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Conserved domains on  [gi|302393675|sp|Q5TCS8|]
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RecName: Full=Adenylate kinase 9; AltName: Full=Adenylate kinase domain-containing protein 1; AltName: Full=Adenylate kinase domain-containing protein 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 993-1161 8.22e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 8.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1072
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1149
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 302393675 1150 QVDDQDIFDRLL 1161
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1413-1535 6.88e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.38  E-value: 6.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 302393675 1493 aGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1535
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 33-276 1.27e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 91.53  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 112
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  113 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 191
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  192 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 271
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 302393675  272 PAEEL 276
Cdd:cd01428   190 DIDEV 194
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 930-985 7.76e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 302393675  930 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 985
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 993-1161 8.22e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 8.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1072
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1149
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 302393675 1150 QVDDQDIFDRLL 1161
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1413-1535 6.88e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.38  E-value: 6.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 302393675 1493 aGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1535
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 33-276 1.27e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.53  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 112
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  113 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 191
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  192 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 271
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 302393675  272 PAEEL 276
Cdd:cd01428   190 DIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1413-1535 1.34e-18

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 86.13  E-value: 1.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 302393675  1493 AGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1535
Cdd:TIGR01351   79 NGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 33-277 2.58e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.48  E-value: 2.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  107 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPevienh 184
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  185 rkkKKEAQKDGKGEEeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 262
Cdd:COG0563   145 ---KVEGVCDKCGGE--------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 302393675  263 yLIELNGNKPAEELF 277
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
35-180 5.49e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 5.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675    35 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 114
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302393675   115 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 180
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1413-1535 1.97e-16

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 80.17  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCnT 1492
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-A 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 302393675 1493 AGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1535
Cdd:COG0563    79 NGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
PLN02842 PLN02842
nucleotide kinase
 37-277 6.27e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 82.99  E-value: 6.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   37 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 116
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  117 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 196
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  197 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 273
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 302393675  274 EELF 277
Cdd:PLN02842  190 EVVF 193
AAA_17 pfam13207
AAA domain;
1417-1539 1.60e-15

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 74.97  E-value: 1.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1417 VGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCNTAGVV 1496
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AGEGGVI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 302393675  1497 IDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1539
Cdd:pfam13207   76 VDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 1413-1535 2.36e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 302393675 1493 aGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1535
Cdd:PRK00279   80 -GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 993-1161 4.89e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.07  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1072
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1148
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 302393675 1149 IQVDDQDIFDRLL 1161
Cdd:COG0563   113 LDVDDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 930-985 7.76e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 302393675  930 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 985
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 993-1161 1.21e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.16  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1072
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1073 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1151
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 302393675  1152 DDQDIFDRLL 1161
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 993-1161 8.67e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.29  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1072
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1145
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 302393675 1146 AVFIQVDDQDIFDRLL 1161
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
997-1161 1.06e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 49.93  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   997 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1075
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1076 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1149
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 302393675  1150 QVDDQDIFDRLL 1161
Cdd:pfam13207  109 EADPEEILERRL 120
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 935-983 6.33e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 6.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 302393675   935 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 983
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 993-1161 8.22e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 8.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1072
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1149
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 302393675 1150 QVDDQDIFDRLL 1161
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1413-1535 6.88e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.38  E-value: 6.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 302393675 1493 aGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1535
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 33-276 1.27e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.53  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 112
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  113 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 191
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  192 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 271
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 302393675  272 PAEEL 276
Cdd:cd01428   190 DIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1413-1535 1.34e-18

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 86.13  E-value: 1.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 302393675  1493 AGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1535
Cdd:TIGR01351   79 NGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 33-277 2.58e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.48  E-value: 2.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  107 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPevienh 184
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  185 rkkKKEAQKDGKGEEeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 262
Cdd:COG0563   145 ---KVEGVCDKCGGE--------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 302393675  263 yLIELNGNKPAEELF 277
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
35-180 5.49e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 5.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675    35 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 114
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302393675   115 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 180
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1413-1535 1.97e-16

