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Conserved domains on  [gi|313225014|emb|CBY20807|]
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unnamed protein product [Oikopleura dioica]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
21-321 1.03e-102

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 306.84  E-value: 1.03e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 101 VGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 180
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 181 RIWCTSTGQCLKTLidnDPTNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNKKYCIfaNFSvTGGKW 260
Cdd:COG2319  271 RLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKT 344

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313225014 261 IVSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIWKSDN 321
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
21-321 1.03e-102

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 306.84  E-value: 1.03e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 101 VGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 180
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 181 RIWCTSTGQCLKTLidnDPTNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNKKYCIfaNFSvTGGKW 260
Cdd:COG2319  271 RLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKT 344

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313225014 261 IVSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIWKSDN 321
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-318 8.38e-98

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 290.39  E-value: 8.38e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  22 CVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWDV 101
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 102 GTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 181
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 182 IWCTSTGQCLKTLIDNdptNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNkkYCIFANFSvTGGKWI 261
Cdd:cd00200  161 LWDLRTGKCVATLTGH---TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 313225014 262 VSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGLegDKLVKIWK 318
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 33-274 8.16e-17

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 81.29  E-value: 8.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  33 ISCVKFSEDGLWLASASADRTIRIW-------NAYDGNIEAVIAGHKLGISEIAW-SNDSTLLCSASDDKTVKIWDVGTR 104
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWnSYIKSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 105 KCLKTLKGHTNYVLCCGFNPQS-SLIVSGSFDESVRIWDVKTGMALKCLPAHSDpVSAVHFNRD-GSLIVSSSYDGLCRI 182
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYY 644

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 183 WCTSTGQC-LKTLIDNDPTnppVSYVKFSPNGKYILAATlDNTLKLWDYSKGRC------LKQYSGHQNKKYciFANFSV 255
Cdd:PLN00181 645 YDLRNPKLpLCTMIGHSKT---VSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--FVGLSV 718

                        250
                 ....*....|....*....
gi 313225014 256 TGGkWIVSGSEDHKVYLWN 274
Cdd:PLN00181 719 SDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 19-58 5.25e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 5.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 313225014    19 NYKCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWN 58
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
21-58 5.83e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 5.83e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 313225014   21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWN 58
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
21-321 1.03e-102

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 306.84  E-value: 1.03e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 101 VGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 180
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 181 RIWCTSTGQCLKTLidnDPTNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNKKYCIfaNFSvTGGKW 260
Cdd:COG2319  271 RLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKT 344

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313225014 261 IVSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIWKSDN 321
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-318 8.38e-98

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 290.39  E-value: 8.38e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  22 CVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWDV 101
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 102 GTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 181
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 182 IWCTSTGQCLKTLIDNdptNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNkkYCIFANFSvTGGKWI 261
Cdd:cd00200  161 LWDLRTGKCVATLTGH---TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 313225014 262 VSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGLegDKLVKIWK 318
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-317 1.16e-90

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 276.02  E-value: 1.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 101 VGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 180
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 181 RIWCTSTGQCLKTLidnDPTNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNKKYCIfaNFSvTGGKW 260
Cdd:COG2319  229 RLWDLATGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFS-PDGKL 302

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 313225014 261 IVSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIW 317
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
22-317 2.27e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 244.44  E-value: 2.27e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  22 CVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWDV 101
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 102 GTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 181
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 182 IWCTSTGQCLKTLidnDPTNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNKKYCIfaNFSvTGGKWI 261
Cdd:COG2319  188 LWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFS-PDGRLL 261

