
Cdd:cd01184  107 PEKRDKD----GKYSKAASKWFNRLLRKlGIKDDERKSFH----SFRHTFITALKRAGVPEELIAQIVGHS 169
Phage_int_SAM_5 pfam13102
Phage integrase SAM-like domain; A family of uncharacterized proteins found by clustering ...
 6-98 5.29e-05

Phage integrase SAM-like domain; A family of uncharacterized proteins found by clustering human gut metagenomic sequences. This family appears related to the N-terminal domain of phage integrases.


Pssm-ID: 463787 [Multi-domain]  Cd Length: 99  Bit Score: 41.44  E-value: 5.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654    6 NFVKLFVEYL-QIEKNYSQYTIVNYVDSIEEFETFLRVQGINgFEEAayqdTRIFLT--EAY---EKGLSRRTISKKISA 79
Cdd:pfam13102   1 DFLDYFKEYIeELKKKGSKGTARNYKSTLKHLKKFLKKKDIT-FEEI----TVDFLEkfEEYlkkKKGLSENTISKYFRT 75

                          90
                  ....*....|....*....
gi 320021654   80 LRSFYKFLMREKLIEENPF 98
Cdd:pfam13102  76 LRAVLNKAIKEGIIKKNPY 94
INT_P4_C cd00801
Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in ...
 117-273 1.24e-04

Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271182 [Multi-domain]  Cd Length: 180  Bit Score: 41.87  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 117 KELEELFEVSDiSQPAGMRDQALLELLYATGMRVSECCSITINDVDlFMDTVLV----HGKGKKQRYIPFGSYAREALKv 192
Cdd:cd00801    3 DELPELWRALD-TANLSPPTKLALRLLLLTGQRIGELARARWSEID-LEEKTWTipaeRTKNKRPHRVPLSDQALEILE- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654 193 ymnsgrqcLLMKAKEPHDLLFVNQRGGPLTARgiRHILSGLVQKASSTLHIH-PHMLRHTFATHLLNEGADLRSVQELLG 271
Cdd:cd00801   80 --------ELKEFTGDSGYLFPSRRKKKKPIS--ENTINKALKRLGYKGKEFtPHDLRRTFSTLLNELGIDPEVIERLLN 149


                 ..
gi 320021654 272 HS 273
Cdd:cd00801  150 HV 151
Phage_int_SAM_4 pfam13495
Phage integrase, N-terminal SAM-like domain;
11-92 7.36e-04

Phage integrase, N-terminal SAM-like domain;


Pssm-ID: 463898 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 7.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320021654   11 FVEYLQIeKNYSQYTIVNYVDSIEEFETFLRVQGingFEEAAYQDTRIFLTE-AYEKGLSRRTISKKISALRSFYKFLMR 89
Cdd:pfam13495   5 FREALRL-RGYAERTIKAYLRWIRRFLRFHDKKH---PEELTEEDIEAYLSHlANERNVSASTQNQALNALSFFYRWVLE 80


                  ...
gi 320021654   90 EKL 92
Cdd:pfam13495  81 REL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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