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Conserved domains on  [gi|3152599|gb|AAC17080|]
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Strong similarity to lupeol synthase gb|U49919 and cycloartenol synthase gb|U02555 from A. thaliana (the third gene with similar homology) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN03012 PLN03012
Camelliol C synthase
1-759 0e+00

Camelliol C synthase


:

Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1703.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN03012    1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN03012   81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN03012  161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN03012  241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN03012  321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN03012  401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN03012  481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEH 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN03012  561 EYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCEA 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN03012  641 IRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGDF 720
                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 3152599    721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRRRVPLP 759
Cdd:PLN03012  721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
PLN03012 super family cl31551
Camelliol C synthase
779-1565 0e+00

Camelliol C synthase


The actual alignment was detected with superfamily member PLN03012:

Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1688.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN03012    1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN03012   81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN03012  161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN03012  241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN03012  321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN03012  401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN03012  481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLS----------------------------LQSKNGGM 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN03012  533 TAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGN 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN03012  613 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIH 692
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599   1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYRARVSLP 1565
Cdd:PLN03012  693 AGQAERDPIPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
 
Name Accession Description Interval E-value
PLN03012 PLN03012
Camelliol C synthase
1-759 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1703.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN03012    1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN03012   81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN03012  161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN03012  241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN03012  321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN03012  401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN03012  481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEH 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN03012  561 EYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCEA 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN03012  641 IRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGDF 720
                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 3152599    721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRRRVPLP 759
Cdd:PLN03012  721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
PLN03012 PLN03012
Camelliol C synthase
779-1565 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1688.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN03012    1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN03012   81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN03012  161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN03012  241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN03012  321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN03012  401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN03012  481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLS----------------------------LQSKNGGM 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN03012  533 TAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGN 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN03012  613 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIH 692
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599   1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYRARVSLP 1565
Cdd:PLN03012  693 AGQAERDPIPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
99-752 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 918.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    99 LRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlhEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFC 178
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILG---IPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   179 TTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMW 258
Cdd:cd02892   78 TVLNYVALRLLGVSPDDP---HMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   259 CYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHlcAKEDAYCPHPQIQDVIWNCLYIFTepflac 338
Cdd:cd02892  155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWYE------ 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   339 WPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIH-FKKHLLRISDYLWIAEDGMKM-QSFGS 416
Cdd:cd02892  227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPaFKRHLERIDDFLWLGPEGMKMcQTNGS 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   417 QLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPsGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCL 496
Cdd:cd02892  307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQILDNP-GDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   497 LLSMIPPDivGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILF 576
Cdd:cd02892  386 RLQELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLF 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   577 KQLYPNHRtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQKDNG 656
Cdd:cd02892  464 GKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPDG 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   657 GWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFMKNCLLH 736
Cdd:cd02892  543 GWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSE--AVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIR 618
                        650
                 ....*....|....*.
gi 3152599   737 YAAYRNIFPVWALAEY 752
Cdd:cd02892  619 YHNYRNYFPLWALGRY 634
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
877-1558 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 901.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   877 LRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDevfTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTMFC 956
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPI---DPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   957 TTLNYICMRILGESPDGGHdnaCGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMW 1036
Cdd:cd02892   78 TVLNYVALRLLGVSPDDPH---MVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1037 SYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHlcAKEDTYYPRPLVQELVWDSLYIFaepflaR 1116
Cdd:cd02892  155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWY------E 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1117 WPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKM-QSFGS 1194
Cdd:cd02892  227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMcQTNGS 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1195 QLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVgENPSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCL 1274
Cdd:cd02892  307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQI-LDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1275 LFSMLAPDivGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWLELLN 1354
Cdd:cd02892  386 RLQELPPF--GEKVSRERLYDAVDWLLG----------------------------MQNSNGGFAAFEPDNTYHWLENLN 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1355 PTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGL 1434
Cdd:cd02892  436 PFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEAL 514
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1435 AAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaqVGEISNVVQTAWALMGLIHSGQAERDPIplHRAAK 1514
Cdd:cd02892  515 AAAGEDYENSPYIRKACDFLLSKQNPDGGWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSEAV--ERGIK 590
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....
gi 3152599  1515 LIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:cd02892  591 YLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
98-754 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 796.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      98 ALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlheIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:TIGR01787    1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIAD----TPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:TIGR01787   77 GTVLAYVALKILGMSPDDP---AMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     258 WCYCRLVYMPMSYLYGKRFVGPISPlilqlREEIYLQPYAKinwNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEPFLa 337
Cdd:TIGR01787  154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFL- 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     338 cwpfNKLLREKALGVAMKHIHYEDensryiTIGCVEKALCMLACWVED-PNGIHFKKHLLRISDYLWIAEDGMKMQSFGS 416
Cdd:TIGR01787  225 ----RKALRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     417 QLWDSGFALQALVASNLV--NEIPDVLRRGYDFLKNSQVRENPSGDFtNMYRHISK-GSWTFSDRDHGW-QASDCTAESF 492
Cdd:TIGR01787  295 QVWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDW-KVYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     493 KCCLLLSmiPPDivgpKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQA 572
Cdd:TIGR01787  374 KAVLLLQ--EDE----HVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQA 447
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     573 LILFkqlypNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQ 652
Cdd:TIGR01787  448 LGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSRQ 522
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     653 KDNGGWGESYLSCPKKRYIPSEGerSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFM-K 731
Cdd:TIGR01787  523 MPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFpK 598
                          650       660
                   ....*....|....*....|...
gi 3152599     732 NCLLHYAAYRNIFPVWALAEYRR 754
Cdd:TIGR01787  599 NFYLKYTNYRNIFPLWALGRYRQ 621
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
876-1560 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 785.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     876 ALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITghlDEVFTsEHRKEILRYIYCHQKEDGGWGLHIEGHSTMF 955
Cdd:TIGR01787    1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIA---DTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     956 CTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKM 1035
Cdd:TIGR01787   77 GTVLAYVALKILGMSPD---DPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1036 WSYCRMVYLPMSYLYGKRFVGPITSlilqlRKELYLQPYEEinwMKVRHLCAKEDTYYPRPLVQELVWDSLYIFAEPFLA 1115
Cdd:TIGR01787  154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFLR 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1116 RWpfnklLREKALQLAMKHIHYEDensryiTIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKMQSFGS 1194
Cdd:TIGR01787  226 KA-----LRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1195 QLWDTGFAMQALLASNLSS--EISDVLRRGHEFIKNSQVGENPSGDYKsMYRHISK-GAWTFSDRDHGW-QVSDCTAHGL 1270
Cdd:TIGR01787  295 QVWDTAFAIQALRESGDHRlpEFHPALVKAHEWLLLSQIPDNPPGDWK-VYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1271 KCCLLFSmlAPDIVgpkqDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:TIGR01787  374 KAVLLLQ--EDEHV----KRDRLRDAVNWILG----------------------------MQSSNGGFAAYDPDNTGEWL 419
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1351 ELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKqlypdHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1430
Cdd:TIGR01787  420 ELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFV 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1431 LAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGeiSNVVQTAWALMGLIHSGQAERDPIplH 1510
Cdd:TIGR01787  495 LSALAAAGRTYRNCPEVQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSEAI--E 570
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 3152599    1511 RAAKLIINSQLESGDFPQQQATGVFL-KNCTLHYAAYRNIHPLWALAEYRA 1560
Cdd:TIGR01787  571 RGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
98-755 3.07e-148

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 468.14  E-value: 3.07e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    98 ALRKGVNFLSALQASDGHWPAEnAGPLFFLPPLVFCLYvtgHLHEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:COG1657   24 AIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLS 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:COG1657  100 TTVKAYFALKLLGDDPDAP---HMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKF 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   258 WCYCRLVYMPMSYLYGKRFVGPISPLIlqLREEIYLQPYAKIN--WNRARHLCAKEDAYcphpQIQDVIWNclyiFTEPF 335
Cdd:COG1657  177 SYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPRDRSPWSRFF----LALDRLLR----AYERL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   336 LAcwpfnKLLREKALGVAMKHIHYEDENS-RYITIG-CVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAEDGMKMQS 413
Cdd:COG1657  247 PP-----KPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   414 FGSQLWDSGFALQALVASNlVNEIPDVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFK 493
Cdd:COG1657  322 CVSPVWDTALAVQALQEAG-LPEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLM 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   494 CCLLLSMIPPDIVGPKMDPeqlyeAVTILLSLQSKNGGVTAWEPARGQEWLELLNptevFAD--IVVEHEYNECTSSAIQ 571
Cdd:COG1657  399 ALLRLRLPDEPRYREAIER-----AVEWILGMQSRDGGWGAFDKDNTKEWLNKIP----FADhgALLDPPTADVTARCLE 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   572 ALILFKQlypnhrtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:COG1657  470 MLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDP-AIRRAVAWLLSI 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   652 QKDNGGWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGA-FM 730
Cdd:COG1657  542 QNADGGWGEDCRSYEDPRYV--GLGPSTASQTAWALLALLAAGEADSP--AVARGIAYLLSTQREDGSWDEEYFTGTgFP 617
                        650       660
                 ....*....|....*....|....*
gi 3152599   731 KNCLLHYAAYRNIFPVWALAEYRRR 755
Cdd:COG1657  618 RVFYLRYHLYRQYFPLWALARYRNL 642
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
875-1563 1.47e-147

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 466.60  E-value: 1.47e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   875 SALRRGIHFFSALQASDGHWPAEnAGPLFFLPPLVFCLYitgHLDEVFTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTM 954
Cdd:COG1657   23 AAIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   955 FCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAK 1034
Cdd:COG1657   99 STTVKAYFALKLLGDDPD---APHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYK 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1035 MWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPLVQELVWDSLYIFAEPFL 1114
Cdd:COG1657  176 FSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVD-------------YYFPAPRDRSPWSRFFLALDRLL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1115 ARW-PFN-KLLREKALQLAMKHIHYEDENS-RYITIG-CVEKVLCMLACWVEDPNGDYFKKHLSRISDYLWMAEDGMKMQ 1190
Cdd:COG1657  241 RAYeRLPpKPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1191 SFGSQLWDTGFAMQALLASNLsSEISDVLRRGHEFIKNSQVGEnpSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGL 1270
Cdd:COG1657  321 PCVSPVWDTALAVQALQEAGL-PEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVL 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1271 KCcllfsMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:COG1657  398 MA-----LLRLRLPDEPRYREAIERAVEWILG----------------------------MQSRDGGWGAFDKDNTKEWL 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1351 ELLNptemFSD--IVIEHEYSECTSSAIQALSLFKQlypdhrtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTW 1428
Cdd:COG1657  445 NKIP----FADhgALLDPPTADVTARCLEMLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTW 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1429 FALAglaaagkTFN------DCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaQVGEiSNVVQTAWALMGLIHSGQA 1502
Cdd:COG1657  514 SVLT-------GLNaagvdpDDPAIRRAVAWLLSIQNADGGWGEDCRSYEDPRYV-GLGP-STASQTAWALLALLAAGEA 584
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3152599  1503 ERDPIplHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYRARVS 1563
Cdd:COG1657  585 DSPAV--ARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLRG 644
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
877-1135 7.69e-40

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 149.94  E-value: 7.69e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     877 LRRGIHFFSALQASDGHW----------PAEnagplfflppLVFCLYITGHLDEvftsEHRKEILRYIYCHQKEDGGWGL 946
Cdd:pfam13249    1 IARAQDALLSLQHPDGHWvgeleanvtiTAE----------YILLRHFLGPDDP----ELEAKIARYLRSQQREDGGWPL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     947 HIEGHSTMFCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPS 1026
Cdd:pfam13249   67 FHGGPGDLSTTVEAYFALKLLGDSPD---APHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPR 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1027 FFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPlVQELVWDSL 1106
Cdd:pfam13249  144 WFPFNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVR-------------YYPRP-HRLFSWTNL 207
                          250       260       270
                   ....*....|....*....|....*....|.
gi 3152599    1107 YIFAEPFLARW-PFN-KLLREKALQLAMKHI 1135
Cdd:pfam13249  208 FLGLDRVLKLYeRLPpKPLRRRALRKAEEWI 238
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
416-754 1.72e-37

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 144.01  E-value: 1.72e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     416 SQLWDSGFALQALVASNLVNEIPdVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFS-DRDHgWQASDCTAesfkc 494
Cdd:pfam13243    2 SPVWDTALALHALLEAGVPADHP-ALVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQfANDH-YPDVDDTA----- 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     495 CLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGvtaWEPARGQEWLELLN--PtevFADivveHEYNECTSSA-IQ 571
Cdd:pfam13243   73 VVVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGG---WGAFDKDNTKYYLNkiP---FAD----HGALLDPPTAdVT 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     572 ALILfkQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:pfam13243  143 ARVL--EMLGQLGYPDDHPVAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRP-YIRKAVDWLKSR 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     652 QKDNGGWGE---SYlscpkKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITG- 727
Cdd:pfam13243  220 QNPDGGWGEdceSY-----KDPKLAGRGPSTASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTWDEPYFTGt 292
                          330       340
                   ....*....|....*....|....*..
gi 3152599     728 AFMKNCLLHYAAYRNIFPVWALAEYRR 754
Cdd:pfam13243  293 GFPRVFYLKYHGYRNYFPLWALARYRN 319
 
Name Accession Description Interval E-value
PLN03012 PLN03012
Camelliol C synthase
1-759 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1703.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN03012    1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN03012   81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN03012  161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN03012  241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN03012  321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN03012  401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN03012  481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEH 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN03012  561 EYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCEA 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN03012  641 IRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGDF 720
                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 3152599    721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRRRVPLP 759
Cdd:PLN03012  721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
PLN03012 PLN03012
Camelliol C synthase
779-1565 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1688.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN03012    1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN03012   81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN03012  161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN03012  241 PEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN03012  321 QDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRISD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN03012  401 YLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN03012  481 GWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLS----------------------------LQSKNGGM 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN03012  533 TAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGN 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN03012  613 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIH 692
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599   1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYRARVSLP 1565
Cdd:PLN03012  693 AGQAERDPIPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVPLP 759
PLN02993 PLN02993
lupeol synthase
1-754 0e+00

lupeol synthase


Pssm-ID: 215537 [Multi-domain]  Cd Length: 763  Bit Score: 1401.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      1 MWKLKIANGNKEEPYLFSTNNFLGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIP 80
Cdd:PLN02993    1 MWKLKIGEGNGEDPYLFSSNNFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVKGCSDLLWRMQFLKEAKFEQVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     81 PAKVEDANNITSEIATNALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEIFTQDHRREVLRYIYCHQ 160
Cdd:PLN02993   81 PVKIDRGEEITYETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPLVFCLYITGHLEEVFDAEHRKEMLRHIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    161 NEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGPGNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMP 240
Cdd:PLN02993  161 NEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPNGGRENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    241 PEFWILPSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQI 320
Cdd:PLN02993  241 PEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    321 QDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISD 400
Cdd:PLN02993  321 QDLIWDTLHNFVEPFLTRWPLNKLVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACWIENPNGDHFKKHLARIPD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    401 YLWIAEDGMKMQSFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDH 480
Cdd:PLN02993  401 YMWVAEDGMKMQSFGSQLWDTGFAIQALLASDLSDETDDVLRRGHNYIKKSQVRENPSGDFKSMYRHISKGAWTLSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    481 GWQASDCTAESFKCCLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEH 560
Cdd:PLN02993  481 GWQVSDCTAEALKCCMLLSMMPADVVGQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVER 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    561 EYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLA 640
Cdd:PLN02993  561 EYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYNDCLA 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    641 MRKGVHFLLTTQKDNGGWGESYLSCPKKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDF 720
Cdd:PLN02993  641 MRKGVHFLLTIQRDDGGWGESYLSCPEQRYIPLEGNRSNLVQTAWAMMGLIHAGQAERDLIPLHRAAKLIITSQLENGDF 720
                         730       740       750
                  ....*....|....*....|....*....|....
gi 3152599    721 PQQEITGAFMKNCLLHYAAYRNIFPVWALAEYRR 754
Cdd:PLN02993  721 PQQEILGAFMNTCMLHYATYRNTFPLWALAEYRK 754
PLN02993 PLN02993
lupeol synthase
779-1559 0e+00

lupeol synthase


Pssm-ID: 215537 [Multi-domain]  Cd Length: 763  Bit Score: 1358.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    779 MWRLKIGEGNGDDPYLFTTNNFAGRQTWEFDPDGGSPEERHSVVEARRIFYDNRFHVKASSDLLWRMQFLREKKFEQRIA 858
Cdd:PLN02993    1 MWKLKIGEGNGEDPYLFSSNNFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVKGCSDLLWRMQFLKEAKFEQVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    859 PVKVEDSEKVTFETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQ 938
Cdd:PLN02993   81 PVKIDRGEEITYETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPLVFCLYITGHLEEVFDAEHRKEMLRHIYCHQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    939 KEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMP 1018
Cdd:PLN02993  161 NEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPNGGRENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1019 PEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLV 1098
Cdd:PLN02993  241 PEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1099 QELVWDSLYIFAEPFLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISD 1178
Cdd:PLN02993  321 QDLIWDTLHNFVEPFLTRWPLNKLVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACWIENPNGDHFKKHLARIPD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1179 YLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPSGDYKSMYRHISKGAWTFSDRDH 1258
Cdd:PLN02993  401 YMWVAEDGMKMQSFGSQLWDTGFAIQALLASDLSDETDDVLRRGHNYIKKSQVRENPSGDFKSMYRHISKGAWTLSDRDH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1259 GWQVSDCTAHGLKCCLLFSMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGM 1338
Cdd:PLN02993  481 GWQVSDCTAEALKCCMLLSMMPADVVGQKIDPEQLYDSVNLLLS----------------------------LQSENGGV 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1339 TAWEPAGAPKWLELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGN 1418
Cdd:PLN02993  533 TAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGN 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   1419 WGICFTYGTWFALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTAWALMGLIH 1498
Cdd:PLN02993  613 WGICFIYATWFALGGLAAAGKTYNDCLAMRKGVHFLLTIQRDDGGWGESYLSCPEQRYIPLEGNRSNLVQTAWAMMGLIH 692
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3152599   1499 SGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEYR 1559
Cdd:PLN02993  693 AGQAERDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTCMLHYATYRNTFPLWALAEYR 753
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
99-752 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 918.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    99 LRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlhEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFC 178
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILG---IPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   179 TTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMW 258
Cdd:cd02892   78 TVLNYVALRLLGVSPDDP---HMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   259 CYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHlcAKEDAYCPHPQIQDVIWNCLYIFTepflac 338
Cdd:cd02892  155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWYE------ 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   339 WPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIH-FKKHLLRISDYLWIAEDGMKM-QSFGS 416
Cdd:cd02892  227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPaFKRHLERIDDFLWLGPEGMKMcQTNGS 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   417 QLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPsGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCL 496
Cdd:cd02892  307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQILDNP-GDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   497 LLSMIPPDivGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILF 576
Cdd:cd02892  386 RLQELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLF 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   577 KQLYPNHRtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQKDNG 656
Cdd:cd02892  464 GKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPDG 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   657 GWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFMKNCLLH 736
Cdd:cd02892  543 GWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSE--AVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIR 618
                        650
                 ....*....|....*.
gi 3152599   737 YAAYRNIFPVWALAEY 752
Cdd:cd02892  619 YHNYRNYFPLWALGRY 634
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
877-1558 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 901.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   877 LRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDevfTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTMFC 956
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPI---DPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   957 TTLNYICMRILGESPDGGHdnaCGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMW 1036
Cdd:cd02892   78 TVLNYVALRLLGVSPDDPH---MVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1037 SYCRMVYLPMSYLYGKRFVGPITSLILQLRKELYLQPYEEINWMKVRHlcAKEDTYYPRPLVQELVWDSLYIFaepflaR 1116
Cdd:cd02892  155 CWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWY------E 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1117 WPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKM-QSFGS 1194
Cdd:cd02892  227 PLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMcQTNGS 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1195 QLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVgENPSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCL 1274
Cdd:cd02892  307 QVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQI-LDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1275 LFSMLAPDivGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWLELLN 1354
Cdd:cd02892  386 RLQELPPF--GEKVSRERLYDAVDWLLG----------------------------MQNSNGGFAAFEPDNTYHWLENLN 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1355 PTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGL 1434
Cdd:cd02892  436 PFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEAL 514
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1435 AAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaqVGEISNVVQTAWALMGLIHSGQAERDPIplHRAAK 1514
Cdd:cd02892  515 AAAGEDYENSPYIRKACDFLLSKQNPDGGWGESYLSYEDKSYA--GGGRSTVVQTAWALLALMAAGEPDSEAV--ERGIK 590
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....
gi 3152599  1515 LIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:cd02892  591 YLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
98-754 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 796.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      98 ALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGhlheIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:TIGR01787    1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIAD----TPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:TIGR01787   77 GTVLAYVALKILGMSPDDP---AMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     258 WCYCRLVYMPMSYLYGKRFVGPISPlilqlREEIYLQPYAKinwNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEPFLa 337
Cdd:TIGR01787  154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFL- 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     338 cwpfNKLLREKALGVAMKHIHYEDensryiTIGCVEKALCMLACWVED-PNGIHFKKHLLRISDYLWIAEDGMKMQSFGS 416
Cdd:TIGR01787  225 ----RKALRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     417 QLWDSGFALQALVASNLV--NEIPDVLRRGYDFLKNSQVRENPSGDFtNMYRHISK-GSWTFSDRDHGW-QASDCTAESF 492
Cdd:TIGR01787  295 QVWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDW-KVYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     493 KCCLLLSmiPPDivgpKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQA 572
Cdd:TIGR01787  374 KAVLLLQ--EDE----HVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQA 447
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     573 LILFkqlypNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQ 652
Cdd:TIGR01787  448 LGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSRQ 522
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     653 KDNGGWGESYLSCPKKRYIPSEGerSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGAFM-K 731
Cdd:TIGR01787  523 MPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFpK 598
                          650       660
                   ....*....|....*....|...
gi 3152599     732 NCLLHYAAYRNIFPVWALAEYRR 754
Cdd:TIGR01787  599 NFYLKYTNYRNIFPLWALGRYRQ 621
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
876-1560 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 785.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     876 ALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITghlDEVFTsEHRKEILRYIYCHQKEDGGWGLHIEGHSTMF 955
Cdd:TIGR01787    1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIA---DTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     956 CTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKM 1035
Cdd:TIGR01787   77 GTVLAYVALKILGMSPD---DPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKS 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1036 WSYCRMVYLPMSYLYGKRFVGPITSlilqlRKELYLQPYEEinwMKVRHLCAKEDTYYPRPLVQELVWDSLYIFAEPFLA 1115
Cdd:TIGR01787  154 WCRCRMVYLPMSYCYGERLSAPIDP-----REELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFLR 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1116 RWpfnklLREKALQLAMKHIHYEDensryiTIGCVEKVLCMLACWVED-PNGDYFKKHLSRISDYLWMAEDGMKMQSFGS 1194
Cdd:TIGR01787  226 KA-----LRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTGS 294
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1195 QLWDTGFAMQALLASNLSS--EISDVLRRGHEFIKNSQVGENPSGDYKsMYRHISK-GAWTFSDRDHGW-QVSDCTAHGL 1270
Cdd:TIGR01787  295 QVWDTAFAIQALRESGDHRlpEFHPALVKAHEWLLLSQIPDNPPGDWK-VYRHNLKpGGWAFSFLNCGYpDVDDTAVVAL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1271 KCCLLFSmlAPDIVgpkqDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:TIGR01787  374 KAVLLLQ--EDEHV----KRDRLRDAVNWILG----------------------------MQSSNGGFAAYDPDNTGEWL 419
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1351 ELLNPTEMFSDIVIEHEYSECTSSAIQALSLFKqlypdHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1430
Cdd:TIGR01787  420 ELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFV 494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1431 LAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGeiSNVVQTAWALMGLIHSGQAERDPIplH 1510
Cdd:TIGR01787  495 LSALAAAGRTYRNCPEVQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSEAI--E 570
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 3152599    1511 RAAKLIINSQLESGDFPQQQATGVFL-KNCTLHYAAYRNIHPLWALAEYRA 1560
Cdd:TIGR01787  571 RGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
osq_cycl TIGR03463
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ...
106-752 6.56e-165

