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Conserved domains on  [gi|319881636|gb|ADV75101|]
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TLR7, partial [Amazona albifrons]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-234 4.98e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 4.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   1 AFLELKKLTILSLKSNNLTHIPPNLSS--TLKELYIYNNKIQVIQEhDLSTLHNLEILDLSGNcprcynapypcipcpns 78
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  79 TIEIHSKAFYSLKNLRILRLHSNSIQSIPSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfQLKTYS 158
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGN-QLTDLPEP--LANLTNLETLDLSNN-QLTDLP 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 319881636 159 stlnlskSFSSLSNLETLRLRGYVFKELSegnldPLLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKI 234
Cdd:COG4886  245 -------ELGNLTNLEELDLSNNQLTDLP-----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-234 4.98e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 4.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   1 AFLELKKLTILSLKSNNLTHIPPNLSS--TLKELYIYNNKIQVIQEhDLSTLHNLEILDLSGNcprcynapypcipcpns 78
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  79 TIEIHSKAFYSLKNLRILRLHSNSIQSIPSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfQLKTYS 158
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGN-QLTDLPEP--LANLTNLETLDLSNN-QLTDLP 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 319881636 159 stlnlskSFSSLSNLETLRLRGYVFKELSegnldPLLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKI 234
Cdd:COG4886  245 -------ELGNLTNLEELDLSNNQLTDLP-----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-151 1.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.88  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   6 KKLTILSLKSNNLTHIPpNLSST--LKELYIYNNKIQVIQehDLSTLHNLEILDLSGNCPRC----YNAP--------YP 71
Cdd:cd21340   24 KNLKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  72 CIPCPNS-TIEIHSkAFYSLKNLRILRLHSNSIQSIpsSWFKNLRNLKQLDLSQNfLIKEIGD-AQFLKFIPSLVELDLS 149
Cdd:cd21340  101 RLPPGEKlTFDPRS-LAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN-QISDLEElLDLLSSWPSLRELDLT 176


                 ..
gi 319881636 150 FN 151
Cdd:cd21340  177 GN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-235 1.51e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   3 LELKKLTILSLKSNNLT-HIPPNLSS--TLKELYIYNNKIQVIQEHDLSTLHNLEILDLS-----GNCPR--CYNAP-YP 71
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLStnnltGEIPEglCSSGNlFK 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  72 CIPCPNSTIEIHSKAFYSLKNLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNFLIKEIGDAQFLkfIPSLVELDLS-- 149
Cdd:PLN00113 385 LILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWD--MPSLQMLSLArn 462

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 150 -FNFQLKTYSSTLNLSK--------------SFSSLSNLETLRLRGyvfKELSEGNLDPLLSLRNLTVLDLGTNFIKVVD 214
Cdd:PLN00113 463 kFFGGLPDSFGSKRLENldlsrnqfsgavprKLGSLSELMQLKLSE---NKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                        250       260
                 ....*....|....*....|.
gi 319881636 215 LSVFKKFPSLKLIDLSVNKIS 235
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
92-151 7.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 7.36e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   92 NLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNfLIKEIGDAQFLKFiPSLVELDLSFN 151
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGL-PSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-234 4.98e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 4.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   1 AFLELKKLTILSLKSNNLTHIPPNLSS--TLKELYIYNNKIQVIQEhDLSTLHNLEILDLSGNcprcynapypcipcpns 78
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  79 TIEIHSKAFYSLKNLRILRLHSNSIQSIPSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfQLKTYS 158
Cdd:COG4886  170 QLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGN-QLTDLPEP--LANLTNLETLDLSNN-QLTDLP 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 319881636 159 stlnlskSFSSLSNLETLRLRGYVFKELSegnldPLLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKI 234
Cdd:COG4886  245 -------ELGNLTNLEELDLSNNQLTDLP-----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-234 1.95e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   4 ELKKLTILSLKSNNLTHIPPNLSS--TLKELYIYNNKIQVIQEHdLSTLHNLEILDLSGNCprcynapypcipcpnstIE 81
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ-----------------IT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  82 IHSKAFYSLKNLRILRLHSNSIQSIPSSwFKNLRNLKQLDLSQNflikEIGDAQFLKFIPSLVELDLSFNfQLKTYSSTL 161
Cdd:COG4886  196 DLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-QLTDLPPLA 269

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 319881636 162 NlsksfssLSNLETLRLRGYVFKELSEGNLDPLLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKI 234
Cdd:COG4886  270 N-------LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-244 3.63e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 3.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   4 ELKKLTILSLKSNNLTHIPPNLS--STLKELYIYNNKIQVIQEhDLSTLHNLEILDLSGNcprcynapypcipcpnsTIE 81
Cdd:COG4886  157 NLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN-----------------QLT 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  82 IHSKAFYSLKNLRILRLHSNSIQSIPssWFKNLRNLKQLDLSQNflikEIGDAQFLKFIPSLVELDLSFNFQLKTYSSTL 161
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKEL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 162 NLSKSFSSLSNLETLRLRGYVFKELSEGNLDPLLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKISPSSGES 241
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372


