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Conserved domains on  [gi|311088151|gb|ADP68217|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur septentrionalis]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.31e-75

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 223.53  E-value: 1.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWGSLLVGLIMELLVVMWVVGQGSFEVVVGLDDLEDWVAFVGKGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.31e-75

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 223.53  E-value: 1.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWGSLLVGLIMELLVVMWVVGQGSFEVVVGLDDLEDWVAFVGKGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 7.33e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.74  E-value: 7.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   17 MGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPETWGSSVVVWGSLLVGL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088151   97 IMELLVVMWVVGQGSFEVVVGLddledwvafvgkGVGVVREDSLGVAALYNYVSWFMVaAGWSLFISVLIVIEI 170
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAA------------APDVGNIEAIGELLFTDYLLPFEL-ASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.31e-75

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 223.53  E-value: 1.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWGSLLVGLIMELLVVMWVVGQGSFEVVVGLDDLEDWVAFVGKGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 9.93e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 112.16  E-value: 9.93e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVwgSLLVGLIMELLVVMWVVGQGSFEVVVGLDDledwvafVGKGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00138  81 SWGSWSVL--GYVVGYLVGVVLAAGLFWGGWYEGSWVVVD-------ELKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00138 152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.18e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 106.86  E-value: 1.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWgslLVGLIMELLVVMWVvgqgsfeVVVGLDDLEDWVAFVGKGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00065  81 AWGSWSVLV---YVLFYLLLLIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 3.37e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 90.19  E-value: 3.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWGslLVGLIMELLVVMWVVGQGSFEVVVGLDDLEDWvafvgkGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGY--VVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSG------GLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.63e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 67.32  E-value: 1.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWGSLLVGLIMELLVVMWVVGQGSFEVVVglddledwvafvgkGVGVVREDSLGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMG--------------VDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 311088151 161 FISVLIVIEIIR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-170 5.03e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 57.99  E-value: 5.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   1 MIYTMFLLSVVFVLGFMGFSSkpSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151  81 TWGSSVVVWGSLLVGLIMELLVVMWVVGQGSFEVVVGLDDLEdwvafvgkgvgvvredslGVAALYNYVSWFMVAAGWSL 160
Cdd:MTH00045  79 VSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVSLSDLV------------------GSSELYNSGGLYLLLGGFIL 140

                        170
                 ....*....|
gi 311088151 161 FISVLIVIEI 170
Cdd:MTH00045 141 LVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 7.33e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.74  E-value: 7.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088151   17 MGFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEYPETWGSSVVVWGSLLVGL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088151   97 IMELLVVMWVVGQGSFEVVVGLddledwvafvgkGVGVVREDSLGVAALYNYVSWFMVaAGWSLFISVLIVIEI 170
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAA------------APDVGNIEAIGELLFTDYLLPFEL-ASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-78 6.84e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 38.06  E-value: 6.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088151   5 MFLLSVVFVLGFMgFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMMFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   4 SLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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