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Conserved domains on  [gi|316936401|gb|ADU60213|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Drosophila nr. dorsigera RL-2010]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-164 5.45e-40

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 137.26  E-value: 5.45e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   1 MFNNSSKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISN-KKNLMSSESSLKYFLIQALASIILLFSIILNM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  81 LKNNlnneINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLKNLLLISVIFSVI 160
Cdd:MTH00160  80 LNLM----LFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAI 155


                 ....
gi 316936401 161 VGAI 164
Cdd:MTH00160 156 IGAI 159
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-164 5.45e-40

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 137.26  E-value: 5.45e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   1 MFNNSSKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISN-KKNLMSSESSLKYFLIQALASIILLFSIILNM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  81 LKNNlnneINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLKNLLLISVIFSVI 160
Cdd:MTH00160  80 LNLM----LFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAI 155


                 ....
gi 316936401 161 VGAI 164
Cdd:MTH00160 156 IGAI 159
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-164 7.55e-14

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 67.34  E-value: 7.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   24 SNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAVIL-------------LMLKNNLNNEIN 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   91 ESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMN-ALLLMTWQKIAPLMLI--------SYLNLKNLLLISVIFSVIV 161
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLIrrsllylpSSPFIQQILLILAIISMLL 160


                  ...
gi 316936401  162 GAI 164
Cdd:pfam00361 161 GSL 163
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 9-121 6.36e-07

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 47.80  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   9 LFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLF-------------- 74
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYgisllygatgslnl 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 316936401  75 AVILLMLKNNLNNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEG 121
Cdd:COG1007  186 AGIAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEG 232
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-164 6.42e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 47.64  E-value: 6.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   15 IIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAV-----------ILLMLKN 83
Cdd:TIGR01770 112 LLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgslnFEDLLLF 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   84 NLNNEINESFISM---IMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLI----------SYLNLKNL 150
Cdd:TIGR01770 192 LSNGMLNISLLLLgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFlrlflyilfgFSEAWQIF 271

                         170
                  ....*....|....
gi 316936401  151 LLISVIFSVIVGAI 164
Cdd:TIGR01770 272 LAIIAFLSMLIGNF 285
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-164 5.45e-40

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 137.26  E-value: 5.45e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   1 MFNNSSKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISN-KKNLMSSESSLKYFLIQALASIILLFSIILNM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  81 LKNNlnneINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLKNLLLISVIFSVI 160
Cdd:MTH00160  80 LNLM----LFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAI 155


                 ....
gi 316936401 161 VGAI 164
Cdd:MTH00160 156 IGAI 159
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 8-163 8.04e-32

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 116.48  E-value: 8.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   8 ILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLMLKNN--L 85
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMK-KHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGqwT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  86 NNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLI----SYLNLkNLLLISVIFSVIV 161
Cdd:MTH00105  86 ITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqisPSINP-NLLLTLAILSILI 164


                 ..
gi 316936401 162 GA 163
Cdd:MTH00105 165 GG 166
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 6-162 2.45e-31

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 114.92  E-value: 2.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   6 SKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNfKSTEASLKYFLTQALASTVLLFAVILLMLKNNL 85
Cdd:MTH00112   5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHP-RATEAATKYFLTQAAASALILFSSTTNAWNTGQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  86 --NNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAP---LMLISYLNLKNLLLISVIFSVI 160
Cdd:MTH00112  84 wdITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPltlLLMTSNSLNPTLLLTLAILSTL 163


                 ..
gi 316936401 161 VG 162
Cdd:MTH00112 164 IG 165
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 5-164 3.67e-27

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 103.81  E-value: 3.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   5 SSKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFkSTEASLKYFLTQALASTVLLFAVILLMLKNn 84
Cdd:MTH00144   4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSS-ESESVVKYFIIQSLGSSLLIFGSLIMYNLS- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  85 lnneiNESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLN----LKNLLLISVIFSVI 160
Cdd:MTH00144  82 -----FSWFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlywLAYLLCVISVLSAL 156


                 ....
gi 316936401 161 VGAI 164
Cdd:MTH00144 157 VGSI 160
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 10-162 1.19e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 102.69  E-value: 1.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  10 FITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLMLKNNLNNEI 89
Cdd:MTH00070   9 LLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTK-THHPRATEAATKYFLTQASASALILFSSTINAWFTGEWTIM 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 316936401  90 N-ESFISMIMLST-LLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLML---ISYLNLKNLLLISVIFSVIVG 162
Cdd:MTH00070  88 NmQTPLPTIMLTIaLMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALliqISHLLNSNLLIIMGLLSTLIG 165
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 3-164 5.91e-26

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 100.78  E-value: 5.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   3 NNSSKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLMLK 82
Cdd:MTH00041   2 NRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSS-NFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  83 NN--LNNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLN---LKNLLLISVIF 157
Cdd:MTH00041  81 SGswSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISnllNSNILILCGIL 160


                 ....*..
gi 316936401 158 SVIVGAI 164
Cdd:MTH00041 161 SVLVGGW 167
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 16-162 1.42e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 99.88  E-value: 1.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  16 IGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLMLKN--NLNNEINESF 93
Cdd:MTH00135  15 LGTTLTFASSHWLLAWMGLEINTLAIIPLMAQ-HHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTgqWDIQQMSHPL 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 316936401  94 ISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLNLKN--LLLISVIFSVIVG 162
Cdd:MTH00135  94 PTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNptLLITLGLTSTLVG 164
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 9-146 3.84e-23