2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.


Pssm-ID: 274591 [Multi-domain]  Cd Length: 634  Bit Score: 512.62  E-value: 6.56e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     106 LSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLHEiftQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMFCTTLNYIC 185
Cdd:TIGR03463    1 LAALQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPD---AEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVA 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     186 MRILGEGPNGGpgnACKRARDWILDH-GGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKMWCYCRLV 264
Cdd:TIGR03463   78 LRLLGLGKDDA---GLARARAWFHAQpEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLI 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     265 YMPMSYLYGKRFVGPIS-PLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPHPQIQDVIWNCLYIFTEpflACWpfnK 343
Cdd:TIGR03463  155 YLGIAWLSGRGARAPESdPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYER---LAG---K 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     344 LLREKALGVAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAED-GMKMQSFGS-QLWDS 421
Cdd:TIGR03463  229 ALRARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSnALWDT 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     422 GFALQALVAS-NLVNEIPDVLRRGYDFLKNSQVRENpSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFKCCLLLSM 500
Cdd:TIGR03463  309 AFAVQALAALgELDEEAKHALEEAAAFIDAAQMLAD-LADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEE 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     501 IPPDIVGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNPTEVFADIVVEHEYNECTSSAIQALILFKQLY 580
Cdd:TIGR03463  388 LGDNRISEALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHH 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     581 PNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNcLAMRKGVHFLLTTQKDNGGWGE 660
Cdd:TIGR03463  468 PDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD-MALQAAAAFLLEKQRADGAWGE 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     661 SYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDPSplHRAAKLLINSQLENGDFPQQEITGAFMKNCLLHYAAY 740
Cdd:TIGR03463  547 HVESCLEARWV--EGKHGHAVMTAWALLALAAAGEAAHDAA--ERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAY 622
                          650
                   ....*....|..
gi 3152599     741 RNIFPVWALAEY 752
Cdd:TIGR03463  623 LRIFPTWALARC 634
osq_cycl TIGR03463
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ...
886-1558 1.16e-161

2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.


Pssm-ID: 274591 [Multi-domain]  Cd Length: 634  Bit Score: 503.76  E-value: 1.16e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     886 ALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEvftSEHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNYICMR 965
Cdd:TIGR03463    3 ALQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPD---AEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALR 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     966 ILGESPDgghDNACGRAREWILSH-GGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMWSYCRMVYL 1044
Cdd:TIGR03463   80 LLGLGKD---DAGLARARAWFHAQpEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYL 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1045 PMSYLYGKRFVGPITS-LILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLVQELVWDSLYIFaepflARWPFnKLL 1123
Cdd:TIGR03463  157 GIAWLSGRGARAPESDpLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGY-----ERLAG-KAL 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1124 REKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLSRISDYLWMAED-GMKMQSFGS-QLWDTGF 1201
Cdd:TIGR03463  231 RARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSnALWDTAF 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1202 AMQALLAS-NLSSEISDVLRRGHEFIKNSQVGENpSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCLLFSMLA 1280
Cdd:TIGR03463  311 AVQALAALgELDEEAKHALEEAAAFIDAAQMLAD-LADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELG 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1281 PDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWLELLNPTEMFS 1360
Cdd:TIGR03463  390 DNRISEALGAARLQDAVEFILS----------------------------MQNADGGFATYELQRGGKLLELLNPSDMFG 441
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1361 DIVIEHEYSECTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGLAAAGKT 1440
Cdd:TIGR03463  442 QCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAE 521
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1441 FNDcEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAqvGEISNVVQTAWALMGLIHSGQAERDPIplHRAAKLIINSQ 1520
Cdd:TIGR03463  522 PAD-MALQAAAAFLLEKQRADGAWGEHVESCLEARWVE--GKHGHAVMTAWALLALAAAGEAAHDAA--ERGIAWLCEQQ 596
                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 3152599    1521 LESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:TIGR03463  597 GEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
413-752 1.18e-151

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 465.93  E-value: 1.18e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   413 SFGSQLWDSGFALQALVASNLVNEIPDVLRRGYDFLKNSQVRENPsGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESF 492
Cdd:cd02889   20 GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQIRDNP-DDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEAL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   493 KCCLLLSMIPPDivGPKMDPEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELlnPTEVFADIVVEHEYNECTSSAIQA 572
Cdd:cd02889   99 KALLRLQKKPPD--GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   573 LILFKQLYPNHRtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTyNNCLAMRKGVHFLLTTQ 652
Cdd:cd02889  175 LGLFGKLYPEHR-REIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED-ENSPYVRKACDWLLSKQ 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   653 KDNGGWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDPspLHRAAKLLINSQLENGDFPQQEITGAFMKN 732
Cdd:cd02889  253 NPDGGWGESYESYEDPSYA--GGGRSTVVQTAWALLALMAAGEPDSEA--VKRGVKYLLNTQQEDGDWPQEEITGVFFKN 328
                        330       340
                 ....*....|....*....|
gi 3152599   733 CLLHYAAYRNIFPVWALAEY 752
Cdd:cd02889  329 FYIRYHNYRNYFPLWALGRY 348
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
98-755 3.07e-148