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 313225014 262 VSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIW 317
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS--DDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
38-317 6.09e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 6.09e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  38 FSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWDVGTRKCLKTLKGHTNYV 117
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 118 LCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWCTSTGQCLKTLIDN 197
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 198 DptnPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQYSGHQNKKYCIfaNFSvTGGKWIVSGSEDHKVYLWNLQT 277
Cdd:COG2319  162 S---GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKLLASGSADGTVRLWDLAT 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 313225014 278 KEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIW 317
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 21-229 3.67e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.79  E-value: 3.67e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 101 VGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 180
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 313225014 181 RIWCTSTGQCLKTLIDndpTNPPVSYVKFSPNGKYILAATLDNTLKLWD 229
Cdd:cd00200  244 RVWDLRTGECVQTLSG---HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-183 6.29e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.22  E-value: 6.29e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  18 PNYKCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVK 97
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  98 IWDVGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYD 177
Cdd:cd00200  203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*.
gi 313225014 178 GLCRIW 183
Cdd:cd00200  283 GTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
79-317 7.57e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 7.57e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  79 AWSNDSTLLCSASDDKTVKIWDVGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAHSDP 158
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 159 VSAVHFNRDGSLIVSSSYDGLCRIWCTSTGQCLKTLIdndPTNPPVSYVKFSPNGKYILAATLDNTLKLWDYSKGRCLKQ 238
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 313225014 239 YSGHQNKKYCIfaNFSvTGGKWIVSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIW 317
Cdd:COG2319  158 LTGHSGAVTSV--AFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--ADGTVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 33-274 8.16e-17

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 81.29  E-value: 8.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  33 ISCVKFSEDGLWLASASADRTIRIW-------NAYDGNIEAVIAGHKLGISEIAW-SNDSTLLCSASDDKTVKIWDVGTR 104
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWnSYIKSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 105 KCLKTLKGHTNYVLCCGFNPQS-SLIVSGSFDESVRIWDVKTGMALKCLPAHSDpVSAVHFNRD-GSLIVSSSYDGLCRI 182
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYY 644

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 183 WCTSTGQC-LKTLIDNDPTnppVSYVKFSPNGKYILAATlDNTLKLWDYSKGRC------LKQYSGHQNKKYciFANFSV 255
Cdd:PLN00181 645 YDLRNPKLpLCTMIGHSKT---VSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--FVGLSV 718

                        250
                 ....*....|....*....
gi 313225014 256 TGGkWIVSGSEDHKVYLWN 274
Cdd:PLN00181 719 SDG-YIATGSETNEVFVYH 736
PTZ00421 PTZ00421
coronin; Provisional
 83-182 7.66e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.60  E-value: 7.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  83 DSTLLCSASDDKTVKIWDVG----TRKC---LKTLKGHTNYVLCCGFNPQS-SLIVSGSFDESVRIWDVKTGMALKCLPA 154
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPeeglTQNIsdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKC 166

                         90       100
                 ....*....|....*....|....*...
gi 313225014 155 HSDPVSAVHFNRDGSLIVSSSYDGLCRI 182
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNI 194
PTZ00421 PTZ00421
coronin; Provisional
 23-190 9.87e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.22  E-value: 9.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  23 VLSLKGHTKAISCVKF--SEDGLwLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFhpSAMNV-LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 101 VGTRKCLKTLKGH-TNYVLCCGFNPQSSLIVSGSFDES----VRIWDVKTGMAlkclPAHS---DPVSAVHFN------- 165
Cdd:PTZ00421 197 PRDGTIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMAS----PYSTvdlDQSSALFIPffdedtn 272

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 313225014 166 -----------------RDGSLIVSSSYD------GLCRI--WCTSTGQC 190
Cdd:PTZ00421 273 llyigskgegnircfelMNERLTFCSSYSsvephkGLCMMpkWSLDTRKC 322
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 19-58 5.25e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 5.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 313225014    19 NYKCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWN 58
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
21-58 5.83e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 5.83e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 313225014   21 KCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWN 58
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-142 8.51e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 8.51e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 313225014   103 TRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWD 142
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-142 8.11e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 8.11e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 313225014  104 RKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWD 142
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-58 3.19e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 3.19e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 313225014  19 NYKCVLSLKGHTKAISCVKFSEDGLWLASASADRTIRIWN 58
Cdd:cd00200  250 TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 30-174 5.27e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 5.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  30 TKA-ISCVKF-SEDGLWLASASADRTIRIWNAYDGNIE-AVIAGHKLGISEIAWSNDSTLLcSASDDKTVKIWDVG---- 102
Cdd:PLN00181 616 TKAnICCVQFpSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFVDSSTLV-SSSTDNTLKLWDLSmsis 694

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 313225014 103 --TRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGM-ALKCLPAHSDPVSAVHFNrDGSLIVSS 174
Cdd:PLN00181 695 giNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMpVLSYKFKTIDPVSGLEVD-DASQFISS 768
PTZ00420 PTZ00420
coronin; Provisional
 17-105 8.09e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.42  E-value: 8.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  17 PPnykcVLSLKGHTKAISCVKF----SEdglWLASASADRTIRIWNA--YDGNIEAV------IAGHKLGISEIAWSN-D 83
Cdd:PTZ00420  65 PP----VIKLKGHTSSILDLQFnpcfSE---ILASGSEDLTIRVWEIphNDESVKEIkdpqciLKGHKKKISIIDWNPmN 137

                         90       100
                 ....*....|....*....|..
gi 313225014  84 STLLCSASDDKTVKIWDVGTRK 105
Cdd:PTZ00420 138 YYIMCSSGFDSFVNIWDIENEK 159
PTZ00421 PTZ00421
coronin; Provisional
 13-155 8.74e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 8.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  13 KHTP----PPNYKCVLSLKGhtkAISCVKFSE-DGLWLASASADRTIRIWN-AYDG---NIEAVIA---GH--KLGISEI 78
Cdd:PTZ00421  57 KHTDygklASNPPILLGQEG---PIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGltqNISDPIVhlqGHtkKVGIVSF 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 313225014  79 AWSNDStLLCSASDDKTVKIWDVGTRKCLKTLKGHTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALKCLPAH 155
Cdd:PTZ00421 134 HPSAMN-VLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 61-100 2.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 313225014    61 DGNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-183 9.12e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 9.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 313225014   145 TGMALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 183
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
62-100 1.08e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 313225014   62 GNIEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWD 100
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
149-183 2.98e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.98e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 313225014  149 LKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 183
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 113-314 9.92e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 9.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  113 HTNYVLCCGFNPQSSLIVSGSFDESVRIWDVKTGMALK-----------------------CLPAHSDPVSAVHFNRDGS 169
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLYVSVELD 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  170 LIVSSSYDGLCRIWCTSTGQCLKTLidNDPTNPPVSYVKFSPNGKYILAATLDNTLKLWDY---------SKGR--CLKQ 238
Cdd:pfam20426 203 IVISGSKDGTCIFHTLREGRYVRSI--RHPSGCPLSKLVASRHGRIVLYADDDLSLHLYSIngkhiasseSNGRlnCIEL 280

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 313225014  239 YSghqnkkyCifanfsvtgGKWIVSGSEDHKVYLWNLQTKEIVQKLEGHEDVVICTAVHPNQNMIAsGGLEGDKLV 314
Cdd:pfam20426 281 SS-------C---------GEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA-GTKDGSLLV 339
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 114-317 1.18e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 114 TNYVLCCGFNPQSSLIVSGSFDESVRIWD----VKTGMALKcLP----AHSDPVSAVHFNRD-GSLIVSSSYDGLCRIWC 184
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIH-YPvvelASRSKLSGICWNSYiKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 185 TSTGQCLKTLIDNDPTNPPVSYVKFSPNgkYILAATLDNTLKLWDYSKGRCLKQYSGHQNKkYCIfaNFSVTGGKWIVSG 264
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSADPT--LLASGSDDGSVKLWSINQGVSIGTIKTKANI-CCV--QFPSESGRSLAFG 636

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 313225014 265 SEDHKVYLWNLQTKEI-VQKLEGHEDVVICTAVHPNQNMIASgglEGDKLVKIW 317
Cdd:PLN00181 637 SADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS---STDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 277-318 5.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 313225014   277 TKEIVQKLEGHEDVVICTAVHPNQNMIASGGleGDKLVKIWK 318
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 110-183 9.13e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 9.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 110 LKGHTNYVLCCGFNP-QSSLIVSGSFDESVRIWD-------VKTGMALKC-LPAHSDPVSAVHFNRDGSLIV-SSSYDGL 179
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiphndesVKEIKDPQCiLKGHKKKISIIDWNPMNYYIMcSSGFDSF 149


                 ....
gi 313225014 180 CRIW 183
Cdd:PTZ00420 150 VNIW 153
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
48-233 2.65e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 2.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014  48 ASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWSND-STLLCSASDDKTVKIWDVGTRKCLKTLK--GHTNYVlccGFNP 124
Cdd:COG3391   43 GVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADgRRLYVANSGSGRVSVIDLATGKVVATIPvgGGPRGL---AVDP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 125 QSS-LIVSGSFDESVRIWDVKTGMALKCLPAHSDPVSAVhFNRDGS-LIVSSSYDGlcRIWC------TSTGQCLKTLid 196
Cdd:COG3391  120 DGGrLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIA-VDPDGKrLYVANSGSN--TVSVivsvidTATGKVVATI-- 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 313225014 197 ndPTNPPVSYVKFSPNGKYILAA--------TLDNTLKLWDYSKG 233
Cdd:COG3391  195 --PVGGGPVGVAVSPDGRRLYVAnrgsntsnGGSNTVSVIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-229 6.67e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 313225014   187 TGQCLKTLIDNdptNPPVSYVKFSPNGKYILAATLDNTLKLWD 229
Cdd:smart00320   1 SGELLKTLKGH---TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-229 7.92e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 7.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 313225014  188 GQCLKTLIDNDPtnpPVSYVKFSPNGKYILAATLDNTLKLWD 229
Cdd:pfam00400   1 GKLLKTLEGHTG---SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
278-317 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 313225014  278 KEIVQKLEGHEDVVICTAVHPNQNMIASGGLegDKLVKIW 317
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 55-123 1.55e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 1.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 313225014   55 RIWnaydgniEAVIAGHKLGISEIAWSNDSTLLCSASDDKTVKIWDVGTRKCLKTLKGHTNYVLCCGFN 123
Cdd:pfam12894  28 RVW-------TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
233-274 2.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 313225014  233 GRCLKQYSGHQNKKYCIFANFSvtgGKWIVSGSEDHKVYLWN 274
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
204-256 2.39e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 39.24  E-value: 2.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 313225014 204 VSYVKFSPNGKYILAATLdNTLKLWDYSKGR-CLKQYSGHQ------NKKY---CIFANFSVT 256
Cdd:COG5170  283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCdlmdelNDVYendAIFDKFEIS 344
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
132-280 2.54e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 39.59  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313225014 132 GSFDESVRIWDVKTG--MALKCLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRiWCTSTGQCLKTLIDNDPTNPPVSYVKF 209
Cdd:COG3292  287 GTYGGGLFRLDPKTGkfKRYNPNGLPSNSVYSILEDSDGNLWIGTSGGGLYR-YDPKTGKFTKFSEDNGLSNNFIRSILE 365

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 313225014 210 SPNGKyILAATlDNTLKLWDYSKGRcLKQYSGHQNKK-------YCIFANFSvtGGKWIvsGSEDHKVYLWNLQTKEI 280
Cdd:COG3292  366 DSDGN-LWVGT-NGGLYRLDPKTGK-FTNFTHDPDKNglssnyiNSIFEDSD--GRLWI--GTDGGGLYRYDPKTGKF 436
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 24-81 3.20e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 3.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 313225014   24 LSLKGHTKAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAVIAGHKLGISEIAWS 81
Cdd:pfam12894  32 LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 232-274 5.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.82e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 313225014   232 KGRCLKQYSGHQNKKYCIFANFSvtgGKWIVSGSEDHKVYLWN 274
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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