|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
36-446 |
1.98e-105 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 320.35 E-value: 1.98e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 36 KQDIRILPWICVTYLLNYLDRVNLGNARTLNndTPEDnivkmLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKW 115
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMG--MKED-----LKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 116 ISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAI 195
Cdd:cd17327 74 LSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 196 SFLNRRGGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAWLTPEERAFAVKRLGPYAPSMGDKHWDGAVARKTVHDP 275
Cdd:cd17327 154 FKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 276 YFWLFAIMYFLMTNSLNASGFFTPTIVASLGFKGYNAQLLTVPPNVFAMFVIIGNCLHSDRTKERSRHVIGALIFVAAGY 355
Cdd:cd17327 234 RTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 356 LLLAVVKHWGVRYLGLMIIACTNAAVLP-FVAHRTATVQGSTATALATGGMIAIANCGGISAPFLFPSTDSPMYSMGNWT 434
Cdd:cd17327 314 IILLAAPNPPGAYFAAYILGGGSYAGFPiLLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIA 393
|
410
....*....|..
gi 310789585 435 IFAFLVVTALLT 446
Cdd:cd17327 394 LLVCACVSIVLS 405
|
|
| HpaX |
TIGR02332 |
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily ... |
33-441 |
1.01e-64 |
|
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily (pfam07690). Member of this family are found in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterized by Prieto, et al. ( as 4-hydroxyphenylacetate permease in E. coli, where 3-HPA and 3,4-dihydroxyphenylacetate are shown to competitively inhibit 4-HPA transport and therefore also interact specificially.
Pssm-ID: 131385 [Multi-domain] Cd Length: 412 Bit Score: 215.24 E-value: 1.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 33 IVRKQDIRILPWICVTYLLNYLDRVNLGNA-RTLNNDtpednivkmLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFS 111
Cdd:TIGR02332 1 VIKKLFRRLIIFLFILFIFSFLDRINIGFAgLTMGKD---------LGLSATMFGLAATLFYAAYVICGIPSNIMLAIIG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 112 PSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLL 191
Cdd:TIGR02332 72 ARRWIAGIMVLWGIASTATMFATGPESLYLLRILVGIAEAGFLPGILLYLTFWFPAYFRARANALFMIAMPVTMALGLIL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 192 ATAISFLNRRGGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAWLTPEERA-----FAVKRLGPYAPSMGDKHwdGA 266
Cdd:TIGR02332 152 SGYILALDGLMALKGWQWLFLLEGFPSVILGVMTWFWLDDSPDKAKWLDEEDKKalkemIDNDQLTLEQPEGAFAH--AA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 267 VARKT----VHDPYFWLFAIMYFLMTNSLNASGFFTPTIVASLGFKGYNAQ--LLTVPPNVFAMFVIIGNCLHSDRTKER 340
Cdd:TIGR02332 230 MPQRSmlreIFTPAIMLYTLAYFCLTNTLSAINIWTPQILQSFNQGSSNIMigLLAAIPQFCTIFGMIWWSRHSDRLKER 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 341 SRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAPFLF 420
Cdd:TIGR02332 310 KHHTALPYLFAAAGWLLASATDHNLIQLLGIIMASMGSFSAMAIFWTTPDQSISLQARAIAIAVINATGNIGSALSPFLI 389
|
410 420
....*....|....*....|....*
gi 310789585 421 ----PSTDSpmYSMGNWTIFAFLVV 441
Cdd:TIGR02332 390 gilkDATGS--FNSGLWFVAALLVI 412
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-445 |
1.84e-54 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 186.62 E-value: 1.84e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 40 RILPWICVTYLLNYLDRVNLGNArtlnndtpEDNIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRI 119
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVA--------APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISfln 199
Cdd:cd17319 75 MLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL--- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 200 rrgGLVGWQWLFVLEGIPAILVGVLVWFKLPDypqtaawltpeerafavkrlgpyapsmgdkhwdgavarktvhdpyFWL 279
Cdd:cd17319 152 ---LLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------------------------------VWG 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 280 FAIMYFLMTNSLNASGFFTPTIVAS-LGFKGYNAQLLTVPPNVFAMFVIIGNCLHSDR--TKERSRHVIGALIFVAAGYL 356
Cdd:cd17319 184 LALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 357 LLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAP----FLFPSTDSPMYSMgn 432
Cdd:cd17319 264 LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPlligYLVDATGSYTAAF-- 341
|
410
....*....|...
gi 310789585 433 wTIFAFLVVTALL 445
Cdd:cd17319 342 -LFLAAVALLAAL 353
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
47-445 |
1.05e-53 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 186.00 E-value: 1.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 47 VTYLLNYLDRVNLGNAR-TLNNDtpednivkmLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGI 125
Cdd:TIGR00893 1 LVTVINYLDRANLSFAApMLQED---------LGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 126 VTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISFlnrrggLV 205
Cdd:TIGR00893 72 FTGLQAFAGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HF 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 206 GWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAWLTPEERAFAVKRLGPYAPSMGDKHWDGAVARKTVHDPYFWLFAIMYF 285
Cdd:TIGR00893 146 SWQWAFIIEGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 286 LMTNSLNASGFFTPT-IVASLGFKGYNAQLLTVPPNVFAMFVIIGNCLHSDRTKERSRHVIGALIFVAAGYLLLAVVKHw 364
Cdd:TIGR00893 226 LVNIGLGFFLTWFPTyLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMF- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 365 GVRYLGLMIIACTNAAVLPFVAHRTA--------TVQGSTAtALATGGMIAIANCGGISAPFLFPSTDSPMYSM-GNWTI 435
Cdd:TIGR00893 305 ATNYVNIPYAALALVALGFFGLGAGAigwalisdNAPGNIA-GLTGGLINSLGNLGGIVGPIVIGAIAATTGSFaGALMV 383
|
410
....*....|
gi 310789585 436 FAFLVVTALL 445
Cdd:TIGR00893 384 VAALALIGAL 393
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-450 |
4.18e-39 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 145.40 E-value: 4.18e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 32 RIVRKQDIRILPWICVTYLLNYLDRVNLGNARTLnndtpednIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFS 111
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPP--------LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 112 PSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLL 191
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 192 ATAISflnrrgGLVGWQWLFVLEGIPAILVGVLVwfklpdypqtaawltpeerafavkrlgpyapsmgdkhwdgavarkt 271
Cdd:COG2271 154 LGWLL------AAFGWRAAFLILGLPGLLLALLR---------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 272 vhdpyFWLFAIMYFLMTNSLNASGFFTPTI-VASLGFKGYNAQLLTVPPNVFAMFVIIGNCLHSDRTKERSR-HVIGALI 349
Cdd:COG2271 182 -----FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 350 FVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAPFLFPS-TDSPMY 428
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYlLDATGY 336
|
410 420
....*....|....*....|..
gi 310789585 429 SMGNWTIFAFLVVTALLTGYVW 450
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-446 |
1.23e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 116.90 E-value: 1.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 40 RILPWICVTYLLNYLDRVNLGNARTlnndtpedNIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRI 119
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAP--------PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISfln 199
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 200 rrgGLVGWQWLFVLEGIPAILVGVLVWFKLPDypqtaawlTPEERAFAVKRlgpyapsmgdkhwDGAVARKTVHDPYFWL 279
Cdd:COG2223 154 ---AAFGWRNAFLILGILLLVVAVLAWLFLRD--------PPAGAAAAAKA-------------SLRDQLEALRDPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 280 FAIMYFLMTNSLNA-SGFFTPTIVASLGFKGYNAQLLTVPPNVFAMFVIIGNCLHSDRTKERSRHVIGALIFVAAGYLLL 358
Cdd:COG2223 210 LSLLYFGTFGSFIGfSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 359 AVVKHWGVRYLGLMIIACT----NAAVLPFVAHRTatvqGSTATALATGGMIAIANCGGISAPFLF----PSTDSpmYSM 430
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLAlgggNGAVFALVPDIF----PTKNAGAVYGLVGAAGGLGGFLGPLLFgallDATGS--YTA 363
|
410
....*....|....*.
gi 310789585 431 GNWTIFAFLVVTALLT 446
Cdd:COG2223 364 AFLVFAVLALVALVLT 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
78-407 |
5.23e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.88 E-value: 5.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 78 LDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGV 157
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 158 MMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISflnrrgGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAA 237
Cdd:pfam07690 107 LALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 238 WLTPEERAFAVKRLgpyapsmgdkhwdgavaRKTVHDPYFWLFaIMYFLMTNSLNASGFFTPTIVASLGFkgyNAQLLTV 317
Cdd:pfam07690 181 KPAEEARLSLIVAW-----------------KALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEVLGL---SALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 318 PPNVFAMFVIIGNCL---HSDRTKERSR--HVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLP--------- 383
Cdd:pfam07690 240 LLGLGGLLGAIGRLLlgrLSDRLGRRRRllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPalnalvsdl 319
|
330 340
....*....|....*....|....
gi 310789585 384 FVAHRTATVQGSTATALATGGMIA 407
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
74-416 |
1.52e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.81 E-value: 1.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 74 IVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGF 153
Cdd:COG2814 36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 154 FPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAIsflnrrGGLVGWQWLFVLEGIPAILVGVLVWFKLPDYP 233
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL------ADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 234 qtaawltPEERAFAVKRLgpyapsmgdkhwdgavaRKTVHDPYFWLFAIMYFLMTNSLNASGFFTPTIVAS-LGFKGYNA 312
Cdd:COG2814 190 -------PAARARLRGSL-----------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 313 QLLTVPPNVFAMFVIIGNCLHSDRTKERsRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATV 392
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRR-RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|....
gi 310789585 393 QGSTATALATGGMIAIANCGGISA 416
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
45-446 |
2.53e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 2.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 45 ICVTYLLNYLDRVNLGNARTLnndtpednIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWG 124
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPA--------LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 125 IVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISflnrRGGL 204
Cdd:cd06174 73 LGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----SSLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 205 VGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAwltpeerafAVKRLGPYAPSMGDkhwdgavARKTVHDPYFWLFAIMY 284
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLVVPDPPESAR---------AKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 285 FLMTNSLNASGFFTPTIVASLGFKGYN--AQLLTVPPNVFAMFVIIGNCLhSDRTKERSRHVIGALIFVAAGYLLLAVVK 362
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGGLSVAvaGLLLSLFGLAGALGSLLLGLL-SDRLIGRKPLLLIGLLLMALGLALLLLAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 363 HWGVRYLGLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAPFLFP--STDSPMYSMGNWTIFAFLV 440
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGflLAATFGLTGAFLVLAVLLL 371
|
....*.
gi 310789585 441 VTALLT 446
Cdd:cd06174 372 LAAILL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
47-286 |
2.73e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 68.17 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 47 VTYLLNYLDRVNLGNArtlnndTPEdnIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIV 126
Cdd:TIGR00881 2 IGYAAYYLVRKNFALA------MPY--LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 127 TICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFG-GLLATAISFLNRrgglv 205
Cdd:TIGR00881 74 NLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLpPLVLFGIAELYS----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 206 gWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAwLTP--EERAFAVKRLGPYAPSmGDKHWDGAVaRKTVHDPYFWLFAIM 283
Cdd:TIGR00881 149 -WHWVFIVPGIIAIIVSLICFLLLRDSPQSCG-LPPaeEMPNEEPDGDAEKKEE-ELTKKQIFL-QYVLLNKVLWYISLG 224
|
...
gi 310789585 284 YFL 286
Cdd:TIGR00881 225 YVF 227
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
88-446 |
5.81e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.19 E-value: 5.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 88 AVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKP 167
Cdd:cd17324 39 LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 168 EERATRMAVFASSVAVAGAFGGLLATAIsflnrrGGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAWLTPEERAFa 247
Cdd:cd17324 119 EKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSL- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 248 vkrlgpyapsmgdkhwdgavaRKTVHDPYFWLFAIMYFLMTNSLnaSGFFT---PTIVASLGFKGYNAQLLTVppnVFAM 324
Cdd:cd17324 192 ---------------------LLLLRNPRLRLAYLITFLLFGGF--FALYTylaPFLTDVPGFSSSAIIGLLL---LFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 325 FVIIGNCLH---SDRTKeRSRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATVqGSTATALA 401
Cdd:cd17324 246 AGVVGSPLAgrlADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 310789585 402 TGGMIAIANCGGISAPFLF-PSTDSPMYSMGNWTIFAFLVVTALLT 446
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGgLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
139-454 |
1.38e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.06 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 139 LLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAG----AFGGLLATaisflnrrgglVGWQWLFVLE 214
Cdd:cd17473 91 LLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGvvflLLGGALAE-----------IGWRAPFLVY 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 215 GIpAILVGVLVWFKLPDypqtaawltpeerafavkrlgPYAPSMGDKHWDGAVARKTVHDPYFWLFAIMYFLMTnslnas 294
Cdd:cd17473 160 LL-ALPVLILVLLFLPE---------------------PARKSKSAASPGAATAAALPWKRVLPIYFLAFLAML------ 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 295 GFFT-----PTIVASLGfkGYNAQLLTVPPNVFAMFVIIGNCLHSDRTKERSRHVIGALIFV--AAGYLLLAVVKHWGVR 367
Cdd:cd17473 212 LFYVipiqlPFLLQERG--GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAlmALGFLLLALASGLWVV 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 368 YLGLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAPFLFpsTDSPMYSMGNWTIFAFLVVTALLTG 447
Cdd:cd17473 290 LLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL--GPLVNLTGGLSGAFLILGVLALVLA 367
|
....*..
gi 310789585 448 YVWYVFG 454
Cdd:cd17473 368 IVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
78-420 |
1.78e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.68 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 78 LDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGV 157
Cdd:cd17325 26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 158 MMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISflnrrgGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAA 237
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA------DALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 238 WLTPEERAFAVKRlgpyapsmgdkhwdgavaRKTVHDPYFWLFAIMYFLMTNSLNASGFFTPTIVASLGfkGYNAQ---- 313
Cdd:cd17325 180 KRAVSAARLRSGL------------------RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG--GLSPAqigl 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 314 LLTVPPNVFAMFVIIGNCLhSDRtKERSRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMII----ACTNAAVLPFVAHRT 389
Cdd:cd17325 240 LFGAQGLASALSQPPAGKL-SDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLglglGLVFPATLALLADIV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 310789585 390 -----ATVQGSTATALATGGMI------AIANCGGISAPFLF 420
Cdd:cd17325 318 ppegrGTAMGLFNTAFSLGMVLgpllggFLYDAFGFATPFLA 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
131-448 |
9.86e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 60.27 E-value: 9.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 131 AACTTYGGLLAVRIMLGLAeAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISflnrrgGLVGWQWL 210
Cdd:COG2807 101 SLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLA------AALGWRGA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 211 FVLEGIPAILVGVLVWFKLPDYPQTAAWLTPEERAFAVkrlgpyapsmgdkhwdgavarktVHDPYFWLFAIMYFLMtnS 290
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSL-----------------------WRSPLAWLLTLFFGLQ--S 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 291 LNASGFFT--PTIVASLGFKGYNA-------QLLTVPPNVFAMFVIignclhsDRTKERSRHVIGALIFVAAGYLLLAVV 361
Cdd:COG2807 229 LLYYAVVAwlPPILRDAGLSAATAglllslfQLAGIPGSLLVPLLA-------DRLGDRRPLLLLLGLLGLAGLLGLLLA 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 362 KHWGVrYLGLMIIACTNAAVLP----FVAHRTATVQGSTA-TALATGGMIAIANCGGISAPFLFPSTDSPMYSmgnWTIF 436
Cdd:COG2807 302 PGSLP-WLWAVLLGLGQGGLFPlaltLIGLRARTPAEAAAlSGMAQSVGYLLAALGPLLVGALHDATGSWTAA---LLLL 377
|
330
....*....|..
gi 310789585 437 AFLVVTALLTGY 448
Cdd:COG2807 378 AALAVLMLVAGL 389
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
45-300 |
5.34e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.02 E-value: 5.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 45 ICVTYLLNYLDRVNL-GNARTLNNDTPEDNivKMLDLTGqrynvavALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSW 123
Cdd:cd17328 4 LFLINLLNYMDRFTIaGVLPDIQSDFLIDD--SLAGLLQ-------TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 124 GIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISFLNRrgg 203
Cdd:cd17328 75 SAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG--- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 204 lvGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAwltpEERAFAVKRLGPYAPSMgdkhwdGAVARKtvhdPYFWLFAIM 283
Cdd:cd17328 152 --GWRWAFRVTGVLGVLLAILLLLFVREPPRGAA----EGGVMAKSTATSFLADL------KALAKN----PSFILSTLG 215
|
250
....*....|....*..
gi 310789585 284 YFLMTNSLNASGFFTPT 300
Cdd:cd17328 216 FTAVSFVTGALAFWAPT 232
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
87-446 |
5.38e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.02 E-value: 5.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 87 VAVALFFVPyVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYK 166
Cdd:cd17475 36 LLSALNLGV-AVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 167 PEERATRMAVFASSVAVAGAFGGLLATAISFLNrrgglvGWQWLFVLEGIPAILVGVLVWFKLPDyPQTAAWLTPEERAF 246
Cdd:cd17475 115 PRERGLAMGIRQTGVPLGGALAAALLPPLALHY------GWRAAFVVAGLVSILAAVLFWLFYRE-PPAASAATESASTL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 247 AVKRLGPyapsmgdkhwdgavarktVHDPYFWLFAIMYFLMTNSLNAsgFFTPTIVASLGFKGYN----AQLLTVpPNVF 322
Cdd:cd17475 188 LRSLKEV------------------LRNRDVWLIAIAGALLVAPQFA--LLTFLLLFLHDHLGLSvvaaGALLAV-AQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 323 AMFVIIGNCLHSDRTKERSRH-VIGALIFVAAGYLLLAVVKHWGVRYLGLMIIAC-TNAAVL----PFVAHrTATVQGST 396
Cdd:cd17475 247 GALGRIGLGRVSDRVFGGRRRpVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIlLGLFAIgwngLYLTL-VAESAGPE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 310789585 397 ATALATGGMIAIANCGGISAPFLFPS--TDSPMYSMGNWTIFAFLVVTALLT 446
Cdd:cd17475 326 QAGTALGLANTINFIGIAIGPPLFGLlvDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-447 |
6.50e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.67 E-value: 6.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 39 IRILPWICvtYLLNYLDRVNLGNARTLnndtpednIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISR 118
Cdd:cd17312 4 IFLGVFLG--YAAYYVCRKNFSVAKPP--------IVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 119 IMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISfl 198
Cdd:cd17312 74 GLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA-- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 199 nrrgGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPqtaawltpeerafavkrlgpyapsmgdkhwdgavarktvhdPYFW 278
Cdd:cd17312 152 ----SYYGWRAAFLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVW 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 279 LFAIMYFLMTNSLNASGFFTPT-IVASLGFKGYNAQLLTVppnVFAMFVIIG---NCLHSDRTKERSRHVI----GALIF 350
Cdd:cd17312 187 VLSLAYAFVYIVRYACLDWGPLyLYEVKGYSLIDAGWFSS---LYEVGGIAGtilAGLLSDKLFGGRRAPIaviyMLLMT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 351 VAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAPFLFPSTDSpmySM 430
Cdd:cd17312 264 LSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIID---HY 340
|
410
....*....|....*..
gi 310789585 431 GNWTIFAFLVVTALLTG 447
Cdd:cd17312 341 GWSTVFYFLISAALLSV 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
120-329 |
1.46e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.97 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISfln 199
Cdd:COG0477 86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV--- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 200 rrgGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAWLTPEERAFAVKRLGPYAPSMGDKHWDGAVARKTVHDPYFWL 279
Cdd:COG0477 163 ---AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 310789585 280 FAIMYFLMTNSLNASGFFTPTIVASLGFKGYNAQLLTVPPNVFAMFVIIG 329
Cdd:COG0477 240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
120-449 |
2.44e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.69 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISFLN 199
Cdd:cd17316 73 LLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 200 rrGGLVGWQWLFVLEGIPAILvgvlvwfklpdypqtaawltpeerafavkrlgpyapsmgdkhwdGAVARKtvhdpYFWL 279
Cdd:cd17316 153 --SGDWGWRILFLIGALPALL--------------------------------------------ALLLRR-----RTLL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 280 FAIMYFLMTNSLNASGFFTPTI-VASLGFKGYNAQLLTVPPNVFAMFVIIGNCLHSDRTKERSRHVIGALIFVAAGYLLL 358
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 359 AVVKH--WGVRYLGLMIIACTNAAVLPFVAHrTATVQGSTATALATGGMIAIANCGGISAPFLFPSTdspMYSMGNWTIF 436
Cdd:cd17316 262 YLLSGspTLLLLLLFILSFFVGGVWGALYAY-LAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL---LASTGGTGVP 337
|
330
....*....|...
gi 310789585 437 AFLVVTALLTGYV 449
Cdd:cd17316 338 ALILALLAIVALI 350
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
118-419 |
8.73e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.28 E-value: 8.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 118 RIMVSWGIV--TICTAAC---TTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLA 192
Cdd:TIGR00895 82 RRVLLWSILlfSVFTLLCalaTNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 193 taiSFLnrrGGLVGWQWLFVLEGIPAILVGVLVWFKLpdyPQTAAWLTPEERAFAVKRLGPYAPSMG------------- 259
Cdd:TIGR00895 162 ---GWL---IPVFGWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLVSKRPETVRRIVNAIAPQMQaeaqsalpeqkst 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 260 --------DKHWDGAVARKTVH--DPYFWLFAIMYFLMTnslnasgfFTPTIVASLGFKGYNAQLLTVPPNVFAMFVIIG 329
Cdd:TIGR00895 233 qgtkrsvfKALFQGKTARITVLlwLLYFMLLVGVYFLTN--------WLPKLMVELGFSLSLAATGGALFNFGGVIGSII 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 330 NCLHSDRTkeRSRHVigALIFVAAGYLLLAVVKHW----GVRYLGLMIIACTNAAVLPFVAHrTATVQGSTATALATGGM 405
Cdd:TIGR00895 305 FGWLADRL--GPRVT--ALLLLLGAVFAVLVGSTLfsptLLLLLGAIAGFFVNGGQSGLYAL-MALFYPTAIRATGVGWA 379
|
330
....*....|....
gi 310789585 406 IAIANCGGISAPFL 419
Cdd:TIGR00895 380 IGIGRLGAIIGPIL 393
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
92-230 |
1.36e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 53.33 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 92 FFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICT--AACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEE 169
Cdd:cd17380 43 FFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSE 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 310789585 170 RAtrmavFASSVAVAG-AFGGLLATAI-SFLNRRGglvGWQWLFVLEGIPAILVGVLVWFKLP 230
Cdd:cd17380 123 RS-----RAVSIVTAGsYLGTLLGGLIgPLLLEYY---GWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
41-229 |
1.44e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 53.39 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 41 ILPWICvtYLLNYLDRVNLG-------NARTLNNDTPEDNIVKMLDLTGQRYN-------VAVALFFVPYVLMEFPSNIM 106
Cdd:cd17318 2 ILLFLG--FAVVYAMRVNLSvaivamvNSTATHDNNNTSTDKDTLPVEAPEFDwsektqgIILSSFFYGYILTQIPGGYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 107 LKYFSPSKWISRIMVSWGIVTICT--AACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERAtRMAVFASSVAVA 184
Cdd:cd17318 80 AEKYGAKRVLGYSILITALLTLLTplAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERS-RLTSIAYSGSQF 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 310789585 185 GAF-----GGLLATAIsflnrrgglvGWQWLFVLEGIPAILVgVLVWFKL 229
Cdd:cd17318 159 GTViamplSGFLCESL----------GWPSIFYIFGGLGLLW-CLLWFFL 197
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
92-420 |
2.11e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.93 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 92 FFVPYVLMEFPSNIMLKYFSpskwiSRIMVSWGIVTICTAAC-----TTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYk 166
Cdd:COG0738 52 FFLGYLLASLPAGRLIDRFG-----YKRGLLLGLLLMALGLLlfalaPSYPLLLLALFLLGLGLGLLDVAANPYVAALG- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 167 PEERATRMAVFASSVAVAGAFGGLLATAISFLnrrGGLVGWQWLFVLEGIPAILVGVLVWF-KLPDYPQTAAWLTPEERA 245
Cdd:COG0738 126 PETAASRLNLLHAFFSLGALLGPLLGGLLILL---GLSLSWHLPYLILAVLLLLLALLFLRsKLPEIEEEEEEAAGSAAS 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 246 FavkrlgpyapsmgdkhwdgavaRKTVHDPYFWLFAIMYFLMTNSLNASGFFTPTI-VASLGFKGYNAQLLTVppnVFAM 324
Cdd:COG0738 203 L----------------------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYlKDVLGLSEATAALGLS---LFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 325 FVIIGnCLHSDRTKER---SRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLPFVAHRTATVQGsTATALA 401
Cdd:COG0738 258 GMTIG-RFLGGFLLKRfgpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG-KRTAAA 335
|
330
....*....|....*....
gi 310789585 402 TGGMIAIANCGGISAPFLF 420
Cdd:COG0738 336 VSAVLIMGIVGGAIGPPLI 354
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
78-238 |
4.83e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.87 E-value: 4.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 78 LDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTI-CTAACTTYGGLLAVRIMLGLAEAGFFPG 156
Cdd:cd17341 29 LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLaLALAVSSYWGLLVLGFLLGFAGANFASG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 157 vMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAI-SFLNRRGGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQT 235
Cdd:cd17341 109 -QPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIaGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG 187
|
...
