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Conserved domains on  [gi|302786248|ref|XP_002974895|]
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tubulin alpha-2 chain [Selaginella moellendorffii]

Protein Classification

tubulin alpha chain( domain architecture ID 11476498)

tubulin alpha chain dimerizes with the beta chain to form tubulin, the major constituent of microtubules

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN00221 PLN00221
tubulin alpha chain; Provisional
1-450 0e+00

tubulin alpha chain; Provisional


:

Pssm-ID: 177802  Cd Length: 450  Bit Score: 909.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAidrndHQEAMAGATKESFGTFFSEAASAtKHVPRAVMVDLEPTV 80
Cdd:PLN00221   1 MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQM-----PSDKTVGGGDDAFNTFFSETGAG-KHVPRAVFVDLEPTV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  81 IDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLL 160
Cdd:PLN00221  75 IDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 161 ERLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQV 240
Cdd:PLN00221 155 ERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 241 ISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMA 320
Cdd:PLN00221 235 ISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRHGKYMA 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 321 CCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNGDLARVKRAVCMISNNTAVADVFSHINHK 400
Cdd:PLN00221 315 CCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAVAEVFSRIDHK 394
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 302786248 401 FDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAEVAQDGDEDEQ 450
Cdd:PLN00221 395 FDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESAEGEG 444
 
Name Accession Description Interval E-value
PLN00221 PLN00221
tubulin alpha chain; Provisional
1-450 0e+00

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 909.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAidrndHQEAMAGATKESFGTFFSEAASAtKHVPRAVMVDLEPTV 80
Cdd:PLN00221   1 MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQM-----PSDKTVGGGDDAFNTFFSETGAG-KHVPRAVFVDLEPTV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  81 IDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLL 160
Cdd:PLN00221  75 IDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 161 ERLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQV 240
Cdd:PLN00221 155 ERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 241 ISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMA 320
Cdd:PLN00221 235 ISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRHGKYMA 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 321 CCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNGDLARVKRAVCMISNNTAVADVFSHINHK 400
Cdd:PLN00221 315 CCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAVAEVFSRIDHK 394
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 302786248 401 FDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAEVAQDGDEDEQ 450
Cdd:PLN00221 395 FDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESAEGEG 444
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
2-441 0e+00

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 824.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   2 REIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAIDRNDHQEamagaTKESFGTFFSEAaSATKHVPRAVMVDLEPTVI 81
Cdd:cd02186    1 REIISIHVGQAGVQIGNACWELFCLEHGIQPDGQMPSDKTIGG-----DDDNFNTFFSET-GSGKYVPRAVFVDLEPTVI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  82 DEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLLE 161
Cdd:cd02186   75 DEIRTGPYRQLFHPEQLISGKEDAANNFARGYYTIGKEIIDPVLDRIRKLAEQCDGLQGFLIFHSVGGGTGSGLTSLLLE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 162 RLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQVI 241
Cdd:cd02186  155 RLSVDYGKKSKLEFSIYPSPQVSTSVVEPYNSVLTTHSLLEHSDCSILLDNEALYDICRRQLDIERPTYTNLNRLIAQVV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 242 SSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMAC 321
Cdd:cd02186  235 SSLTASLRFDGALNVDLNEFQTNLVPYPRIHFPLVSYAPIISAEKANHEQLSVQEITNSCFEPANQMVKCDPRHGKYMAC 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 322 CMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNGDLARVKRAVCMISNNTAVADVFSHINHKF 401
Cdd:cd02186  315 CLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGSDLAKVDRSVCMLANSTAIAEAFQRLDHKF 394
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 302786248 402 DLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAEV 441
Cdd:cd02186  395 DLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEV 434
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
269-398 8.14e-70

