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Conserved domains on  [gi|311088249|gb|ADP68308|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur seali]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.87e-74

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 220.06  E-value: 3.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVLGSLLVGVIMELLVVVWVVGEGDFEVVVGFGDLEDWIIFVDKEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.87e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 220.06  E-value: 3.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVLGSLLVGVIMELLVVVWVVGEGDFEVVVGFGDLEDWIIFVDKEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 4.62e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.42  E-value: 4.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   17 VGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPETWGSSTVVLGSLLVGV 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088249   97 IMELLVVVWVVGEGDFEVVVGFGdledwiifvdkeVSVVREDSLGVASLYNYVsWFVAIAGCFLFMSVLIVIEI 170
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAA------------PDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.87e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 220.06  E-value: 3.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVLGSLLVGVIMELLVVVWVVGEGDFEVVVGFGDLEDWIIFVDKEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 8.61e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 114.85  E-value: 8.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVlgSLLVGVIMELLVVVWVVGEGDFEVvvgfgdleDWIIFVD-KEVSVVREDSLGVASLYNYVSWFVAIAGCF 159
Cdd:MTH00138  81 SWGSWSVL--GYVVGYLVGVVLAAGLFWGGWYEG--------SWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|...
gi 311088249 160 LFMSVLIVIEIVR 172
Cdd:MTH00138 151 LLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.38e-28

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 103.77  E-value: 1.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVlgsLLVGVIMELLVVVWVvgegdfeVVVGFGDLEDWIIFVDKEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00065  81 AWGSWSVL---VYVLFYLLLLIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 1.08e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 91.35  E-value: 1.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVLGslLVGVIMELLVVVWVVGEGDFEVVVGFGDLEDWiifvdkEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00115  81 AWGDWGVVGY--VVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSG------GLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.51e-13

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 64.62  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVLGSLLVGVIMELLVVvwvvgegdfevvvgFGDLEDWIIFVDKEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGF--------------YFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-172 2.51e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 58.76  E-value: 2.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   1 MVYVMFLLSMIFVLGFVGFSSkpSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249  81 TWGSSTVVLGSLLVGVImellvvvwvvgegdfeVVVGFGDLEDWIifVDKEVSVVREDSLGVASLYNYVSWFVAIAGCFL 160
Cdd:MTH00045  79 VSNLGEVLVLSLLLSLW----------------VFISFDNFLELS--NNNWSLVSLSDLVGSSELYNSGGLYLLLGGFIL 140

                        170
                 ....*....|..
gi 311088249 161 FMSVLIVIEIVR 172
Cdd:MTH00045 141 LVALVVALVISF 152
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 4.62e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.42  E-value: 4.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088249   17 VGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEYPETWGSSTVVLGSLLVGV 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088249   97 IMELLVVVWVVGEGDFEVVVGFGdledwiifvdkeVSVVREDSLGVASLYNYVsWFVAIAGCFLFMSVLIVIEI 170
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAA------------PDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-78 3.41e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.22  E-value: 3.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088249   5 MFLLSMIFVLGFVGFSSKPSPIYGGIGLIVSGAVGCAIIVGFGGTFVGLMMFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   3 LSLLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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