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Conserved domains on  [gi|31542399|ref|NP_079572|]
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probable cytosolic iron-sulfur protein assembly protein CIAO1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 1.97e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 228.76  E-value: 1.97e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  17 SRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 177 YqeEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHTRTIY 256
Cdd:cd00200 162 W--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31542399 257 DVAWCQlTGALATACGDD-AIRVFEEDPGsdpqQPTFSLtahlrQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWE 332
Cdd:cd00200 224 SVAFSP-DGYLLASGSEDgTIRVWDLRTG----ECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 1.97e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 228.76  E-value: 1.97e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  17 SRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 177 YqeEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHTRTIY 256
Cdd:cd00200 162 W--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31542399 257 DVAWCQlTGALATACGDD-AIRVFEEDPGsdpqQPTFSLtahlrQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWE 332
Cdd:cd00200 224 SVAFSP-DGYLLASGSEDgTIRVWDLRTG----ECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-331 7.16e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 7.16e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  10 RVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCIWk 89
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW- 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  90 kNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLSSHTQDVKHVVWHPSQELLASAS 169
Cdd:COG2319 190 -DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 170 YDDTVKLYQEEGDDWVccATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQylpgneqgvacsgsdPSWKCICTLSG 249
Cdd:COG2319 266 ADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL---------------ATGKLLRTLTG 328

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 250 fHTRTIYDVAWCQLTGALATACGDDAIRVFeeDPGSDPQQPTFsltahlrQAHSQDVNCVAWNPKEPgLLASCSDDGEVA 329
Cdd:COG2319 329 -HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTL-------TGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                ..
gi 31542399 330 FW 331
Cdd:COG2319 398 LW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 4.41e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 4.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31542399    183 DWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.55e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 1.55e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 31542399   184 WVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 22-123 5.94e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 5.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399   22 LAWNPS-GTLLASCGGDRKIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420  80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                         90       100       110
                 ....*....|....*....|....*....|..
gi 31542399   93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420 160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 1.97e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 228.76  E-value: 1.97e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  17 SRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 177 YqeEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHTRTIY 256
Cdd:cd00200 162 W--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31542399 257 DVAWCQlTGALATACGDD-AIRVFEEDPGsdpqQPTFSLtahlrQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWE 332
Cdd:cd00200 224 SVAFSP-DGYLLASGSEDgTIRVWDLRTG----ECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-331 7.16e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 7.16e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  10 RVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCIWk 89
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW- 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  90 kNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLSSHTQDVKHVVWHPSQELLASAS 169
Cdd:COG2319 190 -DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 170 YDDTVKLYQEEGDDWVccATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQylpgneqgvacsgsdPSWKCICTLSG 249
Cdd:COG2319 266 ADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL---------------ATGKLLRTLTG 328

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 250 fHTRTIYDVAWCQLTGALATACGDDAIRVFeeDPGSDPQQPTFsltahlrQAHSQDVNCVAWNPKEPgLLASCSDDGEVA 329
Cdd:COG2319 329 -HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTL-------TGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                ..
gi 31542399 330 FW 331
Cdd:COG2319 398 LW 399
WD40 COG2319
WD40 repeat [General function prediction only];
20-222 9.84e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 9.84e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  20 WFLAWNPSGTLLASCGGDRKIRIWGTEGDSWICksvLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVT 99
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW--DLATGELLR 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYqe 179
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-- 357

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 31542399 180 EGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:COG2319 358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-332 6.79e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.10  E-value: 6.79e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 177 YQEEGDDwvCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRqylpgNEQGvacsgsdpswKCICTLSGfHTRTIY 256
Cdd:cd00200  78 WDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----VETG----------KCLTTLRG-HTDWVN 139

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31542399 257 DVAWCQLTGALATACGDDAIRVFEEDPGSdpqqptfslTAHLRQAHSQDVNCVAWNPKEpGLLASCSDDGEVAFWE 332
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWDLRTGK---------CVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
23-331 1.49e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 1.49e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  23 AWNPSGTLLASCGGDRKIRIWGTEGDSWIcksVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTLE 102
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALL---LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL--DAAAGALLATLL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYqeEGD 182
Cdd:COG2319  76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLA 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399 183 DWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWrqylpgneqgvacsgSDPSWKCICTLSGfHTRTIYDVAWC- 261
Cdd:COG2319 151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---------------DLATGKLLRTLTG-HTGAVRSVAFSp 214

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542399 262 --QLtgaLATACGDDAIRVFEEDPGsdpqQPTFSLTahlrqAHSQDVNCVAWNPKEPgLLASCSDDGEVAFW 331
Cdd:COG2319 215 dgKL---LASGSADGTVRLWDLATG----KLLRTLT-----GHSGSVRSVAFSPDGR-LLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
10-135 2.88e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 2.88e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  10 RVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWgtEGDSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCIWk 89
Cdd:COG2319 282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLW- 357

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 31542399  90 kNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD 135
Cdd:COG2319 358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-133 3.59e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 3.59e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  16 DSRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSWICksvLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKnqDDF 95
Cdd:cd00200 177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL--RTG 251

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 31542399  96 ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:cd00200 252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 4.41e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 4.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31542399    183 DWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.55e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 1.55e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 31542399   184 WVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 3.00e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 3.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31542399     94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 3.32e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.32e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 31542399    95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-177 4.25e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 31542399    141 ECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 22-123 5.94e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 5.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399   22 LAWNPS-GTLLASCGGDRKIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420  80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                         90       100       110
                 ....*....|....*....|....*....|..
gi 31542399   93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420 160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
PTZ00420 PTZ00420
coronin; Provisional
 98-182 3.41e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399   98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDEEDEY-------ECvsVLSSHTQDVKHVVWHP-SQELLASA 168
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESvkeikdpQC--ILKGHKKKISIIDWNPmNYYIMCSS 144

                         90
                 ....*....|....
gi 31542399  169 SYDDTVKLYQEEGD 182
Cdd:PTZ00420 145 GFDSFVNIWDIENE 158
WD40 pfam00400
WD domain, G-beta repeat;
141-177 3.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 31542399   141 ECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-89 4.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 4.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31542399     49 SWICKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 22-165 4.51e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 4.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399   22 LAWNP-SGTLLASCGGDRKIRIWG--TEGDSWICKSVLSE--GHQRTVRKVAWSPCG-NYLASASFDATTCIWKKNQDdf 95
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGipEEGLTQNISDPIVHlqGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG-- 158

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399   96 ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVweVDEEDEYECVSVLSSHTQDVKHVVWHPSQELL 165
Cdd:PTZ00421 159 KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI--IDPRDGTIVSSVEAHASAKSQRCLWAKRKDLI 226
PTZ00420 PTZ00420
coronin; Provisional
 190-260 1.04e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 1.04e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542399  190 LEGHESTVWSIAFDPS-GQRLASCSDDRTVRIWRqyLPGNEQGVAcSGSDPswkcICTLSGfHTRTIYDVAW 260
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWE--IPHNDESVK-EIKDP----QCILKG-HKKKISIIDW 133
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 23-135 1.48e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.26  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399    23 AWNPSGTLLASCGG--DRKIRIWGTEGDSwICKsvLSEGHQRTVRkvaWSPCGNYLASASF---DATTCIWkkNQDDFEC 97
Cdd:pfam08662  66 AWSPNGKEFAVIYGymPAKVSFFDLKGNV-IHS--FGEQPRNTIF---WSPFGRLVLLAGFgnlAGDIEFW--DVVNKKK 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 31542399    98 VTTLEgHENEVkSVAWAPSGNLLATCSR------DKSVWVWEVD 135
Cdd:pfam08662 138 IATAE-ASNAT-LCEWSPDGRYFLTATTaprlrvDNGFKIWHYN 179
WD40 pfam00400
WD domain, G-beta repeat;
58-88 1.99e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.99e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 31542399    58 EGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 106-221 3.49e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542399  106 NEVKSVAWAPSGNLLATCSRDKSVWVWEV-----DEEDEYECVSVLSSHTQdVKHVVWHPS-QELLASASYDDTVKLYQE 179
Cdd:PLN00181 484 NLVCAIGFDRDGEFFATAGVNKKIKIFECesiikDGRDIHYPVVELASRSK-LSGICWNSYiKSQVASSNFEGVVQVWDV 562

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 31542399  180 EGDDWVccATLEGHESTVWSIAF---DPSgqRLASCSDDRTVRIW 221
Cdd:PLN00181 563 ARSQLV--TEMKEHEKRVWSIDYssaDPT--LLASGSDDGSVKLW 603
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-43 7.85e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 7.85e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 31542399     14 HPDSRCWFLAWNPSGTLLASCGGDRKIRIW 43
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 300-332 8.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 8.66e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 31542399    300 QAHSQDVNCVAWNPKEPgLLASCSDDGEVAFWE 332
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
16-43 4.78e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*...
gi 31542399    16 DSRCWFLAWNPSGTLLASCGGDRKIRIW 43
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
300-332 6.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 6.49e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 31542399   300 QAHSQDVNCVAWNPKEPgLLASCSDDGEVAFWE 332
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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