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Conserved domains on  [gi|31982053|ref|NP_033072|]
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transcription factor RelB isoform 1 [Mus musculus]

Protein Classification

RHD-n_RelB and IPT_NFkappaB domain-containing protein( domain architecture ID 11069343)

protein containing domains RelB_leu_zip, RHD-n_RelB, IPT_NFkappaB, and RelB_transactiv

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHD-n_RelB cd07886
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral ...
 103-274 3.62e-120

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.


:

Pssm-ID: 143646  Cd Length: 172  Bit Score: 351.47  E-value: 3.62e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07886   1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 262
Cdd:cd07886  81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                       170
                ....*....|..
gi 31982053 263 DPILSEPVYDKK 274
Cdd:cd07886 161 SPVLSEPIYDKK 172
RelB_transactiv pfam16181
RelB transactivation domain; This domain is the transactivation domain of the transcription ...
 381-558 2.02e-87

RelB transactivation domain; This domain is the transactivation domain of the transcription factor RelB.


:

Pssm-ID: 406565  Cd Length: 181  Bit Score: 268.09  E-value: 2.02e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   381 DSYGVDKKRKRGLPDVLGELSSSD-PHGIESKRRKKKPVFLDHFLPGHSSGL-FLPPSALQPaDSDFFPASISLPGLEPP 458
Cdd:pfam16181   1 DSYGVDKKRKRGMPDVLGELNSSDpPHAIESKRPKKKLSSLDHFLPSHSAALaFLPPAALLA-DPDFFLGPVSLPGLEPP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   459 GGPDLLDD-GFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVESSGPEPLSLDSFAAPGPGDVGTASLVGSNMF 537
Cdd:pfam16181  80 GAPDLLDDyGFAYDPSAHFFFTMLDLFPGPGPLASAVPGAGAAGEAPGEPHGPELLSLDSYAAPASADEATASLVGSNMF 159

                         170       180
                  ....*....|....*....|..
gi 31982053   538 PNQYREAAFGG-GLLSPGPEAT 558
Cdd:pfam16181 160 PNQYREAAFGGsGLLPPGPEAT 181
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 282-378 7.31e-53

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


:

Pssm-ID: 465045  Cd Length: 102  Bit Score: 175.06  E-value: 7.31e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   282 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----TASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVN 356
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 31982053   357 VFLQRLTDGVCSEPLPFTYLPR 378
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102
RelB_leu_zip super family cl24683
RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.
 1-76 1.13e-18

RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.


The actual alignment was detected with superfamily member pfam16180:

Pssm-ID: 374415  Cd Length: 84  Bit Score: 80.86  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053     1 MPSRRAARESA-PELGALGSSDLSSLSLTVSRTTdelEIIDEYIKENGFGLDGTQL---SEMPRLVPRGPASLSSVTLGP 76
Cdd:pfam16180   1 MPSRRVARSSAaPELGPLGSADLSSLSLAVSRTT---EIIDEYIKENGFGLAGSQPgsgAGLPRLVSRGAASLSSVTLGP 77
 
Name Accession Description Interval E-value
RHD-n_RelB cd07886
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral ...
 103-274 3.62e-120

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.


Pssm-ID: 143646  Cd Length: 172  Bit Score: 351.47  E-value: 3.62e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07886   1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 262
Cdd:cd07886  81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                       170
                ....*....|..
gi 31982053 263 DPILSEPVYDKK 274
Cdd:cd07886 161 SPVLSEPIYDKK 172
RelB_transactiv pfam16181
RelB transactivation domain; This domain is the transactivation domain of the transcription ...
 381-558 2.02e-87

RelB transactivation domain; This domain is the transactivation domain of the transcription factor RelB.


Pssm-ID: 406565  Cd Length: 181  Bit Score: 268.09  E-value: 2.02e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   381 DSYGVDKKRKRGLPDVLGELSSSD-PHGIESKRRKKKPVFLDHFLPGHSSGL-FLPPSALQPaDSDFFPASISLPGLEPP 458
Cdd:pfam16181   1 DSYGVDKKRKRGMPDVLGELNSSDpPHAIESKRPKKKLSSLDHFLPSHSAALaFLPPAALLA-DPDFFLGPVSLPGLEPP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   459 GGPDLLDD-GFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVESSGPEPLSLDSFAAPGPGDVGTASLVGSNMF 537
Cdd:pfam16181  80 GAPDLLDDyGFAYDPSAHFFFTMLDLFPGPGPLASAVPGAGAAGEAPGEPHGPELLSLDSYAAPASADEATASLVGSNMF 159

