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Conserved domains on  [gi|302425181|sp|A2CEH0|]
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RecName: Full=POC1 centriolar protein homolog B; AltName: Full=WD repeat domain 51B

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 1.88e-97

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 1.88e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   6 EDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVR 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  86 LWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDD 165
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 166 RTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLIS 245
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 302425181 246 GSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTN 300
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 1.88e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 1.88e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   6 EDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVR 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  86 LWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDD 165
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 166 RTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLIS 245
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 302425181 246 GSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTN 300
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 1.33e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 278.06  E-value: 1.33e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  10 LERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVRLWTP 89
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  90 SIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVR 169
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 170 LWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLISGSSD 249
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 302425181 250 STIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWK 298
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-172 2.24e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 2.24e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 302425181   134 KKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWD 172
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 73-215 2.84e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.80  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  73 SLVASSSRDQTVRLWTPSIKGESTVFKAHTASVRSVHFSR-DGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNwVRCAR 151
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302425181 152 FSPD-GRLIASCGDDRTVRLWDTSSHQcINIFTDYGGSAT--FVDFNSSGTCIASSgADNTIKIWDI 215
Cdd:PLN00181 625 FPSEsGRSLAFGSADHKVYYYDLRNPK-LPLCTMIGHSKTvsYVRFVDSSTLVSSS-TDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
134-172 6.68e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 6.68e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 302425181  134 KKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWD 172
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-300 1.88e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 1.88e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   6 EDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVR 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  86 LWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDD 165
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 166 RTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLIS 245
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 302425181 246 GSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTN 300
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
6-318 6.78e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 298.36  E-value: 6.78e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   6 EDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVR 85
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  86 LWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDD 165
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 166 RTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLIS 245
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302425181 246 GSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWktNFDSLNYRELLSKHSKRVT 318
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTLTGHTGAVT 376
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 1.33e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 278.06  E-value: 1.33e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  10 LERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVRLWTP 89
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  90 SIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVR 169
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 170 LWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLISGSSD 249
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 302425181 250 STIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWK 298
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
7-300 2.87e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 265.62  E-value: 2.87e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   7 DPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVRL 86
Cdd:COG2319   25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  87 WTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDDR 166
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 167 TVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLISG 246
Cdd:COG2319  185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302425181 247 SSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTN 300
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-318 2.71e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 241.09  E-value: 2.71e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  56 FVGHTDVITGVNFAPSGSLVASSSRDQTVRLWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKK 135
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 136 FLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDI 215
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 216 RTNKLIQHYKVHNAGVNCFSFHPSGNYLISGSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVL 295
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                        250       260
                 ....*....|....*....|....*
gi 302425181 296 MWktnfDSLNYREL--LSKHSKRVT 318
Cdd:cd00200  245 VW----DLRTGECVqtLSGHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-254 2.58e-74

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 236.08  E-value: 2.58e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   5 MEDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTV 84
Cdd:cd00200   38 LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  85 RLWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGD 164
Cdd:cd00200  118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 165 DRTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLI 244
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        250
                 ....*....|
gi 302425181 245 SGSSDSTIKI 254
Cdd:cd00200  278 SGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
25-318 2.15e-72

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 234.81  E-value: 2.15e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  25 DFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVRLWTPSIKGESTVFKAHTAS 104
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 105 VRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWDTSSHQCINIFTD 184
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 185 YGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLISGSSDSTIKILDLLEGRLIY 264
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302425181 265 TLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWktNFDSLNYRELLSKHSKRVT 318
Cdd:COG2319  241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW--DLATGELLRTLTGHSGGVN 292
WD40 COG2319
WD40 repeat [General function prediction only];
6-217 8.40e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.47  E-value: 8.40e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   6 EDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVR 85
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  86 LWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDD 165
Cdd:COG2319  272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 302425181 166 RTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRT 217
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-214 2.81e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.48  E-value: 2.81e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   6 EDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTVR 85
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  86 LWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGDD 165
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 302425181 166 RTVRLWDTSSHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWD 214
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
5-175 6.59e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.88  E-value: 6.59e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   5 MEDPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSGSLVASSSRDQTV 84
Cdd:COG2319  233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  85 RLWTPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSPDGRLIASCGD 164
Cdd:COG2319  313 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                        170
                 ....*....|.
gi 302425181 165 DRTVRLWDTSS 175
Cdd:COG2319  393 DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-300 6.17e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.51  E-value: 6.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 178 CINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLISGSSDSTIKILDL 257
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 302425181 258 LEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTN 300
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-172 2.24e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 2.24e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 302425181   134 KKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWD 172
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 73-215 2.84e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.80  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  73 SLVASSSRDQTVRLWTPSIKGESTVFKAHTASVRSVHFSR-DGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNwVRCAR 151
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302425181 152 FSPD-GRLIASCGDDRTVRLWDTSSHQcINIFTDYGGSAT--FVDFNSSGTCIASSgADNTIKIWDI 215
Cdd:PLN00181 625 FPSEsGRSLAFGSADHKVYYYDLRNPK-LPLCTMIGHSKTvsYVRFVDSSTLVSSS-TDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
134-172 6.68e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 6.68e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 302425181  134 KKFLYSLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWD 172
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-297 1.16e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 105 VRSVHFSRDGQRLVTASDDKSVKVWGVERkkfLYSLNR--HTNWVRCARFSPDGRL---------IASCGDDRTVRLWDT 173
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECES---IIKDGRdiHYPVVELASRSKLSGIcwnsyiksqVASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 174 SSHQCINIFTDYGGSATFVDFNSSGTCIASSGADN-TIKIWDIRTNKLIQHYKVhNAGVNCFSF-HPSGNYLISGSSDST 251
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHK 641

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 302425181 252 IKILDLLEGRL-IYTLHGHKGPVLTVTFSrDGDLFASGGADSQVLMW 297
Cdd:PLN00181 642 VYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 55-243 1.81e-08

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 56.97  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   55 RFVGHTDVITGVNFAPSGSLVASSSRDQtvrLWTPSIKGESTVFKAHTASV--RSVHFSRDGQRLVTASD-DKSVKVW-- 129
Cdd:COG4946   296 RWVDVSGYLTSFALSPDGKRVAFEARGE---VFTVPAEKGPTRNLTNTPGVreRLPAWSPDGKSIAYFSDaSGEYELYia 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  130 ----GVERKKF-LYSLNRHTNwvrcARFSPDGRLIAScgDDRTVRLW--DTSSHQCINIFTD-YGGSATFVDFNSSGTCI 201
Cdd:COG4946   373 padgSGEPKQLtLGDLGRVFN----PVWSPDGKKIAF--TDNRGRLWvvDLASGKVRKVDTDgYGDGISDLAWSPDSKWL 446

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 302425181  202 A-SSGADNT---IKIWDIRTNKLIQhykVHNAGVNCFS--FHPSGNYL 243
Cdd:COG4946   447 AySKPGPNQlsqIFLYDVETGKTVQ---LTDGRYDDGSpaFSPDGKYL 491
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 217-256 3.30e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 3.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 302425181   217 TNKLIQHYKVHNAGVNCFSFHPSGNYLISGSSDSTIKILD 256
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 116-301 3.64e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.86  E-value: 3.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 116 RLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSP-DGRLIASCGDDRTVRLWdtSSHQCINIFT-DYGGSATFVD 193
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLW--SINQGVSIGTiKTKANICCVQ 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 194 FNS-SGTCIASSGADNTIKIWDIRTNKL-----IQHYKVhnagVNCFSFHPSGNyLISGSSDSTIKILDL------LEGR 261
Cdd:PLN00181 625 FPSeSGRSLAFGSADHKVYYYDLRNPKLplctmIGHSKT----VSYVRFVDSST-LVSSSTDNTLKLWDLsmsisgINET 699

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 302425181 262 LIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTNF 301
Cdd:PLN00181 700 PLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAF 739
PTZ00421 PTZ00421
coronin; Provisional
 19-226 5.55e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 5.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  19 DVISCAdFNP-NNKQLATGSCDKSLMIWNLAPKA-------RAFRFVGHTDVITGVNFAPSGSLV-ASSSRDQTVRLWTP 89
Cdd:PTZ00421  77 PIIDVA-FNPfDPQKLFTASEDGTIMGWGIPEEGltqnisdPIVHLQGHTKKVGIVSFHPSAMNVlASAGADMVVNVWDV 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  90 SIKGESTVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRH--TNWVRCArFSPDGRLIASCG---- 163
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasAKSQRCL-WAKRKDLIITLGcsks 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302425181 164 DDRTVRLWDTSSHQCINIFTDYG-GSATFVDFNSSGT--CIASSGADNTIKIWDIRTNKLIQHYKV 226
Cdd:PTZ00421 235 QQRQIMLWDTRKMASPYSTVDLDqSSALFIPFFDEDTnlLYIGSKGEGNIRCFELMNERLTFCSSY 300
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 97-129 7.81e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.81e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 302425181    97 VFKAHTASVRSVHFSRDGQRLVTASDDKSVKVW 129
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 32-258 1.01e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  32 QLATGSCDKSLMIWNLAPKARAFRFVGHTDVITGVNFAPSG-SLVASSSRDQTVRLWTPSiKGESTVFKAHTASVRSVHF 110
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSIN-QGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 111 SRD-GQRLVTASDDKSVKVWGVERKKF-LYSLNRHTNWVRCARFSPDGRLIASCGDDrTVRLWDTS-SHQCIN-----IF 182
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSSTDN-TLKLWDLSmSISGINetplhSF 704