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 80.17  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCnT 1492
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-A 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 302393675 1493 AGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1535
Cdd:COG0563    79 NGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
PLN02842 PLN02842
nucleotide kinase
 37-277 6.27e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 82.99  E-value: 6.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   37 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 116
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  117 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 196
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  197 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 273
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 302393675  274 EELF 277
Cdd:PLN02842  190 EVVF 193
AAA_17 pfam13207
AAA domain;
1417-1539 1.60e-15

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 74.97  E-value: 1.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1417 VGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCNTAGVV 1496
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AGEGGVI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 302393675  1497 IDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1539
Cdd:pfam13207   76 VDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 33-180 2.11e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:PRK00279    3 LILLGPPGAGKGTQAKFIAEKYG------IPhistgdMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302393675  107 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 180
Cdd:PRK00279   77 -CKNGFLLDGFPrTIPQaEALD-----EMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKV 146
adk PRK00279
adenylate kinase; Reviewed
 1413-1535 2.36e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 302393675 1493 aGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1535
Cdd:PRK00279   80 -GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 27-172 1.41e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 75.22  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   27 LSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:PTZ00088    3 LKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302393675  107 VCHF-GYIITEIPSlsqdamTTLQQIELIKNLNlkPDVIINIKCPDYDLCQRISGQRQHNNTGYIYS 172
Cdd:PTZ00088   83 DDCFkGFILDGFPR------NLKQCKELGKITN--IDLFVNIYLPRNILIKKLLGRRICNTCNRNFN 141
ADK pfam00406
Adenylate kinase;
1416-1535 3.15e-12

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 66.95  E-value: 3.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1416 IVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTaGV 1495
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKS--GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN-GF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 302393675  1496 VIDGYPVTKHQMNLLEA--RSIIPM-VIFELSVPSKEIFKRLL 1535
Cdd:pfam00406   78 LLDGFPRTVPQAEALEEllERGIKLdYVIEFDVPDEVLVERLT 120
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 993-1161 4.89e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.07  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1072
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1148
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 302393675 1149 IQVDDQDIFDRLL 1161
Cdd:COG0563   113 LDVDDEELVERLS 125
PRK14528 PRK14528
adenylate kinase; Provisional
 1413-1543 8.90e-12

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 65.80  E-value: 8.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:PRK14528    3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKN--QTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302393675 1493 aGVVIDGYPVTKHQMNLLEA------RSIIPMVifELSVPSKEIFKRLLLEKENEQR 1543
Cdd:PRK14528   81 -GFLLDGFPRTVEQADALDAllknegKSIDKAI--NLEVPDGELLKRLLGRAEIEGR 134
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1410-1535 1.79e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 64.84  E-value: 1.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1410 VPIrIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV 1489
Cdd:TIGR01360    3 CKI-IFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVAS--GSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAAL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 302393675  1490 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLL 1535
Cdd:TIGR01360   80 GTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLL 125
PRK14527 PRK14527
adenylate kinase; Provisional
 1409-1601 2.13e-11

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 64.81  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1409 TVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALR-YVLNNhpeTELALMLNWHLHKGMTAPDELAIQAL--ELSL 1485
Cdd:PRK14527    4 TKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRdHVARG---TELGQRAKPIMEAGDLVPDELILALIrdELAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1486 MESVcntaGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPyplHNSAQIVAVNNVk 1561
Cdd:PRK14527   81 MEPV----RVIFDGFPRTLAQAEaldrLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSD---DNEETVRRRQQV- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 302393675 1562 YRKNIGEIRQYYQEQHQnWYVIDGFHSKWWVWNEVIKNVQ 1601
Cdd:PRK14527  153 YREQTQPLVDYYEARGH-LKRVDGLGTPDEVYARILKALG 191
PRK14530 PRK14530
adenylate kinase; Provisional
 1413-1534 9.35e-10

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 60.57  E-value: 9.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALR---YVLNNHPETELALMLNWhLHKGMTAPDELAIQALElslmESV 1489
Cdd:PRK14530    5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankQMDISDMDTEYDTPGEY-MDAGELVPDAVVNEIVE----EAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 302393675 1490 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFeLSVPSKEIFKRL 1534
Cdd:PRK14530   80 SDADGFVLDGYPRNLEQAEYLESITDLDVVLY-LDVSEEELVDRL 123
PRK14528 PRK14528
adenylate kinase; Provisional
 34-197 1.49e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 59.25  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   34 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYI 113
Cdd:PRK14528    5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREAD-CKNGFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  114 ITEIPSLSQDAMTTlqqIELIKNLNLKPDVIINIKCPDYDLCQRISGQ-----RQHNNTGYIYSR-DQWDPE---VIENH 184
Cdd:PRK14528   84 LDGFPRTVEQADAL---DALLKNEGKSIDKAINLEVPDGELLKRLLGRaeiegRADDNEATIKNRlDNYNKKtlpLLDFY 160

                         170
                  ....*....|...
gi 302393675  185 RKKKKEAQKDGKG 197
Cdd:PRK14528  161 AAQKKLSQVNGVG 173
adk PRK02496
adenylate kinase; Provisional
 34-195 2.85e-09

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 58.61  E-value: 2.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   34 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 113
Cdd:PRK02496    5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN-GWI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  114 ITEIP-SLSQDAmtTLQqiELIKNLNLKPDVIINIKCPDYDLCQRISGQ-RQHNNTGYIYSR-----DQWDPeVIENHRK 186
Cdd:PRK02496   84 LDGFPrKVTQAA--FLD--ELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDTEEVIRRRlevyrEQTAP-LIDYYRD 158


                  ....*....
gi 302393675  187 KKKEAQKDG 195
Cdd:PRK02496  159 RQKLLTIDG 167
PRK14532 PRK14532
adenylate kinase; Provisional
 1414-1576 9.10e-09

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 57.14  E-value: 9.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1414 IIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHpeTELALMLNWHLHKGMTAPDELAIQALELSLMESVcNTA 1493
Cdd:PRK14532    3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASG--SELGQRVKGIMDRGELVSDEIVIALIEERLPEAE-AAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1494 GVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRlpyPLHNSAQIVaVNNVKYRKNIGEI 1569
Cdd:PRK14532   80 GAIFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKRFEEQGR---PDDNPEVFV-TRLDAYNAQTAPL 155


                  ....*..
gi 302393675 1570 RQYYQEQ 1576
Cdd:PRK14532  156 LPYYAGQ 162
PLN02200 PLN02200
adenylate kinase family protein
 1406-1544 1.75e-08

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 57.21  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1406 PKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPEtELALMLNwHLHKGMTAPDELAIQALELSl 1485
Cdd:PLN02200   38 SKEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSE-HGAMILN-TIKEGKIVPSEVTVKLIQKE- 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302393675 1486 MESVCNTAgVVIDGYPVTKHqmNLLEARSII---PMVIFELSVPSKEIFKRLLleKENEQRL 1544
Cdd:PLN02200  115 MESSDNNK-FLIDGFPRTEE--NRIAFERIIgaePNVVLFFDCPEEEMVKRVL--NRNQGRV 171
adk PRK02496
adenylate kinase; Provisional
 1412-1585 2.07e-08

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 55.91  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1412 IRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESvcN 1491
Cdd:PRK02496    2 TRLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKE--QTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQP--D 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1492 TA-GVVIDGYPVTKHQMNLLEA----------RSIipmvifELSVPSKEIFKRLLL---EKENEQrlpyPLHNSAQIvav 1557
Cdd:PRK02496   78 AAnGWILDGFPRKVTQAAFLDEllqeigqsgeRVV------NLDVPDDVVVERLLArgrKDDTEE----VIRRRLEV--- 144

                         170       180
                  ....*....|....*....|....*...
gi 302393675 1558 nnvkYRKNIGEIRQYYQEQHQnWYVIDG 1585
Cdd:PRK02496  145 ----YREQTAPLIDYYRDRQK-LLTIDG 167
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 930-985 7.76e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 302393675  930 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 985
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 993-1161 1.21e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.16  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1072
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1073 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1151
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 302393675  1152 DDQDIFDRLL 1161
Cdd:TIGR01351  113 PDEELVERLS 122
PLN02842 PLN02842
nucleotide kinase
 1415-1533 3.12e-07