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 468.14  E-value: 3.07e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    98 ALRKGVNFLSALQASDGHWPAEnAGPLFFLPPLVFCLYvtgHLHEIFTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:COG1657   24 AIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLS 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:COG1657  100 TTVKAYFALKLLGDDPDAP---HMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKF 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   258 WCYCRLVYMPMSYLYGKRFVGPISPLIlqLREEIYLQPYAKIN--WNRARHLCAKEDAYcphpQIQDVIWNclyiFTEPF 335
Cdd:COG1657  177 SYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPRDRSPWSRFF----LALDRLLR----AYERL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   336 LAcwpfnKLLREKALGVAMKHIHYEDENS-RYITIG-CVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAEDGMKMQS 413
Cdd:COG1657  247 PP-----KPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   414 FGSQLWDSGFALQALVASNlVNEIPDVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFK 493
Cdd:COG1657  322 CVSPVWDTALAVQALQEAG-LPEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLM 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   494 CCLLLSMIPPDIVGPKMDPeqlyeAVTILLSLQSKNGGVTAWEPARGQEWLELLNptevFAD--IVVEHEYNECTSSAIQ 571
Cdd:COG1657  399 ALLRLRLPDEPRYREAIER-----AVEWILGMQSRDGGWGAFDKDNTKEWLNKIP----FADhgALLDPPTADVTARCLE 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   572 ALILFKQlypnhrtEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:COG1657  470 MLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDP-AIRRAVAWLLSI 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   652 QKDNGGWGESYLSCPKKRYIpsEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITGA-FM 730
Cdd:COG1657  542 QNADGGWGEDCRSYEDPRYV--GLGPSTASQTAWALLALLAAGEADSP--AVARGIAYLLSTQREDGSWDEEYFTGTgFP 617
                        650       660
                 ....*....|....*....|....*
gi 3152599   731 KNCLLHYAAYRNIFPVWALAEYRRR 755
Cdd:COG1657  618 RVFYLRYHLYRQYFPLWALARYRNL 642
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
875-1563 1.47e-147

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 466.60  E-value: 1.47e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   875 SALRRGIHFFSALQASDGHWPAEnAGPLFFLPPLVFCLYitgHLDEVFTSEHRKEILRYIYCHQKEDGGWGLHIEGHSTM 954
Cdd:COG1657   23 AAIAAAQALLLQQQDDGGWWGGE-LEADVTIAAEYILLH---HFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   955 FCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAK 1034
Cdd:COG1657   99 STTVKAYFALKLLGDDPD---APHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYK 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1035 MWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPLVQELVWDSLYIFAEPFL 1114
Cdd:COG1657  176 FSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVD-------------YYFPAPRDRSPWSRFFLALDRLL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1115 ARW-PFN-KLLREKALQLAMKHIHYEDENS-RYITIG-CVEKVLCMLACWVEDPNGDYFKKHLSRISDYLWMAEDGMKMQ 1190
Cdd:COG1657  241 RAYeRLPpKPLRRRALRKAEDWILERLEGDgGLGGIFpAMVNSLMALLALGYPPDHPVVRRALEALEKLLVETEDGARCQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1191 SFGSQLWDTGFAMQALLASNLsSEISDVLRRGHEFIKNSQVGEnpSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGL 1270
Cdd:COG1657  321 PCVSPVWDTALAVQALQEAGL-PEDHPALERAADWLLSKQILV--KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVL 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1271 KCcllfsMLAPDIVGPKQDPERLHDSVNILLSlqvsiirhrieptsskkhpfsgrdsftcLQSKNGGMTAWEPAGAPKWL 1350
Cdd:COG1657  398 MA-----LLRLRLPDEPRYREAIERAVEWILG----------------------------MQSRDGGWGAFDKDNTKEWL 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1351 ELLNptemFSD--IVIEHEYSECTSSAIQALSLFKQlypdhrtTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTW 1428
Cdd:COG1657  445 NKIP----FADhgALLDPPTADVTARCLEMLGQLGL-------TEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTW 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1429 FALAglaaagkTFN------DCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaQVGEiSNVVQTAWALMGLIHSGQA 1502
Cdd:COG1657  514 SVLT-------GLNaagvdpDDPAIRRAVAWLLSIQNADGGWGEDCRSYEDPRYV-GLGP-STASQTAWALLALLAAGEA 584
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3152599  1503 ERDPIplHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYRARVS 1563
Cdd:COG1657  585 DSPAV--ARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLRG 644
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
1191-1558 1.07e-136

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 425.87  E-value: 1.07e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1191 SFGSQLWDTGFAMQALLASNLSSEISDVLRRGHEFIKNSQVGENPsGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGL 1270
Cdd:cd02889   20 GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQIRDNP-DDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEAL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1271 KCCLLFSMLAPDivGPKQDPERLHDSVNILLSLQvsiirhrieptsskkhpfsgrdsftclqSKNGGMTAWEPAGAPKWL 1350
Cdd:cd02889   99 KALLRLQKKPPD--GKKVSRERLYDAVDWLLSMQ----------------------------NSNGGFAAFEPDNTYKYL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1351 ELlnPTEMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRTtEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1430
Cdd:cd02889  149 EL--IPEVDGDIMIDPPYVECTGSVLEALGLFGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFA 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1431 LAGLAAAGKTfNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIaqVGEISNVVQTAWALMGLIHSGQAERDPIplH 1510
Cdd:cd02889  226 LEALAAAGED-ENSPYVRKACDWLLSKQNPDGGWGESYESYEDPSYA--GGGRSTVVQTAWALLALMAAGEPDSEAV--K 300
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 3152599  1511 RAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIHPLWALAEY 1558
Cdd:cd02889  301 RGVKYLLNTQQEDGDWPQEEITGVFFKNFYIRYHNYRNYFPLWALGRY 348
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
870-1559 4.45e-54

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 201.27  E-value: 4.45e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     870 FETATSALRRGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEvftsEHRKEILRYIYCHQKEDGGWGLHIE 949
Cdd:TIGR01507   11 TARTVEAIDRAVDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILDRVDR----DRMEKIRNYLLHEQREDGTWALYPG 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     950 GHSTMFCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFP 1029
Cdd:TIGR01507   87 GPGDLSTTVEAYVALKYIGMSRD---EPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFP 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1030 VHPAKMWSYCRMVYLPMSYLYGKRFVGPITSlilQLR-KELYlqpyeEINWMKVRHLCAKEDTyyprPLVQELVWDSLYI 1108
Cdd:TIGR01507  164 FNIYEFSSWARATVVPLSIVCSRKPVFPLPE---RARvPELY-----ETDVPKPRRRGAKGGT----GWGIFDALDRALH 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1109 FAEPFLARwPFnkllREKALQLAMKHIHYEDENS------------RYITIgcveKVLCMlacwveDPNGDYFKKHLSRI 1176
Cdd:TIGR01507  232 GYEKLSVH-PF----RRAAEIRALDWLLERQAGDgswggiqpamfnALIAL----KILGM------TQHDAFIKLGWEGI 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1177 SDYLWMAEDGMKMQSFGSQLWDTGFAMQALLASNLSSEiSDVLRRGHEFIKNSQVgeNPSGDYKSMYRHISKGAWTFS-D 1255
Cdd:TIGR01507  297 DLYGVELDDSWMFQACVSPVWDTALAVLALREAGLPAD-HDALVKAGEWLLDKQI--TVPGDWAVKRPNLEPGGWAFQfD 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1256 RDHGWQVSDctahglKCCLLFSMLApdIVGPkqDPERLHDSVNILLSLQVSiirhrieptsskkhpfsgrdsftcLQSKN 1335
Cdd:TIGR01507  374 NVYYPDVDD------TAVVVWALNG--LRLP--DERRRRDAMTKAFRWIAG------------------------MQSSN 419
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1336 GGMTAWEPAGAPKWLELLNptemFSDI--VIEHEYSECTSSAIQALSLFKQLYPDHRtteitafIKKAAEYLENMQTRDG 1413
Cdd:TIGR01507  420 GGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDDAWPV-------IERAVEYLKREQEPDG 488
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1414 SWYGNWGICFTYGTWfALAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQvgEISNVVQTAWAL 1493
Cdd:TIGR01507  489 SWFGRWGVNYLYGTG-AVLSALKAVGIDTREPYIQKALAWLESHQNPDGGWGEDCRSYEDPAYAGK--GASTASQTAWAL 565
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599    1494 MGLIHSGQAERDPIplHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYR 1559
Cdd:TIGR01507  566 IALIAAGRAESEAA--RRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMYRHVFPLLALARYK 630
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
392-752 3.19e-46