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 183 TDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAG-------------VNCFSFHPSGNYLISGSSD 249
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDpvsglevddasqfISSVCWRGQSSTLVAANST 784


                 ....*....
gi 302425181 250 STIKILDLL 258
Cdd:PLN00181 785 GNIKILEMV 793
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 260-298 1.09e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 302425181   260 GRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWK 298
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-46 2.41e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 302425181     7 DPTLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWN 46
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-129 2.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 302425181   96 TVFKAHTASVRSVHFSRDGQRLVTASDDKSVKVW 129
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
218-256 7.70e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 7.70e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 302425181  218 NKLIQHYKVHNAGVNCFSFHPSGNYLISGSSDSTIKILD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
9-46 8.09e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 8.09e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302425181    9 TLERHFKGHKDVISCADFNPNNKQLATGSCDKSLMIWN 46
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
260-297 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302425181  260 GRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMW 297
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 113-230 1.45e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 113 DGQRLVTASDDKSVKVWGVERKKF-------LYSLNRHTNWVRCARFSPDGR-LIASCGDDRTVRLWDTSSHQCINIFTD 184
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 302425181 185 YGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHNAG 230
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 144-294 2.43e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 144 TNWVRCARFSPDGRLIASCGDDRTVRLWdtsshQCINIFTDyGGSATF--VDFNS----SGTC--------IASSGADNT 209
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIF-----ECESIIKD-GRDIHYpvVELASrsklSGICwnsyiksqVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 210 IKIWDIRTNKLIQHYKVHNAGVNCFSFHPSGNYLI-SGSSDSTIKILDLLEGRLIYTLHGhKGPVLTVTFSRD-GDLFAS 287
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSEsGRSLAF 635


                 ....*..
gi 302425181 288 GGADSQV 294
Cdd:PLN00181 636 GSADHKV 642
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 71-313 3.30e-06

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 49.15  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  71 SGSLVASSSRDQTVRLWTP---SIKGESTVFKAHTASVRSVHFS---RDGQRLVTASDDKSVKVWGVERK-----KFLYS 139
Cdd:cd22857   43 SEPLLAVARKNGTVEVLDPengDLLASFSDSEPATKLSEEDHFVglhLFSGTLLTCTSKGSLRSTKLPDDstassSPTAW 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 140 LNRHTNwVRCARFSPDGRLIASCGDDRTVRLWDTsSHQCINIFT------DYGG--------SATFVDfNSSGTCIASSG 205
Cdd:cd22857  123 VCLGGN-LLCMRVDPNENYFAFGGKEVELNVWDL-EEKPGKIWRaknvpnDSLGlrvpvwvtDLTFLS-KDDHRKIVTGT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 206 ADNTIKIWDIRTNKL-IQHYKVHNAGVNCFSFHPSGNYLISGSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFS-RDGD 283
Cdd:cd22857  200 GYHQVRLYDTRAQRRpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGGSIRSIARhPELP 279

                        250       260       270
                 ....*....|....*....|....*....|
gi 302425181 284 LFASGGADSQVLMWktnfdSLNYRELLSKH 313
Cdd:cd22857  280 LIASCGLDRYLRIW-----DTETRQLLSKV 304
WD40 pfam00400
WD domain, G-beta repeat;
56-87 3.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.77e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 302425181   56 FVGHTDVITGVNFAPSGSLVASSSRDQTVRLW 87
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 191-294 4.88e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 191 FVDFNSSGTCIASSgaDNTIKIWDIRTNKLIQ-------HYKVHNAGVNCFSFHPSG-NYLISGSSDSTIKILDLLEGRL 262
Cdd:PTZ00421  83 FNPFDPQKLFTASE--DGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKA 160

                         90       100       110
                 ....*....|....*....|....*....|..
gi 302425181 263 IYTLHGHKGPVLTVTFSRDGDLFASGGADSQV 294
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKL 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-87 5.24e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 302425181    54 FRFVGHTDVITGVNFAPSGSLVASSSRDQTVRLW 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 167-299 1.51e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.99  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  167 TVRLWDTSSHQciniftdYGGSATFvdfnssgtciaSSGADNTIKIW-DIRTNKLIQHYKVHNA--GVNCFSF--HPSGN 241
Cdd:pfam20426  33 SVKMWLTTQLQ-------SGGNFTF-----------SGSQDPFFGIGsDVLSPRKIGSPLAENVelGAQCFATlqTPSEN 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 302425181  242 YLIS-GSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKT 299
Cdd:pfam20426  95 FLIScGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 17-164 1.56e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.99  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   17 HKDVISCADFNPNNKQLATGSCDKSLMIW------NLAPKARAFRF-----------------VGHTDVITGVNFAPSGS 73
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWevlrgrSSEKRSRNTQTefprkdhviaetpfhilCGHDDIITCLYVSVELD 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181   74 LVASSSRDQTVrlwtpsikgestVFkaHTAS----VRSVHF-----------SRDGQRLVTASDDKSVKvwgverkkfLY 138
Cdd:pfam20426 203 IVISGSKDGTC------------IF--HTLRegryVRSIRHpsgcplsklvaSRHGRIVLYADDDLSLH---------LY 259