gi 310789585 236 AAW 238
Cdd:cd17341 188 KAS 190
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
76-229 |
1.75e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 76 KMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFP 155
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFP 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 310789585 156 GVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISflnrrgGLVGWQWLFVLEGIPAILVGVLVWFKL 229
Cdd:cd17325 308 ATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY------DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
119-453 |
2.87e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.58 E-value: 2.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 119 IMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAvagaFGGLLATAISF- 197
Cdd:pfam00083 85 LFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAIT----FGILLAYIFGLg 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 198 LNRRGGLVGWQWLFVLEGIPAILVGVLVWFkLPDYPQTAAWLTPEERAFAV-KRLGP----------------YAPSMGD 260
Cdd:pfam00083 161 LNKTSNSDGWRIPLGLQLVPALLLIIGLLF-LPESPRWLVEKGRLEEAREVlAKLRGvpdvdreldeikdsleAGQEAEK 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 261 KHWDGAVARKTVHDPYFWLFAIMYFLMTNSLNASGFFTPTIVASLGFKgyNAQLLTVPPNVFAMFVIIGNCLHSDRTKER 340
Cdd:pfam00083 240 ASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLS--DSFLVTIIVGVVNFVFTFIAIFLVDRFGRR 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 341 SRHVIGA------LIFVAAGYLLLAVVKHWGVRYLGLMI---IACTNAAV--LPFVahrtaTVQGSTATALATGGMIAIA 409
Cdd:pfam00083 318 PLLLLGAagmaicFVILGIVALLGVSKSDWAGIVAIVFIalfIAFFAMGWgpVPWV-----IVSELFPLSVRSKAMALAT 392
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 310789585 410 NCGGIS---APFLFPSTDSpmySMGNWTIFAFLVVTALLTGYVWYVF 453
Cdd:pfam00083 393 AANWLAnflIGFLFPIITD---AIGLGYTFFIFAGLLVLFIIFVFFF 436
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
161-243 |
6.98e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.39 E-value: 6.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 161 LCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISFLnrrGGLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAWLT 240
Cdd:cd17345 120 MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAI---FGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPP 196
|
...
gi 310789585 241 PEE 243
Cdd:cd17345 197 IEE 199
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
125-231 |
1.02e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 45.33 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 125 IVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAIsflnrrGGL 204
Cdd:TIGR00880 40 LSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVL------AQF 113
|
90 100
....*....|....*....|....*..
gi 310789585 205 VGWQWLFVLEGIPAILVGVLVWFKLPD 231
Cdd:TIGR00880 114 LGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
124-287 |
1.06e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 47.65 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 124 GIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGvMMYLCfwykPEERATRMAVFASSVAVAG-AFGGLLATAISFLNrrG 202
Cdd:PRK11551 91 GLFSLATAQAWDFPSLLVARLLTGVGLGGALPN-LIALT----SEAVGPRLRGTAVSLMYCGvPFGGALASVIGVLA--A 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 203 GLVGWQWLFVLEGIPAILVgvlvwfklpdYPQTAAWLtPEERAF-AVKRLGPYAPSMGDKHWDGAVARKTVH--DPYFWL 279
Cdd:PRK11551 164 GDAAWRHIFYVGGVGPLLL----------VPLLMRWL-PESRAFaQAAGAGKQRAPVLRALFGEGRATATLLlwISYFFT 232
|
....*...
gi 310789585 280 FAIMYFLM 287
Cdd:PRK11551 233 LIVLYFLL 240
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
167-420 |
1.23e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 167 PEERaTRMAVFASSVAVAGAFGGLLATAISFLNRRGGLV-GWQWLFVLEGIPAILVGVLVWFKLPDYPQtaawltPEERA 245
Cdd:COG2211 142 YEER-TRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAlGYRLTALIFAVLGLLAFLLTFFGTKERPV------PEEEK 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 246 FAVKRlgpyapsmgdkhwdgaVARKTVHDPYFWLFAIMYFLMTNSLNA-SGFFTPTIVASLGFKGYNAQLLTVPPNVFAM 324
Cdd:COG2211 215 VSLKE----------------SLKALLKNRPFLLLLLAYLLFFLALALvAALLLYYFKYVLGLSAALVGLLLALYFLAAL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 325 FVIIGNCLHSDRTKERSRHVIGALIFvAAGYLLLAVVKH---------WGVRYLGLMIIACTNAAVLPFVAHRTATVQGS 395
Cdd:COG2211 279 LGAPLWPRLAKRFGKKKAFIIGLLLA-ALGLLLLFFLGPgnlwlllvlAALAGIGLGAILVLPWAMLADVVDYDEWKTGR 357
|
250 260
....*....|....*....|....*
gi 310789585 396 TATALATGGMIAIANCGGISAPFLF 420
Cdd:COG2211 358 RREGLYFGIFTFAIKLGQALAGALA 382
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
39-286 |
2.29e-05 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 46.63 E-value: 2.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 39 IRILPWICVTYLLNYLDRvnlgnaRTLNNDTPEdnIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISR 118
Cdd:PRK11663 22 RHILITMYLGYALFYFTR------KSFNAAMPE--MLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 119 IMVSWGIVTICTAACTTygglLAVRIMLGLAEAGF----FPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATA 194
Cdd:PRK11663 94 GLIATGIINILFGFSSS----LWAFALLWVLNAFFqgwgWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 195 ISFLnrrgglVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTaawltpeerafavkrLGpyAPSMGD-----------KHW 263
Cdd:PRK11663 170 IALH------YGWRYGMMIAGIIAIVVGLFLCWRLRDKPQA---------------MG--LPSVGEwrhdalelaqqQEG 226
|
250 260
....*....|....*....|....*...
gi 310789585 264 DGAVARKTVHD-----PYFWLFAIMYFL 286
Cdd:PRK11663 227 AGLSRKEILTKyvllnPYIWLLSFSYVL 254
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
120-225 |
2.64e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAAC---TTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAIs 196
Cdd:cd17321 65 LIGLALFGLASLLCalaPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL- 143
|
90 100
....*....|....*....|....*....
gi 310789585 197 flnrrGGLVGWQWLFVLeGIPAILVGVLV 225
Cdd:cd17321 144 -----LELFGWRWIFLI-NVPIGLVALLL 166
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
120-419 |
6.57e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISfln 199
Cdd:cd17365 71 VALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI--- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 200 rrgGLVGWQWLFVLEGIPAILVGVLVWFKLpdypqtAAWLTpeerafavkrlgpyapsmgdkhwdgavarktvhdpYFWL 279
Cdd:cd17365 148 ---PAFGWRSVFLLGGVPPLILLPLLRGTL------LLWVT-----------------------------------FFMG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 280 FAIMYFLMTnslnasgfFTPTIVASLGFKGYNAQLLTVppnVFAMFVIIGNCLHSDRTKERSRHVIGALIFVAAGYLLLA 359
Cdd:cd17365 184 LLLVYLLNS--------WLPKLMVEAGYSLSQALTITL---LLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLAL 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 310789585 360 V-VKHWGVRYLGLMII---ACTNAAVLPFVAHrTATVQGSTATALATGGMIAIANCGGISAPFL 419
Cdd:cd17365 253 LgVSPASLVLLYVLVFlagACVNGAQVGLYAL-AARFYPTEVRATGVGWALGVGRLGAILGPLL 315
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
121-237 |
9.05e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 9.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 121 VSWGIVT--ICTAAC---TTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRmavfASSVAVAGAFGGLLATAI 195
Cdd:cd17371 67 LVITILLfaVFTLLCgfaQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKA----LGYVQSGWAVGWLLATLL 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 310789585 196 SFL--NRRGGLVGWQWLFVLEGIPAILVgVLVWFKLPDYPQTAA 237
Cdd:cd17371 143 AALlfPLLPPEIAWRVLFLLGALPALLV-LFIRRFVKEPPQWQA 185
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
140-233 |
1.30e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 44.23 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 140 LAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATaiSFLNrrgglVGWQWLFVLEGIPAI 219
Cdd:cd17344 124 VVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAG--IFVS-----SAWGLSFIVPGIIIA 196
|
90
....*....|....
gi 310789585 220 LVGVLVWFKLPDYP 233
Cdd:cd17344 197 AMGVLVFLFLVEHP 210
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
88-383 |
1.35e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 88 AVALFFVPYVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKP 167
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 168 EERATRMAVFASSVAVAGAFGGLLATAISflnrrgGLVGWQWLFVLEGI---PAILVGVLVWFKLPDYPQTAAWLTPEER 244
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLY------QHLGFAVLFIVAAVlalLALLLVFLVKDPPPVAAEEAEAGTRAFR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 245 AFAVKRLgpyapsmgdkhwdgavarktvhdpyfWLFAIMYFLMTNSLNASGFFTPTIVASLGFKGYNAQLLTVPPNVFAM 324
Cdd:cd17489 190 RLVEKKV--------------------------LPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLS 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 310789585 325 FVIIGNClhSDRtKERSRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIACTNAAVLP 383
Cdd:cd17489 244 RPFSGKL--SDR-KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
96-286 |
5.40e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 42.32 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 96 YVLMEFPSNIMLKYFSPSKWISRIMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMA 175
Cdd:cd17343 51 YAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 176 VFASSVAVAGAFGGLLATAISFlnrrggLVGWQWLFVLEGIPAILVGVLVWFKLPDYPQtaawltpeERAFAVKRLGPYA 255
Cdd:cd17343 131 VLSTSMNLAGSLGPILATLLAL------SYGWRSTLSISGTVAVVMSVVCLLFIKNEPS--------DVGLNNIEEEESK 196
|
170 180 190
....*....|....*....|....*....|.
gi 310789585 256 PSMGDKHWDGAVARKTVHDPYFWLFAIMYFL 286
Cdd:cd17343 197 GKKKKSPRGESTLKELLLSPFLWLLSLGYLV 227
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
119-235 |
1.10e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 119 IMVSWGIVTICTAAC---TTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAI 195
Cdd:cd17474 67 LLPGLLLFGIGGLLCglsDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL 146
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 310789585 196 sflnrrgGLVGWQWLFVLEGIpAILVGVLVWFKLPDYPQT 235
Cdd:cd17474 147 -------AAISWRYPFFLLAA-LIPVAFLAILFLLPEPKE 178
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
39-234 |
1.27e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 41.24 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 39 IRILPWICVTYLLNYLDRvnlgnaRTLNNDTPEdnIVKMLDLTGQRYNVAVALFFVPYVLMEFPSNIMLKYFSPSKWISR 118
Cdd:cd17488 2 IHILASMFIGYAVFYLTR------KSFNAAMPA--MLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 119 IMVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAISFL 198
Cdd:cd17488 74 GLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALT 153
|
170 180 190
....*....|....*....|....*....|....*.