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 217.48  E-value: 8.14e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  269 PRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMACCMMYRGDLTPKEVQQAVSNIRTKRSVQ 348
Cdd:pfam03953   1 PRLHFLLTSYAPLTSANKASHEKTSVLDVTRRLFDPKNQMVSCDPRNGKYMACALLYRGDVSPKDVHRAIQRIKEKRSAQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 302786248  349 FVDWCPTGFKCGINYQPPTAVPNGdlarvKRAVCMISNNTAVADVFSHIN 398
Cdd:pfam03953  81 FVEWCPTGIKVAICSQSPYVVPGS-----KVSGLMLANTTSIAELFQRLL 125
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
54-252 2.73e-56

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 185.00  E-value: 2.73e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248    54 FGTFFSEaasaTKHVPRAVMVDLEPTVIDEIRTGSYRELFHPDQLISGKEDAANNFARGHYT-----VGREILEQCLDRI 128
Cdd:smart00864   1 KIKVFGV----GGGGPNAVNVDLEPGVIDGVRANTDAQALNPESLASGKIQAGNNWTRGLGAgadpeVGREAAEESLDEI 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   129 RKLADNCSGLQGF-------------LVfnavgggtgsglgallLERLtCDYGRKSkLGFSIYPspKISTAVVEPYNSVL 195
Cdd:smart00864  77 REELEGADGVFITagmgggtgtgaapVI----------------AEIA-KEYGILT-VAVVTKP--FSFEGVVRPYNAEL 136
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 302786248   196 ATHALLEHSDVVAVLDNEAIYDICRKSLNIeRPSYTNLNRLVSQVISSLTTSLRFNG 252
Cdd:smart00864 137 GLEELREHVDSLIVIDNDALLDICGRKLPL-RPAFKDANDLLAQAVSGITDLIRFPG 192
 
Name Accession Description Interval E-value
PLN00221 PLN00221
tubulin alpha chain; Provisional
1-450 0e+00

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 909.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAidrndHQEAMAGATKESFGTFFSEAASAtKHVPRAVMVDLEPTV 80
Cdd:PLN00221   1 MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQM-----PSDKTVGGGDDAFNTFFSETGAG-KHVPRAVFVDLEPTV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  81 IDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLL 160
Cdd:PLN00221  75 IDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 161 ERLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQV 240
Cdd:PLN00221 155 ERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 241 ISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMA 320
Cdd:PLN00221 235 ISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRHGKYMA 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 321 CCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNGDLARVKRAVCMISNNTAVADVFSHINHK 400
Cdd:PLN00221 315 CCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAVAEVFSRIDHK 394
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 302786248 401 FDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAEVAQDGDEDEQ 450
Cdd:PLN00221 395 FDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESAEGEG 444
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
1-450 0e+00

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 871.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAI-DRNDHQEamagatKESFGTFFSEAASAtKHVPRAVMVDLEPT 79
Cdd:PTZ00335   1 MREVISIHIGQAGIQVGNACWELFCLEHGIQPDGQMPsDKNIGVE------DDAFNTFFSETGAG-KHVPRCVFLDLEPT 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  80 VIDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALL 159
Cdd:PTZ00335  74 VIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFHAVGGGTGSGLGSLL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 160 LERLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQ 239
Cdd:PTZ00335 154 LERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRNLDIERPTYTNLNRLIAQ 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 240 VISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYM 319
Cdd:PTZ00335 234 VISSLTASLRFDGALNVDLTEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPANMMAKCDPRHGKYM 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 320 ACCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNGDLARVKRAVCMISNNTAVADVFSHINH 399
Cdd:PTZ00335 314 ACCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAIAEVFSRIDH 393
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 302786248 400 KFDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAEVAQDGDEDEQ 450
Cdd:PTZ00335 394 KFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADEEG 444
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
2-441 0e+00

