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Conserved domains on  [gi|31983793|ref|NP_858391|]
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replication protein (plasmid) [Shigella flexneri 2a str. 301]

Protein Classification

replication regulatory protein RepA( domain architecture ID 10014355)

replication regulatory protein RepA is involved in the determination of copy number in gene replication and binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein RepA

Gene Ontology:  GO:0006276
PubMed:  1378398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13702 PRK13702
replication regulatory protein RepA;
1-85 1.59e-42

replication regulatory protein RepA;


:

Pssm-ID: 184258  Cd Length: 85  Bit Score: 133.31  E-value: 1.59e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31983793   1 MSQTENAVTSSLSQKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQ 80
Cdd:PRK13702  1 MSQTENAVTSSSGAKRAYRKGNPLSAAEKQRASVARKRATHKEIKVFIQNPLKDKLMELCEEEGLTQAEMIERLIERELA 80


                ....*
gi 31983793  81 RLDIL 85
Cdd:PRK13702 81 RRAML 85
 
Name Accession Description Interval E-value
PRK13702 PRK13702
replication regulatory protein RepA;
1-85 1.59e-42

replication regulatory protein RepA;


Pssm-ID: 184258  Cd Length: 85  Bit Score: 133.31  E-value: 1.59e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31983793   1 MSQTENAVTSSLSQKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQ 80
Cdd:PRK13702  1 MSQTENAVTSSSGAKRAYRKGNPLSAAEKQRASVARKRATHKEIKVFIQNPLKDKLMELCEEEGLTQAEMIERLIERELA 80


                ....*
gi 31983793  81 RLDIL 85
Cdd:PRK13702 81 RRAML 85
RepB-RCR_reg pfam10723
Replication regulatory protein RepB; This is a family of proteins which regulate replication ...
 1-82 1.64e-37

Replication regulatory protein RepB; This is a family of proteins which regulate replication of rolling circle replication (RCR) plasmids that have a double-strand replication origin (dso). Regulation of replication of RCR plasmids occurs mainly at initiation of leading strand synthesis at the dso, such that Rep protein concentration controls plasmid replication.


Pssm-ID: 287668  Cd Length: 81  Bit Score: 120.50  E-value: 1.64e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31983793    1 MSQTENAVTSSLsqKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQ 80
Cdd:pfam10723  1 MSQIENAVTSSL--KRIYRKGNPLTDAEKQRASVSRKKLTHKEINVFIQNPLKDLLVQLCEREGITQAQMIEKIIKDELA 78


                 ..
gi 31983793   81 RL 82
Cdd:pfam10723 79 RL 80
 
Name Accession Description Interval E-value
PRK13702 PRK13702
replication regulatory protein RepA;
1-85 1.59e-42

replication regulatory protein RepA;


Pssm-ID: 184258  Cd Length: 85  Bit Score: 133.31  E-value: 1.59e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31983793   1 MSQTENAVTSSLSQKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQ 80
Cdd:PRK13702  1 MSQTENAVTSSSGAKRAYRKGNPLSAAEKQRASVARKRATHKEIKVFIQNPLKDKLMELCEEEGLTQAEMIERLIERELA 80


                ....*
gi 31983793  81 RLDIL 85
Cdd:PRK13702 81 RRAML 85
RepB-RCR_reg pfam10723
Replication regulatory protein RepB; This is a family of proteins which regulate replication ...
 1-82 1.64e-37

Replication regulatory protein RepB; This is a family of proteins which regulate replication of rolling circle replication (RCR) plasmids that have a double-strand replication origin (dso). Regulation of replication of RCR plasmids occurs mainly at initiation of leading strand synthesis at the dso, such that Rep protein concentration controls plasmid replication.


Pssm-ID: 287668  Cd Length: 81  Bit Score: 120.50  E-value: 1.64e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31983793    1 MSQTENAVTSSLsqKRFVRRGKPMTDSEKQMAAVARKRLTHKEIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQ 80
Cdd:pfam10723  1 MSQIENAVTSSL--KRIYRKGNPLTDAEKQRASVSRKKLTHKEINVFIQNPLKDLLVQLCEREGITQAQMIEKIIKDELA 78


                 ..
gi 31983793   81 RL 82
Cdd:pfam10723 79 RL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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