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Conserved domains on  [gi|305632828|ref|NP_001182215|]
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interferon regulatory factor 4 isoform 2 [Homo sapiens]

Protein Classification

interferon regulatory factor( domain architecture ID 10457095)

interferon regulatory factor (IRF) is a transcriptional regulator that is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 248-417 3.80e-88

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 266.43  E-value: 3.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  248 DCRLHICLYYREILVKELTTSSPEGCRISHGHT------YDASNLDQVLFPYPE---DNGQRKNIEKLLSHLERGVVLWM 318
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSYGPPdpqvalYGPVALQQVRFPDPDgipDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  319 APDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPD-PQRQR 397
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDdKPREK 160

                         170       180
                  ....*....|....*....|
gi 305632828  398 KLITAHVEPLLARQLYYFAQ 417
Cdd:pfam10401 161 KLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 23-128 8.62e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 211.27  E-value: 8.62e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828   23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 305632828  103 KSNDFEELVERSQLDISDPYKVYRIV 128
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 248-417 3.80e-88

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 266.43  E-value: 3.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  248 DCRLHICLYYREILVKELTTSSPEGCRISHGHT------YDASNLDQVLFPYPE---DNGQRKNIEKLLSHLERGVVLWM 318
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSYGPPdpqvalYGPVALQQVRFPDPDgipDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  319 APDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPD-PQRQR 397
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDdKPREK 160

                         170       180
                  ....*....|....*....|
gi 305632828  398 KLITAHVEPLLARQLYYFAQ 417
Cdd:pfam10401 161 KLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 23-128 8.62e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 211.27  E-value: 8.62e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828   23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 305632828  103 KSNDFEELVERSQLDISDPYKVYRIV 128
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 23-130 1.20e-53

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 174.83  E-value: 1.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828    23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 305632828   103 KSNDFEELVERSQlDISDPYKVYRIVPE 130
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 24-129 3.16e-46

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 155.53  E-value: 3.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  24 LRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDyNREEDAALFKAWALFKGKFREGiDKPDPPTWKTRLRCALNK 103
Cdd:cd00103    4 LRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPG-GTPDPAEWKARLLCALRS 81

                         90       100
                 ....*....|....*....|....*.
gi 305632828 104 SNDFEELVERSQLDISDPYKVYRIVP 129
Cdd:cd00103   82 SRGFEEVKDKSKDTPGDPHRVYRLLP 107
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 248-417 3.80e-88

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 266.43  E-value: 3.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  248 DCRLHICLYYREILVKELTTSSPEGCRISHGHT------YDASNLDQVLFPYPE---DNGQRKNIEKLLSHLERGVVLWM 318
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSYGPPdpqvalYGPVALQQVRFPDPDgipDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  319 APDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPD-PQRQR 397
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDdKPREK 160

                         170       180
                  ....*....|....*....|
gi 305632828  398 KLITAHVEPLLARQLYYFAQ 417
Cdd:pfam10401 161 KLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 23-128 8.62e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 211.27  E-value: 8.62e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828   23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 305632828  103 KSNDFEELVERSQLDISDPYKVYRIV 128
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 23-130 1.20e-53

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 174.83  E-value: 1.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828    23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 305632828   103 KSNDFEELVERSQlDISDPYKVYRIVPE 130
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 24-129 3.16e-46

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 155.53  E-value: 3.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632828  24 LRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDyNREEDAALFKAWALFKGKFREGiDKPDPPTWKTRLRCALNK 103
Cdd:cd00103    4 LRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPG-GTPDPAEWKARLLCALRS 81

                         90       100
                 ....*....|....*....|....*.
gi 305632828 104 SNDFEELVERSQLDISDPYKVYRIVP 129
Cdd:cd00103   82 SRGFEEVKDKSKDTPGDPHRVYRLLP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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