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 168.88  E-value: 3.19e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   392 KKHLLRISDYLwIAEDGMKMQSFGSQLWDSGFALQAL----VASNLVNEIPDVLRRGYDFLKNSQvrenpsgdftnmyrh 467
Cdd:cd00688    2 EKHLKYLLRYP-YGDGHWYQSLCGEQTWSTAWPLLALllllAATGIRDKADENIEKGIQRLLSYQ--------------- 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   468 ISKGSWTFSDRdHGWQASDCTAESFKCCLLLSMIPPdivgpkMDPEQLYEAVTILLSLQSKNGGVTAWEPargqewlell 547
Cdd:cd00688   66 LSDGGFSGWGG-NDYPSLWLTAYALKALLLAGDYIA------VDRIDLARALNWLLSLQNEDGGFREDGP---------- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   548 npteVFADIVVEHEYNECTSSAIQALILFKQLYPNhrteeinTSIKKAVQYIESIQMLDGSWyGSWGVCFTYSTWFGLGG 627
Cdd:cd00688  129 ----GNHRIGGDESDVRLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAA 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   628 LAAAGKTynNCLAMRKGVHFLLTTQKDNGGWGESYLSCPKkryipsegeRSNLVQTSWAMMGLLHAGQAeRDPSPLHRAA 707
Cdd:cd00688  197 LALLGDL--DSPDAKKALRWLLSRQRPDGGWGEGRDRTNK---------LSDSCYTEWAAYALLALGKL-GDLEDAEKLV 264
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 3152599   708 KLLINSQLENGDFPQQEItgafmknclLHYAAYRNIFPVWALAEY 752
Cdd:cd00688  265 KWLLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
98-753 8.58e-45

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 173.54  E-value: 8.58e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      98 ALRKGVNFLSALQASDGHWPAENAGPLFFLPPLVFCLYVTGHLheifTQDHRREVLRYIYCHQNEDGGWGLHIEGNSTMF 177
Cdd:TIGR01507   17 AIDRAVDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILDRV----DRDRMEKIRNYLLHEQREDGTWALYPGGPGDLS 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     178 CTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Cdd:TIGR01507   93 TTVEAYVALKYIGMSRDEP---PMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEF 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     258 WCYCRLVYMPMSYLYGKRFVGPIsPLILQLREEIYLQPyakinwnrarhlcAKEDAYCPHPQiqdVIWNClyiftepFLA 337
Cdd:TIGR01507  170 SSWARATVVPLSIVCSRKPVFPL-PERARVPELYETDV-------------PKPRRRGAKGG---TGWGI-------FDA 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     338 CWPFNKLL--------REKALGVAMKHI--HYEDENSRYITIGCVEKALCMLACWVEDPNGIHFKKHLLRISDYLWIAED 407
Cdd:TIGR01507  226 LDRALHGYeklsvhpfRRAAEIRALDWLleRQAGDGSWGGIQPAMFNALIALKILGMTQHDAFIKLGWEGIDLYGVELDD 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     408 GMKMQSFGSQLWDSGFALQALVASNLVNEiPDVLRRGYDFLKNSQVreNPSGDFTNMYRHISKGSWTFSDRDHGWQASDC 487
Cdd:TIGR01507  306 SWMFQACVSPVWDTALAVLALREAGLPAD-HDALVKAGEWLLDKQI--TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDD 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     488 TAeSFKCCLLLSMIPPDivgPKMDpEQLYEAVTILLSLQSKNGGVTAWEPARGQEWLELLNptevFADI--VVEHEYNEC 565
Cdd:TIGR01507  383 TA-VVVWALNGLRLPDE---RRRR-DAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADV 453
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     566 TSSAIQALILFKQLYPNHRteeintsIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGkTYNNCLAMRKGV 645
Cdd:TIGR01507  454 TARVLECLGSFGYDDAWPV-------IERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVG-IDTREPYIQKAL 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     646 HFLLTTQKDNGGWGESYLSCPKKRYipsEGE-RSNLVQTSWAMMGLLHAGQAERdpSPLHRAAKLLINSQLENGDFPQQE 724
Cdd:TIGR01507  526 AWLESHQNPDGGWGEDCRSYEDPAY---AGKgASTASQTAWALIALIAAGRAES--EAARRGVQYLVETQRPDGGWDEPY 600
                          650       660       670
                   ....*....|....*....|....*....|
gi 3152599     725 ITG-AFMKNCLLHYAAYRNIFPVWALAEYR 753
Cdd:TIGR01507  601 YTGtGFPGDFYLGYHMYRHVFPLLALARYK 630
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
877-1135 7.69e-40

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 149.94  E-value: 7.69e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     877 LRRGIHFFSALQASDGHW----------PAEnagplfflppLVFCLYITGHLDEvftsEHRKEILRYIYCHQKEDGGWGL 946
Cdd:pfam13249    1 IARAQDALLSLQHPDGHWvgeleanvtiTAE----------YILLRHFLGPDDP----ELEAKIARYLRSQQREDGGWPL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     947 HIEGHSTMFCTTLNYICMRILGESPDgghDNACGRAREWILSHGGVTYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPS 1026
Cdd:pfam13249   67 FHGGPGDLSTTVEAYFALKLLGDSPD---APHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPR 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1027 FFPVHPAKMWSYCRMVYLPMSYLYGKRFVGPITSLIlqLRKELYLQPYEEINwmkvrhlcakedtYYPRPlVQELVWDSL 1106
Cdd:pfam13249  144 WFPFNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVR-------------YYPRP-HRLFSWTNL 207
                          250       260       270
                   ....*....|....*....|....*....|.
gi 3152599    1107 YIFAEPFLARW-PFN-KLLREKALQLAMKHI 1135
Cdd:pfam13249  208 FLGLDRVLKLYeRLPpKPLRRRALRKAEEWI 238
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
1170-1558 5.30e-38

