NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|311088333|gb|ADP68386|]
View 

NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur tymerlachsoni]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.11e-74

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 221.21  E-value: 1.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVWGSLLMGLIMELLVVVWVMGQNSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088333 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.11e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 221.21  E-value: 1.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVWGSLLMGLIMELLVVVWVMGQNSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088333 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 6.03e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.04  E-value: 6.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   21 SKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPETWGSSIVVWGSLLMGLIMel 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  101 lvvvwvmgqnSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYDCVsWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.11e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 221.21  E-value: 1.11e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVWGSLLMGLIMELLVVVWVMGQNSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088333 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 6.02e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 115.24  E-value: 6.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVwgSLLMGLIMELLVVVWVMGQNSFEVVVGFGDledwvafVGKEIGVVREDSLGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00138  81 SWGSWSVL--GYVVGYLVGVVLAAGLFWGGWYEGSWVVVD-------ELKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|..
gi 311088333 161 FVSVLIVIEIIR 172
Cdd:MTH00138 152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.47e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 106.47  E-value: 1.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGsSIVVWGSLLMGLIMelLVVVWVMgqnsfevVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00065  81 AWG-SWSVLVYVLFYLLL--LIVGYIL-------FGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 311088333 161 FVSVLIVIEIIR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 7.53e-24

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 91.73  E-value: 7.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVWGSLLMGLIMELLVVVWVMGQNSFEVVVGFGDLEDWVafvgkeigVVREDSLGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF--------VVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 311088333 161 FVSVLIVIEIIR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.34e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 67.32  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   1 MIYMMFLLSVIFVLGFMSFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVWGSL--LMGLIMELLVVVWVMGQNSFEVVVGFGDLEdwvafvgkeigvvredSLGVAVLYDCVSWFMVVAGW 158
Cdd:MTH00214  81 SWGGWSVLLFFLfyLLGLGFVGFYFYGGWEMLSWMGVDEANNLD----------------LSGVSDLYSRGFFLLLLGGV 144

                        170
                 ....*....|....
gi 311088333 159 SLFVSVLIVIEIIR 172
Cdd:MTH00214 145 VLFLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 4-170 1.87e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 56.45  E-value: 1.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   4 MMFLLSVIFVLG---FMSFSSkpSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFgstLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  81 TWGSSIVVWGSLLMGLIMELLVVVWVMGQNSFEVVVGFGDLEdwvafvgkeigvvredslGVAVLYDCVSWFMVVAGWSL 160
Cdd:MTH00045  79 VSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVSLSDLV------------------GSSELYNSGGLYLLLGGFIL 140

                        170
                 ....*....|
gi 311088333 161 FVSVLIVIEI 170
Cdd:MTH00045 141 LVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 6.03e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.04  E-value: 6.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333   21 SKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPETWGSSIVVWGSLLMGLIMel 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088333  101 lvvvwvmgqnSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYDCVsWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-78 1.69e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 37.29  E-value: 1.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311088333   4 MMFLLSVIFVLGFMsFSSKPSPIYGGVGLVISGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH