NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|31982042|ref|NP_758493|]
View 

neutral amino acid uniporter 4 isoform 1 [Mus musculus]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
54-469 2.28e-72

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 235.28  E-value: 2.28e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042    54 HGISFLQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKStLGYSDTVSFAM 133
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGKRN-KSYGDLGYRLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   134 easpwsclqrqAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIvsngsdlshacerrsvDLRVYMLCF 213
Cdd:pfam01490  80 -----------GPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTCPI----------------SLVYFIIIF 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   214 LPLIILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNL-PIVAGW-----KKYPLFFGTAVFAFEGIGVV 287
Cdd:pfam01490 133 GLIFIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAVL 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   288 LPLENQMRESKRFPQ---ALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQF 364
Cdd:pfam01490 213 LPIQNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQL 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   365 YVPAEII--------IPGVTARLHAKWKRICEFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILT 436
Cdd:pfam01490 293 FPIRQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKL 372
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 31982042   437 FSKDHYNI-WMIL---KNISIAFTGVVGFLLGTYVTV 469
Cdd:pfam01490 373 KKTKKKSQeKLWKpdiLDVICIVIGLLLMAYGVAGLI 409
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
54-469 2.28e-72

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 235.28  E-value: 2.28e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042    54 HGISFLQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKStLGYSDTVSFAM 133
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGKRN-KSYGDLGYRLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   134 easpwsclqrqAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIvsngsdlshacerrsvDLRVYMLCF 213
Cdd:pfam01490  80 -----------GPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTCPI----------------SLVYFIIIF 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   214 LPLIILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNL-PIVAGW-----KKYPLFFGTAVFAFEGIGVV 287
Cdd:pfam01490 133 GLIFIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAVL 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   288 LPLENQMRESKRFPQ---ALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQF 364
Cdd:pfam01490 213 LPIQNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQL 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   365 YVPAEII--------IPGVTARLHAKWKRICEFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILT 436
Cdd:pfam01490 293 FPIRQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKL 372
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 31982042   437 FSKDHYNI-WMIL---KNISIAFTGVVGFLLGTYVTV 469
Cdd:pfam01490 373 KKTKKKSQeKLWKpdiLDVICIVIGLLLMAYGVAGLI 409
PTZ00206 PTZ00206
amino acid transporter; Provisional
70-469 3.82e-08

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 55.64  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   70 IGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILvrcshflcqrfkksTLGYSDTVSFAMEASPWSCLQRQAAWGR 149
Cdd:PTZ00206  74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYAL--------------GVAADKTNIRTYEGVARVLLGPWGSYYV 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  150 SVVDFFLVITQlgfCSVYIVFLAENVKQVHEGflgstpivSNGSDLSHACERRSVDLRVYMLCF-LPLIIllvfIRELKN 228
Cdd:PTZ00206 140 AATRAFHGFSA---CVAYVISVGDILSATLKG--------TNAPDFLKQKSGNRLLTSLMWLCFmLPLVI----PRHIDS 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  229 LFVLSFLANISMAASLVIIYQYVVRNMPdPHNLPIVAGWKK---YPLFFGTAVFAFEGIGV--------VLPLENQM--- 294
Cdd:PTZ00206 205 LRYVSTIAVSFMVYLVIVIVVHSCMNGL-PENIKNVSVGKDdnaEIILFNSGNRAIEGLGVfifayvfqITAYEVYMdmt 283
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  295 -RESKRFPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITL-----NLPQDMWLYQSVKILysfgIFVTYSIQFYV-- 366
Cdd:PTZ00206 284 nRSVGKFVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLmydpvNEPAIMVGFVGVLVK----LFVSYALLGMAcr 359
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  367 PAEIIIPGVTARLHAKWKRiCEFGIRSLLVSITCagAILIPRLDIVISFVGAVSSSTLALILPPLVEILT--FSKDHYNI 444
Cdd:PTZ00206 360 NALYDVIGWDARKVAFWKH-CIAVVTLSVVMLLC--GLFIPKINTVLGFAGSISGGLLGFILPALLFMYSggFTWQKVGP 436
                        410       420
                 ....*....|....*....|....*
gi 31982042  445 WMILKNISIAFTGVVGFLLGTYVTV 469
Cdd:PTZ00206 437 FYYISTYVVLITGVIAIVFGTGATI 461
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
217-481 9.94e-03

