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Conserved domains on  [gi|31322780|gb|AAP22067|]
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salivary gland metalloprotease [Ixodes scapularis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-400 3.44e-118

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


:

Pssm-ID: 239800  Cd Length: 220  Bit Score: 345.88  E-value: 3.44e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 176 IYPEVHLVVDSTFASAFkFDVYKVTRYFAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYIHnvkgYEKYRNILF 255
Cdd:cd04272   1 VYPELFVVVDYDHQSEF-FSNEQLIRYLAVMVNAANLRYRDLKSPRIRLLLVGITISKDPDFEPYIH----PINYGYIDA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 256 KEALEDFNKQMKSKPFYDTSDIVFL*TGKNMSEWVDGKLQHWVGGYAYLGTACSEWRVGMCEDPPTSYYGAYVFAHELAH 335
Cdd:cd04272  76 AETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTGTGGYAYVGGACTENRVAMGEDTPGSYYGVYTMTHELAH 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31322780 336 NLGCQHDGDGASDWVKGHIGSADCPWDDGYLMSYKMQDERQYQFSYCCQREVRNLYNRPEFKCLR 400
Cdd:cd04272 156 LLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
Salp15 super family cl13541
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 438-483 1.29e-04

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


The actual alignment was detected with superfamily member pfam12115:

Pssm-ID: 314916  Cd Length: 112  Bit Score: 41.22  E-value: 1.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31322780   438 DETYGVRDCKVKCTGNTN------YWRLTvvDGTPCGK-KKACILGKCVDDIK 483
Cdd:pfam12115  60 DKLVDFKNCTFTCGKHNNggtnitLRQLP--DGTPCGPqGKTCKNGKCVGHVP 110
 
Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-400 3.44e-118

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 345.88  E-value: 3.44e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 176 IYPEVHLVVDSTFASAFkFDVYKVTRYFAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYIHnvkgYEKYRNILF 255
Cdd:cd04272   1 VYPELFVVVDYDHQSEF-FSNEQLIRYLAVMVNAANLRYRDLKSPRIRLLLVGITISKDPDFEPYIH----PINYGYIDA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 256 KEALEDFNKQMKSKPFYDTSDIVFL*TGKNMSEWVDGKLQHWVGGYAYLGTACSEWRVGMCEDPPTSYYGAYVFAHELAH 335
Cdd:cd04272  76 AETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTGTGGYAYVGGACTENRVAMGEDTPGSYYGVYTMTHELAH 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31322780 336 NLGCQHDGDGASDWVKGHIGSADCPWDDGYLMSYKMQDERQYQFSYCCQREVRNLYNRPEFKCLR 400
Cdd:cd04272 156 LLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
180-369 8.35e-15

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 72.84  E-value: 8.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780   180 VHLVVDSTFASAFKFDVYKvTRYFAVLTNAANLRYASFvfpKVQLRITGITMNKKPADEPYIHNVKGYekyrnilFKEAL 259
Cdd:pfam13688   7 LLVAADCSYVAAFGGDAAQ-ANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPACSTGD-------SSDRL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780   260 EDFnkQMKSKP-FYDTSDIVFL*TGKNMSEwvdgklqhwvGGYAYLGTACSE-------WRVGMCEDPPTSYYGAYVFAH 331
Cdd:pfam13688  76 SEF--QDFSAWrGTQNDDLAYLFLMTNCSG----------GGLAWLGQLCNSgsagsvsTRVSGNNVVVSTATEWQVFAH 143

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 31322780   332 ELAHNLGCQHDGDGASDWVKGHIGSADCPWDDGYLMSY 369
Cdd:pfam13688 144 EIGHNFGAVHDCDSSTSSQCCPPSNSTCPAGGRYIMNP 181
Salp15 pfam12115
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 438-483 1.29e-04

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


Pssm-ID: 314916  Cd Length: 112  Bit Score: 41.22  E-value: 1.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31322780   438 DETYGVRDCKVKCTGNTN------YWRLTvvDGTPCGK-KKACILGKCVDDIK 483
Cdd:pfam12115  60 DKLVDFKNCTFTCGKHNNggtnitLRQLP--DGTPCGPqGKTCKNGKCVGHVP 110
 
Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-400 3.44e-118

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 345.88  E-value: 3.44e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 176 IYPEVHLVVDSTFASAFkFDVYKVTRYFAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYIHnvkgYEKYRNILF 255
Cdd:cd04272   1 VYPELFVVVDYDHQSEF-FSNEQLIRYLAVMVNAANLRYRDLKSPRIRLLLVGITISKDPDFEPYIH----PINYGYIDA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 256 KEALEDFNKQMKSKPFYDTSDIVFL*TGKNMSEWVDGKLQHWVGGYAYLGTACSEWRVGMCEDPPTSYYGAYVFAHELAH 335
Cdd:cd04272  76 AETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLQTGTGGYAYVGGACTENRVAMGEDTPGSYYGVYTMTHELAH 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31322780 336 NLGCQHDGDGASDWVKGHIGSADCPWDDGYLMSYKMQDERQYQFSYCCQREVRNLYNRPEFKCLR 400
Cdd:cd04272 156 LLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 177-392 2.63e-18

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 82.85  E-value: 2.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 177 YPEVHLVVDSTFASAFKFDVYKVTRYFAVLTNAANLRYASF-VFPKVQLRITGITMNKKPADEPYIhnvkgyekyrnilf 255
Cdd:cd04267   2 EIELVVVADHRMVSYFNSDENILQAYITELINIANSIYRSTnLRLGIRISLEGLQILKGEQFAPPI-------------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 256 kealeDFNKQMKSKPFYDTS-------DIVFL*TGKNMsewVDGKLQhwvgGYAYLGTAC-SEWRVGMCEDPPTSYYGAY 327
Cdd:cd04267  68 -----DSDASNTLNSFSFWRaegpirhDNAVLLTAQDF---IEGDIL----GLAYVGSMCnPYSSVGVVEDTGFTLLTAL 135

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31322780 328 VFAHELAHNLGCQHDGDGASdwvkghigSADCPWDDGYLMSYKMQDERQYQFSYCCQREVRNLYN 392
Cdd:cd04267 136 TMAHELGHNLGAEHDGGDEL--------AFECDGGGNYIMAPVDSGLNSYRFSQCSIGSIREFLD 192
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
180-369 8.35e-15

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 72.84  E-value: 8.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780   180 VHLVVDSTFASAFKFDVYKvTRYFAVLTNAANLRYASFvfpKVQLRITGITMNKKPADEPYIHNVKGYekyrnilFKEAL 259
Cdd:pfam13688   7 LLVAADCSYVAAFGGDAAQ-ANIINMVNTASNVYERDF---NISLGLVNLTISDSTCPYTPPACSTGD-------SSDRL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780   260 EDFnkQMKSKP-FYDTSDIVFL*TGKNMSEwvdgklqhwvGGYAYLGTACSE-------WRVGMCEDPPTSYYGAYVFAH 331
Cdd:pfam13688  76 SEF--QDFSAWrGTQNDDLAYLFLMTNCSG----------GGLAWLGQLCNSgsagsvsTRVSGNNVVVSTATEWQVFAH 143

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 31322780   332 ELAHNLGCQHDGDGASDWVKGHIGSADCPWDDGYLMSY 369
Cdd:pfam13688 144 EIGHNFGAVHDCDSSTSSQCCPPSNSTCPAGGRYIMNP 181
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 177-399 4.64e-11

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 61.86  E-value: 4.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 177 YPEVHLVVDSTFASAFKFDVYKVTRYFAVLTNAANLRYASFvfpKVQLRITGITM----NKKPADEPYIHNVKGYEKYRN 252
Cdd:cd04269   2 YVELVVVVDNSLYKKYGSNLSKVRQRVIEIVNIVDSIYRPL---NIRVVLVGLEIwtdkDKISVSGDAGETLNRFLDWKR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 253 ilfkealEDFNKQMKSkpfydtsDIVFL*TGKNMSEWVDGKlqhwvggyAYLGTACS-EWRVGMCEDPPTSYYG-AYVFA 330
Cdd:cd04269  79 -------SNLLPRKPH-------DNAQLLTGRDFDGNTVGL--------AYVGGMCSpKYSGGVVQDHSRNLLLfAVTMA 136

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31322780 331 HELAHNLGCQHDGDGASdwvkghigsadCPwDDGYLMSYKMQDeRQYQFSYCCQREVRNLYNRPEFKCL 399
Cdd:cd04269 137 HELGHNLGMEHDDGGCT-----------CG-RSTCIMAPSPSS-LTDAFSNCSYEDYQKFLSRGGGQCL 192
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 245-391 4.28e-10

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 58.69  E-value: 4.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 245 KGYEKYRNILFKEALEDFnkqmkskpfyDTSDIVFL*TGKNMsewvDGKLqhwvGGYAYLGTAC-SEWRVGMCED-PPTS 322
Cdd:cd00203  32 QIWRDYLNIRFVLVGVEI----------DKADIAILVTRQDF----DGGT----GGWAYLGRVCdSLRGVGVLQDnQSGT 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31322780 323 YYGAYVFAHELAHNLGCQHDGDGAS--DWVKGHIGSADCPWDDGYLMSY---KMQDERQYQFSYCCQREVRNLY 391
Cdd:cd00203  94 KEGAQTIAHELGHALGFYHDHDRKDrdDYPTIDDTLNAEDDDYYSVMSYtkgSFSDGQRKDFSQCDIDQINKLY 167
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 179-400 9.13e-10

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 58.40  E-value: 9.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 179 EVHLVVDSTFasafkFDVY---KVTRY-FAVLTNAANLRYASFVFPKVQLRITGITMNKKPADEPYI-HNVKGYekyrni 253
Cdd:cd04273   4 ETLVVADSKM-----VEFHhgeDLEHYiLTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLIsGNAQKS------ 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 254 lfkeaLEDFNK-QMKSKPFYDTS----DIVFL*TGKNmsewvdgkLQHWVG-----GYAYLGTACSEWR-VGMCEDppTS 322
Cdd:cd04273  73 -----LKSFCRwQKKLNPPNDSDpehhDHAILLTRQD--------ICRSNGncdtlGLAPVGGMCSPSRsCSINED--TG 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780 323 YYGAYVFAHELAHNLGCQHDGDGASdwvkghigsadCP--WDDGYLMSYKMQ-DERQYQFSYCCQREVRNLYNRPEFKCL 399
Cdd:cd04273 138 LSSAFTIAHELGHVLGMPHDGDGNS-----------CGpeGKDGHIMSPTLGaNTGPFTWSKCSRRYLTSFLDTGDGNCL 206


                .
gi 31322780 400 R 400
Cdd:cd04273 207 L 207
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 201-342 2.44e-06

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 46.59  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780   201 RYFAVLTNAANLRYASFVfpKVQLRITGITMNKkPADEPYIhnvkgyEKYRNILFKEALEDfnkQMKSKPFYDtSDIVFL 280
Cdd:pfam13582   1 ARIVSLVNRANTIYERDL--GIRLQLAAIIITT-SADTPYT------SSDALEILDELQEV---NDTRIGQYG-YDLGHL 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31322780   281 *TGKNMSEwvdgklqhwVGGYAYLGTACSE-WRVGMCED-PPTSYYGAYVFAHELAHNLGCQHD 342
Cdd:pfam13582  68 FTGRDGGG---------GGGIAYVGGVCNSgSKFGVNSGsGPVGDTGADTFAHEIGHNFGLNHT 122
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 276-399 2.37e-05

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 45.37  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322780   276 DIVFL*TGKNmsewvdgkLQHWVGGYAYLGTACS-EWRVGMCEDPPTSYYG-AYVFAHELAHNLGCQHDgdgasdwvkGH 353
Cdd:pfam01421  88 DVAQLLSGVE--------FGGTTVGAAYVGGMCSlEYSGGVNEDHSKNLESfAVTMAHELGHNLGMQHD---------DF 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 31322780   354 IGSADCPWDDGYLMSYKMQDERQYQFSYCCQREVRNLYNRPEFKCL 399
Cdd:pfam01421 151 NGGCKCPPGGGCIMNPSAGSSFPRKFSNCSQEDFEQFLTKQKGACL 196
Salp15 pfam12115
Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary ...
 438-483 1.29e-04

Salivary protein of 15kDa inhibits CD4+ T cell activation; This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.


Pssm-ID: 314916  Cd Length: 112  Bit Score: 41.22  E-value: 1.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31322780   438 DETYGVRDCKVKCTGNTN------YWRLTvvDGTPCGK-KKACILGKCVDDIK 483
Cdd:pfam12115  60 DKLVDFKNCTFTCGKHNNggtnitLRQLP--DGTPCGPqGKTCKNGKCVGHVP 110
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 415-479 3.14e-04

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 38.87  E-value: 3.14e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31322780   415 PGRMTTLSNYCQRVY----RYEKGMHADetygvrDC-KVKCTGNTNYWRLTV----VDGTPCGKKKACILGKCV 479
Cdd:pfam17771   1 PGQLYSADEQCRLIFgpgsTFCPNGDED------VCsKLWCSNPGGSTCTTKnlpaADGTPCGNKKWCLNGKCV 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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