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Conserved domains on  [gi|31711499|dbj|BAC77639|]
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OsCTP [Oryza sativa Indica Group]

Protein Classification

gamma-glutamylcyclotransferase family protein( domain architecture ID 366289)

gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl

CATH:  3.10.490.10
Gene Ontology:  GO:0016746
PubMed:  18515354|20110353
SCOP:  4002485

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGCT_like super family cl22886
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 2-101 6.51e-21

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


The actual alignment was detected with superfamily member pfam04752:

Pssm-ID: 451440  Cd Length: 176  Bit Score: 83.21  E-value: 6.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31711499     2 KYLERRECE--YDQKiSVDFYKEGDSLKPAVTgVLVFVSTPDpvgNKYYLGPAPLEDMARQIATANGPNGNNRDYLFSME 79
Cdd:pfam04752  77 EYLDVREQIngYTTH-EVPFYPDQDTDGRPVN-ALVYVATPK---NPQYLGDDPLEQIAKQIATARGPSGPNAEYLFELA 151

                          90       100
                  ....*....|....*....|....
gi 31711499    80 KALSNICHE--DDSIIELANEVRK 101
Cdd:pfam04752 152 QALRKLGPGvqDDHLFELEKLVKK 175
 
Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 2-101 6.51e-21

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


Pssm-ID: 398428  Cd Length: 176  Bit Score: 83.21  E-value: 6.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31711499     2 KYLERRECE--YDQKiSVDFYKEGDSLKPAVTgVLVFVSTPDpvgNKYYLGPAPLEDMARQIATANGPNGNNRDYLFSME 79
Cdd:pfam04752  77 EYLDVREQIngYTTH-EVPFYPDQDTDGRPVN-ALVYVATPK---NPQYLGDDPLEQIAKQIATARGPSGPNAEYLFELA 151

                          90       100
                  ....*....|....*....|....
gi 31711499    80 KALSNICHE--DDSIIELANEVRK 101
Cdd:pfam04752 152 QALRKLGPGvqDDHLFELEKLVKK 175
ChaC2 COG3703
Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and ...
 34-100 4.75e-14

Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and metabolism];


Pssm-ID: 442917  Cd Length: 190  Bit Score: 65.22  E-value: 4.75e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31711499  34 LVFVSTPDpvgNKYYLGPAPLEDMARQIATANGPNGNNRDYLFSMEKALSNICHEDDSIIELANEVR 100
Cdd:COG3703 120 LAFVADRD---HPQYAGGLSLEEQARIIAQAVGPSGSNADYLLNTAEHLRELGIRDPHLEALARLVR 183
 
Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 2-101 6.51e-21

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


Pssm-ID: 398428  Cd Length: 176  Bit Score: 83.21  E-value: 6.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31711499     2 KYLERRECE--YDQKiSVDFYKEGDSLKPAVTgVLVFVSTPDpvgNKYYLGPAPLEDMARQIATANGPNGNNRDYLFSME 79
Cdd:pfam04752  77 EYLDVREQIngYTTH-EVPFYPDQDTDGRPVN-ALVYVATPK---NPQYLGDDPLEQIAKQIATARGPSGPNAEYLFELA 151

                          90       100
                  ....*....|....*....|....
gi 31711499    80 KALSNICHE--DDSIIELANEVRK 101
Cdd:pfam04752 152 QALRKLGPGvqDDHLFELEKLVKK 175
ChaC2 COG3703
Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and ...
 34-100 4.75e-14

Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and metabolism];


Pssm-ID: 442917  Cd Length: 190  Bit Score: 65.22  E-value: 4.75e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31711499  34 LVFVSTPDpvgNKYYLGPAPLEDMARQIATANGPNGNNRDYLFSMEKALSNICHEDDSIIELANEVR 100
Cdd:COG3703 120 LAFVADRD---HPQYAGGLSLEEQARIIAQAVGPSGSNADYLLNTAEHLRELGIRDPHLEALARLVR 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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