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 824.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   2 REIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAIDRNDHQEamagaTKESFGTFFSEAaSATKHVPRAVMVDLEPTVI 81
Cdd:cd02186    1 REIISIHVGQAGVQIGNACWELFCLEHGIQPDGQMPSDKTIGG-----DDDNFNTFFSET-GSGKYVPRAVFVDLEPTVI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  82 DEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLLE 161
Cdd:cd02186   75 DEIRTGPYRQLFHPEQLISGKEDAANNFARGYYTIGKEIIDPVLDRIRKLAEQCDGLQGFLIFHSVGGGTGSGLTSLLLE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 162 RLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQVI 241
Cdd:cd02186  155 RLSVDYGKKSKLEFSIYPSPQVSTSVVEPYNSVLTTHSLLEHSDCSILLDNEALYDICRRQLDIERPTYTNLNRLIAQVV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 242 SSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMAC 321
Cdd:cd02186  235 SSLTASLRFDGALNVDLNEFQTNLVPYPRIHFPLVSYAPIISAEKANHEQLSVQEITNSCFEPANQMVKCDPRHGKYMAC 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 322 CMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNGDLARVKRAVCMISNNTAVADVFSHINHKF 401
Cdd:cd02186  315 CLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGSDLAKVDRSVCMLANSTAIAEAFQRLDHKF 394
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 302786248 402 DLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAEV 441
Cdd:cd02186  395 DLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEV 434
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
2-438 3.20e-164

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 469.74  E-value: 3.20e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   2 REIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAIDRNDHQEamagatkESFGTFFSEAaSATKHVPRAVMVDLEPTVI 81
Cdd:cd02187    1 REIIHIQIGQCGNQIGAKFWETISKEHGIDPDGTYKGDSDLQL-------ERINVYFNEA-SGGKYVPRAVLVDLEPGTI 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  82 DEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLLE 161
Cdd:cd02187   73 DSVRSGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGLGTLLLS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 162 RLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQVI 241
Cdd:cd02187  153 KLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENADETFCIDNEALYNICQRTLKLTQPTYDDLNHLISQVM 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 242 SSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMAC 321
Cdd:cd02187  233 SGITSSLRFPGQLNSDLRKLATNLVPFPRLHFLTPGFAPLTSRGSQQYRKLTVPELTQQLFDAKNMMAACDPRHGRYLTA 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 322 CMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNgdlarvkrAVCMISNNTAVADVFSHINHKF 401
Cdd:cd02187  313 AAIFRGRISTKEVDEQMSKVQNKNSSYFVEWIPNNVKTSVCDIPPRGLKM--------SATFIGNSTAIQELFKRLSEQF 384
                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 302786248 402 DLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDY 438
Cdd:cd02187  385 TAMFRRKAFLHWYTGEGMDEMEFTEAESNLNDLISEY 421
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
3-440 3.16e-155

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 445.49  E-value: 3.16e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   3 EIISIHVGQAGIQLGNSCWELFclehgiqpngkaidrndhqeamagatkesfgtffseaasatkhvpRAVMVDLEPTVID 82
Cdd:cd06059    1 EIITIQVGQCGNQIGDRFWELA---------------------------------------------RAVLVDMEEGVIN 35
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  83 EIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLLER 162
Cdd:cd06059   36 EVLKGPLGQLFDPNQFVTGVSGAGNNWAVGYYVYGPKYIESILDRIRKQVEKCDSLQGFFILHSLGGGTGSGLGSYLLEL 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 163 LTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRK---SLNIERPSYTNLNRLVSQ 239
Cdd:cd06059  116 LEDEYPKVYRFTFSVFPSPDDDNVITSPYNSVLALNHLTEHADCVLPIDNEALYDICNRqpaTLDIDFPPFDDMNNLVAQ 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 240 VISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYM 319
Cdd:cd06059  196 LLSSLTSSLRFEGSLNVDLNEITTNLVPFPRLHFLLPSLSPLTSANDVTLEPLTLDQLFSDLFSKDNQLVGCDPRHGTYL 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 320 ACCMMYRGD-LTPKEVQQAVSNIRTKRSvqFVDWCPTGFKCGINYQPPTAVPNGdlarvkraVCMISNNTAVADVFSHIN 398
Cdd:cd06059  276 ACALLLRGKvFSLSDVRRNIDRIKPKLK--FISWNPDGFKVGLCSVPPVGQKYS--------LLFLSNNTSIASTFERLI 345
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 302786248 399 HKFDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAE 440
Cdd:cd06059  346 ERFDKLYKRKAFLHHYTGEGMEEGDFSEARESLANLIQEYQE 387
PTZ00010 PTZ00010
tubulin beta chain; Provisional
1-452 1.43e-148

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 430.74  E-value: 1.43e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAIDRNDHQeamagatKESFGTFFSEAASAtKHVPRAVMVDLEPTV 80
Cdd:PTZ00010   1 MREIVHIQAGQCGNQIGSKFWEVISDEHGIDPTGTYQGDSDLQ-------LERINVYYNEATGG-RYVPRAVLMDLEPGT 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  81 IDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLL 160
Cdd:PTZ00010  73 MDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQITHSLGGGTGSGMGTLLI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 161 ERLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQV 240
Cdd:PTZ00010 153 SKLREEYPDRIMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADESMCIDNEALYDICFRTLKLTTPTYGDLNHLVSAV 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 241 ISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMA 320
Cdd:PTZ00010 233 MSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVPELTQQMFDAKNMMCAADPRHGRYLT 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 321 CCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNgdlarvkrAVCMISNNTAVADVFSHINHK 400
Cdd:PTZ00010 313 ASALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPKGLKM--------SVTFIGNSTAIQEMFRRVGEQ 384
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 302786248 401 FDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDY-----AEVAQDGDEDEQSQ 452
Cdd:PTZ00010 385 FTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYqqyqdATVEEEGEFDEEEE 441
PLN00220 PLN00220
tubulin beta chain; Provisional
1-458 9.15e-138

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 403.05  E-value: 9.15e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAIDRNDHQeamagatKESFGTFFSEAaSATKHVPRAVMVDLEPTV 80
Cdd:PLN00220   1 MREILHIQGGQCGNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQ-------LERINVYYNEA-SGGRYVPRAVLMDLEPGT 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  81 IDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLL 160
Cdd:PLN00220  73 MDSVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 161 ERLTCDYGRKSKLGFSIYPSPKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQV 240
Cdd:PLN00220 153 SKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISAT 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 241 ISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMA 320
Cdd:PLN00220 233 MSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLT 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 321 CCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAvpngdlarVKRAVCMISNNTAVADVFSHINHK 400
Cdd:PLN00220 313 ASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPKG--------LKMASTFIGNSTSIQEMFRRVSEQ 384
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302786248 401 FDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDY-----AEVAQDGDEDEQSQVNGAEA 458
Cdd:PLN00220 385 FTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYqqyqdATADEEGEYEDEEEEEEYEE 447
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
3-387 4.34e-104

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 313.19  E-value: 4.34e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   3 EIISIHVGQAGIQLGNSCWELfclehgiqpngkaidrndhqeamagatkesfgtffseaasatkhvprAVMVDLEPTVID 82
Cdd:cd00286    1 EIVTIQVGQCGNQIGAAFWEQ-----------------------------------------------AVLVDLEPAVLD 33
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  83 EIRTGSYRELFHPDQLISGKED--AANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLL 160
Cdd:cd00286   34 ELLSGPLRQLFHPENIILIQKYhgAGNNWAKGHSVAGEEYQEEILDAIRKEVEECDELQGFFITHSLGGGTGSGLGPLLA 113
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 161 ERLTCDYGRKSKLGFSIYPSPKISTaVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVSQV 240
Cdd:cd00286  114 ERLKDEYPNRLVVTFSILPGPDEGV-IVYPYNAALTLKTLTEHADCLLLVDNEALYDICPRPLHIDAPAYDHINELVAQR 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 241 ISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMA 320
Cdd:cd00286  193 LGSLTEALRFEGSLNVDLRELAENLVPLPRGHFLMLGYAPLDSATSATPRSLRVKELTRRAFLPANLLVGCDPDHGEAIA 272
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302786248 321 CCMMYRG--DLTPKEVQQAVSNIRTKRSVQFvDWCPTGFKCGINYQPPTAvpngdlarVKRAVCMISNN 387
Cdd:cd00286  273 ALLVIRGppDLSSKEVERAIARVKETLGHLF-SWSPAGVKTGISPKPPAE--------GEVSVLALLNS 332
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
2-438 1.59e-102

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 312.55  E-value: 1.59e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   2 REIISIHVGQAGIQLGNSCWELFCLEHGIQPNG----KAIDRNDHQEAmagatkesfgtFFSEAaSATKHVPRAVMVDLE 77
Cdd:cd02188    1 REIITLQVGQCGNQIGSEFWKQLCSEHGISPDGsledFATDGNDRKDV-----------FFYQA-DDEHYIPRAILLDLE 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  78 PTVIDEIRTGSYRELFHPDQLISGKED--AANNFARGhYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGL 155
Cdd:cd02188   69 PRVINSIQNSPYKNLFNPENIYLSKEGggAGNNWASG-YSQGEKVQEEILDIIDREAEGSDSLEGFVLCHSIAGGTGSGM 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 156 GALLLERLTCDYGRKSKLGFSIYPSPK-ISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLN 234
Cdd:cd02188  148 GSYLLERLSDRYPKKLIQTYSVFPNQEeSSDVVVQPYNSILTLKRLTLNADCVVVLDNTALNRIATDRLKIDNPSFSQIN 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 235 RLVSQVISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAE-RAFHEQLSVSEITTSVFEPASMMAKCDP 313
Cdd:cd02188  228 SLISTVMSASTSTLRFPGYMNNDLVSLISSLIPTPRLHFLMTSYTPLTSDQvASSVRKTTVLDVMRRLLQPKNRMVSTST 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 314 RHGKYMACCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVPNgdlARVKRAvcMISNNTAVADV 393
Cdd:cd02188  308 KNGCYISILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSKKSPYVQTA---HRVSGL--MLANHTSISSL 382
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 302786248 394 FSHINHKFDLMFSKRAFVHWYVGEGMEEG---EFSEAREDVAALEKDY 438
Cdd:cd02188  383 FEKILSQYDKLRKRNAFLENYRKEDMFQDnleEFDESREVVQSLIDEY 430
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
2-441 6.59e-99

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 303.78  E-value: 6.59e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   2 REIISIHVGQAGIQLGNSCWELFCLEHGiqpNGKAIDRNDhqeamagatkESFGTFF------SEAASATKHVP------ 69
Cdd:cd02190    1 REIITVQVGQCGNQIGCRFWDLALREHA---AYNKDGVYD----------DSMSSFFrnvdtrSGDPGDDGGSPikslka 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  70 RAVMVDLEPTVIDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGG 149
Cdd:cd02190   68 RAVLIDMEEGVVNELLKGPLGDLFDETQLVTDVSGAGNNWAHGYHEYGPQYGESILEKLRRAAEKCDSLQSFFLLHSLGG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 150 GTGSGLGALLLERLTCDYGRKSKLGFSIYPSpKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERP- 228
Cdd:cd02190  148 GTGSGLGSYILELLEDEFPDVYRFVTSVFPS-GDDDVITSPYNSVLALRELTEHADCVLPVENQALMDIVNKIKSSKDKg 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 229 ---------------------SYTNLNRLVSQVISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAERA 287
Cdd:cd02190  227 ktgvlaainssgggqkkgkkkPFDDMNNIVANLLLNLTSSMRFEGSLNVDLNEITTNLVPFPRLHFLLSSLSPLYALADV 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 288 FHEQLSVSEITTSVFEPASMMAKCDPRHGKYMACCMMYRGDLtpkEVQQAVSNI-RTKRSVQFVDWCPTGFKCGINYQPP 366
Cdd:cd02190  307 RLPPRRLDQMFSDAFSRDHQLLKADPKHGLYLACALLVRGNV---SISDLRRNIdRLKRQLKFVSWNQDGWKIGLCSVPP 383
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302786248 367 TAVPNGDLarvkravcMISNNTAVADVFSHINHKFDLMFSKRAFVHWYVgEGMEEGEFSEAREDVAALEKDYAEV 441
Cdd:cd02190  384 VGQPYSLL--------CLANNTCIKPTFTEMHERFDKLYKRKAHLHHYT-QYMEQDDFDEALESLLDLIEEYKDL 449
PTZ00387 PTZ00387
epsilon tubulin; Provisional
1-441 1.99e-84

