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Conserved domains on  [gi|31543630|ref|NP_005406|]
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sodium-dependent phosphate transporter 1 [Homo sapiens]

Protein Classification

inorganic phosphate transporter( domain architecture ID 10475700)

inorganic phosphate transporter is involved in phosphate transport, such as bacterial low-affinity inorganic phosphate transporter and vertebrate sodium-dependent phosphate transporters, which play fundamental housekeeping roles in phosphate transport

Gene Ontology:  GO:0005315|GO:0006817|GO:0016020
TCDB:  2.A.20

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
503-665 6.50e-78

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


:

Pssm-ID: 460184  Cd Length: 322  Bit Score: 251.65  E-value: 6.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   503 WYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLV-ALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGR 581
Cdd:pfam01384 159 IRAKYDNKVERLFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGW 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   582 RVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPIS 661
Cdd:pfam01384 239 RIIKTVGNKITKLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVA 318

                  ....
gi 31543630   662 GVIS 665
Cdd:pfam01384 319 ALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
40-241 6.84e-65

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


:

Pssm-ID: 460184  Cd Length: 322  Bit Score: 217.37  E-value: 6.84e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630    40 GANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMynsTQGLLMAGSVSAMFGSAVWQLV 119
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALLGAAIWLLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   120 ASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADP--------- 190
Cdd:pfam01384  78 ATYLGLPVSSTHALVGALIGAGLAAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   191 ---------VPNGLRALPVFYACTV----GIN------------LFSIMYTGAPLLGFDkLPLW----GTILISVGCAVF 241
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVsfahGANdvqnamgpltaaLYAIGTTGEVASKAP-VPLWvlllGALAIALGTWTG 236
 
Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
503-665 6.50e-78

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 251.65  E-value: 6.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   503 WYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLV-ALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGR 581
Cdd:pfam01384 159 IRAKYDNKVERLFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGW 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   582 RVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPIS 661
Cdd:pfam01384 239 RIIKTVGNKITKLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVA 318

                  ....
gi 31543630   662 GVIS 665
Cdd:pfam01384 319 ALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
40-241 6.84e-65

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 217.37  E-value: 6.84e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630    40 GANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMynsTQGLLMAGSVSAMFGSAVWQLV 119
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALLGAAIWLLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   120 ASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADP--------- 190
Cdd:pfam01384  78 ATYLGLPVSSTHALVGALIGAGLAAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   191 ---------VPNGLRALPVFYACTV----GIN------------LFSIMYTGAPLLGFDkLPLW----GTILISVGCAVF 241
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVsfahGANdvqnamgpltaaLYAIGTTGEVASKAP-VPLWvlllGALAIALGTWTG 236
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
511-676 1.60e-50

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 178.82  E-value: 1.60e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 511 VSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLvydTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKD 590
Cdd:COG0306 168 VNRGFRRLQIVSAALMAFSHGANDAQKAMGIITLALL---AAGLLSGFEVPLWVILLCALAIALGTLLGGWRIIKTLGKK 244
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 591 LTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMA 670
Cdd:COG0306 245 ITKLDPLQGFAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGAARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYL 324

                ....*.
gi 31543630 671 IFRYVI 676
Cdd:COG0306 325 LLSLLG 330
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
22-240 3.32e-46

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 166.88  E-value: 3.32e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630  22 LWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDvemynsTQGL 101
Cdd:COG0306   4 LLLLIVVILLALFFDFNNGFHDAANAIATAVGTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVD------PGIL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 102 LMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVR 181
Cdd:COG0306  78 TLEVVLAALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLAAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLY 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31543630 182 aFILHKADP--VPNGLRALPVFYAC-------------TVGINLFSIMYTGapLLGFDKLPLWGTILISVGCAV 240
Cdd:COG0306 158 -WLFRRANPrrVNRGFRRLQIVSAAlmafshgandaqkAMGIITLALLAAG--LLSGFEVPLWVILLCALAIAL 228
 
Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
503-665 6.50e-78

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 251.65  E-value: 6.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   503 WYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLV-ALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGR 581
Cdd:pfam01384 159 IRAKYDNKVERLFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGW 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   582 RVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPIS 661
Cdd:pfam01384 239 RIIKTVGNKITKLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVA 318

                  ....
gi 31543630   662 GVIS 665
Cdd:pfam01384 319 ALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
40-241 6.84e-65

