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Conserved domains on  [gi|31791006|ref|NP_853652|]
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keratin-associated protein 13-2 [Homo sapiens]

Protein Classification

PMG domain-containing protein( domain architecture ID 12062579)

PMG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-170 5.84e-45

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


:

Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 146.11  E-value: 5.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31791006     1 MSYNCCSGNFSSRSCGDYLRYPASSRGFSYPSNLVYSTDLCSPSTCQLGSSLYRGCQEICWEPTSCQTSYVES------- 73
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHYPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPctsstsy 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31791006    74 ---SPCQTSCYRPRTSLLCSPCKTTYSGSLGFGSSSCRSLGYGSRSCYSVGCGSSGVRSLGYGSCGFPSLGYGSGFCRPT 150
Cdd:pfam05287  81 cvpSPCQRSCYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPS 160

                         170       180
                  ....*....|....*....|
gi 31791006   151 YLASRSCQSPCYRPAYGSTF 170
Cdd:pfam05287 161 YVSSRSYQPSCFRPSCGSGF 180
 
Name Accession Description Interval E-value
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-170 5.84e-45

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 146.11  E-value: 5.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31791006     1 MSYNCCSGNFSSRSCGDYLRYPASSRGFSYPSNLVYSTDLCSPSTCQLGSSLYRGCQEICWEPTSCQTSYVES------- 73
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHYPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPctsstsy 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31791006    74 ---SPCQTSCYRPRTSLLCSPCKTTYSGSLGFGSSSCRSLGYGSRSCYSVGCGSSGVRSLGYGSCGFPSLGYGSGFCRPT 150
Cdd:pfam05287  81 cvpSPCQRSCYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPS 160

                         170       180
                  ....*....|....*....|
gi 31791006   151 YLASRSCQSPCYRPAYGSTF 170
Cdd:pfam05287 161 YVSSRSYQPSCFRPSCGSGF 180
 
Name Accession Description Interval E-value
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-170 5.84e-45

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 146.11  E-value: 5.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31791006     1 MSYNCCSGNFSSRSCGDYLRYPASSRGFSYPSNLVYSTDLCSPSTCQLGSSLYRGCQEICWEPTSCQTSYVES------- 73
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHYPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPctsstsy 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31791006    74 ---SPCQTSCYRPRTSLLCSPCKTTYSGSLGFGSSSCRSLGYGSRSCYSVGCGSSGVRSLGYGSCGFPSLGYGSGFCRPT 150
Cdd:pfam05287  81 cvpSPCQRSCYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPS 160

                         170       180
                  ....*....|....*....|
gi 31791006   151 YLASRSCQSPCYRPAYGSTF 170
Cdd:pfam05287 161 YVSSRSYQPSCFRPSCGSGF 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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