gi 310789585 199 NrrgglvGWQWLFVLEGIPAILVGVLVWFKLPDYPQ 234
Cdd:cd17488 154 Y------GWRAGMYVPGIIAILMGIVLCWRLRDRPP 183
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
114-420 |
1.73e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 114 KWISRIMVSWGIVTIC-----TAACTTYGGLLAVRIMLGLAEAGFFPGVMM-YLCFWYKPEERATRMAVFASSVAVAG-A 186
Cdd:cd17355 64 RFGPRRVMLLGLLLLAaglvlLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGSlV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 187 FGGLLATAISFLnrrgglvGWQWLFVLEGIPAILVGVLVWFKLPDYPqtaawltPEERAFAVKRLGPYAPsmgdkhwdGA 266
Cdd:cd17355 144 FLPLGAALIEAF-------GWRTALLVLALLALLVLVPVLLLLRRRP-------ADLALRAYDDASPASP--------GS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 267 VARKTVHDPYFWLFAIMYFLmtnSLNASGFFTPTIVASLGFKGYNAQLLTVPPNVFAMFVIIGNCLH---SDRTkeRSRH 343
Cdd:cd17355 202 TLKEALRSASFWLLALAFFL---CGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSgwlGDRY--SPRR 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 310789585 344 VIGALIFV-AAGYLLLAVVKHWGVRYLG-LMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIANCGGISAPFLF 420
Cdd:cd17355 277 LLAASYALrALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLG 355
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
120-374 |
2.72e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAACTTYGGLLAVRIMLGLAEAGFFP--GVMMYLCFwykPEERATRMAVFASSVAVAGAFGGLLATAIsf 197
Cdd:cd17478 68 PLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPegARLASQAA---GGRRGLAMSIFSVGGNLGFALGPLIAAAL-- 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 198 LNRRGGLvGWQWLFVlegIPAILVGVLVWFKLPDYPQTAAwltpeerafavkrlgpyapsmgdKHWDGAVARKTVHDPYF 277
Cdd:cd17478 143 VALFGGL-GLLILLI---IPGLAVALLLLRLRPLKKPEAK-----------------------KAAAKSSARSTLKGVWR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 278 WLFAIMYFLMTNSLNASGF--FTPTIVASLGFKGYNAQL-LTvppnVFAMFVIIGNCLH---SDRTKERSrhVIGALIFV 351
Cdd:cd17478 196 ALLLLLIIVFLRSWVLSSLttFLPFYLVQRGYSLVFAGLlLS----LFLFAGAIGTLIGgplSDRFGRRR--VIIASLLL 269
|
250 260
....*....|....*....|...
gi 310789585 352 AAGYLLLAVVKHWGVRYLGLMII 374
Cdd:cd17478 270 AAPFLLLFLLTPGIWSYILLVLA 292
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
184-420 |
6.31e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 6.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 184 AGAFGG-LLATAISFLNRrgglVGWQWLFVLEGIPAILVGVLVWFKLPDYPQTAAwlTPEERAFAVKRLGPYApsmgdkh 262
Cdd:cd17370 135 LGAVLGpLLAALLLYLLG----GNYRTIFLLAAIPALLALLILLFVVKEYPRPPK--LRKKSKKTSLKKLPKA------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 263 wdgavarktvhdpyFWLFAIMYFLMtnslnASGFFtptivaSLGFKGYNAQLLTVPPNVFAMFVIIGNCLH--------- 333
Cdd:cd17370 202 --------------FWLYLLAVALF-----ALGNF------SFAFLILRAQELGLSAALIPLLYALFNLVYalaaypagr 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 334 -SDRtKERSRHVIGALIFVAAGYLLLAVVKHWGVRYLGLMIIAC--------TNAAVLPFV-AHRTATVQGSTATALATG 403
Cdd:cd17370 257 lSDR-IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLymgaqesiERAAVADLVpAELRGTAYGLFNTVVGIG 335
|
250 260
....*....|....*....|...
gi 310789585 404 GMIAIANCG------GISAPFLF 420
Cdd:cd17370 336 WLLASLIAGylwdliSPSAAFLF 358
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
120-409 |
9.51e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 9.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 120 MVSWGIVTICTAAC---TTYGGLLAVRIMLGLAEAGFFPGVMMYLCFWYKPEERATRMAVFASSVAVAGAFGGLLATAIS 196
Cdd:cd17503 65 LTALALFTLGSLLCglaPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 197 flnrrgGLVGWQWLFVLegipAILVGVLvwfklpdypqtAAWLTPeerafaVKRLGPYApsmgdkhwdgavarktvhDPY 276
Cdd:cd17503 145 ------DNLSWRWIFYI----NLPIGIL-----------ALLLAP------LLDLRLFK------------------DRN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310789585 277 FWLFAIMYFLMTNSLNASGFFTPTIVA-SLGFKGYNAQLLTVPPNVFAMFV--IIGNCLhsDRTKERSRHVIGALIFVAA 353
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQnVLGYSAFESGLVLAPGGLASAILspLVGRLL--DKFGPRLLLLAGLLLLALG 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 310789585 354 GYLLLAVVKHWGVRYL-----------GLMIIACTNAAVLPFVAHRTATVQGSTATALATGGMIAIA 409
Cdd:cd17503 258 TLLLAFLTPDTSLWLIilplfirglgmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTA 324
|
|
| |
