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Conserved domains on  [gi|313765629|gb|EFS36993|]
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hypothetical protein HMPREF9567_00036 [Cutibacterium acnes HL013PA1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cas1_I-II-III super family cl00656
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 5-47 1.55e-10

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


The actual alignment was detected with superfamily member cd09719:

Pssm-ID: 469862  Cd Length: 262  Bit Score: 56.13  E-value: 1.55e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 313765629   5 HQTSGGTVHVPASIIGALLLGPGTNVTHQAMVLLTESG---AATGD 47
Cdd:cd09719   25 IDAEGGRVQIPVASLSCLLLGPGTSVTHAAVKLLARHGclvVWVGE 70
 
Name Accession Description Interval E-value
Cas1_I-E cd09719
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 5-47 1.55e-10

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187850  Cd Length: 262  Bit Score: 56.13  E-value: 1.55e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 313765629   5 HQTSGGTVHVPASIIGALLLGPGTNVTHQAMVLLTESG---AATGD 47
Cdd:cd09719   25 IDAEGGRVQIPVASLSCLLLGPGTSVTHAAVKLLARHGclvVWVGE 70
cas1_ECOLI TIGR03638
CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; The CRISPR-associated protein Cas1 is ...
 5-47 2.23e-10

CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.


Pssm-ID: 274693  Cd Length: 268  Bit Score: 55.75  E-value: 2.23e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 313765629    5 HQTSGGTVHVPASIIGALLLGPGTNVTHQAMVLLTESG---AATGD 47
Cdd:TIGR03638  31 IDAEGIRVHIPVASLSCLLLGPGTSVTHAAVRLLARHGclvVWVGE 76
 
Name Accession Description Interval E-value
Cas1_I-E cd09719
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 5-47 1.55e-10

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187850  Cd Length: 262  Bit Score: 56.13  E-value: 1.55e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 313765629   5 HQTSGGTVHVPASIIGALLLGPGTNVTHQAMVLLTESG---AATGD 47
Cdd:cd09719   25 IDAEGGRVQIPVASLSCLLLGPGTSVTHAAVKLLARHGclvVWVGE 70
cas1_ECOLI TIGR03638
CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; The CRISPR-associated protein Cas1 is ...
 5-47 2.23e-10

CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.


Pssm-ID: 274693  Cd Length: 268  Bit Score: 55.75  E-value: 2.23e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 313765629    5 HQTSGGTVHVPASIIGALLLGPGTNVTHQAMVLLTESG---AATGD 47
Cdd:TIGR03638  31 IDAEGIRVHIPVASLSCLLLGPGTSVTHAAVRLLARHGclvVWVGE 76
GT_MraY cd06852
Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the ...
 2-57 9.24e-03

Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. It is an integral membrane protein with possibly ten transmembrane domains.


Pssm-ID: 133462  Cd Length: 280  Bit Score: 34.00  E-value: 9.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 313765629   2 PSRHQ------TSGGTVHVPASIIGALLLGPGTNVTHQAMVLLTESGAATGDIDDLAGVTRR 57
Cdd:cd06852    2 PKSHLkkagtpTMGGILFILAILISTLLWADLDSPEVLLLLLLTLGFGLIGFLDDYLKVVKK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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