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Conserved domains on  [gi|303522479|ref|NP_001181943|]
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T-cell surface glycoprotein CD4 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD4-extracel pfam09191
CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with ...
 28-137 9.42e-60

CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.


:

Pssm-ID: 462712  Cd Length: 106  Bit Score: 185.19  E-value: 9.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303522479   28 ASSIVYKKEGEQVEFSFPLAFTVEKLtgSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQ 107
Cdd:pfam09191   1 VSNTVYKKEGEQVEFSFPLTFEDENL--SGELRWQAEGASSSQSWITFSLKNRKVSVQKVTQDPKLQMKEKLPLTLTLPQ 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 303522479  108 ALPQYAGSGNLTLALEAktGKLHQEVNLVV 137
Cdd:pfam09191  79 ALLQYAGSGNLTLTLDK--GKLHQEVNLVV 106
CD4_CD cd22570
cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called ...
 222-265 2.63e-23

cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called T-cell surface antigen T4/Leu-3, is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD4 functions primarily as a coreceptor for MHC class II molecule:peptide complex. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. CD4 participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. The model corresponds to cytoplasmic domain of CD4, which is responsible for the interaction with HIV-1 Nef protein that suppresses multiple immune surveillance mechanisms to promote viral pathogenesis.


:

Pssm-ID: 439337  Cd Length: 44  Bit Score: 89.49  E-value: 2.63e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 303522479 222 VLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKT 265
Cdd:cd22570    1 VLGGAAGLLLFIGLCIFCCVRCRHRRRQAERMSQIKRLLSEKKT 44
C2-set pfam05790
Immunoglobulin C2-set domain;
138-210 2.26e-16

Immunoglobulin C2-set domain;


:

Pssm-ID: 399065  Cd Length: 80  Bit Score: 71.99  E-value: 2.26e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 303522479  138 MRATQLQKNLTCEVWGPTSPK---LMLSLKLENKEAKVSKREKAVWVLNP---EAGMWQCLLSDSGQVLLESNIKVLPT 210
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTLPKgskMDPSLKLKGQEAKSLETKKLESTFQPtteDSGTWVCLASDNDQKKLESVIEVLVL 79
 
Name Accession Description Interval E-value
CD4-extracel pfam09191
CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with ...
 28-137 9.42e-60

CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.


Pssm-ID: 462712  Cd Length: 106  Bit Score: 185.19  E-value: 9.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303522479   28 ASSIVYKKEGEQVEFSFPLAFTVEKLtgSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQ 107
Cdd:pfam09191   1 VSNTVYKKEGEQVEFSFPLTFEDENL--SGELRWQAEGASSSQSWITFSLKNRKVSVQKVTQDPKLQMKEKLPLTLTLPQ 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 303522479  108 ALPQYAGSGNLTLALEAktGKLHQEVNLVV 137
Cdd:pfam09191  79 ALLQYAGSGNLTLTLDK--GKLHQEVNLVV 106
IgV_3_CD4 cd07695
Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of ...
 29-135 2.44e-50

Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the third immunoglobulin variable (IgV) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409492  Cd Length: 107  Bit Score: 161.29  E-value: 2.44e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303522479  29 SSIVYKKEGEQVEFSFPLAFTVEKL--TGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLP 106
Cdd:cd07695    1 SEIVYTKVGEQVEFSFPLNFTKEKWkeGGSGELWWQAEGASSSKSWITFSLKNKEVSVKRVTQDPKLQMGKKLPLDLTLP 80

                         90       100
                 ....*....|....*....|....*....
gi 303522479 107 QALPQYAGSGNLTLALEakTGKLHQEVNL 135
Cdd:cd07695   81 QVLPQHAGSGNLTLALE--TGKLEQEVNL 107
CD4_CD cd22570
cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called ...
 222-265 2.63e-23

cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called T-cell surface antigen T4/Leu-3, is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD4 functions primarily as a coreceptor for MHC class II molecule:peptide complex. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. CD4 participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. The model corresponds to cytoplasmic domain of CD4, which is responsible for the interaction with HIV-1 Nef protein that suppresses multiple immune surveillance mechanisms to promote viral pathogenesis.


Pssm-ID: 439337  Cd Length: 44  Bit Score: 89.49  E-value: 2.63e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 303522479 222 VLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKT 265
Cdd:cd22570    1 VLGGAAGLLLFIGLCIFCCVRCRHRRRQAERMSQIKRLLSEKKT 44
C2-set pfam05790
Immunoglobulin C2-set domain;
138-210 2.26e-16

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 71.99  E-value: 2.26e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 303522479  138 MRATQLQKNLTCEVWGPTSPK---LMLSLKLENKEAKVSKREKAVWVLNP---EAGMWQCLLSDSGQVLLESNIKVLPT 210
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTLPKgskMDPSLKLKGQEAKSLETKKLESTFQPtteDSGTWVCLASDNDQKKLESVIEVLVL 79
Tcell_CD4_C pfam12104
T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell ...
 247-274 2.70e-03

T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalization. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure.