                         170       180
                  ....*....|....*....|..
gi 31982053   538 PNQYREAAFGG-GLLSPGPEAT 558
Cdd:pfam16181 160 PNQYREAAFGGsGLLPPGPEAT 181
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 105-273 3.76e-84

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 259.16  E-value: 3.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   105 LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGKDCTDG 184
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDG--PAVIRVSLVTKDEPHRPHPHSLVGKDCKDG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   185 VCRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYN--AGSLKNHQEVDMNVVRICFQASYRDQQG-HLHR 261
Cdd:pfam00554  79 VCEVELGPE-DMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNvgFEALRQIKDMDLNVVRLCFQAFLPDTRGnFTTP 157

                         170
                  ....*....|..
gi 31982053   262 MDPILSEPVYDK 273
Cdd:pfam00554 158 LPPVVSNPIYDK 169
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 282-378 7.31e-53

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 175.06  E-value: 7.31e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   282 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----TASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVN 356
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 31982053   357 VFLQRLTDGVCSEPLPFTYLPR 378
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102
IPT_NFkappaB cd01177
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ...
 281-377 8.26e-50

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.


Pssm-ID: 238582  Cd Length: 102  Bit Score: 167.11  E-value: 8.26e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 281 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----STASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTV 355
Cdd:cd01177   1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                        90       100
                ....*....|....*....|..
gi 31982053 356 NVFLQRLTDGVCSEPLPFTYLP 377
Cdd:cd01177  81 KIQLKRPSDGERSESVPFTYVP 102
RelB_leu_zip pfam16180
RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.
 1-76 1.13e-18

RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.


Pssm-ID: 374415  Cd Length: 84  Bit Score: 80.86  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053     1 MPSRRAARESA-PELGALGSSDLSSLSLTVSRTTdelEIIDEYIKENGFGLDGTQL---SEMPRLVPRGPASLSSVTLGP 76
Cdd:pfam16180   1 MPSRRVARSSAaPELGPLGSADLSSLSLAVSRTT---EIIDEYIKENGFGLAGSQPgsgAGLPRLVSRGAASLSSVTLGP 77
IPT smart00429
ig-like, plexins, transcription factors;
280-376 1.11e-17

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 78.23  E-value: 1.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053    280 ELRICRINKESGPCTGGEELyLLCDKVQKEDISVVFSTASWEGRADFSQAdvhRQIAIVFKTPPYEDLEISEPVTvNVFL 359
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 31982053    360 QRltDGVCSEPLPFTYL 376
Cdd:smart00429  76 RN--GGVPSSPQPFTYV 90
 
Name Accession Description Interval E-value
RHD-n_RelB cd07886
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral ...
 103-274 3.62e-120

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.


Pssm-ID: 143646  Cd Length: 172  Bit Score: 351.47  E-value: 3.62e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07886   1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 262
Cdd:cd07886  81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                       170
                ....*....|..
gi 31982053 263 DPILSEPVYDKK 274
Cdd:cd07886 161 SPVLSEPIYDKK 172
RHD-n cd07827
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 103-274 4.28e-88

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


Pssm-ID: 143640  Cd Length: 174  Bit Score: 269.24  E-value: 4.28e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGK-DC 181
Cdd:cd07827   1 PYLEITEQPKQRGHRFRYECEGRSAGSIPGENSTADRKTFPTVKLRNYNG--PAKIVVSLVTKDDPPKPHPHQLVGKtDC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 182 TDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPY--NAGSLKNHQEVDMNVVRICFQASYRDQQG-H 258
Cdd:cd07827  79 RDGVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRIQLGIDPFmvHKGPEGNASDIDLNRVRLCFQAFIEDSDGgF 158

                       170
                ....*....|....*.
gi 31982053 259 LHRMDPILSEPVYDKK 274
Cdd:cd07827 159 TLPLPPVLSNPIYDKK 174
RelB_transactiv pfam16181
RelB transactivation domain; This domain is the transactivation domain of the transcription ...
 381-558 2.02e-87

RelB transactivation domain; This domain is the transactivation domain of the transcription factor RelB.


