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Conserved domains on  [gi|317373472|sp|P33076|]
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RecName: Full=MHC class II transactivator; Short=CIITA

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 789-1114 2.80e-80

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 265.37  E-value: 2.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  789 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 866
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  867 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 941
Cdd:cd00116    71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  942 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1019
Cdd:cd00116   150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472 1020 LNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRRC 1099
Cdd:cd00116   226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                         330
                  ....*....|....*
gi 317373472 1100 PHVETLAMWTPTIPF 1114
Cdd:cd00116   305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 414-583 5.42e-52

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 179.81  E-value: 5.42e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 492
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   493 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 570
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 317373472   571 MEQAQAYVMRYFE 583
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 713-818 8.30e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.43  E-value: 8.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   713 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 781
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 317373472   782 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 818
Cdd:pfam17776   81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 789-1114 2.80e-80

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 265.37  E-value: 2.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  789 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 866
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  867 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 941
Cdd:cd00116    71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  942 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1019
Cdd:cd00116   150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472 1020 LNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRRC 1099
Cdd:cd00116   226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                         330
                  ....*....|....*
gi 317373472 1100 PHVETLAMWTPTIPF 1114
Cdd:cd00116   305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 414-583 5.42e-52

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 179.81  E-value: 5.42e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 492
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   493 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 570
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 317373472   571 MEQAQAYVMRYFE 583
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 984-1105 4.78e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 72.52  E-value: 4.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  984 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNcICDVGAES 1063
Cdd:COG5238   264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNG-IGAQGAIA 339

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 317373472 1064 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1105
Cdd:COG5238   340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 713-818 8.30e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.43  E-value: 8.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   713 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 781
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 317373472   782 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 818
Cdd:pfam17776   81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1014-1039 6.55e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 6.55e-04
                            10        20
                    ....*....|....*....|....*.
gi 317373472   1014 LKSLETLNLSQNNITDLGAYKLAEAL 1039
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 985-1034 1.60e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 317373472   985 SLQHLDLdalSENKIGDEGVsqlsatFPQLKSLETLNLSQNN-ITDLGAYK 1034
Cdd:pfam12799    2 NLEVLDL---SNNQITDIPP------LAKLPNLETLDLSGNNkITDLSDLA 43
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 789-1114 2.80e-80

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 265.37  E-value: 2.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  789 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 866
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  867 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 941
Cdd:cd00116    71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  942 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1019
Cdd:cd00116   150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472 1020 LNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRRC 1099
Cdd:cd00116   226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                         330
                  ....*....|....*
gi 317373472 1100 PHVETLAMWTPTIPF 1114
Cdd:cd00116   305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 414-583 5.42e-52

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 179.81  E-value: 5.42e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 492
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   493 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 570
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 317373472   571 MEQAQAYVMRYFE 583
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 984-1105 4.78e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 72.52  E-value: 4.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  984 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNcICDVGAES 1063
Cdd:COG5238   264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNG-IGAQGAIA 339

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 317373472 1064 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1105
Cdd:COG5238   340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 987-1122 1.08e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 71.36  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  987 QHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALpSLAASLLRLSLYNNCICDVGAESLAR 1066
Cdd:COG5238   180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472 1067 VLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPF----SVQEHLQQ 1122
Cdd:COG5238   259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 976-1127 1.35e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 71.36  E-value: 1.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  976 LVRILTAFSSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALpSLAASLLRLSLYNNC 1055
Cdd:COG5238   284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL-QENTTLHSLDLSDNQ 359

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373472 1056 ICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRcPHVETLAMWTPTIPFSVQEHLQQQDSRI 1127
Cdd:COG5238   360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
329-995 5.00e-11

