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Conserved domains on  [gi|309951097|ref|NP_001185480|]
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Wilms tumor protein isoform E [Homo sapiens]

Protein Classification

SUF4-like and COG5048 domain-containing protein( domain architecture ID 11646583)

SUF4-like and COG5048 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WT1 super family cl03474
Wilm's tumour protein;
3-177 1.60e-97

Wilm's tumour protein;


The actual alignment was detected with superfamily member pfam02165:

Pssm-ID: 460471  Cd Length: 289  Bit Score: 288.70  E-value: 1.60e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097    3 KGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNL 82
Cdd:pfam02165 130 QGYGAVAFDGNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097   83 YQMTSQLECMTWNQMN-LGATLKGvaagssssvkwtegqsnHSTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRV 159
Cdd:pfam02165 210 YQMASQLECVTWNQMNsLASTIKS-----------------HATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRV 272

                         170
                  ....*....|....*...
gi 309951097  160 PGVAPTLVRSaSETSEKR 177
Cdd:pfam02165 273 PGITPPIVKS-SEASEKR 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-295 3.94e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 3.94e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 309951097 237 KPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 295
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-234 5.50e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 5.50e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 309951097 169 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHT 234
Cdd:COG5048   24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
 
Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
3-177 1.60e-97

Wilm's tumour protein;


Pssm-ID: 460471  Cd Length: 289  Bit Score: 288.70  E-value: 1.60e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097    3 KGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNL 82
Cdd:pfam02165 130 QGYGAVAFDGNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097   83 YQMTSQLECMTWNQMN-LGATLKGvaagssssvkwtegqsnHSTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRV 159
Cdd:pfam02165 210 YQMASQLECVTWNQMNsLASTIKS-----------------HATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRV 272

                         170
                  ....*....|....*...
gi 309951097  160 PGVAPTLVRSaSETSEKR 177
Cdd:pfam02165 273 PGITPPIVKS-SEASEKR 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-295 3.94e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 3.94e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 309951097 237 KPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 295
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-234 5.50e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 5.50e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 309951097 169 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHT 234
Cdd:COG5048   24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-250 3.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.23e-04
                          10        20
                  ....*....|....*....|....*
gi 309951097  226 LKRHQRRHTGVKPFQCKTCQRKFSR 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
195-222 1.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|....*...
gi 309951097  195 HLQMHSRKHTGEKPYQCDFkdCERRFSR 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-257 5.18e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.22  E-value: 5.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 309951097 216 CERRFSRSDQLKRHQR-RHtgvkpFQCKTCQRKFSRSDHLKTH 257
Cdd:cd20908    7 CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
3-177 1.60e-97

Wilm's tumour protein;


Pssm-ID: 460471  Cd Length: 289  Bit Score: 288.70  E-value: 1.60e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097    3 KGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNL 82
Cdd:pfam02165 130 QGYGAVAFDGNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097   83 YQMTSQLECMTWNQMN-LGATLKGvaagssssvkwtegqsnHSTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRV 159
Cdd:pfam02165 210 YQMASQLECVTWNQMNsLASTIKS-----------------HATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRV 272

                         170
                  ....*....|....*...
gi 309951097  160 PGVAPTLVRSaSETSEKR 177
Cdd:pfam02165 273 PGITPPIVKS-SEASEKR 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-295 3.94e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 3.94e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 309951097 237 KPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 295
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-234 5.50e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 5.50e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 309951097 169 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHT 234
Cdd:COG5048   24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-294 4.25e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097 169 SASETSEKRPFMCAYpgCNKRYFKLSHLQMHSRK--HTGE--KPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKT- 243
Cdd:COG5048  280 SSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLl 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097 244 ------------------------------------CQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRH 287
Cdd:COG5048  358 nssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437


                 ....*..
gi 309951097 288 HNMHQRN 294
Cdd:COG5048  438 KKIHTNH 444
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-294 1.46e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097 184 PGCNKRYFKLSHLQMHSRKHTG-EKPYQCdfKDCERRFSRSDQLKRHQR--RHTG--VKPFQC--KTCQRKFSRSDHLKT 256
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKR 341

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 309951097 257 HTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 294
Cdd:COG5048  342 HILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYK 379
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-259 2.59e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097 174 SEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCqRKFSRSDH 253
Cdd:COG5048  382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                 ....*.
gi 309951097 254 LKTHTR 259
Cdd:COG5048  461 LSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-250 3.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.23e-04
                          10        20
                  ....*....|....*....|....*
gi 309951097  226 LKRHQRRHTGVKPFQCKTCQRKFSR 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 173-262 5.24e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 5.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309951097 173 TSEKRPFMCAYPGCNKRYFKLSHLQMHsRKHTGEKPYQCDFKDCErrfsrsdqlkRHQRRHTGVKPFQCKTCQRKFSRSD 252
Cdd:COG5189  344 VKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE----------KMNIFSAKDKPYRCEVCDKRYKNLN 412

                         90
                 ....*....|
gi 309951097 253 HLKTHtRTHT 262
Cdd:COG5189  413 GLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
195-222 1.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|....*...
gi 309951097  195 HLQMHSRKHTGEKPYQCDFkdCERRFSR 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-261 1.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 309951097  239 FQCKTCQRKFSRSDHLKTHTRTH 261
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-257 5.18e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.22  E-value: 5.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 309951097 216 CERRFSRSDQLKRHQR-RHtgvkpFQCKTCQRKFSRSDHLKTH 257
Cdd:cd20908    7 CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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