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 55.25  E-value: 3.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1415 IIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAG 1494
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSA--GTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKG 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 302393675 1495 VVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKR 1533
Cdd:PLN02842   79 WLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDR 117
adk PRK02496
adenylate kinase; Provisional
 993-1161 8.67e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.29  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1072
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1073 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1145
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 302393675 1146 AVFIQVDDQDIFDRLL 1161
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
PLN02674 PLN02674
adenylate kinase
 1413-1511 1.01e-06

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 52.20  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:PLN02674   33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVA--AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQK 110

                          90
                  ....*....|....*....
gi 302393675 1493 aGVVIDGYPVTKHQMNLLE 1511
Cdd:PLN02674  111 -GFILDGFPRTVVQAQKLD 128
AAA_17 pfam13207
AAA domain;
997-1161 1.06e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 49.93  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   997 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1075
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1076 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1149
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 302393675  1150 QVDDQDIFDRLL 1161
Cdd:pfam13207  109 EADPEEILERRL 120
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1411-1535 1.49e-06

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 51.34  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1411 PIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV- 1489
Cdd:PTZ00088    6 PLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKA--KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTd 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 302393675 1490 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIfELSVPSKEIFKRLL 1535
Cdd:PTZ00088   84 DCFKGFILDGFPRNLKQCKELGKITNIDLFV-NIYLPRNILIKKLL 128
PRK14531 PRK14531
adenylate kinase; Provisional
 1413-1535 1.54e-06

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 50.58  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGmtapdELAIQALELSLMES---V 1489
Cdd:PRK14531    4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVA--AGSALGQEAEAVMNRG-----ELVSDALVLAIVESqlkA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 302393675 1490 CNTAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSvpSKEIFKRLL 1535
Cdd:PRK14531   77 LNSGGWLLDGFPRTVAQAEALEPlleelkQPIEAVVLLELD--DAVLIERLL 126
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1414-1447 5.45e-06

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 48.57  E-value: 5.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 302393675  1414 IIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALR 1447
Cdd:TIGR02173    3 ITISGPPGSGKTTVAKILAEKLSLKLISAGDIFR 36
ADK pfam00406
Adenylate kinase;
996-1161 7.56e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 48.46  E-value: 7.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   996 LVGPQGSGK-TMCGRqLAEKLNIFHIQFEEVLQEklllktekkvgpefeedsenEQAAKQELEELAiqanvkveeentKK 1074
Cdd:pfam00406    1 LLGPPGAGKgTQAEK-IVQKYGLPHLSTGDLLRA--------------------EIKSGTELGKEA------------KE 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1075 QLPEVQLTEEEEVIKssLMENEplppeilevilsewwLKEPIRSTGFILDGFPRYPEEAQFLGD---RGFFPDAAVFIQV 1151
Cdd:pfam00406   48 YMDKGELVPDEVVVG--LVKER---------------LEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFDV 110

                          170
                   ....*....|
gi 302393675  1152 DDQDIFDRLL 1161
Cdd:pfam00406  111 PDEVLVERLT 120
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1414-1543 7.78e-06

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 48.52  E-value: 7.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1414 IIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNwHLHKGMTAPDELAIQALElSLMESVCNTA 1493
Cdd:TIGR01359    2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIES-YIKEGKIVPSEVTVELLK-KAIQEDGSSK 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 302393675  1494 GVVIDGYPvtKHQMNL-----LEARSIIPMVIFELSVPSKEIFKRLLLEKENEQR 1543
Cdd:TIGR01359   80 KFLIDGFP--RNEENLeawekLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGR 132
PRK04182 PRK04182
cytidylate kinase; Provisional
 1413-1443 1.74e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 47.11  E-value: 1.74e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIG 1443
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAG 32
adk PRK00279
adenylate kinase; Reviewed
 992-1161 2.20e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.45  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  992 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqaakqeleelaiqANVKVEEEN 1071
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR-----------------------------------AAVKAGTEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1072 TKKqlpevqlteeeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQ----FLGDRGFFPDAAV 1147
Cdd:PRK00279   46 GKE-------------AKSYMDAGELVPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVI 111

                         170
                  ....*....|....
gi 302393675 1148 FIQVDDQDIFDRLL 1161
Cdd:PRK00279  112 EIDVPDEELVERLS 125
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 1413-1444 6.70e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 44.78  E-value: 6.70e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGG 1444
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGG 32
PLN02200 PLN02200
adenylate kinase family protein
 30-163 7.77e-05

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 46.04  E-value: 7.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   30 PVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCH 109
Cdd:PLN02200   43 PFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 302393675  110 FgyIITEIPSlsqdamTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQ 163
Cdd:PLN02200  123 F--LIDGFPR------TEENRIAFERIIGAEPNVVLFFDCPEEEMVKRVLNRNQ 168
PRK14526 PRK14526
adenylate kinase; Provisional
 1412-1511 1.17e-04

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 45.23  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1412 IRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALElSLMESVCN 1491
Cdd:PRK14526    1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILN--STPLGKEIKQIVENGQLVPDSITIKIVE-DKINTIKN 77

                          90       100
                  ....*....|....*....|
gi 302393675 1492 TAGVVIDGYPVTKHQMNLLE 1511
Cdd:PRK14526   78 NDNFILDGFPRNINQAKALD 97
PRK13808 PRK13808
adenylate kinase; Provisional
 1412-1512 1.43e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 46.03  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1412 IRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALElSLMESVCN 1491
Cdd:PRK13808    1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVA--AGTPVGLKAKDIMASGGLVPDEVVVGIIS-DRIEQPDA 77

                          90       100
                  ....*....|....*....|.
gi 302393675 1492 TAGVVIDGYPVTKHQMNLLEA 1512
Cdd:PRK13808   78 ANGFILDGFPRTVPQAEALDA 98
PRK13808 PRK13808
adenylate kinase; Provisional
 34-158 1.88e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 45.65  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   34 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 113
Cdd:PRK13808    4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-GFI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 302393675  114 ITEIPSlsqdamtTLQQIE----LIKNLNLKPDVIINIKCPDYDLCQRI 158
Cdd:PRK13808   83 LDGFPR-------TVPQAEaldaLLKDKQLKLDAVVELRVNEGALLARV 124
AAA_18 pfam13238
AAA domain;
994-1067 4.11e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.03  E-value: 4.11e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302393675   994 ICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKV 1067
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN 74
PLN02459 PLN02459
probable adenylate kinase
 1415-1520 5.36e-04

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 44.07  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675 1415 IIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCN-TA 1493
Cdd:PLN02459   33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKS--SGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgES 110

                          90       100
                  ....*....|....*....|....*..
gi 302393675 1494 GVVIDGYPVTKHQMNLLEARSIIPMVI 1520
Cdd:PLN02459  111 GFILDGFPRTVRQAEILEGVTDIDLVV 137
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 968-1038 6.21e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.52  E-value: 6.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302393675  968 EAKEKFLEHPEDYVAHEEPlkaPPLRICLVGPQGSGKTMCGRQLAEKL--NIFHIQFEEVLQeKLLLKTEKKV 1038
Cdd:COG0464   171 ELVALPLKRPELREEYGLP---PPRGLLLYGPPGTGKTLLARALAGELglPLIEVDLSDLVS-KYVGETEKNL 239
AAA_17 pfam13207
AAA domain;
36-157 6.69e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.84  E-value: 6.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675    36 FGKPGVGKTTLARYITQAWKcirveaLPILE--EQIAAETESG--VMLQSMLISGQSIPDELVIKLMLEKLNSpEVCHFG 111
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLG------FPHISagDLLREEAKERglVEDRDEMRKLPLEPQKELQKLAAERIAE-EAGEGG 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 302393675   112 YIITEIPS-LSQDAMTTLQQIELIKnlNLKPDVIINIKCPDYDLCQR 157
Cdd:pfam13207   74 VIVDGHPRiKTPAGYLPGLPVEVLR--ELKPDAIILLEADPEEILER 118
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 990-1044 8.06e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 8.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302393675  990 PPLRICLVGPQGSGKTMCGRQLAEKLNI--FHIQFEEvLQEKLLLKTEKKVGPEFEE 1044
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLplIVVKLSS-LLSKYVGESEKNLRKIFER 80
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 1387-1445 1.41e-03

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 41.45  E-value: 1.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302393675 1387 KETKE--KFMKNPIKYiRQPKPKPtvPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGA 1445
Cdd:cd19501    14 EELKEvvEFLKNPEKF-TKLGAKI--PKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGS 71
THEP1 COG1618
Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];
1413-1444 2.02e-03

Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];


Pssm-ID: 441225 [Multi-domain]  Cd Length: 175  Bit Score: 41.04  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGG 1444
Cdd:COG1618     2 KIFITGRPGVGKTTLLLKVVEELRDEGLRVGG 33
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
966-1030 2.43e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 41.79  E-value: 2.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  966 SAEAKEKFLEHPEDYVAHEEPLK---APPLRICLVGPQGSGKTMCGRQLAEKLN--IFHIQFEEVLQEKL 1030
Cdd:COG1223     7 QEEAKKKLKLIIKELRRRENLRKfglWPPRKILFYGPPGTGKTMLAEALAGELKlpLLTVRLDSLIGSYL 76
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
992-1110 3.43e-03

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 42.20  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  992 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllKTEKKVGPEFEEDSEN--EQAAKQELEELAIQANVKV-- 1067
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIER----REGRSVRRIFEEDGEEyfRLKEKELLRELVERDNVVVat 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 302393675 1068 --------EEENTKKQLPEVQLTEEEEVIKSSL-MENEPLPPEILEVILSEW 1110
Cdd:PRK13951   77 gggvvidpENRELLKKEKTLFLYAPPEVLMERVtTENRPLLREGKERIREIW 128
AAA_18 pfam13238
AAA domain;
1414-1541 4.86e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 38.95  E-value: 4.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675  1414 IIIVGPPKSGKTTVAKKItseygLKHLSIGGALR-YVLNNHPETElalmlNWHLHKGMTAPDELAIQALELSLMESVCNT 1492
Cdd:pfam13238    1 ILITGTPGVGKTTLAKEL-----SKRLGFGDNVRdLALENGLVLG-----DDPETRESKRLDEDKLDRLLDLLEENAALE 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 302393675  1493 AG--VVIDGypvtkhQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEKENE 1541
Cdd:pfam13238   71 EGgnLIIDG------HLAELEPERAKDLVGIVLRASPEELLERLEKRGYEE 115
rho_factor_C cd01128
C-terminal ATP binding domain of transcription termination factor rho; Transcription ...
 1413-1462 5.84e-03

C-terminal ATP binding domain of transcription termination factor rho; Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal oligonucleotide/oligosaccharide binding fold (OB-fold) domain which binds cysteine-rich nucleotides, and a C-terminal ATP binding domain. This alignment is of the C-terminal ATP binding domain.


Pssm-ID: 410872 [Multi-domain]  Cd Length: 249  Bit Score: 40.65  E-value: 5.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 302393675 1413 RIIIVGPPKSGKTTVAKKITseyglkhlsiggalRYVLNNHPETELALML 1462
Cdd:cd01128    18 RGLIVAPPKAGKTTLLQNIA--------------NAIAKNHPEVELIVLL 53
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 935-983 6.33e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 6.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 302393675   935 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 983
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
PRK14526 PRK14526
adenylate kinase; Provisional
 33-172 7.81e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 39.83  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393675   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVcHFGY 112
Cdd:PRK14526    3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDNF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302393675  113 IITEIPSlsqdamTTLQQIELIKNL-NLKpdvIINIKCPDYDLCQRISGQRQHNNTGYIYS 172
Cdd:PRK14526   82 ILDGFPR------NINQAKALDKFLpNIK---IINFLIDEELLIKRLSGRRICKSCNNIFN 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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