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Conserved domains on  [gi|311088253|gb|ADP68311|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Lepilemur wrightae]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 2-347 5.50e-161

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 453.92  E-value: 5.50e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   2 KPTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHS 81
Cdd:MTH00105   2 NPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  82 GQWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSS 161
Cdd:MTH00105  82 GQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAILS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 162 IMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMIS 241
Cdd:MTH00105 162 ILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 242 LTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTK 321
Cdd:MTH00105 242 SLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENTK 321

                        330       340
                 ....*....|....*....|....*.
gi 311088253 322 QARLMPPLIILATLSLPLSPTLSILY 347
Cdd:MTH00105 322 PMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 2-347 5.50e-161

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 453.92  E-value: 5.50e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   2 KPTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHS 81
Cdd:MTH00105   2 NPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  82 GQWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSS 161
Cdd:MTH00105  82 GQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAILS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 162 IMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMIS 241
Cdd:MTH00105 162 ILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 242 LTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTK 321
Cdd:MTH00105 242 SLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENTK 321

                        330       340
                 ....*....|....*....|....*.
gi 311088253 322 QARLMPPLIILATLSLPLSPTLSILY 347
Cdd:MTH00105 322 PMTLLPTLIILSTMLLPLTPMLSILE 347
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-281 5.15e-19

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 85.83  E-value: 5.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   23 SSHWFLMWVGLEINMLGIIP-ILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNIINFHNQLTPLTTTIA 101
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  102 LTM-----------KLGMTPFHFWVPEVTQGISLMTGMLLL-TWQKLAPISIM-----LQIHPWTNLNILLMIATSSIMV 164
Cdd:pfam00361  81 LLLlfllilvgflfKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIrrsllYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  165 GGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTM---------LTLSNLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGSVIyrrvhtrniRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 311088253  236 KTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATI 281
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLA 286
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-297 6.12e-19

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 87.31  E-value: 6.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253    6 LPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQW 84
Cdd:TIGR01770 104 FYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   85 NIINFHNQLTPLTTTI------------ALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQI------- 145
Cdd:TIGR01770 184 NFEDLLLFLSNGMLNIsllllgivlilvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLflyilfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  146 --HPWTNlnILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNT 223
Cdd:TIGR01770 264 fsEAWQI--FLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALMSLGAFGVL 341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  224 NTTMLT----------LSNLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFY 293
Cdd:TIGR01770 342 SLLRSYkdewieyisdFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYY 421


                  ....
gi 311088253  294 MRLI 297
Cdd:TIGR01770 422 LRVV 425
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 7-298 1.86e-18

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 85.94  E-value: 1.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   7 PLIMITIFTGTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWN 85
Cdd:COG1007  105 YALLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSLN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  86 IINF-----HNQLTPLTTTIALTM-------KLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQI-------- 145
Cdd:COG1007  185 LAGIaaalaAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafpgl 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 146 -HPWTNlnILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYL---------ALTIIM 215
Cdd:COG1007  265 aADWQL--LLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLlaylfmnlgAFAVIL 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 216 FTTLNLNTNTTMLTLSNLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMR 295
Cdd:COG1007  343 LLSRKGGEAEEIEDLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLR 422


                 ...
gi 311088253 296 LIY 298
Cdd:COG1007  423 VVK 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 2-347 5.50e-161

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 453.92  E-value: 5.50e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   2 KPTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHS 81
Cdd:MTH00105   2 NPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  82 GQWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSS 161
Cdd:MTH00105  82 GQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAILS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 162 IMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMIS 241
Cdd:MTH00105 162 ILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 242 LTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTK 321
Cdd:MTH00105 242 SLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENTK 321

                        330       340
                 ....*....|....*....|....*.
gi 311088253 322 QARLMPPLIILATLSLPLSPTLSILY 347
Cdd:MTH00105 322 PMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 3-343 8.23e-111

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 326.39  E-value: 8.23e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   3 PTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSG 82
Cdd:MTH00112   3 PHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  83 QWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSSI 162
Cdd:MTH00112  83 QWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAILST 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 163 MVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISL 242
Cdd:MTH00112 163 LIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNT 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 243 TIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFqTTKQ 322
Cdd:MTH00112 243 TLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRT-KPKK 321

                        330       340
                 ....*....|....*....|.
gi 311088253 323 ARLMPPLIILATLSLPLSPTL 343
Cdd:MTH00112 322 NTLTATLTTLSTLLLPLSPMI 342
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 3-346 1.13e-110

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 325.99  E-value: 1.13e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   3 PTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSG 82
Cdd:MTH00135   3 PYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  83 QWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPwTNLNILLMIATSSI 162
Cdd:MTH00135  83 QWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAP-TNPTLLITLGLTST 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 163 MVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISL 242
Cdd:MTH00135 162 LVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 243 TIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTKQ 322
Cdd:MTH00135 242 LTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQL 321

                        330       340
                 ....*....|....*....|....
gi 311088253 323 ARLMPPLIILATLSLPLSPTLSIL 346
Cdd:MTH00135 322 TLPLAISTTATLMLLPLTPAILAL 345
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 3-343 6.42e-108

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 319.17  E-value: 6.42e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   3 PTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSG 82
Cdd:MTH00070   3 PYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  83 QWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSSI 162
Cdd:MTH00070  83 EWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLLST 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 163 MVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISL 242
Cdd:MTH00070 163 LIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 243 TIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTKQ 322
Cdd:MTH00070 243 MMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFKNKTN 322

                        330       340
                 ....*....|....*....|.
gi 311088253 323 ArLMPPLIILATLSLPLSPTL 343
Cdd:MTH00070 323 N-LLSLTIILSLMLLPITPTI 342
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 3-346 9.61e-80

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 247.19  E-value: 9.61e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   3 PTILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSG 82
Cdd:MTH00200   3 PLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  83 QWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSSI 162
Cdd:MTH00200  83 QWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLLSV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 163 MVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISL 242
Cdd:MTH00200 163 LVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 243 TIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTKQ 322
Cdd:MTH00200 243 LLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSNSN 322

                        330       340
                 ....*....|....*....|....
gi 311088253 323 aRLMPPLIILATLSLPLSPTLSIL 346
Cdd:MTH00200 323 -LLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 4-347 1.18e-75

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 236.75  E-value: 1.18e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   4 TILPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQ 83
Cdd:MTH00041   4 NVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  84 WNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSSIM 163
Cdd:MTH00041  84 WSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGILSVL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 164 VGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISLT 243
Cdd:MTH00041 164 VGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAFL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 244 IMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKWQFQTTKQA 323
Cdd:MTH00041 244 FILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGNITV 323

                        330       340
                 ....*....|....*....|....*.
gi 311088253 324 R--LMPPLIILATLSLPLSPTLSILY 347
Cdd:MTH00041 324 YgvILSILSSISILGLLLIPLFLSFL 349
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 8-346 1.00e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 166.54  E-value: 1.00e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   8 LIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMhsgqwnII 87
Cdd:MTH00160   9 LFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML------NL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  88 NFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIhpwTNLNILLMIATSSIMVGGW 167
Cdd:MTH00160  83 MLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL---INNNFIIIIIILSAIIGAI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 168 GGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISLTIMIV 247
Cdd:MTH00160 160 GGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 248 LLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYStslTLFPTFNTMKMKWQFQTTKQARLMP 327
Cdd:MTH00160 240 LLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYS---SLMLNYNKNKWNLKKKKNKFSLILN 316

                        330
                 ....*....|....*....
gi 311088253 328 PLIILATLSLPLSPTLSIL 346
Cdd:MTH00160 317 FLSFISLFGLILSSLLFLL 335
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 8-315 2.13e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 165.44  E-value: 2.13e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   8 LIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNII 87
Cdd:MTH00144   8 LFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFSM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  88 NFhnqltpltTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNL-NILLMIATSSIMVGG 166
Cdd:MTH00144  88 SL--------LLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVISVLSALVGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 167 WGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLwNKTPMISLTIMI 246
Cdd:MTH00144 160 IGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPSYKTGLSIIS 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311088253 247 VLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYSTSLTLFPTFNTMKMKW 315
Cdd:MTH00144 239 LLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 8-312 6.89e-45

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 156.48  E-value: 6.89e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   8 LIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNII 87
Cdd:MTH00011  10 LFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLLKNI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  88 nfhnqlTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNILLMIATSSIMVGGW 167
Cdd:MTH00011  90 ------TALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 168 GGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISLTIMIV 247
Cdd:MTH00011 164 GGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIM 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311088253 248 LLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYStSLTLFPTFNTMK 312
Cdd:MTH00011 244 LLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN-FMYLSPTFSSLK 307
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-300 1.96e-36

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 134.03  E-value: 1.96e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   8 LIMITIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHsgqwnii 87
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSN------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  88 NFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHpwTNLNILLMIATSSIMVGGW 167
Cdd:MTH00197  75 LYLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNS--SSFMGLLICSVLSSLIGGI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 168 GGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWNKTPMISLTIMIV 247
Cdd:MTH00197 153 GGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLS 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 311088253 248 LLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYST 300
Cdd:MTH00197 233 FLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 7-298 1.07e-24

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 103.94  E-value: 1.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   7 PLIMITIFTGTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWN 85
Cdd:MTH00199 100 PILILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  86 IINFHNQLT----PLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPWTnlNILLMIATSS 161
Cdd:MTH00199 180 IQGINSILTgdvgKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVT--NVVLICAVLS 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 162 IMVGGWGGLNQTQLRKILAYSSIAHMG---WMMAIITFCP-SLTVLNLFIYLALTIIMFTTLNLNTNTTMLT--LSNLWN 235
Cdd:MTH00199 258 IIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESiQASLIYMIIYVIMSICSFSIILSLKLTKGLIveVSGLSR 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 311088253 236 KTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIY 298
Cdd:MTH00199 338 KNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRVVQ 400
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-297 9.53e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 97.41  E-value: 9.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  16 GTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIV-------------FNAMHS 81
Cdd:MTH00196   5 GILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCAllcgttgglhlsyINLVLN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  82 GQWNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHPwtNLNILLMIATSS 161
Cdd:MTH00196  85 SGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGGLFS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 162 IMVGGWGGLNQTQLRKILAYSSIAHMGWMM------AIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTMLTLSNLWN 235
Cdd:MTH00196 163 LFVGAIGALNQTKIKRLLAYSGIGHMGFVLwgieigSFESIQASLVYLFIYIIMSICVFSIILALNVYKNLIIEFSGLSR 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 311088253 236 KTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLI 297
Cdd:MTH00196 243 RLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIV 304
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-281 5.15e-19

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 85.83  E-value: 5.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   23 SSHWFLMWVGLEINMLGIIP-ILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNIINFHNQLTPLTTTIA 101
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  102 LTM-----------KLGMTPFHFWVPEVTQGISLMTGMLLL-TWQKLAPISIM-----LQIHPWTNLNILLMIATSSIMV 164
Cdd:pfam00361  81 LLLlfllilvgflfKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIrrsllYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  165 GGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNTNTTM---------LTLSNLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGSVIyrrvhtrniRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 311088253  236 KTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATI 281
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLA 286
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-297 6.12e-19

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 87.31  E-value: 6.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253    6 LPLIMITIFTGTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQW 84
Cdd:TIGR01770 104 FYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   85 NIINFHNQLTPLTTTI------------ALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQI------- 145
Cdd:TIGR01770 184 NFEDLLLFLSNGMLNIsllllgivlilvGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLflyilfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  146 --HPWTNlnILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLALTIIMFTTLNLNT 223
Cdd:TIGR01770 264 fsEAWQI--FLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALMSLGAFGVL 341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  224 NTTMLT----------LSNLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFY 293
Cdd:TIGR01770 342 SLLRSYkdewieyisdFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYY 421


                  ....
gi 311088253  294 MRLI 297
Cdd:TIGR01770 422 LRVV 425
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 7-298 1.86e-18

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 85.94  E-value: 1.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   7 PLIMITIFTGTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWN 85
Cdd:COG1007  105 YALLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSLN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  86 IINF-----HNQLTPLTTTIALTM-------KLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQI-------- 145
Cdd:COG1007  185 LAGIaaalaAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafpgl 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 146 -HPWTNlnILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYL---------ALTIIM 215
Cdd:COG1007  265 aADWQL--LLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLlaylfmnlgAFAVIL 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 216 FTTLNLNTNTTMLTLSNLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMR 295
Cdd:COG1007  343 LLSRKGGEAEEIEDLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLR 422


                 ...
gi 311088253 296 LIY 298
Cdd:COG1007  423 VVK 425
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
7-297 2.22e-15

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 76.78  E-value: 2.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   7 PLIMITIFtGTMLTMISSHWFLMWVGLEINMLGI-IPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWN 85
Cdd:PRK05777 107 LLVLFALL-GMMVMVSANDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLYGATGSLS 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  86 IINFHNQLTPLTTT------------IALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQI-------H 146
Cdd:PRK05777 186 FAGIAKALADGSGNsllllfglvfllVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafggL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 147 PWTNLNILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYLAL---------TIIMFT 217
Cdd:PRK05777 266 SEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAylfmtlgafGVISLL 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 218 TLNLNTNTTMLTLSNLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLI 297
Cdd:PRK05777 346 RRKGGEAESISDFAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVI 425
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 7-301 1.93e-14

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 73.64  E-value: 1.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   7 PLIMITIFtGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNI 86
Cdd:COG0651  111 PLFLLLLA-GMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNM 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  87 INFHNQLTPLTTTIALT----------MKLGMTPFHFWVPE-----------VTQGISLMTGM--LLLTWQKLAPISIML 143
Cdd:COG0651  190 ADLAARLAELDPGLLLAafalllvgfgIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVLTLLFGADPAL 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 144 QIHPWtnlniLLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMAIITFCPSLTVLNLFIYL---ALTIIMF---- 216
Cdd:COG0651  270 FLGTL-----LLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhALAKALLflaa 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 217 -TTLNLNTNTTMLTLSNLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMR 295
Cdd:COG0651  345 gAIERATGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVR 424


                 ....*.
gi 311088253 296 LIYSTS 301
Cdd:COG0651  425 IFGRAQ 430
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 6-191 1.11e-09

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 59.49  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   6 LPLIMItIFTGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRST---------EAATKYFLVQTTASMLLMFAIVF 76
Cdd:MTH00198 191 FALVLI-VGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCAL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  77 NAMHSGQ--------------WNIINFHNQLTPLTTTIALTMKLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIM 142
Cdd:MTH00198 270 YFGFTGNegmlgtilsatletTNIELRQGSLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL 349

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 311088253 143 LQIHPWTNLniLLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:MTH00198 350 TSLVITSKL--LLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-341 2.40e-09

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 52.65  E-value: 2.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 311088253  291 YFYMRLIYSTSLTLFPTFNTMKMKWQFQTTKQARLMPPLIILATLSLPLSP 341
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 10-191 7.11e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 53.95  E-value: 7.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  10 MITIFTGTMLTM-ISSHWFLMWVGLEINML-GIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIvfnAMHSGQWNII 87
Cdd:PRK08376 126 LILLLELGMLGMaITGDLFNFFVFLEIMSIaSYALVAFRNDTWEAIEAGIKYMFVGSLASSMVLLGI---ALLYGQYGTL 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  88 NF-----HNQLTPLTTTI--------ALTMKLGMTPFHFWVPEV-TQGISLMTGMLLLTWQ----KLAPISIML---QIH 146
Cdd:PRK08376 203 NMaylavKMSENPTVVAKialalfiaGLAMKSGAVPVHMWLPDAyPAAPSSISAMLLVIKQaglyALARVLFSIygpAIN 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 311088253 147 PWTNLNILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:PRK08376 283 LATVGWVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYML 327
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 55-192 3.17e-07

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 51.62  E-value: 3.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  55 AATKYFLVQTTASMLLMFAIVFNAMHSGQW--NIINFHNQLTPLTTT--------IALTMKLGMTPFHFWVPEV-----T 119
Cdd:COG1008  162 AAIKFFLYTLAGSLLMLVAILALYFLAGALtfDIAELAAAPLPLTAQlllflaffIAFAVKVPMFPFHTWLPDAhveapT 241

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311088253 120 QGISLMTGMLLltwqKLAP---ISIMLQIHP--WTNLNILLMI-ATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMA 192
Cdd:COG1008  242 AGSVLLAGVLL----KMGGyglLRFALPLFPeaSAYFAPLLAAlGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLL 316
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 27-191 3.66e-07

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 51.48  E-value: 3.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   27 FLMWVGLEINMLGIIPILMKNHKPRsteAATKYFLVQTTASMLLMFAIVFNA-MHSGQWNIINFHNQLTPLTTT------ 99
Cdd:TIGR01972 132 YVFWEAMLIPMYLLIGVWGGPNRIY---AAMKFFLYTLAGSLLMLLAILGLYfLGGGTFDLLELLNLPLPFGVQtwlfla 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  100 --IALTMKLGMTPFHFWVPEV-----TQGISLMTGMLLltwqKLAPISIM---LQIHPWTNLN---ILLMIATSSIMVGG 166
Cdd:TIGR01972 209 ffIAFAVKVPLFPLHTWLPDAhveapTAGSVILAGVLL----KMGTYGFLrfnLPLFPDASLYfapVLAALGVIAIIYGA 284

                         170       180
                  ....*....|....*....|....*
gi 311088253  167 WGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:TIGR01972 285 LIALAQTDIKRLIAYSSISHMGFVL 309
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 11-192 5.10e-07

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 51.31  E-value: 5.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  11 ITIFTGTMLTM-ISSHWFLMWVGLEinMLGIIPILM---KNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNI 86
Cdd:COG1009  117 LLLFMAAMLGLvLSDNLLLLFVFWE--LVGLCSYLLigfWYEKPSARRAARKAFLVTRVGDLGLLLGILLLGAIAGTLNF 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  87 ----INFHNQLTPLTTTIALTM-------KLGMTPFHFWVPE-----------------VTQGISLMTgmllltwqKLAP 138
Cdd:COG1009  195 sellAAAPTILSSPLLTLILLLlllgafgKSAQFPLHFWLPDamegptpvsallhaatmVKAGVYLLA--------RLSP 266

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 311088253 139 IsimLQIHPWTnLNILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMMA 192
Cdd:COG1009  267 L---FALSPVW-LTVVAIIGAITALFAALIALAQTDIKRVLAYSTVSQLGYMFL 316
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 15-191 1.31e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 49.88  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  15 TGTMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNIINFHNQLT 94
Cdd:PRK08375 117 AGLLGALLTADLFNLFVFLEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNMADLAGALA 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  95 PLTTT--------IALTMKLGMTPFHFWVP----EVTQGISLMTGMLLLTWQKLAPISIMLQI------HPWTNLNILLM 156
Cdd:PRK08375 197 ENPTVvtafgfvlLALALKAAVFPLHTWLPraypAAPPVVTALLSGLVTKVAVYALIRIYFTVfggdfrFALGLGWLLAV 276

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 311088253 157 IATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:PRK08375 277 LALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYIL 311
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
9-191 3.84e-06

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 48.51  E-value: 3.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253   9 IMITIFTGTMLTMISSHWFLMWVGLEinMLGIIPILMKNH---KPRSTEAATKYFLVQTTASMLLMFAI-VFNAMHSGQW 84
Cdd:PRK02504 115 ILLTATLGGMFLSGATELVMIFISLE--TLSIASYLLTGYmkrDPRSNEAALKYLLIGAASSAIFLYGSsLLYGLSGGST 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  85 NIINFHNQLT---PLTTTIALTM-------KLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLA----PISIMLQIHP--- 147
Cdd:PRK02504 193 QLSAIALALItspSLGLALALVFviagiafKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPsfd 272

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 311088253 148 --WTNLNILLMIAtsSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:PRK02504 273 eqWKLLFTALAIL--SMVLGNVVALAQTSMKRMLAYSSIGQAGFVM 316
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 55-191 1.53e-05

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 46.56  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  55 AATKYFLVQTTASMLLMFAIVFNAMHSGQ--WNIINFHNQLTPLTTT--------IALTMKLGMTPFHFWVP----EVTQ 120
Cdd:PRK12561 138 AATKFILYTALASIFILVAGLALALSGDTftFDLAELGAKSYPLALElllyagflIAFGVKLPIFPLHTWLPdahgEASA 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088253 121 GISLMTGMLLLTWQKLAPISIMLQIHPWTNLN---ILLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:PRK12561 218 PVSMILAGVLLKMGGYALIRFNVQMLPDAHVYfapALAILGVVNIIYGALNAFAQDNVKRRLAYSSVSHMGFVL 291
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 55-191 8.27e-05

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 44.04  E-value: 8.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  55 AATKYFLVQTTASMLLMFAI----VFNAMHSGQWNIINFHNqlTPLTTT----------IALTMKLGMTPFHFWVPEV-- 118
Cdd:PRK05846 162 AATKFFLYTLLGSLLMLVAIiylvVVYYNATGTFDIADLLN--LPLPPGvqywlflaffIAFAVKMPMFPLHTWLPDAhv 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 119 ---TQGISLMTGMLLltwqKLAP---ISIMLQIHPWTNLNIL-LMIATSSIMV--GGWGGLNQTQLRKILAYSSIAHMGW 189
Cdd:PRK05846 240 qapTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEFApIIITLGVIAIiyGALVALAQTDIKKLIAYSSISHMGF 315


                 ..
gi 311088253 190 MM 191
Cdd:PRK05846 316 VT 317
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 17-346 5.74e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 41.73  E-value: 5.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  17 TMLTMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMF---AIVFNAMHSGQW---NIINFH 90
Cdd:PRK06589 129 GVLIALSSDLFTMFVCYELLTISTAFLIGHTRNNISLSGGYKYLKILMISALLLFLpavILIYTKTGNLDFvsgGLFSKN 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  91 NQLTPLTTTIALTMKLGMTPFHFWVPEV----TQGISLMTGMLLLTWQKLAPISIMLQIHPWTNL-------NILLMIAT 159
Cdd:PRK06589 209 QSIILLLMFIYGIAKTAIFPVHSWLPAAmvahYPVSALLHAVIVVKTGLFCIYKILLYIFGLSYLqrifaefNWLIFIPI 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 160 SSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM--AIITFCPSLTVLNL------FIYLALTIIMFTTLNLNTNTTMLTLS 231
Cdd:PRK06589 289 VSIFYSSLKALKTDNIKKILAYSTISQLSLALlsAFILTPKALGAAILhlvshsFAKICLFYSMGSIYSLKKEDQVDKLH 368

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 232 NLWNKTPMISLTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIM----ALLNLYFYMRLIYStslTLFPT 307
Cdd:PRK06589 369 GTSKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLSIIVMLVviasSILSALYLLKILSS---IYKPS 445

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 311088253 308 FNtmkmKWQFQTTKQARLMPPLIILATLSLPLSPTLSIL 346
Cdd:PRK06589 446 LS----ENSFITKSLPYLMQISVITCCCALTLFYFIQIL 480
PRK12650 PRK12650
DUF4040 family protein;
94-194 7.55e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 41.57  E-value: 7.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  94 TPLTTTIALTM------KLGMTPFHFWVPEVTQGISLMTGMLLLTWQKLAPISIMLQIHP-------WtnlNILLMIA-- 158
Cdd:PRK12650 204 PGLTTVVAVLIavaaftKSAQFPFHFWLPEAMAAITPVSAFLHAAAVVKAGIYLLLRFSPvfhdvavW---NWLLIIVgm 280

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 311088253 159 TSSIMvGGWGGLNQTQLRKILAYSSIAHMGWMMAII 194
Cdd:PRK12650 281 ITALM-GAVFAVQKTDLKKLTAYSTVSQLGWIVATI 315
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
55-191 2.26e-03

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 39.70  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  55 AATKyFLVQTTASMLLMFA----IVF-NAMHSGQWNIINFHNqLTPLTTTIALTM-------KLGMTPFHFWVP----EV 118
Cdd:PRK07363 158 ASIK-FLIYTAVSGLLVLAaflgIVWlSGSTSFDYDAISTQN-LSLNTQLILLTGlllgfgiKIPLVPLHTWLPdaytEA 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 311088253 119 TQGISLMTGMLLLTWQKLAPISIMLQIHPWTNLNI---LLMIATSSIMVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:PRK07363 236 SPAVAILLGGVLAKLGTYGLLRFGLQLFPQTWSLVapgLAIIGTISVIYGALSAIAQKDIKRMVAYSSIGHMGYIL 311
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 10-196 2.78e-03

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 39.53  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  10 MITIFTGTML-TMISSHWFLMWVGLEINMLGIIPILMKNHKPRSTEAATKYFLVQTTASMLLMFAIVF------NAMHSG 82
Cdd:PRK06458 113 MYQLFLFTMLlALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIICSVGVAFALFGTILvyanaaTVMGDG 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  83 Q----WNIINFHN-QLTPLTTTIALTM-------KLGMTPFHFWVP----EVTQGISLMTGMLLLTWQKLAPIS---IML 143
Cdd:PRK06458 193 EmailWTELLKHAsLLDPTLMKLAFVFlligfgtKVGLFPMHAWLPdahsEAPSPVSALLSGVLLNVALYAVLRyyiLID 272

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 311088253 144 QIHPWTNLNILLMI-ATSSIMVGGWGGLNQTQLRKILAYSSIAHMGwmmaIITF 196
Cdd:PRK06458 273 AAIGSDFPGRLLLIfGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMG----LIAF 322
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 48-299 3.88e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 38.80  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253  48 HKPRSTEAATKYFLVQTTASMLLMFAIVFNAMHSGQWNIIN----FHNQLTPLTT-----------------TIALTMKL 106
Cdd:PRK12667 158 DRGDAVEAAIKYALIGAVGTTLYFLALAFLYATFGTLNMADlsakIRGLSFPLTGglagnpplalgvalalaLWAFTIKA 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 107 GMTPFHFWVPEV----TQGISLMTGMLLLTWQKLAPISIMLQIHPWTN---------LNILLMIATSSIMVGGWGGLNQT 173
Cdd:PRK12667 238 AIFPNHFWLPDAhpaaPSPVSAMLSGLVVNVGAYAIIRFLYTIFGISPslidfraalSPILIILGAVSAIIGALMMVVQK 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 174 QLRKILAYSSIAHMGW-MMAIITfcPSLTVLNLFIY-----------LALTIIMFttLNLNTNTTMLTLSNLWNKTPMIS 241
Cdd:PRK12667 318 DVKRLLAYSTISHMGYiFMGIGI--GTQLGLAAALFhiinhaiakslLFLASGVF--IHAAGTRDIDELAGLGRKMPIAS 393

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 311088253 242 LTIMIVLLSLGGLPPLTGFLPKWAIIQELSKNNNIIMATIMAIMALLNLYFYMRLIYS 299
Cdd:PRK12667 394 FAFLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
100-191 8.73e-03

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 37.76  E-value: 8.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088253 100 IALTMKLGMTPFHFWVP----EVTQGIS-LMTGMLL-LTWQKLAPISIMLQIHPWTNLN-ILLMIATSSIMVGGWGGLNQ 172
Cdd:PRK06473 213 VGFGIKIPLVPFHTWLPdahvEASTPVSvLLAGVLLkLGTYGLLRFGVGLFPEAWVYLApWLATWAVVSVLYGASCAIAQ 292

                         90
                 ....*....|....*....
gi 311088253 173 TQLRKILAYSSIAHMGWMM 191
Cdd:PRK06473 293 KDMKKMVAYSSIGHMGYIL 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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