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 145.00  E-value: 5.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1170 KKHLSRISDYLwmAEDGMKMQSF-GSQLWDTGFAMQALL----ASNLSSEISDVLRRGHEFIKNSQvgenpsgdyksmyr 1244
Cdd:cd00688    2 EKHLKYLLRYP--YGDGHWYQSLcGEQTWSTAWPLLALLlllaATGIRDKADENIEKGIQRLLSYQ-------------- 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1245 hISKGAWTFSDRdHGWQVSDCTAHGLKCcllFSMLAPDIvgpKQDPERLHDSVNILLSLQvsiirhrieptsskkhpfsg 1324
Cdd:cd00688   66 -LSDGGFSGWGG-NDYPSLWLTAYALKA---LLLAGDYI---AVDRIDLARALNWLLSLQ-------------------- 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1325 rdsftclqSKNGGMTAWEPagapkwlellnpteMFSDIVIEHEYSECTSSAIQALSLFKQLYPDHRtteitafIKKAAEY 1404
Cdd:cd00688  118 --------NEDGGFREDGP--------------GNHRIGGDESDVRLTAYALIALALLGKLDPDPL-------IEKALDY 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1405 LENMQTRDGSWyGNWGICFTYGTWFALAGLAAAGKTfnDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKiyiaqvgeiS 1484
Cdd:cd00688  169 LLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDL--DSPDAKKALRWLLSRQRPDGGWGEGRDRTNKL---------S 236
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599  1485 NVVQTAWALMGLIHSGQAeRDPIPLHRAAKLIINSQLESGDFPQQQAtgvflknctLHYAAYRNIHPLWALAEY 1558
Cdd:cd00688  237 DSCYTEWAAYALLALGKL-GDLEDAEKLVKWLLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
416-754 1.72e-37

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 144.01  E-value: 1.72e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     416 SQLWDSGFALQALVASNLVNEIPdVLRRGYDFLKNSQVREnpSGDFTNMYRHISKGSWTFS-DRDHgWQASDCTAesfkc 494
Cdd:pfam13243    2 SPVWDTALALHALLEAGVPADHP-ALVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQfANDH-YPDVDDTA----- 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     495 CLLLSMIPPDIVGPKMDPEQLYEAVTILLSLQSKNGGvtaWEPARGQEWLELLN--PtevFADivveHEYNECTSSA-IQ 571
Cdd:pfam13243   73 VVVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGG---WGAFDKDNTKYYLNkiP---FAD----HGALLDPPTAdVT 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     572 ALILfkQLYPNHRTEEINTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNClAMRKGVHFLLTT 651
Cdd:pfam13243  143 ARVL--EMLGQLGYPDDHPVAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRP-YIRKAVDWLKSR 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     652 QKDNGGWGE---SYlscpkKRYIPSEGERSNLVQTSWAMMGLLHAGQAERDpsPLHRAAKLLINSQLENGDFPQQEITG- 727
Cdd:pfam13243  220 QNPDGGWGEdceSY-----KDPKLAGRGPSTASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTWDEPYFTGt 292
                          330       340
                   ....*....|....*....|....*..
gi 3152599     728 AFMKNCLLHYAAYRNIFPVWALAEYRR 754
Cdd:pfam13243  293 GFPRVFYLKYHGYRNYFPLWALARYRN 319
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
99-357 9.74e-30

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 120.67  E-value: 9.74e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599      99 LRKGVNFLSALQASDGHWpaenagplfflpplVFCL---------YVTghLHEIF-TQDHRRE--VLRYIYCHQNEDGGW 166
Cdd:pfam13249    1 IARAQDALLSLQHPDGHW--------------VGELeanvtitaeYIL--LRHFLgPDDPELEakIARYLRSQQREDGGW 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     167 GLHIEGNSTMFCTTLNYICMRILGEGPNGGpgnACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWIL 246
Cdd:pfam13249   65 PLFHGGPGDLSTTVEAYFALKLLGDSPDAP---HMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLL 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     247 PSFLPIHPAKMWCYCRLVYMPMSYLYGKRFVGPISPLIlqLREEIYLQPYAKINWNRARHlcakedaycphpqiQDVIWN 326
Cdd:pfam13249  142 PRWFPFNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVRYYPRPH--------------RLFSWT 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 3152599     327 CLYIFTEPFLACW-PFN-KLLREKALGVAMKHI 357
Cdd:pfam13249  206 NLFLGLDRVLKLYeRLPpKPLRRRALRKAEEWI 238
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
1194-1559 1.24e-29

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 121.29  E-value: 1.24e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1194 SQLWDTGFAMQALLASNLSSEIsDVLRRGHEFIKNSQVGEnpSGDYKSMYRHISKGAWTFS-DRDHgwqvsdctahglkc 1272
Cdd:pfam13243    2 SPVWDTALALHALLEAGVPADH-PALVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQfANDH-------------- 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1273 cllfsmlAPDIvgpkqdperlHDSVNILLSLQVSIIRHRIEPTSSKKHpfsGRDSFTCLQSKNGGMTAWEpagAPKWLEL 1352
Cdd:pfam13243   65 -------YPDV----------DDTAVVVLALDRVRLPDERRRDDAIAR---GIEWILGMQSKNGGWGAFD---KDNTKYY 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1353 LN--PtemFSDI--VIEHEYSECTSsaiQALSLFKQL-YPDHRTTeitafIKKAAEYLENMQTRDGSWYGNWGICFTYGT 1427
Cdd:pfam13243  122 LNkiP---FADHgaLLDPPTADVTA---RVLEMLGQLgYPDDHPV-----AARALEYLKKEQEPDGSWFGRWGVNYIYGT 190
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1428 WFALAGLAAAGKTFNDcEAIRKGVQFLLAAQKDNGGWGE---SYlscsKKIYIAQVGEiSNVVQTAWALMGLIHSGQAER 1504
Cdd:pfam13243  191 WSVLCGLAAVGEDHNR-PYIRKAVDWLKSRQNPDGGWGEdceSY----KDPKLAGRGP-STASQTAWALLALMAAGEVDS 264
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 3152599    1505 DpiPLHRAAKLIINSQLESGDFPQQQATGV-FLKNCTLHYAAYRNIHPLWALAEYR 1559
Cdd:pfam13243  265 P--AVRRGIQYLLETQKPDGTWDEPYFTGTgFPRVFYLKYHGYRNYFPLWALARYR 318
squa_tetra_cyc TIGR04277
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ...
513-754 2.89e-13

squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.


Pssm-ID: 212000 [Multi-domain]  Cd Length: 624  Bit Score: 74.67  E-value: 2.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     513 EQLYEAVTILLSLQSKNGGVTAWEPARGQEwlellNPTEVFA----DIVVEHEYNECTSSAIQALILFKQLYPNHRTEei 588
Cdd:TIGR04277  383 DAIDEGAEFLFSMQNDDGGFPAFDKGKMED-----NLLFKFAfkiaGIADSAEIFDPSCPDITAHILEGLGEFGDQAN-- 455
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     589 NTSIKKAVQYIESIQMLDGSWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAmRKGVHFLLTTQKDNGGWGESYLSC--P 666
Cdd:TIGR04277  456 HDQIQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGWA-KNAINWLLNKQNADGGFGECTLSYndP 534
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599     667 KKRyipSEGERSNLVQTSWAMMGLLHA-GQAERDPSPLHRAAK-LLINSQLENGDFPQQEITGAFMKNCL-LHYAAYRNI 743
Cdd:TIGR04277  535 EKW---NGIGKSTVTQTSWGLLALLAVeDHNDQIKEAADKAAQyLLDQFKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQS 611
                          250
                   ....*....|.
gi 3152599     744 FPVWALAEYRR 754
Cdd:TIGR04277  612 FPLIALGRFLD 622
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
592-632 1.88e-09

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 54.44  E-value: 1.88e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 3152599     592 IKKAVQYIESIQMLDGSWYGSWGVC-FTYSTWFGLGGLAAAG 632
Cdd:pfam00432    3 KEKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
1398-1526 2.45e-07

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 54.48  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1398 IKKAAEYLENMQTRDGSWYG------NWGICF-TYGTWFALAGLAAAGKTFndcEAIRKGVQFLLAAQKDNGGWGESYLS 1470
Cdd:cd00688    1 IEKHLKYLLRYPYGDGHWYQslcgeqTWSTAWpLLALLLLLAATGIRDKAD---ENIEKGIQRLLSYQLSDGGFSGWGGN 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 3152599  1471 CSkkiyiaqvgeiSNVVQTAWALMGLIHSGQAE-RDPIPLHRAAKLIINSQLESGDF 1526
Cdd:cd00688   78 DY-----------PSLWLTAYALKALLLAGDYIaVDRIDLARALNWLLSLQNEDGGF 123
squa_tetra_cyc TIGR04277
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ...
1398-1558 2.99e-07

squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.


Pssm-ID: 212000 [Multi-domain]  Cd Length: 624  Bit Score: 55.02  E-value: 2.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1398 IKKAAEYLENMQTRDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDcEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYI 1477
Cdd:TIGR04277  459 IQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNE-GWAKNAINWLLNKQNADGGFGECTLSYNDPEKW 537
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    1478 AQVGeISNVVQTAWALMGLIH-SGQAERDPIPLHRAAK-LIINSQLESGDFPQQQATGVFLKNCT-LHYAAYRNIHPLWA 1554
Cdd:TIGR04277  538 NGIG-KSTVTQTSWGLLALLAvEDHNDQIKEAADKAAQyLLDQFKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIA 616

                   ....
gi 3152599    1555 LAEY 1558
Cdd:TIGR04277  617 LGRF 620
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
925-968 4.55e-06

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 44.81  E-value: 4.55e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 3152599     925 EHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNYICMRILG 968
Cdd:pfam00432    1 IDKEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
147-189 5.20e-05

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 41.73  E-value: 5.20e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 3152599     147 DHRREVLRYIYCHQNEDGGWGLHIEGNSTMFCTTLNYICMRIL 189
Cdd:pfam00432    1 IDKEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALL 43
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
93-226 1.72e-04

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 45.62  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    93 EIATNALRKGVNFLSALQASDGHWPAENAGPlfflPPLVFC-LYVTGHL-----HEIFTQDHRREVLRYIYCHQNEDGGW 166
Cdd:cd00688   48 DKADENIEKGIQRLLSYQLSDGGFSGWGGND----YPSLWLtAYALKALllagdYIAVDRIDLARALNWLLSLQNEDGGF 123
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599   167 GLHIEGNSTMFC----TTLNYICMRILGEGPNGGPGNACKRARDWILDHggATYIPSWGKTWLS 226
Cdd:cd00688  124 REDGPGNHRIGGdesdVRLTAYALIALALLGKLDPDPLIEKALDYLLSC--QNYDGGFGPGGES 185
A2M_like cd02891
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ...
1375-1507 3.00e-04

Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239221 [Multi-domain]  Cd Length: 282  Bit Score: 44.69  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599  1375 AIQALSLFKQLYPDHRTtEITAFIKKAAEYLENMQTRDGSwYGNWGICFTYGTW--------FALAGLAaagkTFNDCEA 1446
Cdd:cd02891   29 VLKYLDATGQLTPEIRE-KALEYIRKGYQRLLTYQRSDGS-FSAWGNSDSGSTWltayvvkfLSQARKY----IDVDENV 102
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3152599  1447 IRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISnvvQTAWALMGLIHSGQAERDPI 1507
Cdd:cd02891  103 LARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVS---LTAYVLIALAEAGKACDASI 160
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
871-1004 4.11e-04

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 44.08  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   871 ETATSALRRGIHFFSALQASDGHWPAENAGPlfflPPLVF-------CLYITGHLDEVfTSEHRKEILRYIYCHQKEDGG 943
Cdd:cd00688   48 DKADENIEKGIQRLLSYQLSDGGFSGWGGND----YPSLWltayalkALLLAGDYIAV-DRIDLARALNWLLSLQNEDGG 122
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3152599   944 WGLHIEGHSTMFC----TTLNYICMRILGESPDGGHDNACGRAREWILSHggVTYIPSWGKTWLS 1004
Cdd:cd00688  123 FREDGPGNHRIGGdesdVRLTAYALIALALLGKLDPDPLIEKALDYLLSC--QNYDGGFGPGGES 185
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
877-1003 4.52e-04

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 44.52  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   877 LRRGIHFFSALQASDGHWPAEnagplfFLPPLVFCLYITGHLDEVFTSEHRKEI---LRYI--------------YCHQK 939
Cdd:cd02889    1 IRRALDFLLSLQAPDGHWPGE------YSQVWDTALALQALLEAGLAPEFDPALkkaLEWLlksqirdnpddwkvKYRHL 74
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599   940 EDGGWGLHIEGHS-TMF-CTTLNYICMRILGESPDGG---HDNACGRAREWILS----HGGV-TYIPSWGKTWL 1003
Cdd:cd02889   75 RKGGWAFSTANQGyPDSdDTAEALKALLRLQKKPPDGkkvSRERLYDAVDWLLSmqnsNGGFaAFEPDNTYKYL 148
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
641-719 5.67e-04

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 44.13  E-value: 5.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   641 MRKGVHFLLTTQKDNGGWGesylscpkkryipseGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQ-LENGD 719
Cdd:cd02889    1 IRRALDFLLSLQAPDGHWP---------------GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQiRDNPD 65
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
1398-1429 8.48e-04

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 38.65  E-value: 8.48e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3152599    1398 IKKAAEYLENMQTRDGSWYGNWGIC-FTYGTWF 1429
Cdd:pfam00432    3 KEKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYC 35
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
877-989 2.01e-03

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 42.15  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599   877 LRRGIHFFSALQASDGHWPAENAGP---LFFLPPLVFCLYITGHLDEVFTSEHRKEILRYIYCHQKEDGGWGLHIEGHST 953
Cdd:cd00688    1 IEKHLKYLLRYPYGDGHWYQSLCGEqtwSTAWPLLALLLLLAATGIRDKADENIEKGIQRLLSYQLSDGGFSGWGGNDYP 80
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 3152599   954 -MFCTTLNYICMRILGESPDGGHDNACgRAREWILSH 989
Cdd:cd00688   81 sLWLTAYALKALLLAGDYIAVDRIDLA-RALNWLLSL 116
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
1447-1520 2.43e-03

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 41.82  E-value: 2.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3152599  1447 IRKGVQFLLAAQKDNGGWgesylscskkiyiaqVGEISNVVQTAWALMGLIHSGQAERDPIPLHRAAKLIINSQ 1520
Cdd:cd02889    1 IRRALDFLLSLQAPDGHW---------------PGEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQ 59
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
93-179 7.62e-03

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 40.23  E-value: 7.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3152599    93 EIATNALRKGVNFLSALQASDGHWPAEnaGPLFFLPPLV--------FCLYVTGHLHEIFTQDHRREVLRYIYCHQNEDG 164
Cdd:cd00688  100 AVDRIDLARALNWLLSLQNEDGGFRED--GPGNHRIGGDesdvrltaYALIALALLGKLDPDPLIEKALDYLLSCQNYDG 177
                         90
                 ....*....|....*..
gi 3152599   165 GWGLHIE--GNSTMFCT 179
Cdd:cd00688  178 GFGPGGEshGYGTACAA 194
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
99-119 8.70e-03

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 40.28  E-value: 8.70e-03
                         10        20
                 ....*....|....*....|.
gi 3152599    99 LRKGVNFLSALQASDGHWPAE 119
Cdd:cd02889    1 IRRALDFLLSLQAPDGHWPGE 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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