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 67.14  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  329 NKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHR 408
Cdd:COG5635    88 ESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERI 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  409 RPRET--------RVIAVLGKAGQGKS----YWAgavSRAWACGRLPQYDFVFSVPCHCLNRPGDaygLQDLLFSLGPQP 476
Cdd:COG5635   168 ESLKRlelleakkKRLLILGEPGSGKTtllrYLA---LELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKR 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  477 LVAADEVFSHILKRpDRVLLILDGFEELeaqdgflhstcgPAPAEPCSLRGLLAGLFQKklLRGCTLLLTARPRGRLVQS 556
Cdd:COG5635   242 GGEPEDALERLLRN-GRLLLLLDGLDEV------------PDEADRDEVLNQLRRFLER--YPKARVIITSRPEGYDSSE 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  557 LSKADAlFELSGFSMEQAQAYVMRYFESsgMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLsealleLGEDAKLPST 636
Cdd:COG5635   307 LEGFEV-LELAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALL------LRERGELPDT 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  637 LTGLYVGLL---------GRAALDSPPGALAE----LAKLAWELgrrHQStlQEDQFPSADVRTWAMAKGLVQHPPRAAE 703
Cdd:COG5635   378 RAELYEQFVelllerwdeQRGLTIYRELSREElrelLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALL 452

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  704 SELAFPSFLLQC---------------FLGALWLAlsgeikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLI--FQPP 766
Cdd:COG5635   453 DELLLRTGLLVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLddVKQI 524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  767 ARCLGALL-GPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDA 845
Cdd:COG5635   525 KELIDALLaRDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLL 604

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  846 HVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGL--SCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAK 923
Cdd:COG5635   605 LLLLLLLLLLLLALALLLALLLLLLLLLLAELLLlaLLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLA 684

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373472  924 SLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALS 995
Cdd:COG5635   685 LLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESS 756
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
980-1105 8.33e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 8.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  980 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGAY-----KLaEALpslaasllrlSLYNN 1054
Cdd:COG4886   109 LSNLTNLESLDL---SGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEPlgnltNL-KSL----------DLSNN 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 317373472 1055 CICDVGAEslarvLPDMVSLRVMDVQYNKFTAagaqqLAASLRRCPHVETL 1105
Cdd:COG4886   170 QLTDLPEE-----LGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEEL 210
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 994-1105 1.16e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472  994 LSENKIGDEGVSQLS-ATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLyNNCICDVGAESLARVLPDMV 1072
Cdd:COG5238   158 LLGLAARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLK-RNPIGDEGAEILAEALKGNK 236

                          90       100       110
                  ....*....|....*....|....*....|...
gi 317373472 1073 SLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1105
Cdd:COG5238   237 SLTTLDLSNNQIGDEGVIALAEALKNNTTVETL 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
980-1030 1.47e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 317373472  980 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDL 1030
Cdd:COG4886   201 LGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL 243
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 713-818 8.30e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.43  E-value: 8.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373472   713 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 781
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 317373472   782 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 818
Cdd:pfam17776   81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
980-1032 1.23e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373472  980 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGA 1032
Cdd:COG4886   178 LGNLTNLKELDL---SNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPE 222
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1014-1039 6.55e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 6.55e-04
                            10        20
                    ....*....|....*....|....*.
gi 317373472   1014 LKSLETLNLSQNNITDLGAYKLAEAL 1039
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1073-1097 1.04e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 1.04e-03
                            10        20
                    ....*....|....*....|....*
gi 317373472   1073 SLRVMDVQYNKFTAAGAQQLAASLR 1097
Cdd:smart00368    3 SLRELDLSNNKLGDEGARALAEALK 27
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 978-1030 1.24e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 317373472  978 RILTAFS-SLQHLDLdalSENKIGDegVSQLSAtfpqLKSLETLNLSQNNITDL 1030
Cdd:cd21340   113 RSLAALSnSLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDL 157
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 985-1034 1.60e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 317373472   985 SLQHLDLdalSENKIGDEGVsqlsatFPQLKSLETLNLSQNN-ITDLGAYK 1034
Cdd:pfam12799    2 NLEVLDL---SNNQITDIPP------LAKLPNLETLDLSGNNkITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
984-1030 5.15e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 5.15e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 317373472   984 SSLQHLDLDAlseNKIgdEGVSQlsATFPQLKSLETLNLSQNNITDL 1030
Cdd:pfam13855    1 PNLRSLDLSN---NRL--TSLDD--GAFKGLSNLKVLDLSNNLLTTL 40
LRR_8 pfam13855
Leucine rich repeat;
981-1027 7.95e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 7.95e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 317373472   981 TAFSSLQHL-DLDaLSENKIgdegvSQLSA-TFPQLKSLETLNLSQNNI 1027
Cdd:pfam13855   19 GAFKGLSNLkVLD-LSNNLL-----TTLSPgAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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