NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|307776542]
View 

Chain B, Prolactin receptor

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2-96 7.63e-32

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 111.36  E-value: 7.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542    2 LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMhECPDYITGGPNS-----CHFGKQYTSMWRTYI 76
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVK-ECPLYSTSGANStrlfiCFFPKNDVSLFVPLH 84

                          90       100
                  ....*....|....*....|
gi 307776542   77 MMVNATNQMGSSFSDELYVD 96
Cdd:pfam09067  85 ITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 103-201 7.36e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 7.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542 103 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 180
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 307776542 181 QVRCKPDAGyWSAWSPATFIQ 201
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 2-96 7.63e-32

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 111.36  E-value: 7.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542    2 LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMhECPDYITGGPNS-----CHFGKQYTSMWRTYI 76
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVK-ECPLYSTSGANStrlfiCFFPKNDVSLFVPLH 84

                          90       100
                  ....*....|....*....|
gi 307776542   77 MMVNATNQMGSSFSDELYVD 96
Cdd:pfam09067  85 ITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 103-201 7.36e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 7.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542 103 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 180
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 307776542 181 QVRCKPDAGyWSAWSPATFIQ 201
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 103-190 3.10e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542   103 PDPPLELAVEVKQPEdrkpYLWIKWSPPTliDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQV 182
Cdd:smart00060   1 PSPPSNLRVTDVTST----SVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 307776542   183 RCKPDAGY 190
Cdd:smart00060  75 RAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
73-198 3.54e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.92  E-value: 3.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542  73 RTYIMMVNATNQMG--SSFSDELYVdVTYIVQPDPPLELAVEVKqpEDRKPYLwiKWSPPTLIDLKTgwftllYEIRLKP 150
Cdd:COG3401  296 TTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAV--GSSSITL--SWTASSDADVTG------YNVYRST 364

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 307776542 151 EKAAEWE-IHFAGQQTEFKILSLHPGQKYLVQVRCKPDAGYWSAWSPAT 198
Cdd:COG3401  365 SGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEV 413
fn3 pfam00041
Fibronectin type III domain;
104-195 2.63e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542  104 DPPLELAVEVKQPEdrkpYLWIKWSPPTLIDLK-TGwftllYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQKYLV 180
Cdd:pfam00041   1 SAPSNLTVTDVTST----SLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEV 71

                          90
                  ....*....|....*
gi 307776542  181 QVRCKPDAGyWSAWS 195
Cdd:pfam00041  72 RVQAVNGGG-EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4-88 9.82e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 34.39  E-value: 9.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542   4 PGKPEIFKCRSPNKETFTCWW-RPGTDGGLPTNYSLTYHREGETLMHECPdyiTGGPNSCHfgkqYT----SMWRTYIMM 78
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETS----YTltglKPGTEYEFR 73

                         90
                 ....*....|
gi 307776542  79 VNATNQMGSS 88
Cdd:cd00063   74 VRAVNGGGES 83
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 2-96 7.63e-32

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 111.36  E-value: 7.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542    2 LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMhECPDYITGGPNS-----CHFGKQYTSMWRTYI 76
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVK-ECPLYSTSGANStrlfiCFFPKNDVSLFVPLH 84

                          90       100
                  ....*....|....*....|
gi 307776542   77 MMVNATNQMGSSFSDELYVD 96
Cdd:pfam09067  85 ITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 103-201 7.36e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 7.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542 103 PDPPLELAVEVKQPEdrkpYLWIKWSPPTlidlKTGWFTLLYEIRLKPEKAAEWEI--HFAGQQTEFKILSLHPGQKYLV 180
Cdd:cd00063    1 PSPPTNLRVTDVTST----SVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 307776542 181 QVRCKPDAGyWSAWSPATFIQ 201
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 103-190 3.10e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542   103 PDPPLELAVEVKQPEdrkpYLWIKWSPPTliDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQV 182
Cdd:smart00060   1 PSPPSNLRVTDVTST----SVTLSWEPPP--DDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 307776542   183 RCKPDAGY 190
Cdd:smart00060  75 RAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
73-198 3.54e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.92  E-value: 3.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542  73 RTYIMMVNATNQMG--SSFSDELYVdVTYIVQPDPPLELAVEVKqpEDRKPYLwiKWSPPTLIDLKTgwftllYEIRLKP 150
Cdd:COG3401  296 TTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAV--GSSSITL--SWTASSDADVTG------YNVYRST 364

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 307776542 151 EKAAEWE-IHFAGQQTEFKILSLHPGQKYLVQVRCKPDAGYWSAWSPAT 198
Cdd:COG3401  365 SGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEV 413
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
73-197 2.08e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.53  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542  73 RTYIMMVNATNQMG-SSFSDELYVdVTYIVQPDPPLELAVEVKQPEDRKpylwIKWSPPTLIDLKTgwftllYEIRLKPE 151
Cdd:COG3401  203 TTYYYRVAATDTGGeSAPSNEVSV-TTPTTPPSAPTGLTATADTPGSVT----LSWDPVTESDATG------YRVYRSNS 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 307776542 152 KAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDAGYWSAWSPA 197
Cdd:COG3401  272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNV 317
fn3 pfam00041
Fibronectin type III domain;
104-195 2.63e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542  104 DPPLELAVEVKQPEdrkpYLWIKWSPPTLIDLK-TGwftllYEIRLKPEKAAEWEIHF--AGQQTEFKILSLHPGQKYLV 180
Cdd:pfam00041   1 SAPSNLTVTDVTST----SLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEV 71

                          90
                  ....*....|....*
gi 307776542  181 QVRCKPDAGyWSAWS 195
Cdd:pfam00041  72 RVQAVNGGG-EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4-88 9.82e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 34.39  E-value: 9.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307776542   4 PGKPEIFKCRSPNKETFTCWW-RPGTDGGLPTNYSLTYHREGETLMHECPdyiTGGPNSCHfgkqYT----SMWRTYIMM 78
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETS----YTltglKPGTEYEFR 73

                         90
                 ....*....|
gi 307776542  79 VNATNQMGSS 88
Cdd:cd00063   74 VRAVNGGGES 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH