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Conserved domains on  [gi|31377681|ref|NP_079085|]
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tectonic-2 isoform 1 precursor [Homo sapiens]

Protein Classification

tectonic family protein( domain architecture ID 10544302)

tectonic family protein is a DUF1619 domain-containing protein similar to Homo sapiens tectonic proteins which are components of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 171-444 3.18e-80

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


:

Pssm-ID: 462260  Cd Length: 315  Bit Score: 257.86  E-value: 3.18e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   171 CPCNLTAGACDVRCCCDQECSSNLTTLFRrSCFTGVFGGDVnppfdQLCSAGT----------------TTRGVPDWFpf 234
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFS-SCLVGVVSGDS-----QLCSQKSaifrsnlppqrlfglvTDQINPDLF-- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   235 lCVQSPLANTPfLGYFYHGAVSPKQDSSFEVYVDTDAKDFA-----------DFGYKQGDPIMTVK----KAYFTIPQVS 299
Cdd:pfam07773  73 -CVQSSNNNSP-LGSFFQPPTSVPTPSNFEDSLYKKFTGFSfasesdvssstSSGYKVGDPIQTYNpsssVGYLTLPQSS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   300 LAGQCMQNAPVAFLHNFDVKCVTNLELYQER---DGIINAK--IKNVALGGI-------VTPKVIYEEATDLDKFITNTE 367
Cdd:pfam07773 151 LSGQCVDNNPVAFLQNQSTSCTRRVTDLLDScttLPALSAAsyTSNFILPAVpnsqvvpVTVQSTYLQSLNSGLLTTLTS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   368 T-------PLNNGSTPRIVNVEEHYIFKWNNN-TISEINVKIFRAEINAHQKgIMTQRFVVKFLSYNSGNE-EELSGNPG 438
Cdd:pfam07773 231 TslrgspsPLLNNGTCRNVVLEVKYVITYNGTgGITEATVSLVLANVSASQL-PLQQRFQVSFLSANSESAsESRSGNPG 309


                  ....*.
gi 31377681   439 YQLGKP 444
Cdd:pfam07773 310 YVVGKP 315
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 171-444 3.18e-80

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 257.86  E-value: 3.18e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   171 CPCNLTAGACDVRCCCDQECSSNLTTLFRrSCFTGVFGGDVnppfdQLCSAGT----------------TTRGVPDWFpf 234
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFS-SCLVGVVSGDS-----QLCSQKSaifrsnlppqrlfglvTDQINPDLF-- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   235 lCVQSPLANTPfLGYFYHGAVSPKQDSSFEVYVDTDAKDFA-----------DFGYKQGDPIMTVK----KAYFTIPQVS 299
Cdd:pfam07773  73 -CVQSSNNNSP-LGSFFQPPTSVPTPSNFEDSLYKKFTGFSfasesdvssstSSGYKVGDPIQTYNpsssVGYLTLPQSS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   300 LAGQCMQNAPVAFLHNFDVKCVTNLELYQER---DGIINAK--IKNVALGGI-------VTPKVIYEEATDLDKFITNTE 367
Cdd:pfam07773 151 LSGQCVDNNPVAFLQNQSTSCTRRVTDLLDScttLPALSAAsyTSNFILPAVpnsqvvpVTVQSTYLQSLNSGLLTTLTS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   368 T-------PLNNGSTPRIVNVEEHYIFKWNNN-TISEINVKIFRAEINAHQKgIMTQRFVVKFLSYNSGNE-EELSGNPG 438
Cdd:pfam07773 231 TslrgspsPLLNNGTCRNVVLEVKYVITYNGTgGITEATVSLVLANVSASQL-PLQQRFQVSFLSANSESAsESRSGNPG 309


                  ....*.
gi 31377681   439 YQLGKP 444
Cdd:pfam07773 310 YVVGKP 315
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 171-444 3.18e-80

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 257.86  E-value: 3.18e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   171 CPCNLTAGACDVRCCCDQECSSNLTTLFRrSCFTGVFGGDVnppfdQLCSAGT----------------TTRGVPDWFpf 234
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFS-SCLVGVVSGDS-----QLCSQKSaifrsnlppqrlfglvTDQINPDLF-- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   235 lCVQSPLANTPfLGYFYHGAVSPKQDSSFEVYVDTDAKDFA-----------DFGYKQGDPIMTVK----KAYFTIPQVS 299
Cdd:pfam07773  73 -CVQSSNNNSP-LGSFFQPPTSVPTPSNFEDSLYKKFTGFSfasesdvssstSSGYKVGDPIQTYNpsssVGYLTLPQSS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   300 LAGQCMQNAPVAFLHNFDVKCVTNLELYQER---DGIINAK--IKNVALGGI-------VTPKVIYEEATDLDKFITNTE 367
Cdd:pfam07773 151 LSGQCVDNNPVAFLQNQSTSCTRRVTDLLDScttLPALSAAsyTSNFILPAVpnsqvvpVTVQSTYLQSLNSGLLTTLTS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377681   368 T-------PLNNGSTPRIVNVEEHYIFKWNNN-TISEINVKIFRAEINAHQKgIMTQRFVVKFLSYNSGNE-EELSGNPG 438
Cdd:pfam07773 231 TslrgspsPLLNNGTCRNVVLEVKYVITYNGTgGITEATVSLVLANVSASQL-PLQQRFQVSFLSANSESAsESRSGNPG 309


                  ....*.
gi 31377681   439 YQLGKP 444
Cdd:pfam07773 310 YVVGKP 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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