                 ...
gi 319881636 242 NFH 244
Cdd:COG4886  373 GLL 375
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-235 7.24e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 7.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   3 LELKKLTILSLKSNNLTHIPPNLSSTLKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNcprcynapypcipcpnstiei 82
Cdd:COG4886   48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------------------- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  83 hsKAFYSLKNLRILRLHSNSIQSIPSSwFKNLRNLKQLDLSQNfLIKEIGDAqfLKFIPSLVELDLSFNfQLKTYSSTL- 161
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNN-QLTDLPEP--LGNLTNLKSLDLSNN-QLTDLPEELg 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 162 ----------------NLSKSFSSLSNLETLRLRGYVFKELSEgnldPLLSLRNLTVLDLGTNfiKVVDLSVFKKFPSLK 225
Cdd:COG4886  180 nltnlkeldlsnnqitDLPEPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLDLSNN--QLTDLPELGNLTNLE 253

                        250
                 ....*....|
gi 319881636 226 LIDLSVNKIS 235
Cdd:COG4886  254 ELDLSNNQLT 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-151 1.22e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.88  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   6 KKLTILSLKSNNLTHIPpNLSST--LKELYIYNNKIQVIQehDLSTLHNLEILDLSGNCPRC----YNAP--------YP 71
Cdd:cd21340   24 KNLKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  72 CIPCPNS-TIEIHSkAFYSLKNLRILRLHSNSIQSIpsSWFKNLRNLKQLDLSQNfLIKEIGD-AQFLKFIPSLVELDLS 149
Cdd:cd21340  101 RLPPGEKlTFDPRS-LAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN-QISDLEElLDLLSSWPSLRELDLT 176


                 ..
gi 319881636 150 FN 151
Cdd:cd21340  177 GN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-235 1.51e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   3 LELKKLTILSLKSNNLT-HIPPNLSS--TLKELYIYNNKIQVIQEHDLSTLHNLEILDLS-----GNCPR--CYNAP-YP 71
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLStnnltGEIPEglCSSGNlFK 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  72 CIPCPNSTIEIHSKAFYSLKNLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNFLIKEIGDAQFLkfIPSLVELDLS-- 149
Cdd:PLN00113 385 LILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWD--MPSLQMLSLArn 462

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 150 -FNFQLKTYSSTLNLSK--------------SFSSLSNLETLRLRGyvfKELSEGNLDPLLSLRNLTVLDLGTNFIKVVD 214
Cdd:PLN00113 463 kFFGGLPDSFGSKRLENldlsrnqfsgavprKLGSLSELMQLKLSE---NKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                        250       260
                 ....*....|....*....|.
gi 319881636 215 LSVFKKFPSLKLIDLSVNKIS 235
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
92-151 7.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 7.36e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   92 NLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNfLIKEIGDAQFLKFiPSLVELDLSFN 151
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGL-PSLRYLDLSGN 59
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 200-229 9.85e-08

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 47.34  E-value: 9.85e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 319881636  200 LTVLDLGTNFIKVVDLSVFKKFPSLKLIDL 229
Cdd:pfam18837   1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-208 5.17e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 5.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   5 LKKLTILSLKSNNLT-HIPPNLSS--TLKELYI-YNNKIQVIqEHDLSTLHNLEILDLsgncprCYNapypcipcpNSTI 80
Cdd:PLN00113 187 LTSLEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEI-PYEIGGLTSLNHLDL------VYN---------NLTG 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  81 EIHSkAFYSLKNLRILRLHSNSIQ-SIPSSWFkNLRNLKQLDLSQNFLIKEIGDaqflkFIPSLVELDLsfnFQLKTYSS 159
Cdd:PLN00113 251 PIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPE-----LVIQLQNLEI---LHLFSNNF 320

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 319881636 160 TLNLSKSFSSLSNLETL-----RLRGYVFKELSEGNldpllslrNLTVLDLGTN 208
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
LRR_8 pfam13855
Leucine rich repeat;
7-61 7.29e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 7.29e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 319881636    7 KLTILSLKSNNLTHIPP----NLSStLKELYIYNNKIQVIQEHDLSTLHNLEILDLSGN 61
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgafkGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-229 9.22e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 9.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   4 ELKKLTILSLKSNNLTHIPPNLS--STLKELYIYNNKIQVIQEhdLSTLHNLEILDLSGNcprcynaPYPCIPcpnstie 81
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN-------QLTDLP------- 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  82 ihskAFYSLKNLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNFLIKEIGDAQFLKFIPSLVELDLSFNFQLKTYSSTL 161
Cdd:COG4886  267 ----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 319881636 162 NLSKSFSSLSNLETLRLRGYVFKELSEGNLDPLLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDL 229
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
LRR_8 pfam13855
Leucine rich repeat;
77-125 3.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 319881636   77 NSTIEIHSKAFYSLKNLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQN 125
Cdd:pfam13855  11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-235 3.65e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   1 AFLELKKLTILSLKSNNLT----HIPPNL--SSTLKELYIYNNKI-----QVIQEHDLSTLHNLEILDLSGNcpRCYNAp 69
Cdd:cd00116   76 GLTKGCGLQELDLSDNALGpdgcGVLESLlrSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRN--RLEGA- 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  70 ypcipcpnSTIEIhSKAFYSLKNLRILRLHSNSI--QSIPS--SWFKNLRNLKQLDLSQNFlIKEIGDAQFLKFIPSLVE 145
Cdd:cd00116  153 --------SCEAL-AKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNG-LTDEGASALAETLASLKS 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 146 LdlsfnfqlktysSTLNLSksfsslSNLetLRLRGYVfkELSEGNLDPLLSLRNLtvlDLGTNFIK---VVDLS-VFKKF 221
Cdd:cd00116  223 L------------EVLNLG------DNN--LTDAGAA--ALASALLSPNISLLTL---SLSCNDITddgAKDLAeVLAEK 277

                        250
                 ....*....|....
gi 319881636 222 PSLKLIDLSVNKIS 235
Cdd:cd00116  278 ESLLELDLRGNKFG 291
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-235 1.01e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  87 FYSLKNLRILRLHSNSIQSIPSswFKNLRNLKQLDLSQNFlIKEIGDAQFLKfipSLVELDLSFNfqlktysstlNLSK- 165
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQ-IEKIENLENLV---NLKKLYLGGN----------RISVv 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 319881636 166 -SFSSLSNLETLRLRGyvfKELSEGN---LDP--LLSLRN-LTVLDLGTNfiKVVDLSVFKKFPSLKLIDLSVNKIS 235
Cdd:cd21340   84 eGLENLTNLEELHIEN---QRLPPGEkltFDPrsLAALSNsLRVLNISGN--NIDSLEPLAPLRNLEQLDASNNQIS 155
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-241 5.35e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 116 NLKQLDLSQNFLIKEIGD--AQFLKFIPSLVELDLSFNfQLkTYSSTLNLSKSFSSLSNLETLRLRGYVF-----KELSE 188
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEalAKALRANRDLKELNLANN-GI-GDAGIRALAEGLKANCNLEVLDLNNNGLtdegaSALAE 215

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 319881636 189 GnldpLLSLRNLTVLDLGTNFIKVVDLSVFKK-----FPSLKLIDLSVNKISPSSGES 241
Cdd:cd00116  216 T----LASLKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDITDDGAKD 269
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
6-108 6.72e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.30  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   6 KKLTILSLKSNNLTHIPPNLSSTLKELYIYNNKIQVIQEhdlsTLHN-LEILDLSGNcpRCYNAPYPcIPCPNSTIEIHS 84
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA----TLPDtIQEMELSIN--RITELPER-LPSALQSLDLFH 271

                         90       100
                 ....*....|....*....|....*....
gi 319881636  85 KAFYSL-----KNLRILRLHSNSIQSIPS 108
Cdd:PRK15370 272 NKISCLpenlpEELRYLSVYDNSIRTLPA 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 8-256 8.39e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 8.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   8 LTILSLKSNNLT-HIPPNLSSTLKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNCPRCYnapypcipCPNSTIEIHSka 86
Cdd:PLN00113 120 LRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK--------IPNSLTNLTS-- 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636  87 fyslknLRILRLHSNSIQSIPSSWFKNLRNLKQLDLSQNFLIKEIGDAqfLKFIPSLVELDLSFNfqlktySSTLNLSKS 166
Cdd:PLN00113 190 ------LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN------NLTGPIPSS 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636 167 FSSLSNLETLrlrgYVFKELSEGNLDP-LLSLRNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKISPSSGEsnfhG 245
Cdd:PLN00113 256 LGNLKNLQYL----FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPV----A 327

                        250
                 ....*....|.
gi 319881636 246 FCSNPRISVEQ 256
Cdd:PLN00113 328 LTSLPRLQVLQ 338
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 91-133 2.35e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 319881636   91 KNLRILRLHSNSIQSIPSswFKNLRNLKQLDLSQNFLIKEIGD 133
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
LRR_8 pfam13855
Leucine rich repeat;
27-103 2.57e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 319881636   27 STLKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNCPRCynapypcipcpnstieIHSKAFYSLKNLRILRLHSNSI 103
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------------LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
198-235 2.16e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 319881636  198 RNLTVLDLGTNFIKVVDLSVFKKFPSLKLIDLSVNKIS 235
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-151 8.27e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 8.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319881636   4 ELKKLTILSLKSNNLTHIPPNL--SSTLKELYIYNNKIQVIQEHDLSTLHNLEILDLSGNcprcynapypcipcpNSTIE 81
Cdd:PLN00113 450 DMPSLQMLSLARNKFFGGLPDSfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN---------------KLSGE 514

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 319881636  82 IHSKaFYSLKNLRILRL-HSNSIQSIPSSwFKNLRNLKQLDLSQNFLIKEIgdAQFLKFIPSLVELDLSFN 151
Cdd:PLN00113 515 IPDE-LSSCKKLVSLDLsHNQLSGQIPAS-FSEMPVLSQLDLSQNQLSGEI--PKNLGNVESLVQVNISHN 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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