NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|313834847|gb|EFS72561|]
View 

arginine repressor, C-terminal domain protein [Cutibacterium acnes HL056PA1]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArgR super family cl29386
Arginine repressor [Transcription];
1-71 7.48e-25

Arginine repressor [Transcription];


The actual alignment was detected with superfamily member COG1438:

Pssm-ID: 441047  Cd Length: 152  Bit Score: 90.58  E-value: 7.48e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313834847   1 MTKELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQMA 71
Cdd:COG1438   79 LLRELVVSIDHSGNLVVIKTLPGAAQAVASAIDSLGLPEILGTIAGDDTILVIPRSEEDAEELAERLLKLL 149
 
Name Accession Description Interval E-value
ArgR COG1438
Arginine repressor [Transcription];
1-71 7.48e-25

Arginine repressor [Transcription];


Pssm-ID: 441047  Cd Length: 152  Bit Score: 90.58  E-value: 7.48e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313834847   1 MTKELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQMA 71
Cdd:COG1438   79 LLRELVVSIDHSGNLVVIKTLPGAAQAVASAIDSLGLPEILGTIAGDDTILVIPRSEEDAEELAERLLKLL 149
PRK03341 PRK03341
arginine repressor; Provisional
 15-71 2.71e-19

arginine repressor; Provisional


Pssm-ID: 235116  Cd Length: 168  Bit Score: 76.60  E-value: 2.71e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 313834847  15 LVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQMA 71
Cdd:PRK03341 109 LAVLRTPPGAAQYLASAIDRAALPEVVGTIAGDDTVLVIARDPMTGAELAARLLRLA 165
Arg_repressor_C pfam02863
Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, ...
 3-69 4.79e-19

Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460726  Cd Length: 68  Bit Score: 73.19  E-value: 4.79e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 313834847   3 KELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQ 69
Cdd:pfam02863  2 REAVVSIDHAGNLVVIKTLPGNAQAVAAAIDSLNWPEILGTIAGDDTILVICRSEEDAEELAERLKK 68
argR_whole TIGR01529
arginine repressor; This model includes most members of the arginine-responsive ...
 2-68 1.51e-15

arginine repressor; This model includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family, Regulatory functions, DNA interactions]


Pssm-ID: 130592  Cd Length: 146  Bit Score: 66.58  E-value: 1.51e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 313834847    2 TKELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFS 68
Cdd:TIGR01529  77 LKNLVLSIDRAGNLIVIRTKPGEASVIANLLDRLDKDEILGTIAGDDTILVICRDPETAELLMERLL 143
 
Name Accession Description Interval E-value
ArgR COG1438
Arginine repressor [Transcription];
1-71 7.48e-25

Arginine repressor [Transcription];


Pssm-ID: 441047  Cd Length: 152  Bit Score: 90.58  E-value: 7.48e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313834847   1 MTKELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQMA 71
Cdd:COG1438   79 LLRELVVSIDHSGNLVVIKTLPGAAQAVASAIDSLGLPEILGTIAGDDTILVIPRSEEDAEELAERLLKLL 149
PRK03341 PRK03341
arginine repressor; Provisional
 15-71 2.71e-19

arginine repressor; Provisional


Pssm-ID: 235116  Cd Length: 168  Bit Score: 76.60  E-value: 2.71e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 313834847  15 LVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQMA 71
Cdd:PRK03341 109 LAVLRTPPGAAQYLASAIDRAALPEVVGTIAGDDTVLVIARDPMTGAELAARLLRLA 165
Arg_repressor_C pfam02863
Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, ...
 3-69 4.79e-19

Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460726  Cd Length: 68  Bit Score: 73.19  E-value: 4.79e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 313834847   3 KELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQ 69
Cdd:pfam02863  2 REAVVSIDHAGNLVVIKTLPGNAQAVAAAIDSLNWPEILGTIAGDDTILVICRSEEDAEELAERLKK 68
argR_whole TIGR01529
arginine repressor; This model includes most members of the arginine-responsive ...
 2-68 1.51e-15

arginine repressor; This model includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family, Regulatory functions, DNA interactions]


Pssm-ID: 130592  Cd Length: 146  Bit Score: 66.58  E-value: 1.51e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 313834847    2 TKELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFS 68
Cdd:TIGR01529  77 LKNLVLSIDRAGNLIVIRTKPGEASVIANLLDRLDKDEILGTIAGDDTILVICRDPETAELLMERLL 143
PRK04280 PRK04280
transcriptional regulator ArgR;
15-70 2.81e-11

transcriptional regulator ArgR;


Pssm-ID: 179807  Cd Length: 148  Bit Score: 55.40  E-value: 2.81e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 313834847  15 LVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQM 70
Cdd:PRK04280  92 LLVLKTLPGNANSIGALIDNLDWDEILGTICGDDTCLIICRTEEDAEEVKDRFLNM 147
PRK05066 PRK05066
transcriptional regulator ArgR;
3-50 1.51e-09

transcriptional regulator ArgR;


Pssm-ID: 179922 [Multi-domain]  Cd Length: 156  Bit Score: 51.15  E-value: 1.51e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 313834847   3 KELCTGVRNNEYLVVLKTPPGAAQYYGSAIDKAG-LDIVLGTIAGDDTI 50
Cdd:PRK05066  83 KNLVLDIDHNDALIVIHTSPGAAQLIARLLDSLGkAEGILGTIAGDDTI 131
argR PRK00441
arginine repressor; Provisional
 7-70 1.65e-08

arginine repressor; Provisional


Pssm-ID: 179027 [Multi-domain]  Cd Length: 149  Bit Score: 48.51  E-value: 1.65e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 313834847   7 TGVRNNEYLVVLKTPPGAAQYYGSAIDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSQM 70
Cdd:PRK00441  84 ISVENVDNMIVIKTISGSASAAAEAIDTLNFDGIAGTIAGDNTIFVLVRSEEKAQEIVEKIKKL 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH