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Conserved domains on  [gi|311088137|gb|ADP68204|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur betsileo]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 7.72e-74

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 219.29  E-value: 7.72e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVLGSMLVGVIMELLMVVWVMGEGDFGVVVGFGDLEDWIAFADKEVSVVREDSLGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 7.72e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 219.29  E-value: 7.72e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVLGSMLVGVIMELLMVVWVMGEGDFGVVVGFGDLEDWIAFADKEVSVVREDSLGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 3.39e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.81  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   21 SKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSAVVLGSMLVGVIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  101 LMVVWVMGEGDFgvvvgfgdledwIAFADKEVSVVREDSLGVASLYNYVsWFVAVAGWFLFMSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLT------------PAAAAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 7.72e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 219.29  E-value: 7.72e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVLGSMLVGVIMELLMVVWVMGEGDFGVVVGFGDLEDWIAFADKEVSVVREDSLGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 2.22e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 116.39  E-value: 2.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGsSAVVLGSM---LVGVIMELLMVVWVMGEGDFGVVVGFGDLedwiafadkevSVVREDSLGVASLYNYVSWFVAVAG 157
Cdd:MTH00138  81 SWG-SWSVLGYVvgyLVGVVLAAGLFWGGWYEGSWVVVDELKEF-----------SVLRGDVGGVALMYSSGGGMLVICA 148

                        170
                 ....*....|....*
gi 311088137 158 WFLFMSVLIVIEIVR 172
Cdd:MTH00138 149 WVLLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 2.54e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 105.70  E-value: 2.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVlgsMLVGVIMELLMVVWVMgegdfgvVVGFGDLEDWIAFADKEVSVVREDSLGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00065  81 AWGSWSVL---VYVLFYLLLLIVGYIL-------FGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 3.03e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 90.19  E-value: 3.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVLGSMLVGVIMELLMVVWVMGEGDFGVVVGFGDLEDWiafadkevSVVREDSLGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGL--------FVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.41e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 67.32  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   1 MVYMMFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVLGSMLVGVIMELLMVVWVMGEGDFGVVVGfgdledwiafadkeVSVVREDSLGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGV--------------DEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 4-172 1.49e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 59.15  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   4 MMFLLSVIFVLG---FVSFSSkpSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFgstLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  81 TWGSSAVVLGSMLVGVIMELLMVVWVMGEGDFGVVVGFGDLEdwiafadkevsvvredslGVASLYNYVSWFVAVAGWFL 160
Cdd:MTH00045  79 VSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVSLSDLV------------------GSSELYNSGGLYLLLGGFIL 140

                        170
                 ....*....|..
gi 311088137 161 FMSVLIVIEIVR 172
Cdd:MTH00045 141 LVALVVALVISF 152
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 3.39e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.81  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137   21 SKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSAVVLGSMLVGVIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088137  101 LMVVWVMGEGDFgvvvgfgdledwIAFADKEVSVVREDSLGVASLYNYVsWFVAVAGWFLFMSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLT------------PAAAAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-78 1.33e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 40.37  E-value: 1.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088137   5 MFLLSVIFVLGFVSFSSKPSPIYGGVGLIVSGAVGCVIVVGFGGTFVGLMVFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   3 LSLLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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