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 266.98  E-value: 1.99e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   1 MREIISIHVGQAGIQLGNSCWELFCLEHgiqpngKAIDRNDHQEamagatkESFGTFFsEAASATKHVP-------RAVM 73
Cdd:PTZ00387   1 PREIVTVQVGQCGNQLGHRFWDVALKEH------KKINANPQYD-------DARDSFF-ENVSENVNRPgkenlkaRAVL 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  74 VDLEPTVIDEIRTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGS 153
Cdd:PTZ00387  67 VDMEEGVLNQILKSPLGDLFDENFFVSDVSGAGNNWAVGHMEYGDKYIDSISESVRRQVEQCDSLQSFFLMHSLGGGTGS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 154 GLGALLLERLTCDYGRKSKLGFSIYPSpKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSL---------- 223
Cdd:PTZ00387 147 GLGTRILGMLEDEFPHVFRFCPVVFPS-AVDDVITSPYNSFFALRELIEHADCVLPLDNDALANIADSALsrkkkklakg 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 224 NIERPS-----------------YTNLNRLVSQVISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPVISAER 286
Cdd:PTZ00387 226 NIKRGPqphkysvakptetkklpYDKMNNIVAQLLSNLTSSMRFEGSLNVDINEITTNLVPYPRLHFLTSSIAPLVSLKD 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 287 AFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMACCMMYRGDLTPKEVQQavsNI-RTKRSVQFVDWCPTGFKCGINYQP 365
Cdd:PTZ00387 306 VAVGPRRLDQMFKDCLDPDHQMVAATPEAGKYLATALIVRGPQNVSDVTR---NIlRLKEQLNMIYWNEDGFKTGLCNVS 382
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302786248 366 PTAVPngdlarvkRAVCMISNNTAVADVFSHINHKFDLMFSKRAFVHWYVgEGMEEGEFSEAREDVAALEKDYAEV 441
Cdd:PTZ00387 383 PLGQP--------YSLLCLANNCCIRNKFESMLERFNKLYKRKSHVHHYT-EYLEQAYFDETLETIQNLIDDYAYL 449
PLN00222 PLN00222
tubulin gamma chain; Provisional
2-439 9.05e-80

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 254.77  E-value: 9.05e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   2 REIISIHVGQAGIQLGNSCWELFCLEHGIQPNGKAIDRNDHqeamAGATKESFgtFFSeaASATKHVPRAVMVDLEPTVI 81
Cdd:PLN00222   3 REIITLQVGQCGNQIGMEFWKQLCLEHGISKDGILEDFATQ----GGDRKDVF--FYQ--ADDEHYIPRALLIDLEPRVI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  82 DEIRTGSYRELFHPDQLISGKED--AANNFARGhYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALL 159
Cdd:PLN00222  75 NGIQNSEYRNLYNHENIFVSDHGggAGNNWASG-YHQGEQVEEDIMDMIDREADGSDSLEGFVLCHSIAGGTGSGMGSYL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 160 LERLTCDYGRKSKLGFSIYPS-PKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERPSYTNLNRLVS 238
Cdd:PLN00222 154 LEALNDRYSKKLVQTYSVFPNqMETSDVVVQPYNSLLTLKRLTLNADCVVVLDNTALNRIAVDRLHLENPTFAQTNSLVS 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 239 QVISSLTTSLRFNGALNVDISEFQTNLVPFPRIHFMLSSYAPV-ISAERAFHEQLSVSEITTSVFEPASMMAKCDPR--- 314
Cdd:PLN00222 234 TVMSASTTTLRYPGYMNNDLVGLLASLIPTPRCHFLMTGYTPLtVERQANVIRKTTVLDVMRRLLQTKNIMVSSYARtke 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 315 --HGKYMACCMMYRGDLTPKEVQQAVSNIRTKRSVQFVDWCPTGFKCGINYQPPTAVpngdlARVKRAVCMISNNTAVAD 392
Cdd:PLN00222 314 asQAKYISILNIIQGEVDPTQVHKSLQRIRERKLANFIEWGPASIQVALSRKSPYVQ-----TAHRVSGLMLANHTSIRH 388
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 302786248 393 VFSHINHKFDLMFSKRAFVHWYVGEGM----EEGEFSEAREDVAALEKDYA 439
Cdd:PLN00222 389 LFSKCLSQYDKLRKKQAFLDNYRKFPMfadnDLSEFDESREIVESLVDEYK 439
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
269-398 8.14e-70

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 217.48  E-value: 8.14e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  269 PRIHFMLSSYAPVISAERAFHEQLSVSEITTSVFEPASMMAKCDPRHGKYMACCMMYRGDLTPKEVQQAVSNIRTKRSVQ 348
Cdd:pfam03953   1 PRLHFLLTSYAPLTSANKASHEKTSVLDVTRRLFDPKNQMVSCDPRNGKYMACALLYRGDVSPKDVHRAIQRIKEKRSAQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 302786248  349 FVDWCPTGFKCGINYQPPTAVPNGdlarvKRAVCMISNNTAVADVFSHIN 398
Cdd:pfam03953  81 FVEWCPTGIKVAICSQSPYVVPGS-----KVSGLMLANTTSIAELFQRLL 125
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
3-219 2.53e-61

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 197.83  E-value: 2.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248    3 EIISIHVGQAGIQLGNSCWELFCLEHGIqpngkaidrndhqeamagatkESFGTFFSEAASAtKHVPRAVMVDLEPTVID 82
Cdd:pfam00091   1 EIIVIGVGGAGNNIGNALWELLCLEHGI---------------------DSLNVFFSESGSV-EFIPRSLAIDTDPQALN 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   83 EIRTGsyrelFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLLER 162
Cdd:pfam00091  59 EIKAG-----FNPNKILLGKEGTGGNGAGGYPEIGREAAEESLEEIRKEVEGCDMLQGFFITASLGGGTGSGAAPVIAEI 133
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302786248  163 LTCDYGRKSKLGFSIYPSpKISTAVVEPYNSVLATHALLEHSDVVAVLDNEAIYDIC 219
Cdd:pfam00091 134 LKELYPGALTVAVVTFPF-GFSEGVVRPYNAILGLKELIEHSDSVIVIDNDALYDIC 189
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
54-252 2.73e-56

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 185.00  E-value: 2.73e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248    54 FGTFFSEaasaTKHVPRAVMVDLEPTVIDEIRTGSYRELFHPDQLISGKEDAANNFARGHYT-----VGREILEQCLDRI 128
Cdd:smart00864   1 KIKVFGV----GGGGPNAVNVDLEPGVIDGVRANTDAQALNPESLASGKIQAGNNWTRGLGAgadpeVGREAAEESLDEI 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   129 RKLADNCSGLQGF-------------LVfnavgggtgsglgallLERLtCDYGRKSkLGFSIYPspKISTAVVEPYNSVL 195
Cdd:smart00864  77 REELEGADGVFITagmgggtgtgaapVI----------------AEIA-KEYGILT-VAVVTKP--FSFEGVVRPYNAEL 136
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 302786248   196 ATHALLEHSDVVAVLDNEAIYDICRKSLNIeRPSYTNLNRLVSQVISSLTTSLRFNG 252
Cdd:smart00864 137 GLEELREHVDSLIVIDNDALLDICGRKLPL-RPAFKDANDLLAQAVSGITDLIRFPG 192
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
4-440 1.80e-41

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 152.81  E-value: 1.80e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   4 IISIHVGQAGIQLGNSCWELFCLEhgiqpngkAIDRNDHqeamagATKESFGTFFSEAASATKHVPRAVMVDLEPTVIDE 83
Cdd:cd02189    2 IVTVQVGQCGNQLGDELFDTLADE--------ADSSASE------GDQNSSATRFFSPFSDGKLKARCVLVDMEPKVVQQ 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248  84 I--RTGSYRELFHPDQLISGKEDAANNFARGHYTVGREILEQCLDRIRKLADNCSGLQGFLVFNAVGGGTGSGLGALLLE 161
Cdd:cd02189   68 VlsRARSGAWSYDPKNVVCGQSGSGNNWALGYYVHGPSLLEDILEALRREAERCDRLSGFLVLHSLAGGTGSGLGSRVTE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 162 RLTCDYGRKSKLGFSIYPSpkiSTA--VVEPYNSVLATHALLEHSDVVAVLDNEAIYDICRKSLNIERP-SYTNLNRLVS 238
Cdd:cd02189  148 LLRDEYPKAYLLNTVVWPY---SSGevPVQNYNTLLTLSHLQESSDGILLFENDDLHKICSKLLGLKNPvSFSDINRVIA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 239 QVISSL---TTSLRFNGALNVD-ISEFQTNLVPFPRIHFMLSSYAPVISAE-------------RAFHEQLSVSEITTSV 301
Cdd:cd02189  225 RQLAGVllpSSSPTSPSPLRRCpLGDLLEHLCPHPAYKLLTLRSLPQMPEPsrafstytwpsllKRLRQMLITGAKLEEG 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248 302 FEPASMMAKCDPRHGKYMACCMMYRGDLTPKEVQQAVSNIrtKRSVQFVDWCPTGFkcgiNYQPPTAVPNGDLarvkRAV 381
Cdd:cd02189  305 IDWQLLDTSGSHNPNKSLAALLVLRGKDAMKVHSADLSAF--KDPVLYSPWVPNPF----NVSVSPRPFNGYE----KSV 374
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 302786248 382 CMISNNTAVADVFSHINHKFDLMFSKRAFVHWYVGEGMEEGEFSEAREDVAALEKDYAE 440
Cdd:cd02189  375 TLLSNSQNIVGPLDSLLEKAWQMFKAGAYLHQYEKYGVEEEDFLDAFATLEQIIAAYKS 433
Tubulin_C smart00865
Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and ...
254-399 6.42e-23

Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


Pssm-ID: 214868 [Multi-domain]  Cd Length: 120  Bit Score: 93.38  E-value: 6.42e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   254 LNVDISEFQTNLVPFPrihFMLSSYAPVISAERAfheqLSVSEITTS--VFEPASMMAKCDPRHgkYMACCMmyrgDLTP 331
Cdd:smart00865   1 INVDFADVKTVMVPMG---FAMMGIGPASGENRA----LEAAELAISspLLEDSNIMGAKGVLV--NITGGP----DLTL 67
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302786248   332 KEVQQAVSNIRTKRS-VQFVDWCptgfkcginyqpPTAVPNgdlarVKRAVCMISN-NTAVADVFSHINH 399
Cdd:smart00865  68 KEVNEAMERIREKADpDAFIIWG------------PVIDEE-----LGGDEIRVTViATGIGSLFKRLSE 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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