Pssm-ID: 406565  Cd Length: 181  Bit Score: 268.09  E-value: 2.02e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   381 DSYGVDKKRKRGLPDVLGELSSSD-PHGIESKRRKKKPVFLDHFLPGHSSGL-FLPPSALQPaDSDFFPASISLPGLEPP 458
Cdd:pfam16181   1 DSYGVDKKRKRGMPDVLGELNSSDpPHAIESKRPKKKLSSLDHFLPSHSAALaFLPPAALLA-DPDFFLGPVSLPGLEPP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   459 GGPDLLDD-GFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVESSGPEPLSLDSFAAPGPGDVGTASLVGSNMF 537
Cdd:pfam16181  80 GAPDLLDDyGFAYDPSAHFFFTMLDLFPGPGPLASAVPGAGAAGEAPGEPHGPELLSLDSYAAPASADEATASLVGSNMF 159

                         170       180
                  ....*....|....*....|..
gi 31982053   538 PNQYREAAFGG-GLLSPGPEAT 558
Cdd:pfam16181 160 PNQYREAAFGGsGLLPPGPEAT 181
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 105-273 3.76e-84

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 259.16  E-value: 3.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   105 LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGKDCTDG 184
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDG--PAVIRVSLVTKDEPHRPHPHSLVGKDCKDG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   185 VCRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYN--AGSLKNHQEVDMNVVRICFQASYRDQQG-HLHR 261
Cdd:pfam00554  79 VCEVELGPE-DMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNvgFEALRQIKDMDLNVVRLCFQAFLPDTRGnFTTP 157

                         170
                  ....*....|..
gi 31982053   262 MDPILSEPVYDK 273
Cdd:pfam00554 158 LPPVVSNPIYDK 169
RHD-n_RelA cd07885
N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel ...
 103-274 1.06e-56

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.


Pssm-ID: 143645  Cd Length: 169  Bit Score: 187.77  E-value: 1.06e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07885   1 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRIS--LVTKDPPHKPHPHELVGKDCK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRLRPHVSPrHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 262
Cdd:cd07885  79 DGYYEAELSPDRCI-HSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQRADYDLNAVRLCFQVTVRDPSGRLLPL 157

                       170
                ....*....|..
gi 31982053 263 DPILSEPVYDKK 274
Cdd:cd07885 158 PPVLSQPIYDNR 169
RHD-n_Dorsal_Dif cd07887
N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal; ...
 103-274 3.80e-56

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Dorsal and Dif (Dorsal-related immunity factor), and similar proteins. Dorsal and Dif are Rel-like transcription factors, which play roles in mediating innate immunity in Drosophila. They are activated via the Toll pathway. Cytoplasmic Dorsal/Dif are inactivated via forming a complex with Cactus, the Drosophila homologue of mammalian I-kappa B proteins. In response to signals, Cactus is degraded and Dorsal/Dif can be transported into the nucleus, where they act as transcription factors. Dorsal is also an essential gene in establishing the proper dorsal/ventral polarity in the developing embryo.


Pssm-ID: 143647  Cd Length: 173  Bit Score: 186.15  E-value: 3.80e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlREVEVTAClVWKDWPHRVHPHSLVGK-DC 181
Cdd:cd07887   1 PYVRIVEQPTSRALRFRYECEGRSAGSIPGANSTSEGKTFPTIQVVNYDG-RAVVVVSC-VTKDEPFRPHPHNLVGKeGC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 182 TDGVCRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG-SLKNH-QEVDMNVVRICFQASYRDQQGHL 259
Cdd:cd07887  79 KKGVCTKKINPT-EMRIVFQKLGIQCVKKKDVEESLKLREEINVDPFRTGfDHKDQiNSIDLNVVRLCFQVFLEDENGRF 157

                       170
                ....*....|....*.
gi 31982053 260 HR-MDPILSEPVYDKK 274
Cdd:cd07887 158 TVpLPPVVSDPIYDKK 173
RHD-n_c-Rel cd07933
N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel ...
 103-274 2.85e-55

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.


Pssm-ID: 143649  Cd Length: 172  Bit Score: 183.92  E-value: 2.85e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07933   1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRIT--LVTKNEPYKPHPHDLVGKDCR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRLRPHVSPRhSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG--SLKNHQEVDMNVVRICFQASYRDQQGHLH 260
Cdd:cd07933  79 DGYYEAEFGPERRVL-AFQNLGIQCVRRREVKEAIMLRISRGINPFNVPeeQLLQIEEYDLNVVRLCFQIFLPDEHGNYT 157

                       170
                ....*....|....*
gi 31982053 261 RM-DPILSEPVYDKK 274
Cdd:cd07933 158 TAlPPIVSNPIYDNR 172
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 282-378 7.31e-53

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 175.06  E-value: 7.31e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053   282 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----TASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVN 356
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 31982053   357 VFLQRLTDGVCSEPLPFTYLPR 378
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102
IPT_NFkappaB cd01177
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ...
 281-377 8.26e-50

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.


Pssm-ID: 238582  Cd Length: 102  Bit Score: 167.11  E-value: 8.26e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 281 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----STASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTV 355
Cdd:cd01177   1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                        90       100
                ....*....|....*....|..
gi 31982053 356 NVFLQRLTDGVCSEPLPFTYLP 377
Cdd:cd01177  81 KIQLKRPSDGERSESVPFTYVP 102
RHD-n_NFkB cd07883
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa light ...
 103-274 3.62e-46

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-kappa B); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 and B2 families of transcription factors, also referred to as class I members of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. Family members include NF-kappa B1 and NF-kappa B2. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form), while NF-kappa B2 is called p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). p105 and p100 may also act as I-kappa Bs due to their C-terminal ankyrin repeats.


Pssm-ID: 143643  Cd Length: 197  Bit Score: 160.72  E-value: 3.62e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07883   1 PYLEILEQPKQRGFRFRYGCEGPSHGGLPGASSEKNKKSYPTVKICNYQGPARIVVQ--LVTNSEPPRLHAHSLVGKHCE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRlrphVSPRH---SFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNH----------------------- 236
Cdd:cd07883  79 DGICTVQ----VGPKDmtaQFPNLGILHVTKKNVVETLEARLLAQCTRGYNPGDLVHvdaegggdrqltdeeqaeirqka 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 31982053 237 ----QEVDMNVVRICFQASYRDQQGHLHRM-DPILSEPVYDKK 274
Cdd:cd07883 155 kqqaKSMDLSVVRLCFQAFLPDSNGSFTRPlKPVISDAIYDSK 197
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 281-377 7.07e-37

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 132.02  E-value: 7.07e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 281 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----STASWEGRADFSQADVHrQIAIVFKTPPYEDLEISEPVTV 355
Cdd:cd00602   1 LPICRVSSLSGSVNGGDEVFLLCDKVNKPDIKVWFgekgpGETVWEAEAMFRQEDVR-QVAIVFKTPPYHNKWITRPVQV 79

                        90       100
                ....*....|....*....|..
gi 31982053 356 NVFLQRLTDGVCSEPLPFTYLP 377
Cdd:cd00602  80 PIQLVRPDDRKRSEPLTFTYTP 101
RHD-n_NFkB2 cd07934
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2) ...
 103-274 5.62e-31

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B2 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B2 is commonly referred to as p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B2 is involved in the alternative NF-kappa B signaling pathway which is activated by few agonists and plays an important role in secondary lymphoid organogenesis, maturation of B-cells, and adaptive humoral immunity. p100 may also act as an I-kappa B due to its C-terminal ankyrin repeats.


Pssm-ID: 143650  Cd Length: 185  Bit Score: 118.85  E-value: 5.62e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07934   1 PYLVIIEQPKQRGFRFRYVCEGPSHGGLPGASSEKGRKTYPTVKICNYVGMARIEVD--LVTHTDPPRVHAHSLVGKHCN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 D-GVCRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGI----DPY---NAGSLKNHQEV-------DMNVVRIC 247
Cdd:cd07934  79 EsGNCSVDVGPK-DMTAQFSNLGILHVTKKNMMEILKEKLKRQKlrntGPYkltEAEERELEQEAkelkkvmDLSIVRLK 157

                       170       180
                ....*....|....*....|....*...
gi 31982053 248 FQASYRDQQGHLHR-MDPILSEPVYDKK 274
Cdd:cd07934 158 FTAYLRDSNGSYTLaLKPVISDPIHDSK 185
RHD-n_NFkB1 cd07935
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa ...
 103-274 8.57e-31

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B1 is involved in the canonical NF-kappa B signaling pathway which is activated by many agonists and is essential in immune and inflammatory responses, as well as cell survival. p105 is involved in its own specific NF-kappa B signaling pathway which is also implicated in immune and inflammatory responses. p105 may also act as an I-kappa B due to its C-terminal ankyrin repeats. It is also involved in mitogen-activated protein kinase (MAPK) signaling as its degradation leads to the activation of TPL-2, a MAPK kinase kinase which activates ERK pathways.


