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Conserved domains on  [gi|301617401|ref|XP_002938131|]
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phosphatidylethanolamine-binding protein 1 [Xenopus tropicalis]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 24-170 3.91e-56

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 174.10  E-value: 3.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  24 PLKVAFGSVCVEELGQVLTPTQVQHCPNIEWESMDS-SKLYTVIFTDPDVPSRKECHLGEWHHFLAVNVKGNDL-----S 97
Cdd:cd00866    2 DLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEDPpDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDTttglvS 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301617401  98 SGCILTAYVGSGPGKGTGLHRYTILVYEQAGRVQCTERILGNTSAEHRGKFKASEFRKKYKLAAPIAGTCFQA 170
Cdd:cd00866   82 KGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 24-170 3.91e-56

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 174.10  E-value: 3.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  24 PLKVAFGSVCVEELGQVLTPTQVQHCPNIEWESMDS-SKLYTVIFTDPDVPSRKECHLGEWHHFLAVNVKGNDL-----S 97
Cdd:cd00866    2 DLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEDPpDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDTttglvS 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301617401  98 SGCILTAYVGSGPGKGTGLHRYTILVYEQAGRVQCTERILGNTSAEHRGKFKASEFRKKYKLAAPIAGTCFQA 170
Cdd:cd00866   82 KGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PBP pfam01161
Phosphatidylethanolamine-binding protein;
50-166 3.25e-13

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 63.51  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401   50 PNIEWESMDS-SKLYTVIFTDPDVPSRKEchlGEWHHFLAVNVKGNDLS------SGCI-------LTAYVGSGPGKGTG 115
Cdd:pfam01161  15 PPLAWSGAPAgTKSFALVMIDPDAPKVGG---SGWLHWVVTNIPATVTElpegapAGAVqglndfgGAGYGGPCPPAGDG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 301617401  116 LHRYTILVYeqAGRVQCTERILGNTSAEHRGKFkasefrKKYKLA-APIAGT 166
Cdd:pfam01161  92 PHRYVFTLY--ALDVPLLDRNWGFTKAELGVAF------AGHVLAlAVLAGN 135
PLN00169 PLN00169
CETS family protein; Provisional
 25-168 7.62e-13

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 63.29  E-value: 7.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  25 LKVAFGSVCVEElGQVLTPTQVQHCPNIEWESMDSSKLYTVIFTDPDVPSRKECHLGEWHHFLAVNVKGNDLSS-GCILT 103
Cdd:PLN00169  28 LRVTYGSREVNN-GCELKPSQVVNQPRVDIGGEDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATTGATfGQEVV 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301617401 104 AYvgSGPGKGTGLHRYTILVYEQAGRVQCterilgnTSAEHRGKFKASEFRKKYKLAAPIAGTCF 168
Cdd:PLN00169 107 CY--ESPRPTAGIHRFVFVLFRQLGRQTV-------YAPGWRQNFNTRDFAELYNLGSPVAAVYF 162
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 24-170 3.91e-56

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 174.10  E-value: 3.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  24 PLKVAFGSVCVEELGQVLTPTQVQHCPNIEWESMDS-SKLYTVIFTDPDVPSRKECHLGEWHHFLAVNVKGNDL-----S 97
Cdd:cd00866    2 DLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEDPpDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDTttglvS 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301617401  98 SGCILTAYVGSGPGKGTGLHRYTILVYEQAGRVQCTERILGNTSAEHRGKFKASEFRKKYKLAAPIAGTCFQA 170
Cdd:cd00866   82 KGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 34-170 4.66e-20

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 82.06  E-value: 4.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  34 VEELGQVLTP----TQVQHCPNIEWESMDSS-KLYTVIFTDPDVPsrkecHLGEWHHFLAVNVKGNDLS----------- 97
Cdd:cd00457    7 VGPSGSVLPPeysfEGVGRFPSLSWDGPPPDvKEYVLVMEDPDAP-----LGRPIVHGLVYGIPANKTSlsnddfvvtdn 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  98 -SGCI-----------LTAYVGSGPGKGTGLHRYTILVYEQAGRVQCTErilgntSAEHRGKFKASEFRKKYKLaAPIAG 165
Cdd:cd00457   82 gKGGLqggfkygknrgGTVYIGPRPPLGHGPHRYFFQVYALDEPLDRSK------LGDGRTKFEVARFAEGNVL-GAVGE 154


                 ....*
gi 301617401 166 TCFQA 170
Cdd:cd00457  155 WVGQF 159
PBP pfam01161
Phosphatidylethanolamine-binding protein;
50-166 3.25e-13

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 63.51  E-value: 3.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401   50 PNIEWESMDS-SKLYTVIFTDPDVPSRKEchlGEWHHFLAVNVKGNDLS------SGCI-------LTAYVGSGPGKGTG 115
Cdd:pfam01161  15 PPLAWSGAPAgTKSFALVMIDPDAPKVGG---SGWLHWVVTNIPATVTElpegapAGAVqglndfgGAGYGGPCPPAGDG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 301617401  116 LHRYTILVYeqAGRVQCTERILGNTSAEHRGKFkasefrKKYKLA-APIAGT 166
Cdd:pfam01161  92 PHRYVFTLY--ALDVPLLDRNWGFTKAELGVAF------AGHVLAlAVLAGN 135
PLN00169 PLN00169
CETS family protein; Provisional
 25-168 7.62e-13

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 63.29  E-value: 7.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301617401  25 LKVAFGSVCVEElGQVLTPTQVQHCPNIEWESMDSSKLYTVIFTDPDVPSRKECHLGEWHHFLAVNVKGNDLSS-GCILT 103
Cdd:PLN00169  28 LRVTYGSREVNN-GCELKPSQVVNQPRVDIGGEDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATTGATfGQEVV 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301617401 104 AYvgSGPGKGTGLHRYTILVYEQAGRVQCterilgnTSAEHRGKFKASEFRKKYKLAAPIAGTCF 168
Cdd:PLN00169 107 CY--ESPRPTAGIHRFVFVLFRQLGRQTV-------YAPGWRQNFNTRDFAELYNLGSPVAAVYF 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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