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Conserved domains on  [gi|309303584|gb|EFP80175|]
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hypothetical protein PGTG_05400 [Puccinia graminis f. sp. tritici CRL 75-36-700-3]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
290-391 2.71e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100
                 ....*....|....*....|..
gi 309303584 370 LAEKPKTKEPAEDGKTGRSLAL 391
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAF 338
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
290-391 2.71e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100
                 ....*....|....*....|..
gi 309303584 370 LAEKPKTKEPAEDGKTGRSLAL 391
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-373 1.35e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 284 PPYPSTAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDgaEIWGLRFRPDGLAICATSDKG 363
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDG 199

                         90
                 ....*....|
gi 309303584 364 TIHVWSLAEK 373
Cdd:cd00200  200 TIKLWDLSTG 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 290-325 4.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 309303584   290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWN 325
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
290-391 2.71e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100
                 ....*....|....*....|..
gi 309303584 370 LAEKPKTKEPAEDGKTGRSLAL 391
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
290-390 5.74e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 5.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLLASGSADGTVRLWD 274

                         90       100
                 ....*....|....*....|.
gi 309303584 370 LAEKPKTKEPAEDGKTGRSLA 390
Cdd:COG2319  275 LATGELLRTLTGHSGGVNSVA 295
WD40 COG2319
WD40 repeat [General function prediction only];
289-390 3.97e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 3.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 289 TAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDG--LAicATSDKGTIH 366
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGA--VTSVAFSPDGklLA--SGSDDGTVR 187

                         90       100
                 ....*....|....*....|....
gi 309303584 367 VWSLAEKPKTKEPAEDGKTGRSLA 390
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVA 211
WD40 COG2319
WD40 repeat [General function prediction only];
290-371 1.51e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGA--VTSVAFSPDGRTLASGSADGTVRLWD 400


                 ..
gi 309303584 370 LA 371
Cdd:COG2319  401 LA 402
WD40 COG2319
WD40 repeat [General function prediction only];
290-371 1.77e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA--VRSVAFSPDGKTLASGSDDGTVRLWD 358


                 ..
gi 309303584 370 LA 371
Cdd:COG2319  359 LA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-373 1.35e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 284 PPYPSTAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDgaEIWGLRFRPDGLAICATSDKG 363
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDG 199

                         90
                 ....*....|
gi 309303584 364 TIHVWSLAEK 373
Cdd:cd00200  200 TIKLWDLSTG 209
WD40 COG2319
WD40 repeat [General function prediction only];
225-390 1.79e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 225 TARRDKLVVVLLERVVLFGGRQSGKVQIVHLPLFEPDRPASSSSSGRISDRTSADRRQHPPypstAILVAHTTPLASLAI 304
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL----ATLLGHTAAVLSVAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 305 TPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWSLAEKPKTKEPAEDGK 384
Cdd:COG2319   87 SPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163


                 ....*.
gi 309303584 385 TGRSLA 390
Cdd:COG2319  164 AVTSVA 169
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 289-369 2.15e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 289 TAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRrGTDGAeIWGLRFRPDGLAICATSDKGTIHVW 368
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLS-GHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288


                 .
gi 309303584 369 S 369
Cdd:cd00200  289 D 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 292-371 7.86e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 7.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 292 LVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDgaEIWGLRFRPDGLAICATSDKGTIHVWSLA 371
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGECVRTLTGHTS--YVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 290-373 9.68e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 9.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVWS 369
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRGHENG--VNSVAFSPDGYLLASGSEDGTIRVWD 247


                 ....
gi 309303584 370 LAEK 373
Cdd:cd00200  248 LRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 288-370 3.55e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 288 STAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHV 367
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKGHTGP--VRDVAASADGTYLASGSSDKTIRL 77


                 ...
gi 309303584 368 WSL 370
Cdd:cd00200   78 WDL 80
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 289-371 5.48e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 5.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309303584 289 TAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKSAALVRELRRGTDGaeIWGLRFRPDGLAICATSDKGTIHVW 368
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLRGHTDW--VNSVAFSPDGTFVASSSQDGTIKLW 162


                 ...
gi 309303584 369 SLA 371
Cdd:cd00200  163 DLR 165
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 290-325 4.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 309303584   290 AILVAHTTPLASLAITPCGKLIATASVTGTlIRIWN 325
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
289-328 6.77e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 6.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 309303584 289 TAILVAHTTPLASLAITPCGKLIATASVTGTlIRIWNAKS 328
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGT-VRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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