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Conserved domains on  [gi|31982561|ref|NP_703187|]
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reticulon-1 isoform A [Mus musculus]

Protein Classification

reticulon family protein( domain architecture ID 10493657)

reticulon family protein associates with the endoplasmic reticulum (ER) through a C-terminal di-lysine ER retention motif; such as mammalian RTN4/Nogo, a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching

Gene Ontology:  GO:0005789|GO:0005783
PubMed:  12832288|18177508|22425683|33924890

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 595-757 3.29e-40

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


:

Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 144.93  E-value: 3.29e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   595 DLLYWRDIKQTGIVFGSFLLL--LFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVqktdeGHPFKaylelEITLS 672
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGATALwlLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELELS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   673 QEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQ 752
Cdd:pfam02453  73 EETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDA 152


                  ....*
gi 31982561   753 YLGLV 757
Cdd:pfam02453 153 YVEKA 157
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 389-586 5.97e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   389 RSGLPTIPSPLDQEASSAESGDSEIE------LVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAEL 462
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILqtqppvLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   463 DSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATEEraPSHQGPVEPDPM-LSFAPA-----AALQSRP 536
Cdd:pfam03154 222 QSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ--PSLHGQMPPMPHsLQTGPShmqhpVPPQPFP 299

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 31982561   537 EPSSGDGASVPEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLP 586
Cdd:pfam03154 300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP 349
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 595-757 3.29e-40

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 144.93  E-value: 3.29e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   595 DLLYWRDIKQTGIVFGSFLLL--LFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVqktdeGHPFKaylelEITLS 672
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGATALwlLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELELS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   673 QEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQ 752
Cdd:pfam02453  73 EETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDA 152


                  ....*
gi 31982561   753 YLGLV 757
Cdd:pfam02453 153 YVEKA 157
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 389-586 5.97e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   389 RSGLPTIPSPLDQEASSAESGDSEIE------LVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAEL 462
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILqtqppvLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   463 DSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATEEraPSHQGPVEPDPM-LSFAPA-----AALQSRP 536
Cdd:pfam03154 222 QSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ--PSLHGQMPPMPHsLQTGPShmqhpVPPQPFP 299

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 31982561   537 EPSSGDGASVPEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLP 586
Cdd:pfam03154 300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP 349
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 595-757 3.29e-40

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 144.93  E-value: 3.29e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   595 DLLYWRDIKQTGIVFGSFLLL--LFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVqktdeGHPFKaylelEITLS 672
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGATALwlLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRP-----PPPIP-----ELELS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   673 QEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQ 752
Cdd:pfam02453  73 EETVRELADSLRVLINFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDA 152


                  ....*
gi 31982561   753 YLGLV 757
Cdd:pfam02453 153 YVEKA 157
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 389-586 5.97e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   389 RSGLPTIPSPLDQEASSAESGDSEIE------LVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAEL 462
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILqtqppvLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982561   463 DSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATEEraPSHQGPVEPDPM-LSFAPA-----AALQSRP 536
Cdd:pfam03154 222 QSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ--PSLHGQMPPMPHsLQTGPShmqhpVPPQPFP 299

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 31982561   537 EPSSGDGASVPEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLP 586
Cdd:pfam03154 300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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