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Conserved domains on  [gi|302148741]
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Chain M, Staphylococcal complement inhibitor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CompInhib_SCIN super family cl13061
Staphylococcal complement inhibitor SCIN; SCIN is released by Staphylococcus aureus to ...
 3-86 7.53e-33

Staphylococcal complement inhibitor SCIN; SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.


The actual alignment was detected with superfamily member pfam11546:

Pssm-ID: 371594  Cd Length: 114  Bit Score: 109.68  E-value: 7.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302148741    3 SSTSLPTSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDE 82
Cdd:pfam11546  31 ASSLDKTSHTYQHQALADELHELLANTNVNKLAYGSLNAYYKRTILAAHYIAKSALKTKDFDQMTKAKQRLEKIYNEIDE 110


                  ....
gi 302148741   83 ALKS 86
Cdd:pfam11546 111 PLHS 114
 
Name Accession Description Interval E-value
CompInhib_SCIN pfam11546
Staphylococcal complement inhibitor SCIN; SCIN is released by Staphylococcus aureus to ...
 3-86 7.53e-33

Staphylococcal complement inhibitor SCIN; SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.


Pssm-ID: 371594  Cd Length: 114  Bit Score: 109.68  E-value: 7.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302148741    3 SSTSLPTSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDE 82
Cdd:pfam11546  31 ASSLDKTSHTYQHQALADELHELLANTNVNKLAYGSLNAYYKRTILAAHYIAKSALKTKDFDQMTKAKQRLEKIYNEIDE 110


                  ....
gi 302148741   83 ALKS 86
Cdd:pfam11546 111 PLHS 114
 
Name Accession Description Interval E-value
CompInhib_SCIN pfam11546
Staphylococcal complement inhibitor SCIN; SCIN is released by Staphylococcus aureus to ...
 3-86 7.53e-33

Staphylococcal complement inhibitor SCIN; SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.


Pssm-ID: 371594  Cd Length: 114  Bit Score: 109.68  E-value: 7.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302148741    3 SSTSLPTSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDE 82
Cdd:pfam11546  31 ASSLDKTSHTYQHQALADELHELLANTNVNKLAYGSLNAYYKRTILAAHYIAKSALKTKDFDQMTKAKQRLEKIYNEIDE 110


                  ....
gi 302148741   83 ALKS 86
Cdd:pfam11546 111 PLHS 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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