                         170       180       190
                  ....*....|....*....|....*....|.
gi 302425181  139 SLN-RHTNWVRCarfspDGRL----IASCGD 164
Cdd:pfam20426 260 SINgKHIASSES-----NGRLncieLSSCGE 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-214 2.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.11e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 302425181   175 SHQCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWD 214
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 21-129 3.24e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  21 ISCADF-NPNNKQLATGSCDKSLMIWNLA-PKARAFRFVGHTDVITGVNFAPSGSLVaSSSRDQTVRLW--TPSIKG--E 94
Cdd:PLN00181 620 ICCVQFpSESGRSLAFGSADHKVYYYDLRnPKLPLCTMIGHSKTVSYVRFVDSSTLV-SSSTDNTLKLWdlSMSISGinE 698

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 302425181  95 STV--FKAHTASVRSVHFSRDGQRLVTASDDKSVKVW 129
Cdd:PLN00181 699 TPLhsFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 133-309 3.78e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 133 RKKFLYSLNRHTNWVRCARFSP-DGRLIASCGDDRTVRLWDTSSH----------QCIniFTDYGGSATFVDFNSSGTCI 201
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYI 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 202 -ASSGADNTIKIWDIRTNK----LIQHYKvhnagVNCFSFHPSGNYLISGSSDSTIKILDLLEGRLIYTLHGHKGPVLTV 276
Cdd:PTZ00420 141 mCSSGFDSFVNIWDIENEKrafqINMPKK-----LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTK 215

                        170       180       190
                 ....*....|....*....|....*....|...
gi 302425181 277 TFSRDGdlfaSGGADSQVLmwKTNFDSLNYREL 309
Cdd:PTZ00420 216 NIWIDG----LGGDDNYIL--STGFSKNNMREM 242
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 211-279 1.24e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302425181  211 KIWDIRTNKliqhykvHNAGVNCFSFHPSGNYLISGSSDSTIKILDLLEGRLIYTLHGHKGPVLTVTFS 279
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
177-214 2.00e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302425181  177 QCINIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWD 214
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 262-307 2.23e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 302425181 262 LIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTNFDSLNYR 307
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT 46
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
180-294 3.83e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 180 NIFTDYGGSATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVhNAGVNCFSFHPSGNYL-ISGSSDSTIKILDLL 258
Cdd:COG3391   62 LGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPV-GGGPRGLAVDPDGGRLyVADSGNGRVSVIDTA 140

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 302425181 259 EGRLIYTLHGHKGPVlTVTFSRDGD-LFASGGADSQV 294
Cdd:COG3391  141 TGKVVATIPVGAGPH-GIAVDPDGKrLYVANSGSNTV 176
PTZ00420 PTZ00420
coronin; Provisional
 58-216 5.26e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 5.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  58 GHTDVITGVNFAPSGS-LVASSSRDQTVRLW--------TPSIKGESTVFKAHTASVRSVHFSRDGQRLVTASD-DKSVK 127
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSeILASGSEDLTIRVWeiphndesVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181 128 VWGVERKKFLYSLNRHTNwVRCARFSPDGRLIASCGDDRTVRLWDTSSHQCINIFTDY-GGSAT---FVD-FNSSGTCIA 202
Cdd:PTZ00420 152 IWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHdGGKNTkniWIDgLGGDDNYIL 230

                        170
                 ....*....|....*...
gi 302425181 203 SSGADNT----IKIWDIR 216
Cdd:PTZ00420 231 STGFSKNnmreMKLWDLK 248
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 150-233 2.72e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  150 ARFSPDGRLIASCGDDRTVRLWDTSSHQCINIFTDYGGS-ATFVDFNSSGTCIASSGADNTIKIWDIRTNKLIQHYKVHN 228
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLeVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80


                  ....*
gi 302425181  229 AGVNC 233
Cdd:pfam12894  81 DLITC 85
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 127-196 7.36e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 7.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302425181  127 KVWGVerkkflySLNRHTNWVRCARFSPDGRLIASCGDDRTVRLWDTSSHQCINIFTDYGGSATFVDFNS 196
Cdd:pfam12894  28 RVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGE 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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