F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 301614681   4 HLLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKIAK 50
Cdd:cd20090    1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIAR 47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 134 AVFLDHREDV--CRFVLNNSHIISGGGDGRIAIHKVHSAFSIH-FTAHDQDVNCVDC--HRGIIVSGSRDRTAKVWSLtp 208
Cdd:cd00200    3 RTLKGHTGGVtcVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 209 sRDGHCLHTIQT-DDRVWSVAINP----ILSSFITGTaccghtspLRIWDLQSGALMTCLGTdfkRGAGVLDVRY-ETPY 282
Cdd:cd00200   81 -ETGECVRTLTGhTSYVSSVAFSPdgriLSSSSRDKT--------IKVWDVETGKCLTTLRG---HTDWVNSVAFsPDGT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 283 TLLSCGYDTFIRYWDLRTStrRCVKEWEEpHDSALYCMQ--SDGNHMIASGSAyyGVVRLWDKRMNQCLHsfsLSSPTSS 360
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTG--KCVATLTG-HTGEVNSVAfsPDGEKLLSSSSD--GTIKLWDLSTGKCLG---TLRGHEN 220

                        250
                 ....*....|....*....
gi 301614681 361 PVYCLQFNTRHLYAALASA 379
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSE 239

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 301614681    5 LLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKI 48
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44

WD domain, G-beta repeat;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 301614681  175 FTAHDQDVNCVDCHRG--IIVSGSRDRTAKVWS 205
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDgkLLASGSDDGTVKVWD 39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 134 AVFLDHREDV--CRFVLNNSHIISGGGDGRIAIHKVHSAFSIH-FTAHDQDVNCVDC--HRGIIVSGSRDRTAKVWSLtp 208
Cdd:cd00200    3 RTLKGHTGGVtcVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 209 sRDGHCLHTIQT-DDRVWSVAINP----ILSSFITGTaccghtspLRIWDLQSGALMTCLGTdfkRGAGVLDVRY-ETPY 282
Cdd:cd00200   81 -ETGECVRTLTGhTSYVSSVAFSPdgriLSSSSRDKT--------IKVWDVETGKCLTTLRG---HTDWVNSVAFsPDGT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 283 TLLSCGYDTFIRYWDLRTStrRCVKEWEEpHDSALYCMQ--SDGNHMIASGSAyyGVVRLWDKRMNQCLHsfsLSSPTSS 360
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTG--KCVATLTG-HTGEVNSVAfsPDGEKLLSSSSD--GTIKLWDLSTGKCLG---TLRGHEN 220

                        250
                 ....*....|....*....
gi 301614681 361 PVYCLQFNTRHLYAALASA 379
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSE 239

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 301614681   4 HLLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKIAK 50
Cdd:cd20090    1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIAR 47

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 130 RQPFAVFLDHREDV--CRFVLNNSHIISGGGDGRIAIHKVHSAFSIH-FTAHDQDVNCVDCHRG--IIVSGSRDRTAKVW 204
Cdd:COG2319  236 GKLLRTLTGHSGSVrsVAFSPDGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLW 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301614681 205 SLtpsRDGHCLHTIQ-TDDRVWSVAINPILSSFITGTAccGHTspLRIWDLQSGalmTCLGTDFKRGAGVLDVRYeTPY- 282
Cdd:COG2319  316 DL---ATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSD--DGT--VRLWDLATG---ELLRTLTGHTGAVTSVAF-SPDg 384

                        170
                 ....*....|....*....
gi 301614681 283 -TLLSCGYDTFIRYWDLRT 300
Cdd:COG2319  385 rTLASGSADGTVRLWDLAT 403

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 301614681    5 LLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKI 48
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 301614681   5 LLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRK 47
Cdd:cd22102    1 ILDLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQR 43

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 301614681   5 LLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKI 48
Cdd:cd22139    1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 301614681   6 LHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTS 40
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 301614681   8 LPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKI 48
Cdd:cd22093    4 LPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 301614681   8 LPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKI 48
Cdd:cd22117    4 LPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKEL 44

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 301614681   4 HLLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKIAK 50
Cdd:cd22098    1 SLLDLPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWRRLCR 47

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20
                 ....*....|....*....|....*..
gi 301614681   8 LPEEILLLLFSYLDTQALGRLAQVCRK 34
Cdd:cd22115    7 LPKELLLRIFSFLDVVTLCRCAQVSKY 33

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 301614681  11 EILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWR 46
Cdd:cd22125    6 EILAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVWR 41

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 301614681   4 HLLHLPEEILLLLFSY----LDTQALGRLAQVCRKLQHFTSKDAVWRKI 48
Cdd:cd22089    2 HISALPSEILLYILRWvvsdLDLRSLEQLSLVCRKFYLLARDPSIWRLA 50

F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 301614681   5 LLHLPEEILLLLFSYLDTQALGRLAQVCRKLQhftskdavwrKIAKKCLNSGFVQ 59
Cdd:cd22100    1 LLELPDEIIEKILSYLSYDEISKLRLVCRRFN----------EVCQRILNQGFKK 45

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 301614681   8 LPEEILLLLFSYLDTQALGRLAQVCRKLQHFTS-KDAVWRK 47
Cdd:cd22113    4 LPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIEnSDYLWRP 44

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 301614681   7 HLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRkiaKKCLNSGF 57
Cdd:cd22173    5 VLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWM---PKCVKFGW 52

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 301614681   7 HLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVW 45
Cdd:cd22124    3 LLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 301614681   8 LPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWR 46
Cdd:cd22123    4 LPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 301614681   7 HLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRK 47
Cdd:cd22149    3 RLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 301614681   175 FTAHDQDVNCVDCH--RGIIVSGSRDRTAKVWS 205
Cdd:smart00320   8 LKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 301614681   5 LLHLPEEILLLLFSY--LDTQALGRLAQVCRKLQHFTSKDAVWRKIAK 50
Cdd:cd22096    1 LLELPDELLEYILCSdnLDHHDIIRLSCTCRRLREVCQSGKVWREKFF 48

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 301614681   5 LLHLPEEILLLLFSYLDTQALGRLAQVCRKlqhftskdavWRKIAKKC 52
Cdd:cd22131    3 LKLLPLELSFYLLSFLDPESLLTCCLVSKQ----------WNKVISSC 40