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 217.37  E-value: 6.84e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630    40 GANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMynsTQGLLMAGSVSAMFGSAVWQLV 119
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALLGAAIWLLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   120 ASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADP--------- 190
Cdd:pfam01384  78 ATYLGLPVSSTHALVGALIGAGLAAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   191 ---------VPNGLRALPVFYACTV----GIN------------LFSIMYTGAPLLGFDkLPLW----GTILISVGCAVF 241
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVsfahGANdvqnamgpltaaLYAIGTTGEVASKAP-VPLWvlllGALAIALGTWTG 236
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
511-676 1.60e-50

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 178.82  E-value: 1.60e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 511 VSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLvydTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKD 590
Cdd:COG0306 168 VNRGFRRLQIVSAALMAFSHGANDAQKAMGIITLALL---AAGLLSGFEVPLWVILLCALAIALGTLLGGWRIIKTLGKK 244
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 591 LTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMA 670
Cdd:COG0306 245 ITKLDPLQGFAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGAARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYL 324

                ....*.
gi 31543630 671 IFRYVI 676
Cdd:COG0306 325 LLSLLG 330
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
22-240 3.32e-46

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 166.88  E-value: 3.32e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630  22 LWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDvemynsTQGL 101
Cdd:COG0306   4 LLLLIVVILLALFFDFNNGFHDAANAIATAVGTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVD------PGIL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 102 LMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVR 181
Cdd:COG0306  78 TLEVVLAALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLAAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLY 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31543630 182 aFILHKADP--VPNGLRALPVFYAC-------------TVGINLFSIMYTGapLLGFDKLPLWGTILISVGCAV 240
Cdd:COG0306 158 -WLFRRANPrrVNRGFRRLQIVSAAlmafshgandaqkAMGIITLALLAAG--LLSGFEVPLWVILLCALAIAL 228
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
531-679 2.03e-21

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 95.64  E-value: 2.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630   531 GGNDVSNAIGPLValylvydtgdvSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSG------FSIEL 604
Cdd:pfam01384   1 GANDVANAFATSV-----------GSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSFDPGvlmlgmLAALL 69
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543630   605 ASALTVVIASNIGLPISTTHCKVGSVVSVGW-LRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM 679
Cdd:pfam01384  70 GAAIWLLIATYLGLPVSSTHALVGALIGAGLaAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLILRR 145
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
520-679 3.73e-19

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 89.07  E-value: 3.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 520 ILTACFGSFAHGGNDVSNAIGPLValylvydtgdvSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTP---ITP 596
Cdd:COG0306  11 ILLALFFDFNNGFHDAANAIATAV-----------GTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDpgiLTL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 597 SSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGW-LRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYV 675
Cdd:COG0306  80 EVVLAALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLaAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLYWL 159

                ....
gi 31543630 676 ILRM 679
Cdd:COG0306 160 FRRA 163
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
29-184 1.02e-18

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 87.91  E-value: 1.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630  29 FIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQAC--------ILASIFETVGSVLLGAKVSETIRKGLIDVemyNSTQG 100
Cdd:COG0306 177 IVSAALMAFSHGANDAQKAMGIITLALLAAGLLSGfevplwviLLCALAIALGTLLGGWRIIKTLGKKITKL---DPLQG 253
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630 101 llmagsVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLvAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLV 180
Cdd:COG0306 254 ------FAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGA-ARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYLLL 326

                ....
gi 31543630 181 RAFI 184
Cdd:COG0306 327 SLLG 330
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
23-173 5.59e-17

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 82.55  E-value: 5.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630    23 WMLILgfiIAFVLAFSVGANDVANSFG-------TAVGSGVVTLKQAC-----ILASIFETVGSVLLGAKVSETIRKGLI 90
Cdd:pfam01384 173 FLQIL---SAALVSFAHGANDVQNAMGpltaalyAIGTTGEVASKAPVplwvlLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543630    91 DVemyNSTQGllmagsVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLvAKGQEGVKWSELIKIVMSWFVSPLLSG 170
Cdd:pfam01384 250 KL---TPSRG------FAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGL-ARGLSAVNWGVVGNIVLAWVLTLPVAA 319

                  ...
gi 31543630   171 IMS 173
Cdd:pfam01384 320 LLS 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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