Pssm-ID: 143651  Cd Length: 202  Bit Score: 118.84  E-value: 8.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELrdCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 182
Cdd:cd07935   1 PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKI--CNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 183 DGVCRVRLRPHVSpRHSFNNLGIQCVRKKEIEAAIE-RKIQLGIDPYNAG------------------SLKNHQ------ 237
Cdd:cd07935  79 DGICTVTAGPKDM-VVGFANLGILHVTKKKVFETLEaRMTEACKKGYNPGllvhpelaylqaegggdrQLTEREkeiirq 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 31982053 238 -------EVDMNVVRICFQASYRDQQGHL-HRMDPILSEPVYDKK 274
Cdd:cd07935 158 aavqqtkEMDLSVVRLMFTAFLPDSTGGFtRRLEPVVSDAIYDSK 202
RHD-n_Relish cd07884
N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish; ...
 103-274 1.16e-25

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Relish protein, in which the RHD domain co-occurs with C-terminal ankyrin repeats. Family members are sometimes referred to as p110 or p68 (proteolytically processed form). Relish is an NF-kappa B-like transcription factor, which plays a role in mediating innate immunity in Drosophila. It is activated via the Imd (immune deficiency) pathway, which triggers phosphorylation of Relish. IKK-dependent proteolytic cleavage of Relish (which involves Dredd) results in a smaller active form (without the C-terminal ankyrin repeats), which is transported into the nucleus and functions as a transactivator.


Pssm-ID: 143644  Cd Length: 159  Bit Score: 103.28  E-value: 1.16e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 103 PYLVITEQPKQRgMRFRYECEGR-SAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLV-WKDWPHRVHPHSLVGKD 180
Cdd:cd07884   1 PFLRIVEQPVDK-FRFRYKSEMHgTHGSLLGERSTSSKKTFPTVKLCNYRG--QAVIRCSLYqADDNRRKPHVHKLVGKQ 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 181 CTDGVCRVRLrPHVSPRH----SFNNLGIQCVRKKEIEAAIERKiqlgidpynagslKNhqeVDMNVVRICFQASYRDQQ 256
Cdd:cd07884  78 GDDDVCDPHD-IEVSPEGdyvaMFQNMGIIHTAKKNIPEELYKK-------------KN---MNLNQVVLRFQAFAVSAN 140

                       170
                ....*....|....*....
gi 31982053 257 GHLHRM-DPILSEPVYDKK 274
Cdd:cd07884 141 GHLRPIcPPVYSNPINNLK 159
RelB_leu_zip pfam16180
RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.
 1-76 1.13e-18

RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.


Pssm-ID: 374415  Cd Length: 84  Bit Score: 80.86  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053     1 MPSRRAARESA-PELGALGSSDLSSLSLTVSRTTdelEIIDEYIKENGFGLDGTQL---SEMPRLVPRGPASLSSVTLGP 76
Cdd:pfam16180   1 MPSRRVARSSAaPELGPLGSADLSSLSLAVSRTT---EIIDEYIKENGFGLAGSQPgsgAGLPRLVSRGAASLSSVTLGP 77
IPT smart00429
ig-like, plexins, transcription factors;
280-376 1.11e-17

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 78.23  E-value: 1.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053    280 ELRICRINKESGPCTGGEELyLLCDKVQKEDISVVFSTASWEGRADFSQAdvhRQIAIVFKTPPYEDLEISEPVTvNVFL 359
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 31982053    360 QRltDGVCSEPLPFTYL 376
Cdd:smart00429  76 RN--GGVPSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 281-377 3.37e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.48  E-value: 3.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 281 LRICRINKESGPCTGGEELYLLCDKVQKE-DISVVFStasweGRADFSQADVHrQIAIVFKTPPYEDleiSEPVTVNVFL 359
Cdd:cd00102   1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFG-----GGVPCSVLSVS-STAIVCTTPPYAN---PGPGPVEVTV 71

                        90
                ....*....|....*...
gi 31982053 360 QRLTDGVCSEPLPFTYLP 377
Cdd:cd00102  72 DRGNGGITSSPLTFTYVP 89
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 283-377 1.04e-06

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 47.09  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982053 283 ICRINKESGPCTGGEELYLLCDKVQKeDISVVF------STASWEGRADFSQADVHrQIAIVFKTPPYEDLEISEPVTVN 356
Cdd:cd01178   4 IEKKSLNSCSVNGGEELFLTGKNFLK-DSKVVFqekgqdGEAQWEAEATIDKEKSH-QNHLVVEVPPYHNKHVAAPVQVQ 81

                        90       100
                ....*....|....*....|....*..
gi 31982053 357 VFlqrltdgVC------SEPLPFTYLP 377
Cdd:cd01178  82 FY-------VVngkrkrSQPQTFTYTP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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