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 38.34  E-value: 9.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042 217 IILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRE 296
Cdd:COG0531 138 LLNLRGVKESAKVNNILTVLKLLVLLLFIVVGLFAFDPANFTPFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKN 217
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042 297 SKR-FPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDM------WLYQSVKILYSFGIFVTYSIQFYVPAE 369
Cdd:COG0531 218 PKRnIPRAIILSLLIVGVLYILVSLALTGVVPYDELAASGAPLADAAeavfgpWGAILIALGALLSLLGALNASILGASR 297
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042 370 II--------IPGVTARLHAKWKriceFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKDH 441
Cdd:COG0531 298 LLyamardglLPKVFAKVHPRFG----TPVNAILLTGVIALLLLLLGAASFTALASLASVGVLLAYLLVALAVIVLRRRR 373
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31982042 442 YNI---WMILKNIsIAFTGVVGFLLGTYVTVEEIIYPTTAVVA 481
Cdd:COG0531 374 PDLprpFRVPLPL-IPILGILLCLFLLYLLGPGALLIGLVLLA 415
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
54-469 2.28e-72

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 235.28  E-value: 2.28e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042    54 HGISFLQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKStLGYSDTVSFAM 133
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGKRN-KSYGDLGYRLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   134 easpwsclqrqAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIvsngsdlshacerrsvDLRVYMLCF 213
Cdd:pfam01490  80 -----------GPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTCPI----------------SLVYFIIIF 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   214 LPLIILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNL-PIVAGW-----KKYPLFFGTAVFAFEGIGVV 287
Cdd:pfam01490 133 GLIFIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAVL 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   288 LPLENQMRESKRFPQ---ALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQF 364
Cdd:pfam01490 213 LPIQNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQL 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   365 YVPAEII--------IPGVTARLHAKWKRICEFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILT 436
Cdd:pfam01490 293 FPIRQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKL 372
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 31982042   437 FSKDHYNI-WMIL---KNISIAFTGVVGFLLGTYVTV 469
Cdd:pfam01490 373 KKTKKKSQeKLWKpdiLDVICIVIGLLLMAYGVAGLI 409
PTZ00206 PTZ00206
amino acid transporter; Provisional
70-469 3.82e-08

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 55.64  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042   70 IGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILvrcshflcqrfkksTLGYSDTVSFAMEASPWSCLQRQAAWGR 149
Cdd:PTZ00206  74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYAL--------------GVAADKTNIRTYEGVARVLLGPWGSYYV 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  150 SVVDFFLVITQlgfCSVYIVFLAENVKQVHEGflgstpivSNGSDLSHACERRSVDLRVYMLCF-LPLIIllvfIRELKN 228
Cdd:PTZ00206 140 AATRAFHGFSA---CVAYVISVGDILSATLKG--------TNAPDFLKQKSGNRLLTSLMWLCFmLPLVI----PRHIDS 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  229 LFVLSFLANISMAASLVIIYQYVVRNMPdPHNLPIVAGWKK---YPLFFGTAVFAFEGIGV--------VLPLENQM--- 294
Cdd:PTZ00206 205 LRYVSTIAVSFMVYLVIVIVVHSCMNGL-PENIKNVSVGKDdnaEIILFNSGNRAIEGLGVfifayvfqITAYEVYMdmt 283
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  295 -RESKRFPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITL-----NLPQDMWLYQSVKILysfgIFVTYSIQFYV-- 366
Cdd:PTZ00206 284 nRSVGKFVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLmydpvNEPAIMVGFVGVLVK----LFVSYALLGMAcr 359
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042  367 PAEIIIPGVTARLHAKWKRiCEFGIRSLLVSITCagAILIPRLDIVISFVGAVSSSTLALILPPLVEILT--FSKDHYNI 444
Cdd:PTZ00206 360 NALYDVIGWDARKVAFWKH-CIAVVTLSVVMLLC--GLFIPKINTVLGFAGSISGGLLGFILPALLFMYSggFTWQKVGP 436
                        410       420
                 ....*....|....*....|....*
gi 31982042  445 WMILKNISIAFTGVVGFLLGTYVTV 469
Cdd:PTZ00206 437 FYYISTYVVLITGVIAIVFGTGATI 461
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
217-481 9.94e-03

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 38.34  E-value: 9.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042 217 IILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRE 296
Cdd:COG0531 138 LLNLRGVKESAKVNNILTVLKLLVLLLFIVVGLFAFDPANFTPFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKN 217
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042 297 SKR-FPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQDM------WLYQSVKILYSFGIFVTYSIQFYVPAE 369
Cdd:COG0531 218 PKRnIPRAIILSLLIVGVLYILVSLALTGVVPYDELAASGAPLADAAeavfgpWGAILIALGALLSLLGALNASILGASR 297
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982042 370 II--------IPGVTARLHAKWKriceFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKDH 441
Cdd:COG0531 298 LLyamardglLPKVFAKVHPRFG----TPVNAILLTGVIALLLLLLGAASFTALASLASVGVLLAYLLVALAVIVLRRRR 373
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31982042 442 YNI---WMILKNIsIAFTGVVGFLLGTYVTVEEIIYPTTAVVA 481
Cdd:COG0531 374 PDLprpFRVPLPL-IPILGILLCLFLLYLLGPGALLIGLVLLA 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH