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Conserved domains on  [gi|313104067|sp|Q05481|]
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RecName: Full=Zinc finger protein 91; AltName: Full=Zinc finger protein HPF7; AltName: Full=Zinc finger protein HTF10

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 2.75e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 122.32  E-value: 2.75e-33
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313104067     13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWN 73
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
320-708 1.08e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 90.53  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  320 KPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKAFKRLSTLTKHK 397
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  398 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRFHTREKPFKCKEcgkAFIWS 474
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  475 STLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKA 554
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  555 FKQFSTLTTHKIIH-------AGKKLYKCEECGKAFNHSSSLSTHK--IIHTGE--KSYKCEE--CGKAFLWSSTLRRHK 621
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  622 RIHTGEKPYKC--EECGKAFSHSSALAKHKRI--HTGEKPYKCKE-----CGKAFSNSSTLANHKITHTEEKP--YKCKE 690
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410
                  ....*....|....*...
gi 313104067  691 CDKTFKRLSTLTKHKIIH 708
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
628-1069 7.09e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 7.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  628 KPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKTFKRLSTLTKHK 705
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  706 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRIHTREKPFKCKEcgkAFIWS 782
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  783 STLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTgekpykckecgkafkhSSALAKHKIIHAGEKLYKCEecgka 862
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS----------------SSSLPLTTNSQLSPKSLLSQ----- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  863 fNQSSNLTTHKIIHTKEKPSKSeECDKAFIWSS----TLTEHKRIHTRektYKCEECGKAFSQPSHLTTHKRM--HTGE- 935
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSS-LPTASSQSSSpnesDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  936 -KPYKCEE--CGKAFSQSSTLTTHKIIHTGEKPYKC--EECGKAFRKSST-----LTEHKIIHTGEKPYKCE--ECGKAF 1003
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 313104067 1004 SQSSTLTRHTRMHTGEKP--YKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHK 1069
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1075-1154 4.56e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 4.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1075 EKPYKCE--ECGKAFSQSSTLTRHkRLHtgekpykcGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNH 1152
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 313104067 1153 KK 1154
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 3.52e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.52e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   281 LTRHKRIHTGEKPYKCEECGKAFSH 305
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 2.75e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 122.32  E-value: 2.75e-33
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313104067     13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWN 73
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 7.51e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 7.51e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 313104067    12 LLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLG 53
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
320-708 1.08e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 90.53  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  320 KPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKAFKRLSTLTKHK 397
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  398 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRFHTREKPFKCKEcgkAFIWS 474
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  475 STLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKA 554
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  555 FKQFSTLTTHKIIH-------AGKKLYKCEECGKAFNHSSSLSTHK--IIHTGE--KSYKCEE--CGKAFLWSSTLRRHK 621
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  622 RIHTGEKPYKC--EECGKAFSHSSALAKHKRI--HTGEKPYKCKE-----CGKAFSNSSTLANHKITHTEEKP--YKCKE 690
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410
                  ....*....|....*...
gi 313104067  691 CDKTFKRLSTLTKHKIIH 708
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 4.33e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 4.33e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 313104067   13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFL 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
628-1069 7.09e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 7.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  628 KPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKTFKRLSTLTKHK 705
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  706 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRIHTREKPFKCKEcgkAFIWS 782
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  783 STLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTgekpykckecgkafkhSSALAKHKIIHAGEKLYKCEecgka 862
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS----------------SSSLPLTTNSQLSPKSLLSQ----- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  863 fNQSSNLTTHKIIHTKEKPSKSeECDKAFIWSS----TLTEHKRIHTRektYKCEECGKAFSQPSHLTTHKRM--HTGE- 935
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSS-LPTASSQSSSpnesDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  936 -KPYKCEE--CGKAFSQSSTLTTHKIIHTGEKPYKC--EECGKAFRKSST-----LTEHKIIHTGEKPYKCE--ECGKAF 1003
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 313104067 1004 SQSSTLTRHTRMHTGEKP--YKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHK 1069
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1075-1154 4.56e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 4.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1075 EKPYKCE--ECGKAFSQSSTLTRHkRLHtgekpykcGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNH 1152
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 313104067 1153 KK 1154
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
617-641 9.93e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 9.93e-05
                           10        20
                   ....*....|....*....|....*
gi 313104067   617 LRRHKRIHTGEKPYKCEECGKAFSH 641
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.52e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   281 LTRHKRIHTGEKPYKCEECGKAFSH 305
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
785-809 3.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.70e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   785 LTRHKRIHTGEKPYKCEECGKAFSR 809
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1093-1116 3.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.08e-03
                           10        20
                   ....*....|....*....|....