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 92.92  E-value: 3.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   9 LFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNfKSTEASLKYFLTQALASTVLLFAVILLMLKNNLNNe 88
Cdd:MTH00011  10 LFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMN-QESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLLK- 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 316936401  89 ineSFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYLN 146
Cdd:MTH00011  88 ---NITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFT 142
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 9-164 3.03e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 88.10  E-value: 3.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   9 LFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNfKSTEASLKYFLTQALASTVLLFAVILLMLKNNL--N 86
Cdd:MTH00200   8 LFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHP-RKVEATTKYFIIQATASALLLFGGLLNAWTSGQwgI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  87 NEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLML---ISYLNLKNLLLISVIFSVIVGA 163
Cdd:MTH00200  87 SEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALliqLAPALNSNILLLLGLLSVLVGG 166


                 .
gi 316936401 164 I 164
Cdd:MTH00200 167 W 167
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 9-164 1.02e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 83.57  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   9 LFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDdNNNFKSTEASLKYFLTQALASTVLLFAVILLMLKNNLnne 88
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQ-NKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYL--- 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 316936401  89 inESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLISYL-NLKNLLLISVIFSVIVGAI 164
Cdd:MTH00197  78 --SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNsSSFMGLLICSVLSSLIGGI 152
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-164 7.55e-14

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 67.34  E-value: 7.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   24 SNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAVIL-------------LMLKNNLNNEIN 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   91 ESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMN-ALLLMTWQKIAPLMLI--------SYLNLKNLLLISVIFSVIV 161
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVsALLAATLVKAGGYGLIrrsllylpSSPFIQQILLILAIISMLL 160


                  ...
gi 316936401  162 GAI 164
Cdd:pfam00361 161 GSL 163
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-164 8.22e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 67.75  E-value: 8.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  13 MMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAVI--------------- 77
Cdd:MTH00196   1 MVALGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCAllcgttgglhlsyin 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  78 LLMLKNNLNNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPL-MLISYLNLKNLLLISVI 156
Cdd:MTH00196  81 LVLNSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFsILVSIGLNVNILLIGGL 160


                 ....*...
gi 316936401 157 FSVIVGAI 164
Cdd:MTH00196 161 FSLFVGAI 168
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 5-164 7.91e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 61.96  E-value: 7.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   5 SSKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAVILLM---- 80
Cdd:MTH00199  97 QSSPILILIVALGSLLLVSSINWLSIYLAIELQTLTLFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYgltg 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  81 ------LKNNLNNEINESFISMimlsTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPL-MLISYLNLKNLLLI 153
Cdd:MTH00199 177 etsiqgINSILTGDVGKILITI----SLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFsILVQIGPVTNVVLI 252

                        170
                 ....*....|.
gi 316936401 154 SVIFSVIVGAI 164
Cdd:MTH00199 253 CAVLSIIYGAI 263
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
13-121 7.30e-08

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 50.59  E-value: 7.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  13 MMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLL--------------FAVIL 78
Cdd:PRK05777 111 FALLGMMVMVSANDLLTLFLGLELLSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLygmsllygatgslsFAGIA 190

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 316936401  79 LMLKNNLNNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEG 121
Cdd:PRK05777 191 KALADGSGNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEG 233
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 9-121 6.36e-07

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 47.80  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   9 LFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLF-------------- 74
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYgisllygatgslnl 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 316936401  75 AVILLMLKNNLNNEINESFISMIMLSTLLLKSGAAPFHFWFPNLMEG 121
Cdd:COG1007  186 AGIAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEG 232
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-164 6.42e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 47.64  E-value: 6.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   15 IIGTLITVTSNSWLGAWMGLEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAV-----------ILLMLKN 83
Cdd:TIGR01770 112 LLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgslnFEDLLLF 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   84 NLNNEINESFISM---IMLSTLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLMLI----------SYLNLKNL 150
Cdd:TIGR01770 192 LSNGMLNISLLLLgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFlrlflyilfgFSEAWQIF 271

                         170
                  ....*....|....
gi 316936401  151 LLISVIFSVIVGAI 164
Cdd:TIGR01770 272 LAIIAFLSMLIGNF 285
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 6-163 7.07e-05

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 41.77  E-value: 7.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401   6 SKILFITMMIIGTLITVTSNSWLGAWMGLEINLLSFIPLM---SDDNNNFKST-----EASLKYFLTQALASTVLLFA-- 75
Cdd:MTH00198 189 SGFALVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAgegSQPGSHFPSPgntppESGLKYWILGAMSSGFYLFGca 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  76 -------------VILLMLKNNLNNEINESFISMIMLS-TLLLKSGAAPFHFWFPNLMEGLTWMNALLLMTWQKIAPLML 141
Cdd:MTH00198 269 lyfgftgnegmlgTILSATLETTNIELRQGSLGYLFITvAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYIL 348

                        170       180
                 ....*....|....*....|...
gi 316936401 142 ISYLNLKNLLLISV-IFSVIVGA 163
Cdd:MTH00198 349 LTSLVITSKLLLSVaIISLVVGA 371
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 34-117 1.00e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 38.54  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 316936401  34 LEINLLSFIPLMSDDNNNFKSTEASLKYFLTQALASTVLLFAV--------ILLMLKNNLNNEINESFISMIMLS----T 101
Cdd:PRK08376 150 LEIMSIASYALVAFRNDTWEAIEAGIKYMFVGSLASSMVLLGIallygqygTLNMAYLAVKMSENPTVVAKIALAlfiaG 229

                         90
                 ....*....|....*.
gi 316936401 102 LLLKSGAAPFHFWFPN 117
Cdd:PRK08376 230 LAMKSGAVPVHMWLPD 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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