Pssm-ID: 403359  Cd Length: 28  Bit Score: 34.79  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*...
gi 303522479  247 RRQAERMSQIKRLLSEKKTCQCPHRFQK 274
Cdd:pfam12104   1 RKRARRMAQAKQYLLEKKTCQCQRRMYK 28
 
Name Accession Description Interval E-value
CD4-extracel pfam09191
CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with ...
 28-137 9.42e-60

CD4, extracellular; Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.


Pssm-ID: 462712  Cd Length: 106  Bit Score: 185.19  E-value: 9.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303522479   28 ASSIVYKKEGEQVEFSFPLAFTVEKLtgSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQ 107
Cdd:pfam09191   1 VSNTVYKKEGEQVEFSFPLTFEDENL--SGELRWQAEGASSSQSWITFSLKNRKVSVQKVTQDPKLQMKEKLPLTLTLPQ 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 303522479  108 ALPQYAGSGNLTLALEAktGKLHQEVNLVV 137
Cdd:pfam09191  79 ALLQYAGSGNLTLTLDK--GKLHQEVNLVV 106
IgV_3_CD4 cd07695
Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of ...
 29-135 2.44e-50

Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the third immunoglobulin variable (IgV) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409492  Cd Length: 107  Bit Score: 161.29  E-value: 2.44e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303522479  29 SSIVYKKEGEQVEFSFPLAFTVEKL--TGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLP 106
Cdd:cd07695    1 SEIVYTKVGEQVEFSFPLNFTKEKWkeGGSGELWWQAEGASSSKSWITFSLKNKEVSVKRVTQDPKLQMGKKLPLDLTLP 80

                         90       100
                 ....*....|....*....|....*....
gi 303522479 107 QALPQYAGSGNLTLALEakTGKLHQEVNL 135
Cdd:cd07695   81 QVLPQHAGSGNLTLALE--TGKLEQEVNL 107
CD4_CD cd22570
cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called ...
 222-265 2.63e-23

cytoplasmic domain of T-cell surface glycoprotein CD4 and similar proteins; CD4, also called T-cell surface antigen T4/Leu-3, is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, CD4 functions primarily as a coreceptor for MHC class II molecule:peptide complex. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. CD4 participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. The model corresponds to cytoplasmic domain of CD4, which is responsible for the interaction with HIV-1 Nef protein that suppresses multiple immune surveillance mechanisms to promote viral pathogenesis.


Pssm-ID: 439337  Cd Length: 44  Bit Score: 89.49  E-value: 2.63e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 303522479 222 VLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKT 265
Cdd:cd22570    1 VLGGAAGLLLFIGLCIFCCVRCRHRRRQAERMSQIKRLLSEKKT 44
C2-set pfam05790
Immunoglobulin C2-set domain;
138-210 2.26e-16

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 71.99  E-value: 2.26e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 303522479  138 MRATQLQKNLTCEVWGPTSPK---LMLSLKLENKEAKVSKREKAVWVLNP---EAGMWQCLLSDSGQVLLESNIKVLPT 210
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTLPKgskMDPSLKLKGQEAKSLETKKLESTFQPtteDSGTWVCLASDNDQKKLESVIEVLVL 79
Tcell_CD4_C pfam12104
T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell ...
 247-274 2.70e-03

T cell CD4 receptor C terminal region; This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalization. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure.


Pssm-ID: 403359  Cd Length: 28  Bit Score: 34.79  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*...
gi 303522479  247 RRQAERMSQIKRLLSEKKTCQCPHRFQK 274
Cdd:pfam12104   1 RKRARRMAQAKQYLLEKKTCQCQRRMYK 28
TM_EGFR-like cd12087
Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine ...
 209-249 6.70e-03

Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane (TM) helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. They are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. The TM domain not only serves as a membrane anchor, but also plays an important role in receptor dimerization and optimal activation. Mutations in the TM domain of EGFR family RTKs have been associated with increased breast cancer risk.


Pssm-ID: 213052  Cd Length: 38  Bit Score: 33.66  E-value: 6.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 303522479 209 PTWSTPVqpMALIVLGGVAGLLLfIGLGIFFCVRCRHRRRQ 249
Cdd:cd12087    1 RTSKTTS--IAAGVVGGLLVLVI-LGLIVFLFRRRRHIKRK 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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