gi 313104067  1093 LTRHKRLHTGEKPYKCGECGKAFK 1116
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 684-732 4.55e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 4.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 313104067  684 KPYkCKECDKTFKRLSTLtkhkIIHAGEKLYKCEECGKAFNRSSNLTIH 732
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 2.75e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 122.32  E-value: 2.75e-33
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313104067     13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWN 73
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 7.51e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 7.51e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 313104067    12 LLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLG 53
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
320-708 1.08e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 90.53  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  320 KPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKAFKRLSTLTKHK 397
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  398 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRFHTREKPFKCKEcgkAFIWS 474
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  475 STLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKA 554
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  555 FKQFSTLTTHKIIH-------AGKKLYKCEECGKAFNHSSSLSTHK--IIHTGE--KSYKCEE--CGKAFLWSSTLRRHK 621
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  622 RIHTGEKPYKC--EECGKAFSHSSALAKHKRI--HTGEKPYKCKE-----CGKAFSNSSTLANHKITHTEEKP--YKCKE 690
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410
                  ....*....|....*...
gi 313104067  691 CDKTFKRLSTLTKHKIIH 708
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 4.33e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 4.33e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 313104067   13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFL 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
628-1069 7.09e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 7.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  628 KPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKTFKRLSTLTKHK 705
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  706 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRIHTREKPFKCKEcgkAFIWS 782
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  783 STLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTgekpykckecgkafkhSSALAKHKIIHAGEKLYKCEecgka 862
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS----------------SSSLPLTTNSQLSPKSLLSQ----- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  863 fNQSSNLTTHKIIHTKEKPSKSeECDKAFIWSS----TLTEHKRIHTRektYKCEECGKAFSQPSHLTTHKRM--HTGE- 935
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSS-LPTASSQSSSpnesDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  936 -KPYKCEE--CGKAFSQSSTLTTHKIIHTGEKPYKC--EECGKAFRKSST-----LTEHKIIHTGEKPYKCE--ECGKAF 1003
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 313104067 1004 SQSSTLTRHTRMHTGEKP--YKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHK 1069
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
740-1154 1.33e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 1.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  740 KPYKCEECGKAFNWSSSLTKHKRIHTREKPFKC--KECGKAFIWSSTLTRHKRIHTGEKPYkcEECGKAFSRSSTLTKHK 817
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  818 TIHTGEKP-YKCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEEcdkAFIWSST 896
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  897 LTEHKRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTgEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFR 976
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  977 KSSTLTEHKIIHTGE-------KPYKCEECGKAFSQSSTLTRHTRM--HTGE--KPYKCEE--CGKAFNRSSKLTTHKII 1043
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1044 HTGEKPYKC--EECGKAFISSSTLNGHKRIHTR-----EKPYKCE--ECGKAFSQSSTLTRHKRLHTGEKP--YKCGECG 1112
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 313104067 1113 KAFKESSALTKHKIIHTGEKPYKCEKCGKaFNQSSILTNHKK 1154
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
712-1097 5.17e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.44  E-value: 5.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  712 KLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKC--EECGKAFNWSSSLTKHKRIHTREKPFKC-KECGKAFIWSSTLTRH 788
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  789 KRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKEC-GKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSS 867
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  868 NLTTHKIIHTKEKPSKS---------EECDKAFIWSSTLTEHKRIHTREKTYK------------CEECG------KAFS 920
Cdd:COG5048   192 VSTSIPSSSENSPLSSSysipssssdQNLENSSSSLPLTTNSQLSPKSLLSQSpsslsssdssssASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  921 QPSHLTTHKRMHTG-EKPYKCEECGKAFSQSSTLTTHK--IIHTGE--KPYKCEE--CGKAFRKSSTLTEHKIIHTGEKP 993
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  994 YKC--EECGKAFSQSST--LTRHTRMHTGEKPYKCEE-----CGKAFNRSSKLTTHKIIHTGEKP--YKCEECGKAFISS 1062
Cdd:COG5048   352 AKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 313104067 1063 STLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHK 1097
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
571-957 3.01e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  571 KKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKC--EECGKAFLWSSTLRRHKRIHTGEKPYkcEECGKAFSHSSALAKH 648
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  649 KRIHTGEKP-YKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLSTL--TKHKIIHAGEKLYKCEECGKAFNR 725
Cdd:COG5048   109 SLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsNSLHPPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  726 SSNLT-----IHKFIHTG-----------------EKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFIWSS 783
Cdd:COG5048   189 SSNVStsipsSSENSPLSssysipssssdqnlensSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  784 TLTRHKRIHTGE-------KPYKCEECGKAFSRSSTLTKHK--TIHTGE--KPYKCKE--CGKAFKHSSALAKHKIIHAG 850
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  851 EKLYKC--EECGKAFNQSSN------LTTHKIIHTKEKPSKSEECDKAFIWS-STLTEHKRIHTREKT--YKCEECGKAF 919
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 313104067  920 SQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHK 957
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-597 1.59e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  235 DKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKC--EECGKAFLWSSTLTRHKRIHTGEKPYKCE-ECGKAFSHSSTLAK 311
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  312 HKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPykckeCDKAFKRLS 391
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL-----SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  392 TLTKHKIIHAGEKLYKCEECGKA------------FNRSSNLTIHKFIHTGEKPYKCE---------------ECGKAFN 444
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  445 WSSSLTKHKRFHT-------REKPFKCKECGKAFIWSSTLTRHKR--IHTGE--KPYKCEE--CGKAFRQSSTLTKHKII 511
Cdd:COG5048   266 PTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  512 HTG--EKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKE-------CGKAFKQFSTLTTHKIIHAGK--KLYKCEECG 580
Cdd:COG5048   346 HTSisPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFrpYNCKNPPCS 425

                         410
                  ....*....|....*..
gi 313104067  581 KAFNHSSSLSTHKIIHT 597
Cdd:COG5048   426 KSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
320-509 1.75e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  320 KPYKCEECGKAFSRSSTLAKHKR--IHTGE--KPYKCKE--CGKAFSNSSTLANHKITHTEEKPYKCK--ECDKAFKRLS 391
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  392 TLTKHKIIHageklykceecgkafNRSSNLTIHKFIHTGEKpykceeCGKAFNWSSSLTKHKRFHTREKP--FKCKECGK 469
Cdd:COG5048   368 NNEPPQSLQ---------------QYKDLKNDKKSETLSNS------CIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 313104067  470 AFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHK 509
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 277-397 3.80e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.87  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  277 WSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTL---AKHKRIHT-GEKPYKCE--ECGKAFSRSSTLAKHKrihtgekpy 350
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 313104067  351 KCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHK 397
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1075-1154 4.56e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 4.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1075 EKPYKCE--ECGKAFSQSSTLTRHkRLHtgekpykcGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNH 1152
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 313104067 1153 KK 1154
Cdd:COG5189   418 RK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 613-705 1.33e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.95  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  613 WSSTLRRHKRIHTGEKPYKCEECGKAFSHSSAL---AKHKRIHT-GEKPYKCK--ECGKAFSNSSTLANHK-------IT 679
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKL 380

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 313104067  680 H------------TEEKPYKCKECDKTFKRLSTLTKHK 705
Cdd:COG5189   381 HenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 486-565 4.97e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  486 GEKPYKCE--ECGKAFRQSSTLTKHKiihtgekpyKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFSTLTT 563
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 313104067  564 HK 565
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
866-1157 5.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 5.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  866 SSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKC--EECGKAFSQPSHLTTHKRMHTGEKPYkcEEC 943
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  944 GKAFSQSSTLTTHKIIHTGEKPYKCE-----ECGKAFRKSSTLTEHKIIHTGEKPYK-CEECGKAFSQSS---------- 1007
Cdd:COG5048    96 KSLPLSNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNslhpplpans 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1008 ---------TLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAF----ISSSTLNGHKRIHTR 1074
Cdd:COG5048   176 lskdpssnlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1075 EKPYKCEECGKafSQSSTLTRHKRLHTGE-----KPYKCGECGKAFKESSALTKHK--IIHTGE--KPYKC--EKCGKAF 1143
Cdd:COG5048   256 SASESPRSSLP--TASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLF 333

                         330
                  ....*....|....
gi 313104067 1144 NQSSILTNHKKIHT 1157
Cdd:COG5048   334 SRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
617-641 9.93e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 9.93e-05
                           10        20
                   ....*....|....*....|....*
gi 313104067   617 LRRHKRIHTGEKPYKCEECGKAFSH 641
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 893-1017 1.48e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  893 WSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLT--THKRMH--TGEKPYKCE--ECGKAFSQSSTLTTHKiihtgekpy 966
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNidTPSRMLkvKDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 313104067  967 KCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHtRMHT 1017
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.52e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   281 LTRHKRIHTGEKPYKCEECGKAFSH 305
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
785-809 3.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.70e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   785 LTRHKRIHTGEKPYKCEECGKAFSR 809
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-501 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.77e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   477 LTRHKRIHTGEKPYKCEECGKAFRQ 501
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1009-1033 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.87e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067  1009 LTRHTRMHTGEKPYKCEECGKAFNR 1033
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-669 6.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.04e-04
                           10        20
                   ....*....|....*....|....*.
gi 313104067   644 ALAKHKRIHTGEKPYKCKECGKAFSN 669
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
924-949 6.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 313104067   924 HLTTHKRMHTGEKPYKCEECGKAFSQ 949
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 753-873 7.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 7.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  753 WSSSLTKHKRIHTREKPFKCKECGKAFIWSSTL---TRHKRIHT-GEKPYKCE--ECGKAFSRSSTLTKHKtihtgekpy 826
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 313104067  827 KCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHK 873
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 7.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.95e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   309 LAKHKRIHTGEKPYKCEECGKAFSR 333
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-361 8.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 8.35e-04
                           10        20
                   ....*....|....*....|....*
gi 313104067   337 LAKHKRIHTGEKPYKCKECGKAFSN 361
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 346-425 1.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  346 GEKPYKCK--ECGKAFSNSSTLANHKItHTEEKPYKCKECDKafkrlstlTKHKIIHAGEKLYKCEECGKAFNRSSNLTI 423
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 313104067  424 HK 425
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 990-1069 1.91e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  990 GEKPYKCE--ECGKAFSQSSTLTRHtRMHTgekpykceECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFissSTLNG 1067
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY---KNLNG 413


                  ..
gi 313104067 1068 HK 1069
Cdd:COG5189   414 LK 415
zf-H2C2_2 pfam13465
Zinc-finger double domain;
813-837 2.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 2.56e-03
                           10        20
                   ....*....|....*....|....*
gi 313104067   813 LTKHKTIHTGEKPYKCKECGKAFKH 837
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1048-1159 2.92e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067 1048 KPYKCEECGKAFISSSTLNGHKRIHTREKPYKC--EECGKAFSQSSTLTRHKRLHTGEKPYKCgeCGKAFKESSALTKHK 1125
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 313104067 1126 IIHTGEKPYKCEKC-GKAFNQSSILTNHKKIHTIT 1159
Cdd:COG5048   110 LSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSIS 144
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1093-1116 3.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.08e-03
                           10        20
                   ....*....|....*....|....
gi 313104067  1093 LTRHKRLHTGEKPYKCGECGKAFK 1116
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-538 3.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  321 PYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEE-------KPYKCKECDKAFKRLSTL 393
Cdd:COG5048   226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  394 TKHK--IIHAGEKLYKCEE----CGKAFNRSSNLTIHKFIHTGEKPYKCEEC-------GKAFNWSSSLTKHKRFHTREK 460
Cdd:COG5048   306 TRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDK 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104067  461 PFKC--KECGKAFIWSSTLTRHKRIHTGEKP--YKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKH 536
Cdd:COG5048   386 KSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464


                  ..
gi 313104067  537 KI 538
Cdd:COG5048   465 GK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1120-1145 4.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.06e-03
                           10        20
                   ....*....|....*....|....*.
gi 313104067  1120 ALTKHKIIHTGEKPYKCEKCGKAFNQ 1145
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
981-1005 4.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.22e-03
                           10        20
                   ....*....|....*....|....*
gi 313104067   981 LTEHKIIHTGEKPYKCEECGKAFSQ 1005
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 684-732 4.55e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 4.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 313104067  684 KPYkCKECDKTFKRLSTLtkhkIIHAGEKLYKCEECGKAFNRSSNLTIH 732
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-389 6.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.90e-03
                           10        20
                   ....*....|....*....|....*
gi 313104067   365 LANHKITHTEEKPYKCKECDKAFKR 389
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
756-779 7.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.25e-03
                           10        20
                   ....*....|....*....|....
gi 313104067   756 SLTKHKRIHTREKPFKCKECGKAF 779
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
673-697 9.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 9.27e-03
                           10        20
                   ....*....|....*....|....*
gi 313104067   673 LANHKITHTEEKPYKCKECDKTFKR 697
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1037-1061 9.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 9.64e-03
                           10        20
                   ....*....|....*....|....*
gi 313104067  1037 LTTHKIIHTGEKPYKCEECGKAFIS 1061
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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